A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis
Maier, Marcel, Welt, Tobias, Wirth, Fabian, Montrasio, Fabio, Preisig, Daniel, McAfoose, Jordan, Vieira, Fernando G, Kulic, Luka, Späni, Claudia, Stehle, Thilo, Perrin, Steve, Weber, Markus, Hock, Christoph, Nitsch, Roger M, Grimm, Jan
Published in Science translational medicine (05.12.2018)
Published in Science translational medicine (05.12.2018)
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Journal Article
PERK modulation, with GSK2606414, Sephin1 or salubrinal, failed to produce therapeutic benefits in the SOD1G93A mouse model of ALS
Vieira, Fernando G, Tassinari, Valerie R, Kidd, Joshua D, Moreno, Andrew, Thompson, Kenneth, Perrin, Steven, Gill, Alan, Hatzipetros, Theo
Published in PloS one (15.02.2024)
Published in PloS one (15.02.2024)
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Journal Article
Reduced C9orf72 expression exacerbates polyGR toxicity in patient iPSC-derived motor neurons and a Type I protein arginine methyltransferase inhibitor reduces that toxicity
Dane, Therese L, Gill, Anna L, Vieira, Fernando G, Denton, Kyle R
Published in Frontiers in cellular neuroscience (17.04.2023)
Published in Frontiers in cellular neuroscience (17.04.2023)
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Hypothesis and Theory: Roles of Arginine Methylation in C9orf72-Mediated ALS and FTD
Gill, Anna L, Premasiri, Alan S, Vieira, Fernando G
Published in Frontiers in cellular neuroscience (23.03.2021)
Published in Frontiers in cellular neuroscience (23.03.2021)
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Journal Article
Type I PRMT Inhibition Protects Against C9ORF72 Arginine-Rich Dipeptide Repeat Toxicity
Premasiri, Alan S, Gill, Anna L, Vieira, Fernando G
Published in Frontiers in pharmacology (08.09.2020)
Published in Frontiers in pharmacology (08.09.2020)
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Journal Article
Guanabenz Treatment Accelerates Disease in a Mutant SOD1 Mouse Model of ALS
Vieira, Fernando G, Ping, Qinggong, Moreno, Andy J, Kidd, Joshua D, Thompson, Kenneth, Jiang, Bingbing, Lincecum, John M, Wang, Monica Z, De Zutter, Gerard S, Tassinari, Valerie R, Levine, Beth, Hatzipetros, Theo, Gill, Alan, Perrin, Steven
Published in PloS one (19.08.2015)
Published in PloS one (19.08.2015)
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Journal Article
From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis
Vieira, Fernando G, Levine, Beth A, Moreno, Andrew, Thompson, Kenneth, Sanchez, Ricardo, Lincecum, John M, Wang, Monica Z, Gill, Alan, Perrin, Steven, Al-Nakhala, Bashar M, De Zutter, Gerald S, Kidd, Joshua, Carrion, Isarelis J, Sullivan, Shawn M
Published in Nature genetics (01.05.2010)
Published in Nature genetics (01.05.2010)
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Dexpramipexole is ineffective in two models of ALS related neurodegeneration
Vieira, Fernando G, LaDow, Eva, Moreno, Andy, Kidd, Joshua D, Levine, Beth, Thompson, Kenneth, Gill, Alan, Finkbeiner, Steven, Perrin, Steven
Published in PloS one (19.12.2014)
Published in PloS one (19.12.2014)
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A machine-learning based objective measure for ALS disease severity
Vieira, Fernando G., Venugopalan, Subhashini, Premasiri, Alan S., McNally, Maeve, Jansen, Aren, McCloskey, Kevin, Brenner, Michael P., Perrin, Steven
Published in NPJ digital medicine (08.04.2022)
Published in NPJ digital medicine (08.04.2022)
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SOD1-positive aggregate accumulation in the CNS predicts slower disease progression and increased longevity in a mutant SOD1 mouse model of ALS
Gill, Cindy, Phelan, James P., Hatzipetros, Theo, Kidd, Joshua D., Tassinari, Valerie R., Levine, Beth, Wang, Monica Z., Moreno, Andrew, Thompson, Kenneth, Maier, Marcel, Grimm, Jan, Gill, Alan, Vieira, Fernando G.
Published in Scientific reports (30.04.2019)
Published in Scientific reports (30.04.2019)
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A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS
Hatzipetros, Theo, Kidd, Joshua D, Moreno, Andy J, Thompson, Kenneth, Gill, Alan, Vieira, Fernando G
Published in Journal of visualized experiments (06.10.2015)
Published in Journal of visualized experiments (06.10.2015)
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C57BL/6J congenic Prp-TDP43A315T mice develop progressive neurodegeneration in the myenteric plexus of the colon without exhibiting key features of ALS
Hatzipetros, Theo, Bogdanik, Laurent P, Tassinari, Valerie R, Kidd, Joshua D, Moreno, Andy J, Davis, Crystal, Osborne, Melissa, Austin, Andrew, Vieira, Fernando G, Lutz, Cathleen, Perrin, Steve
Published in Brain research (10.10.2014)
Published in Brain research (10.10.2014)
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Conference Proceeding
Primary Neurons and Differentiated NSC-34 Cells Are More Susceptible to Arginine-Rich ALS Dipeptide Repeat Protein-Associated Toxicity than Non-Differentiated NSC-34 and CHO Cells
Gill, Anna L, Wang, Monica Z, Levine, Beth, Premasiri, Alan, Vieira, Fernando G
Published in International journal of molecular sciences (11.12.2019)
Published in International journal of molecular sciences (11.12.2019)
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Journal Article
Design, power, and interpretation of studies in the standard murine model of ALS
Scott, Sean, Kranz, Janice E., Cole, Jeff, Lincecum, John M., Thompson, Kenneth, Kelly, Nancy, Bostrom, Alan, Theodoss, Jill, Al-Nakhala, Bashar M., Vieira, Fernando G., Ramasubbu, Jeyanthi, Heywood, James A.
Published in Amyotrophic lateral sclerosis (2008)
Published in Amyotrophic lateral sclerosis (2008)
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Journal Article
CuATSM efficacy is independently replicated in a SOD1 mouse model of ALS while unmetallated ATSM therapy fails to reveal benefits
Vieira, Fernando G., Hatzipetros, Theo, Thompson, Kenneth, Moreno, Andy J., Kidd, Joshua D., Tassinari, Valerie R., Levine, Beth, Perrin, Steven, Gill, Alan
Published in IBRO reports (01.06.2017)
Published in IBRO reports (01.06.2017)
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Journal Article
신경변성 질환의 치료를 위한 CuPTSM
GILL ALAN, LUKASHEV MATVEY, PERRIN STEVEN, VIEIRA FERNANDO G, DENTON KYLE, HATZIPETROS THEO
Year of Publication 17.08.2022
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Year of Publication 17.08.2022
Patent
항-CD40L 항체 및 CD40L-관련 질환 또는 장애의 치료 방법
LINCECUM JOHN M, GILL CYNTHIA A, GILL ALAN, PERRIN STEVEN N, VIEIRA FERNANDO G, JIANG BINGBING
Year of Publication 26.09.2017
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Year of Publication 26.09.2017
Patent
Impact of IL-1β on flow-induced outward arterial remodeling
Jiang, Zhihua, Berceli, Scott A., Pfahnl, Chun L., Wu, Lizhen, Killingsworth, Chris D., Vieira, Fernando G., Ozaki, C.Keith
Published in Surgery (01.08.2004)
Published in Surgery (01.08.2004)
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Conference Proceeding