Discovery of (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor: A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection
Venkatraman, Srikanth, Bogen, Stéphane L, Arasappan, Ashok, Bennett, Frank, Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond, Hendrata, Siska, Huang, Yuhua, Pan, Weidong, Parekh, Tejal, Pinto, Patrick, Popov, Veljko, Pike, Russel, Ruan, Sumei, Santhanam, Bama, Vibulbhan, Bancha, Wu, Wanli, Yang, Weiying, Kong, Jianshe, Liang, Xiang, Wong, Jesse, Liu, Rong, Butkiewicz, Nancy, Chase, Robert, Hart, Andrea, Agrawal, Sony, Ingravallo, Paul, Pichardo, John, Kong, Rong, Baroudy, Bahige, Malcolm, Bruce, Guo, Zhuyan, Prongay, Andrew, Madison, Vincent, Broske, Lisa, Cui, Xiaoming, Cheng, Kuo-Chi, Hsieh, Yunsheng, Brisson, Jean-Marc, Prelusky, Danial, Korfmacher, Walter, White, Ronald, Bogdanowich-Knipp, Susan, Pavlovsky, Anastasia, Bradley, Prudence, Saksena, Anil K, Ganguly, Ashit, Piwinski, John, Girijavallabhan, Viyyoor, Njoroge, F. George
Published in Journal of medicinal chemistry (05.10.2006)
Published in Journal of medicinal chemistry (05.10.2006)
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Structure–Activity Relationship (SAR) Optimization of 6‑(Indol-2-yl)pyridine-3-sulfonamides: Identification of Potent, Selective, and Orally Bioavailable Small Molecules Targeting Hepatitis C (HCV) NS4B
Zhang, Nanjing, Zhang, Xiaoyan, Zhu, Jin, Turpoff, Anthony, Chen, Guangming, Morrill, Christie, Huang, Song, Lennox, William, Kakarla, Ramesh, Liu, Ronggang, Li, Chunshi, Ren, Hongyu, Almstead, Neil, Venkatraman, Srikanth, Njoroge, F. George, Gu, Zhengxian, Clausen, Valerie, Graci, Jason, Jung, Stephen P., Zheng, Yingcong, Colacino, Joseph M., Lahser, Fred, Sheedy, Josephine, Mollin, Anna, Weetall, Marla, Nomeir, Amin, Karp, Gary M.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Potent inhibitors of HCV-NS3 protease derived from boronic acids
Venkatraman, Srikanth, Wu, Wanli, Prongay, Andrew, Girijavallabhan, Viyyoor, George Njoroge, F.
Published in Bioorganic & medicinal chemistry letters (01.01.2009)
Published in Bioorganic & medicinal chemistry letters (01.01.2009)
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Design, Synthesis, and Evaluation of Novel and Selective G‑protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists
Cox, Jason M, Chu, Hong D, Chelliah, Mariappan V, Debenham, John S, Eagen, Keith, Lan, Ping, Lombardo, Matthew, London, Clare, Plotkin, Michael A, Shah, Unmesh, Sun, Zhongxiang, Vaccaro, Henry M, Venkatraman, Srikanth, Suzuki, Takao, Wang, Nengxue, Ashley, Eric R, Crespo, Alejandro, Madeira, Maria, Leung, Dennis H, Alleyne, Candice, Ogawa, Aimie M, Souza, Sarah, Thomas-Fowlkes, Brande, Di Salvo, Jerry, Weinglass, Adam, Kirkland, Melissa, Pachanski, Michele, Powles, Mary Ann, Tozzo, Effie, Akiyama, Taro E, Ujjainwalla, Feroze, Tata, James R, Sinz, Christopher J
Published in ACS medicinal chemistry letters (12.01.2017)
Published in ACS medicinal chemistry letters (12.01.2017)
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Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor
Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L, Venkatraman, Srikanth, Blackman, Melissa, Chen, Kevin X, Hendrata, Siska, Huang, Yuhua, Huelgas, Regina M, Nair, Latha, Padilla, Angela I, Pan, Weidong, Pike, Russell, Pinto, Patrick, Ruan, Sumei, Sannigrahi, Mousumi, Velazquez, Francisco, Vibulbhan, Bancha, Wu, Wanli, Yang, Weiying, Saksena, Anil K, Girijavallabhan, Viyyoor, Shih, Neng-Yang, Kong, Jianshe, Meng, Tao, Jin, Yan, Wong, Jesse, McNamara, Paul, Prongay, Andrew, Madison, Vincent, Piwinski, John J, Cheng, Kuo-Chi, Morrison, Richard, Malcolm, Bruce, Tong, Xiao, Ralston, Robert, Njoroge, F. George
Published in ACS medicinal chemistry letters (13.05.2010)
Published in ACS medicinal chemistry letters (13.05.2010)
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Impact of Naturally Occurring Variants of HCV Protease on the Binding of Different Classes of Protease Inhibitors
Tong, Xiao, Guo, Zhuyan, Wright-Minogue, Jacquelyn, Xia, Ellen, Prongay, Andrew, Madison, Vincent, Qiu, Ping, Venkatraman, Srikanth, Velazquez, Francisco, Njoroge, F. George, Malcolm, Bruce A.
