Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1)
Kanouni, Toufike, Severin, Christophe, Cho, Robert W, Yuen, Natalie Y.-Y, Xu, Jiangchun, Shi, Lihong, Lai, Chon, Del Rosario, Joselyn R, Stansfield, Ryan K, Lawton, Lee N, Hosfield, David, O’Connell, Shawn, Kreilein, Matt M, Tavares-Greco, Paula, Nie, Zhe, Kaldor, Stephen W, Veal, James M, Stafford, Jeffrey A, Chen, Young K
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders
Ambrus-Aikelin, Geza, Takeda, Katsuyuki, Joetham, Anthony, Lazic, Milos, Povero, Davide, Santini, Angelina M., Pranadinata, Rama, Johnson, Casey D., McGeough, Matthew D., Beasley, Federico C., Stansfield, Ryan, McBride, Christopher, Trzoss, Lynnie, Hoffman, Hal M., Feldstein, Ariel E., Stafford, Jeffrey A., Veal, James M., Bain, Gretchen, Gelfand, Erwin W.
Published in Scientific reports (19.08.2023)
Published in Scientific reports (19.08.2023)
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Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor
Harris, Philip A, Boloor, Amogh, Cheung, Mui, Kumar, Rakesh, Crosby, Renae M, Davis-Ward, Ronda G, Epperly, Andrea H, Hinkle, Kevin W, Hunter, Robert N, Johnson, Jennifer H, Knick, Victoria B, Laudeman, Christopher P, Luttrell, Deirdre K, Mook, Robert A, Nolte, Robert T, Rudolph, Sharon K, Szewczyk, Jerzy R, Truesdale, Anne T, Veal, James M, Wang, Liping, Stafford, Jeffrey A
Published in Journal of medicinal chemistry (14.08.2008)
Published in Journal of medicinal chemistry (14.08.2008)
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Journal Article
Author Correction: JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders
Ambrus-Aikelin, Geza, Takeda, Katsuyuki, Joetham, Anthony, Lazic, Milos, Povero, Davide, Santini, Angelina M., Pranadinata, Rama, Johnson, Casey D., McGeough, Matthew D., Beasley, Federico C., Stansfield, Ryan, McBride, Christopher, Trzoss, Lynnie, Hoffman, Hal M., Feldstein, Ariel E., Stafford, Jeffrey A., Veal, James M., Bain, Gretchen, Gelfand, Erwin W.
Published in Scientific reports (16.11.2023)
Published in Scientific reports (16.11.2023)
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Fluorescence Linked Enzyme Chemoproteomic Strategy for Discovery of a Potent and Selective DAPK1 and ZIPK Inhibitor
Carlson, David A, Franke, Aaron S, Weitzel, Douglas H, Speer, Brittany L, Hughes, Philip F, Hagerty, Laura, Fortner, Christopher N, Veal, James M, Barta, Thomas E, Zieba, Bartosz J, Somlyo, Avril V, Sutherland, Cindy, Deng, Jing Ti, Walsh, Michael P, MacDonald, Justin A, Haystead, Timothy A. J
Published in ACS chemical biology (20.12.2013)
Published in ACS chemical biology (20.12.2013)
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Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90
BARTA, Thomas E, VEAL, James M, BARABASZ, Amy F, FOLEY, Briana E, OTTO, James, HALL, Steven E, RICE, John W, PARTRIDGE, Jeffrey M, FADDEN, R. Patrick, WEI MA, JENKS, Matthew, LIFENG GENG, HANSON, Gunnar J, HUANG, Kenneth H
Published in Bioorganic & medicinal chemistry (15.06.2008)
Published in Bioorganic & medicinal chemistry (15.06.2008)
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Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis
Povero, Davide, Lazic, Milos, McBride, Christopher, Ambrus-Aikelin, Geza, Stansfield, Ryan, Johnson, Casey D, Santini, Angelina M, Pranadinata, Rama F, McGeough, Matthew D, Stafford, Jeffrey A, Hoffman, Hal M, Feldstein, Ariel E, Veal, James M, Bain, Gretchen
Published in The Journal of pharmacology and experimental therapeutics (01.08.2023)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2023)
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Structure-based design and discovery of potent and selective KDM5 inhibitors
Nie, Zhe, Shi, Lihong, Lai, Chon, O'Connell, Shawn M., Xu, Jiangchun, Stansfield, Ryan K., Hosfield, David J., Veal, James M., Stafford, Jeffrey A.
