Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain
Horowitz, Alana M, Fan, Xuelai, Bieri, Gregor, Smith, Lucas K, Sanchez-Diaz, Cesar I, Schroer, Adam B, Gontier, Geraldine, Casaletto, Kaitlin B, Kramer, Joel H, Williams, Katherine E, Villeda, Saul A
Published in Science (American Association for the Advancement of Science) (10.07.2020)
Published in Science (American Association for the Advancement of Science) (10.07.2020)
Get full text
Journal Article
Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain
Gontier, Geraldine, Iyer, Manasi, Shea, Jeremy M., Bieri, Gregor, Wheatley, Elizabeth G., Ramalho-Santos, Miguel, Villeda, Saul A.
Published in Cell reports (Cambridge) (20.02.2018)
Published in Cell reports (Cambridge) (20.02.2018)
Get full text
Journal Article
Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation
White, Charles W., Fan, Xuelai, Maynard, Jason C., Wheatley, Elizabeth G., Bieri, Gregor, Couthouis, Julien, Burlingame, Alma L., Villeda, Saul A.
Published in Proceedings of the National Academy of Sciences - PNAS (08.09.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (08.09.2020)
Get full text
Journal Article
Preclinical Assessment of Young Blood Plasma for Alzheimer Disease
Middeldorp, Jinte, Lehallier, Benoit, Villeda, Saul A, Miedema, Suzanne S M, Evans, Emily, Czirr, Eva, Zhang, Hui, Luo, Jian, Stan, Trisha, Mosher, Kira I, Masliah, Eliezer, Wyss-Coray, Tony
Published in JAMA neurology (01.11.2016)
Published in JAMA neurology (01.11.2016)
Get more information
Journal Article
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions
Ho, Theodore T, Dellorusso, Paul V, Verovskaya, Evgenia V, Bakker, Sietske T, Flach, Johanna, Smith, Lucas K, Ventura, Patrick B, Lansinger, Olivia M, Hérault, Aurélie, Zhang, Si Yi, Kang, Yoon-A, Mitchell, Carl A, Villeda, Saul A, Passegué, Emmanuelle
Published in The Journal of experimental medicine (05.07.2021)
Published in The Journal of experimental medicine (05.07.2021)
Get full text
Journal Article
Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice
Leiter, Odette, Brici, David, Fletcher, Stephen J., Yong, Xuan Ling Hilary, Widagdo, Jocelyn, Matigian, Nicholas, Schroer, Adam B., Bieri, Gregor, Blackmore, Daniel G., Bartlett, Perry F., Anggono, Victor, Villeda, Saul A., Walker, Tara L.
Published in Nature communications (16.08.2023)
Published in Nature communications (16.08.2023)
Get full text
Journal Article
Neuronal activation of Gαq EGL-30/GNAQ late in life rejuvenates cognition across species
Stevenson, Morgan E., Bieri, Gregor, Kaletsky, Rachel, St. Ange, Jonathan, Remesal, L., Pratt, Karishma J.B., Zhou, Shiyi, Weng, Yifei, Murphy, Coleen T., Villeda, Saul A.
Published in Cell reports (Cambridge) (26.09.2023)
Published in Cell reports (Cambridge) (26.09.2023)
Get full text
Journal Article
The aged hematopoietic system promotes hippocampal‐dependent cognitive decline
Smith, Lucas K., Verovskaya, Evgenia, Bieri, Gregor, Horowitz, Alana M., von Ungern‐Sternberg, Saskia N. I., Lin, Karin, Seizer, Peter, Passegué, Emmanuelle, Villeda, Saul A.
Published in Aging cell (01.08.2020)
Published in Aging cell (01.08.2020)
Get full text
Journal Article
Microglia communication: Parallels between aging and Alzheimer's disease
Udeochu, Joe C., Shea, Jeremy M., Villeda, Saul A.
Published in Clinical & experimental neuroimmunology (01.05.2016)
Published in Clinical & experimental neuroimmunology (01.05.2016)
Get full text
Journal Article
Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function
Pratt, Karishma J.B., Shea, Jeremy M., Remesal-Gomez, Laura, Bieri, Gregor, Smith, Lucas K., Couthouis, Julien, Chen, Christopher P., Roy, Irena J., Gontier, Geraldine, Villeda, Saul A.
Published in Cell reports (Cambridge) (28.02.2023)
Published in Cell reports (Cambridge) (28.02.2023)
Get full text
Journal Article
MHC class I H2-Kb negatively regulates neural progenitor cell proliferation by inhibiting FGFR signaling
Lin, Karin, Bieri, Gregor, Gontier, Geraldine, Müller, Sören, Smith, Lucas K, Snethlage, Cedric E, White, 3rd, Charles W, Maybury-Lewis, Sun Y, Villeda, Saul A
Published in PLoS biology (01.06.2021)
Published in PLoS biology (01.06.2021)
Get full text
Journal Article
Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration
Bieri, Gregor, Lucin, Kurt M, O'Brien, Caitlin E, Zhang, Hui, Villeda, Saul A, Wyss-Coray, Tony
Published in Molecular neurodegeneration (29.12.2018)
Published in Molecular neurodegeneration (29.12.2018)
Get full text
Journal Article
The platelet transcriptome and proteome in Alzheimer's disease and aging: an exploratory cross-sectional study
de Sousa, Diana M Bessa, Poupardin, Rodolphe, Villeda, Saul A, Schroer, Adam B, Fröhlich, Thomas, Frey, Vanessa, Staffen, Wolfgang, Mrowetz, Heike, Altendorfer, Barbara, Unger, Michael S, Iglseder, Bernhard, Paulweber, Bernhard, Trinka, Eugen, Cadamuro, Janne, Drerup, Martin, Schallmoser, Katharina, Aigner, Ludwig, Kniewallner, Kathrin M
Published in Frontiers in molecular biosciences (30.06.2023)
Published in Frontiers in molecular biosciences (30.06.2023)
Get full text
Journal Article
Mechanisms of Hippocampal Aging and the Potential for Rejuvenation
Fan, Xuelai, Wheatley, Elizabeth G, Villeda, Saul A
Published in Annual review of neuroscience (25.07.2017)
Published in Annual review of neuroscience (25.07.2017)
Get full text
Journal Article
Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming
Schneider, Christoph, Lee, Jinwoo, Koga, Satoshi, Ricardo-Gonzalez, Roberto R., Nussbaum, Jesse C., Smith, Lucas K., Villeda, Saul A., Liang, Hong-Erh, Locksley, Richard M.
Published in Immunity (Cambridge, Mass.) (18.06.2019)
Published in Immunity (Cambridge, Mass.) (18.06.2019)
Get full text
Journal Article