Published in Biochemistry (Easton) (07.02.2006)
Published in Biochemistry (Easton) (07.02.2006)
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Ultra-performance liquid chromatography/tandem mass spectrometric determination of diastereomers of SCH 503034 in monkey plasma
Wang, Ganfeng, Hsieh, Yunsheng, Cheng, Kuo-Chi, Morrison, Richard A., Venkatraman, Srikanth, Njoroge, F. George, Heimark, Larry, Korfmacher, Walter A.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.06.2007)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (01.06.2007)
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DISC-a, the First in a Novel Class of Potent and Selective Matriptase-2 Inhibitors for the Treatment of Hematologic Disorders Characterized By Low Hepcidin
Hong, Vu, Babu, Ravi Krishna, Blaustein, Cecile, Nguyen, Sophia, Rao, Venkateshwar, Savage, Will, MacDonald, Brian, Beconi, Maria G., Venkatraman, Srikanth
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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DISC-0974, a Novel, First-in-Class, Anti-Hemojuvelin Monoclonal Antibody Decreases Hepcidin and Increases Transferrin Saturation in a Non-Human Primate Model of Cytokine (IL-6) Induced Hypoferremia
MacDonald, Brian, Blaustein, Cecile, Nguyen, Sophia, King, Christopher, Hong, Vu, Savage, Will, Venkatraman, Srikanth, Beconi, Maria G.
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Design and Synthesis of P2–P4 Macrocycles Containing a Unique Spirocyclic Proline: A New Class of HCV NS3/4A Inhibitors
Velázquez, Francisco, Chelliah, Mariappan, Clasby, Martin, Guo, Zhuyan, Howe, John, Miller, Randy, Neelamkavil, Santhosh, Shah, Unmesh, Soriano, Aileen, Xia, Yan, Venkatraman, Srikanth, Chackalamannil, Samuel, Davies, Ian W
Published in ACS medicinal chemistry letters (08.12.2016)
Published in ACS medicinal chemistry letters (08.12.2016)
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Discovery of Chromane Propionic Acid Analogues as Selective Agonists of GPR120 with in Vivo Activity in Rodents
Adams, Gregory L, Velazquez, Francisco, Jayne, Charles, Shah, Unmesh, Miao, Shouwu, Ashley, Eric R, Madeira, Maria, Akiyama, Taro E, Di Salvo, Jerry, Suzuki, Takao, Wang, Nengxue, Truong, Quang, Gilbert, Eric, Zhou, Dan, Verras, Andreas, Kirkland, Melissa, Pachanski, Michele, Powles, Maryann, Yin, Wu, Ujjainwalla, Feroze, Venkatraman, Srikanth, Edmondson, Scott D
Published in ACS medicinal chemistry letters (12.01.2017)
Published in ACS medicinal chemistry letters (12.01.2017)
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Synthesis of New 4,5-Dihydrofuranoindoles and Their Evaluation as HCV NS5B Polymerase Inhibitors
Velázquez, Francisco, Venkatraman, Srikanth, Lesburg, Charles A, Duca, José, Rosenblum, Stuart B, Kozlowski, Joseph A, Njoroge, F. George
Published in Organic letters (20.01.2012)
Published in Organic letters (20.01.2012)
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Cyclic Sulfones as Novel P3-Caps for Hepatitis C Virus NS3/4A (HCV NS3/4A) Protease Inhibitors: Synthesis and Evaluation of Inhibitors with Improved Potency and Pharmacokinetic Profiles
Velázquez, Francisco, Sannigrahi, Mousumi, Bennett, Frank, Lovey, Raymond G, Arasappan, Ashok, Bogen, Stéphane, Nair, Latha, Venkatraman, Srikanth, Blackman, Melissa, Hendrata, Siska, Huang, Yuhua, Huelgas, Regina, Pinto, Patrick, Cheng, Kuo-Chi, Tong, Xiao, McPhail, Andrew T, Njoroge, F. George
Published in Journal of medicinal chemistry (22.04.2010)
Published in Journal of medicinal chemistry (22.04.2010)
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