Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers
De Felice, Fernanda G, Vieira, Marcelo N.N, Bomfim, Theresa R, Decker, Helena, Velasco, Pauline T, Lambert, Mary P, Viola, Kirsten L, Zhao, Wei-Qin, Ferreira, Sergio T, Klein, William L
Published in Proceedings of the National Academy of Sciences - PNAS (10.02.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (10.02.2009)
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Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated Aβ Oligomers
Wilcox, Kyle C, Marunde, Matthew R, Das, Aditi, Velasco, Pauline T, Kuhns, Benjamin D, Marty, Michael T, Jiang, Haoming, Luan, Chi-Hao, Sligar, Stephen G, Klein, William L
Published in PloS one (30.04.2015)
Published in PloS one (30.04.2015)
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Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine
De Felice, Fernanda G., Velasco, Pauline T., Lambert, Mary P., Viola, Kirsten, Fernandez, Sara J., Ferreira, Sergio T., Klein, William L.
Published in The Journal of biological chemistry (13.04.2007)
Published in The Journal of biological chemistry (13.04.2007)
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Towards non-invasive diagnostic imaging of early-stage Alzheimer's disease
Viola, Kirsten L., Sbarboro, James, Sureka, Ruchi, De, Mrinmoy, Bicca, Maíra A., Wang, Jane, Vasavada, Shaleen, Satpathy, Sreyesh, Wu, Summer, Joshi, Hrushikesh, Velasco, Pauline T., MacRenaris, Keith, Waters, E. Alex, Lu, Chang, Phan, Joseph, Lacor, Pascale, Prasad, Pottumarthi, Dravid, Vinayak P., Klein, William L.
Published in Nature nanotechnology (01.01.2015)
Published in Nature nanotechnology (01.01.2015)
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Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers
De Felice, Fernanda G, Wu, Diana, Lambert, Mary P, Fernandez, Sara J, Velasco, Pauline T, Lacor, Pascale N, Bigio, Eileen H, Jerecic, Jasna, Acton, Paul J, Shughrue, Paul J, Chen-Dodson, Elizabeth, Kinney, Gene G, Klein, William L
Published in Neurobiology of aging (01.09.2008)
Published in Neurobiology of aging (01.09.2008)
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Monoclonal antibodies that target pathological assemblies of Aβ
Lambert, Mary P, Velasco, Pauline T, Chang, Lei, Viola, Kirsten L, Fernandez, Sara, Lacor, Pascale N, Khuon, Daliya, Gong, Yuesong, Bigio, Eileen H, Shaw, Pamela, De Felice, Fernanda G, Krafft, Grant A, Klein, William L
Published in Journal of neurochemistry (2007)
Published in Journal of neurochemistry (2007)
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Synaptic targeting by Alzheimer's-related amyloid beta oligomers
Lacor, Pascale N, Buniel, Maria C, Chang, Lei, Fernandez, Sara J, Gong, Yuesong, Viola, Kirsten L, Lambert, Mary P, Velasco, Pauline T, Bigio, Eileen H, Finch, Caleb E, Krafft, Grant A, Klein, William L
Published in The Journal of neuroscience (10.11.2004)
Published in The Journal of neuroscience (10.11.2004)
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A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid‐β oligomers
Sebollela, Adriano, Cline, Erika N., Popova, Izolda, Luo, Kevin, Sun, Xiaoxia, Ahn, Jay, Barcelos, Milena A., Bezerra, Vanessa N., Lyra e Silva, Natalia M., Patel, Jason, Pinheiro, Nathalia R., Qin, Lei A., Kamel, Josette M., Weng, Anthea, DiNunno, Nadia, Bebenek, Adrian M., Velasco, Pauline T., Viola, Kirsten L., Lacor, Pascale N., Ferreira, Sergio T., Klein, William L.
Published in Journal of neurochemistry (01.09.2017)
Published in Journal of neurochemistry (01.09.2017)
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Self-Assembly of Aβ1 - 42 into Globular Neurotoxins
Chromy, Brett A, Nowak, Richard J, Lambert, Mary P, Viola, Kirsten L, Chang, Lei, Velasco, Pauline T, Jones, Bryan W, Fernandez, Sara J, Lacor, Pascale N, Horowitz, Peleg, Finch, Caleb E, Krafft, Grant A, Klein, William L
Published in Biochemistry (Easton) (11.11.2003)
Published in Biochemistry (Easton) (11.11.2003)
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Modulation of Amyloid-β Aggregation by Histidine-Coordinating Cobalt(III) Schiff Base Complexes
Heffern, Marie C., Velasco, Pauline T., Matosziuk, Lauren M., Coomes, Joseph L., Karras, Constantine, Ratner, Mark A., Klein, William L., Eckermann, Amanda L., Meade, Thomas J.
