Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures
Singer, Jack W, Al-Fayoumi, Suliman, Taylor, Jason, Velichko, Sharlene, O'Mahony, Alison
Published in PloS one (27.09.2019)
Published in PloS one (27.09.2019)
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Journal Article
Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
Picaud, Sarah, Fedorov, Oleg, Thanasopoulou, Angeliki, Leonards, Katharina, Jones, Katherine, Meier, Julia, Olzscha, Heidi, Monteiro, Octovia, Martin, Sarah, Philpott, Martin, Tumber, Anthony, Filippakopoulos, Panagis, Yapp, Clarence, Wells, Christopher, Che, Ka Hing, Bannister, Andrew, Robson, Samuel, Kumar, Umesh, Parr, Nigel, Lee, Kevin, Lugo, Dave, Jeffrey, Philip, Taylor, Simon, Vecellio, Matteo L, Bountra, Chas, Brennan, Paul E, O'Mahony, Alison, Velichko, Sharlene, Müller, Susanne, Hay, Duncan, Daniels, Danette L, Urh, Marjeta, La Thangue, Nicholas B, Kouzarides, Tony, Prinjha, Rab, Schwaller, Jürg, Knapp, Stefan
Published in Cancer research (Chicago, Ill.) (01.12.2015)
Published in Cancer research (Chicago, Ill.) (01.12.2015)
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Journal Article
A Novel Nuclear Function for the Interleukin-17 Signaling Adaptor Protein Act1
Velichko, Sharlene, Zhou, Xu, Zhu, Lingxiang, Anderson, Johnathon David, Wu, Reen, Chen, Yin
Published in PloS one (10.10.2016)
Published in PloS one (10.10.2016)
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Journal Article
IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against Infection
Wu, Reen, Hung, Li-Yin, Velichko, Sharlene, Tsai, Hsing-Chuan
Published in Clinical & developmental immunology (01.01.2013)
Published in Clinical & developmental immunology (01.01.2013)
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Journal Article
Interferon receptor expression regulates the antiproliferative effects of interferons on cancer cells and solid tumors
Wagner, T. Charis, Velichko, Sharlene, Chesney, Steven K., Biroc, Sandra, Harde, Dean, Vogel, David, Croze, Ed
Published in International journal of cancer (10.08.2004)
Published in International journal of cancer (10.08.2004)
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Journal Article
Interferon-beta attenuates angiotensin II-accelerated atherosclerosis and vascular remodeling in apolipoprotein E deficient mice
Zhang, Le-Ning, Velichko, Sharlene, Vincelette, Jon, Fitch, Richard M, Vergona, Ronald, Sullivan, Mark E, Croze, Ed, Wang, Yi-Xin
Published in Atherosclerosis (01.03.2008)
Published in Atherosclerosis (01.03.2008)
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Journal Article
Interferonβ-1b Induces the Expression of RGS1 a Negative Regulator of G-Protein Signaling
Tran, Tiffany, Paz, Pedro, Velichko, Sharlene, Cifrese, Jill, Belur, Praveen, Yamaguchi, Ken D., Ku, Karin, Mirshahpanah, Parham, Reder, Anthony T., Croze, Ed
Published in International Journal of Cell Biology (2010)
Published in International Journal of Cell Biology (2010)
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Journal Article
Regulation of Airway MUC5AC Expression by IL-1β and IL-17A; the NF-κB Paradigm
Fujisawa, Tomoyuki, Velichko, Sharlene, Thai, Philip, Hung, Li-Yin, Huang, Fei, Wu, Reen
Published in The Journal of immunology (1950) (15.11.2009)
Published in The Journal of immunology (1950) (15.11.2009)
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Journal Article
STAT3 Activation by Type I Interferons Is Dependent on Specific Tyrosines Located in the Cytoplasmic Domain of Interferon Receptor Chain 2c
Velichko, Sharlene, Wagner, T. Charis, Turkson, James, Jove, Richard, Croze, Ed
