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Published in Cancer research (Chicago, Ill.) (15.09.2015)
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Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)‑ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors
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Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells
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Published in Cancer research (Chicago, Ill.) (15.01.2007)
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Activation of Liver X Receptors and Retinoid X Receptors Prevents Bacterial-Induced Macrophage Apoptosis
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Published in Proceedings of the National Academy of Sciences - PNAS (21.12.2004)
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A Nuclear Receptor Corepressor Transcriptional Checkpoint Controlling Activator Protein 1-Dependent Gene Networks Required for Macrophage Activation
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Pomalidomide and Lenalidomide Induce p21WAF-1 Expression in Both Lymphoma and Multiple Myeloma through a LSD1-Mediated Epigenetic Mechanism
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Published in Cancer research (Chicago, Ill.) (15.09.2009)
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An Induced Ets Repressor Complex Regulates Growth Arrest during Terminal Macrophage Differentiation
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PE-1/METS, an Antiproliferative Ets Repressor Factor, Is Induced by CREB-1/CREM-1 during Macrophage Differentiation
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Published in The Journal of biological chemistry (23.04.2004)
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Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)
Kung, Pei-Pei, Bingham, Patrick, Brooun, Alexei, Collins, Michael, Deng, Ya-Li, Dinh, Dac, Fan, Connie, Gajiwala, Ketan S., Grantner, Rita, Gukasyan, Hovhannes J., Hu, Wenyue, Huang, Buwen, Kania, Robert, Kephart, Susan E., Krivacic, Cody, Kumpf, Robert A., Khamphavong, Penney, Kraus, Manfred, Liu, Wei, Maegley, Karen A., Nguyen, Lisa, Ren, Shijian, Richter, Dan, Rollins, Robert A., Sach, Neal, Sharma, Shikhar, Sherrill, John, Spangler, Jillian, Stewart, Albert E., Sutton, Scott, Uryu, Sean, Verhelle, Dominique, Wang, Hui, Wang, Shuiwang, Wythes, Martin, Xin, Shuibo, Yamazaki, Shinji, Zhu, Huichun, Zhu, JinJiang, Zehnder, Luke, Edwards, Martin
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Published in Journal of medicinal chemistry (08.02.2018)
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Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786
Sawka-Verhelle, D, Tartare-Deckert, S, White, M F, Van Obberghen, E
Published in The Journal of biological chemistry (15.03.1996)
Published in The Journal of biological chemistry (15.03.1996)
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Evidence for a Differential Interaction of SHC and the Insulin Receptor Substrate-1 (IRS-1) with the Insulin-like Growth Factor-I (IGF-I) Receptor in the Yeast Two-hybrid System (∗)
Tartare-Deckert, Sophie, Sawka-Verhelle, Dominique, Murdaca, Joseph, Van Obberghen, Emmanuel
Published in The Journal of biological chemistry (06.10.1995)
Published in The Journal of biological chemistry (06.10.1995)
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Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34+ cells
Moutouh-de Parseval, Laure A, Verhelle, Dominique, Glezer, Emilia, Jensen-Pergakes, Kristen, Ferguson, Gregory D, Corral, Laura G, Morris, Christopher L, Muller, George, Brady, Helen, Chan, Kyle
Published in The Journal of clinical investigation (01.01.2008)
Published in The Journal of clinical investigation (01.01.2008)
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Abstract 3518: Growth inhibition of SCLC cell lines by treatment with LSD1 inhibitors is associated with modulation of neuroendocrine pathways
Paul, Thomas A., Sharma, Shikhar, Hallin, Jill, Xie, Tao, Nichols, Timothy, Greig, Mike, Hardwick, James, Wythes, Martin, Verhelle, Dominique
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Preclinical target validation using patient-derived cells
Edwards, Aled M, Arrowsmith, Cheryl H, Bountra, Chas, Bunnage, Mark E, Feldmann, Marc, Knight, Julian C, Patel, Dhavalkumar D, Prinos, Panagiotis, Taylor, Michael D, Sundström, Michael
Published in Nature reviews. Drug discovery (01.03.2015)
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Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growth
Barsotti, Anthony M, Ryskin, Michael, Zhong, Wenyan, Zhang, Wei-Guo, Giannakou, Andreas, Loreth, Christine, Diesl, Veronica, Follettie, Maximillian, Golas, Jonathon, Lee, Michelle, Nichols, Timothy, Fan, Conglin, Li, Gang, Dann, Stephen, Fantin, Valeria R, Arndt, Kim, Verhelle, Dominique, Rollins, Robert A
Published in Oncotarget (20.02.2015)
Published in Oncotarget (20.02.2015)
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Identification of Stat 5B as a Substrate of the Insulin Receptor
Sawka‐Verhelle, Dominique, Filloux, Chantal, Tartare‐Deckert, Sophie, Mothe, Isabelle, Obberghen, Emmanuel
Published in European journal of biochemistry (01.12.1997)
Published in European journal of biochemistry (01.12.1997)
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EZH2 억제제 병용 요법
VERHELLE DOMINIQUE, KUNG PEI PEI, SHARMA SHIKHAR, PAUL THOMAS ANDREW, KRAUS MANFRED
Year of Publication 22.07.2020
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Year of Publication 22.07.2020
Patent
Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)‑ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors
Kung, Pei-Pei, Rui, Eugene, Bergqvist, Simon, Bingham, Patrick, Braganza, John, Collins, Michael, Cui, Mei, Diehl, Wade, Dinh, Dac, Fan, Connie, Fantin, Valeria R, Gukasyan, Hovhannes J, Hu, Wenyue, Huang, Buwen, Kephart, Susan, Krivacic, Cody, Kumpf, Robert A, Li, Gary, Maegley, Karen A, McAlpine, Indrawan, Nguyen, Lisa, Ninkovic, Sacha, Ornelas, Martha, Ryskin, Michael, Scales, Stephanie, Sutton, Scott, Tatlock, John, Verhelle, Dominique, Wang, Fen, Wells, Peter, Wythes, Martin, Yamazaki, Shinji, Yip, Brian, Yu, Xiu, Zehnder, Luke, Zhang, Wei-Guo, Rollins, Robert A, Edwards, Martin
Published in Journal of medicinal chemistry (22.12.2016)
Published in Journal of medicinal chemistry (22.12.2016)
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