Published in Chembiochem : a European journal of chemical biology (21.07.2014)
Published in Chembiochem : a European journal of chemical biology (21.07.2014)
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Brain transit and ameliorative effects of intranasally delivered anti-amyloid-β oligomer antibody in 5XFAD mice
Xiao, Chun, Davis, Francesca J, Chauhan, Balwantsinh C, Viola, Kirsten L, Lacor, Pascale N, Velasco, Pauline T, Klein, William L, Chauhan, Neelima B
Published in Journal of Alzheimer's disease (01.01.2013)
Published in Journal of Alzheimer's disease (01.01.2013)
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Alzheimer's Toxic Amyloid Beta Oligomers: Unwelcome Visitors to the Na/K ATPase alpha3 Docking Station
DiChiara, Thomas, DiNunno, Nadia, Clark, Jeffrey, Bu, Riana Lo, Cline, Erika N, Rollins, Madeline G, Gong, Yuesong, Brody, David L, Sligar, Stephen G, Velasco, Pauline T, Viola, Kirsten L, Klein, William L
Published in The Yale journal of biology & medicine (01.03.2017)
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Published in The Yale journal of biology & medicine (01.03.2017)
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Detection and Identification of Bioanalytes with High Resolution LSPR Spectroscopy and MALDI Mass Spectrometry
Anker, Jeffrey N, Hall, W. Paige, Lambert, Mary P, Velasco, Pauline T, Mrksich, Milan, Klein, William L, Van Duyne, Richard P
Published in Journal of physical chemistry. C (16.04.2009)
Published in Journal of physical chemistry. C (16.04.2009)
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Synapse-Binding Subpopulations of Aβ Oligomers Sensitive to Peptide Assembly Blockers and scFv Antibodies
Velasco, Pauline T, Heffern, Marie C, Sebollela, Adriano, Popova, Izolda A, Lacor, Pascale N, Lee, Kevin B, Sun, Xiaoxia, Tiano, Benjamin N, Viola, Kirsten L, Eckermann, Amanda L, Meade, Thomas J, Klein, William L
Published in ACS chemical neuroscience (21.11.2012)
Published in ACS chemical neuroscience (21.11.2012)
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Elucidating Molecular Mass and Shape of a Neurotoxic Aβ Oligomer
Sebollela, Adriano, Mustata, Gina-Mirela, Luo, Kevin, Velasco, Pauline T, Viola, Kirsten L, Cline, Erika N, Shekhawat, Gajendra S, Wilcox, Kyle C, Dravid, Vinayak P, Klein, William L
Published in ACS chemical neuroscience (17.12.2014)
Published in ACS chemical neuroscience (17.12.2014)
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Soluble state high resolution atomic force microscopy study of Alzheimer's beta-amyloid oligomers
Shekhawat, Gajendra S, Lambert, Mary P, Sharma, Saurabh, Velasco, Pauline T, Viola, Kirsten L, Klein, William L, Dravid, Vinayak P
Published in Applied physics letters (02.11.2009)
Published in Applied physics letters (02.11.2009)
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Severe hypodysfibrinogenemia in compound heterozygotes of the fibrinogen AαIVS4 + 1 G>T mutation and an AαGln328 truncation (fibrinogen Keokuk)
LEFEBVRE, Phil, VELASCO, Pauline T, DEAR, Amy, LOUNES, Karim C, LORD, Susan T, BRENNAN, Stephen O, GREEN, David, LORAND, Laszlo
Published in Blood (01.04.2004)
Published in Blood (01.04.2004)
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Aβ Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease
Lacor, Pascale N., Buniel, Maria C., Furlow, Paul W., Sanz Clemente, Antonio, Velasco, Pauline T., Wood, Margaret, Viola, Kirsten L., Klein, William L.
Published in The Journal of neuroscience (24.01.2007)
Published in The Journal of neuroscience (24.01.2007)
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