Published in The Journal of biological chemistry (20.09.2002)
Published in The Journal of biological chemistry (20.09.2002)
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Journal Article
NF-κB mediates IL-1β- and IL-17A-induced MUC5B expression in airway epithelial cells
Fujisawa, Tomoyuki, Chang, Mary Mann-Jong, Velichko, Sharlene, Thai, Philip, Hung, Li-Yin, Huang, Fei, Phuong, Newton, Chen, Yin, Wu, Reen
Published in American journal of respiratory cell and molecular biology (01.08.2011)
Published in American journal of respiratory cell and molecular biology (01.08.2011)
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Journal Article
Phenotypic profiling in BioMAP human primary cell systems identifies a Tox alert signature for skin irritation
Berg, Ellen, O'Mahony, Alison, Velichko, Sharlene, Folias, Alexandra, Pappaioannou, Dimitri
Published in Journal of pharmacological and toxicological methods (01.09.2018)
Published in Journal of pharmacological and toxicological methods (01.09.2018)
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Journal Article
Abstract C116: Phenotypic strategies for anticancer drug discovery
Garner, Steven M., Croff, Alyssa M., Lipner, Justin H., O'Mahony, Alison, Velichko, Sharlene, King, Alastair J., Parry, Jesse J.
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Journal Article
Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators
Shah, Falgun, Stepan, Antonia F., O'Mahony, Alison, Velichko, Sharlene, Folias, Alexandra E., Houle, Christopher, Shaffer, Christopher L., Marcek, John, Whritenour, Jessica, Stanton, Robert, Berg, Ellen L.
Published in Cell chemical biology (20.07.2017)
Published in Cell chemical biology (20.07.2017)
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Journal Article
Phenotypic Profiling in BioMAP Human Primary Cell Systems Identifies a Tox Alert Signature for Skin Irritation
Berg, Ellen, O'Mahony, Alison, Velichko, Sharlene, Folias, Alexandra, Best, Adam
Published in Journal of pharmacological and toxicological methods (01.11.2017)
Published in Journal of pharmacological and toxicological methods (01.11.2017)
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Journal Article
Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer
Tsimberidou, Apostolia M, Alayli, Farah A, Okrah, Kwame, Drakaki, Alexandra, Khalil, Danny N, Kummar, Shivaani, Khan, Saad A, Hodi, F Stephen, Oh, David Y, Cabanski, Christopher R, Gautam, Shikha, Meier, Stefanie L, Amouzgar, Meelad, Pfeiffer, Shannon M, Kageyama, Robin, Yang, EnJun, Spasic, Marko, Tetzlaff, Michael T, Foo, Wai Chin, Hollmann, Travis J, Li, Yanyun, Adamow, Matthew, Wong, Phillip, Moore, Jonni S, Velichko, Sharlene, Chen, Richard O, Kumar, Dinesh, Bucktrout, Samantha, Ibrahim, Ramy, Dugan, Ute, Salvador, Lisa, Hubbard-Lucey, Vanessa M, O'Donnell-Tormey, Jill, Santulli-Marotto, Sandra, Butterfield, Lisa H, Da Silva, Diane M, Fairchild, Justin, LaVallee, Theresa M, Padrón, Lacey J, Sharma, Padmanee
Published in The Journal of experimental medicine (07.10.2024)
Published in The Journal of experimental medicine (07.10.2024)
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Journal Article
Interferon Signaling Is Dependent on Specific Tyrosines Located within the Intracellular Domain of IFNAR2c
Wagner, T. Charis, Velichko, Sharlene, Vogel, David, Rani, M.R. Sandhya, Leung, Stewart, Ransohoff, Richard M., Stark, George R., Perez, H. Daniel, Croze, Ed
Published in The Journal of biological chemistry (01.01.2002)
Published in The Journal of biological chemistry (01.01.2002)
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