Published in Bioorganic & medicinal chemistry letters (15.05.2018)
Published in Bioorganic & medicinal chemistry letters (15.05.2018)
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Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity
Putcha, Preeti, Danzer, Karin M, Kranich, Lisa R, Scott, Anisa, Silinski, Melanie, Mabbett, Sarah, Hicks, Carol D, Veal, James M, Steed, Paul M, Hyman, Bradley T, McLean, Pamela J
Published in The Journal of pharmacology and experimental therapeutics (01.03.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2010)
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Discovery of Novel Benzimidazoles as Potent Inhibitors of TIE-2 and VEGFR-2 Tyrosine Kinase Receptors
Hasegawa, Masaichi, Nishigaki, Naohiko, Washio, Yoshiaki, Kano, Kazuya, Harris, Philip A, Sato, Hideyuki, Mori, Ichiro, West, Rob I, Shibahara, Megumi, Toyoda, Hiroko, Wang, Liping, Nolte, Robert T, Veal, James M, Cheung, Mui
Published in Journal of medicinal chemistry (06.09.2007)
Published in Journal of medicinal chemistry (06.09.2007)
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Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase
Sammond, Douglas M., Nailor, Kristen E., Veal, James M., Nolte, Robert T., Wang, Liping, Knick, Victoria B., Rudolph, Sharon K., Truesdale, Anne T., Nartey, Eldridge N., Stafford, Jeffrey A., Kumar, Rakesh, Cheung, Mui
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
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Journal Article
Structure-based design and discovery of potent and selective lysine-specific demethylase 1 (LSD1) inhibitors
Nie, Zhe, Shi, Lihong, Lai, Chon, Severin, Christophe, Xu, Jiangchun, Del Rosario, Joselyn R., Stansfield, Ryan K., Cho, Robert W., Kanouni, Toufike, Veal, James M., Stafford, Jeffrey A., Chen, Young K.
Published in Bioorganic & medicinal chemistry letters (01.01.2019)
Published in Bioorganic & medicinal chemistry letters (01.01.2019)
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Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors
Bennett, Michael J., Wu, Yiqin, Boloor, Amogh, Matuszkiewicz, Jennifer, O'Connell, Shawn M., Shi, Lihong, Stansfield, Ryan K., Del Rosario, Joselyn R., Veal, James M., Hosfield, David J., Xu, Jiangchun, Kaldor, Stephen W., Stafford, Jeffrey A., Betancort, Juan M.
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
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Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models
Chen, Young K, Bonaldi, Tiziana, Cuomo, Alessandro, Del Rosario, Joselyn R, Hosfield, David J, Kanouni, Toufike, Kao, Shih-chu, Lai, Chon, Lobo, Neethan A, Matuszkiewicz, Jennifer, McGeehan, Andrew, O’Connell, Shawn M, Shi, Lihong, Stafford, Jeffrey A, Stansfield, Ryan K, Veal, James M, Weiss, Michael S, Yuen, Natalie Y, Wallace, Michael B
Published in ACS medicinal chemistry letters (10.08.2017)
Published in ACS medicinal chemistry letters (10.08.2017)
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Discovery and Evaluation of 2-Anilino-5-aryloxazoles as a Novel Class of VEGFR2 Kinase Inhibitors
Harris, Philip A, Cheung, Mui, Hunter, Robert N, Brown, Matthew L, Veal, James M, Nolte, Robert T, Wang, Liping, Liu, Wendy, Crosby, Renae M, Johnson, Jennifer H, Epperly, Andrea H, Kumar, Rakesh, Luttrell, Deirdre K, Stafford, Jeffrey A
Published in Journal of medicinal chemistry (10.03.2005)
Published in Journal of medicinal chemistry (10.03.2005)
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Oxindole-Based Inhibitors of Cyclin-Dependent Kinase 2 (CDK2): Design, Synthesis, Enzymatic Activities, and X-ray Crystallographic Analysis
Bramson, H. Neal, Corona, John, Davis, Stephen T, Dickerson, Scott H, Edelstein, Mark, Frye, Stephen V, Gampe, Robert T, Harris, Phil A, Hassell, Anne, Holmes, William D, Hunter, Robert N, Lackey, Karen E, Lovejoy, Brett, Luzzio, Michael J, Montana, Val, Rocque, Warren J, Rusnak, David, Shewchuk, Lisa, Veal, James M, Walker, Duncan H, Kuyper, Lee F
Published in Journal of medicinal chemistry (06.12.2001)
Published in Journal of medicinal chemistry (06.12.2001)
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Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis
Rice, John W., Veal, James M., Fadden, R. Patrick, Barabasz, Amy F., Partridge, Jeffrey M., Barta, Thomas E., Dubois, Laura G., Huang, Kenneth H., Mabbett, Sarah R., Silinski, Melanie A., Steed, Paul M., Hall, Steven E.
Published in Arthritis and rheumatism (01.12.2008)
Published in Arthritis and rheumatism (01.12.2008)
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Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90
Huang, Kenneth H., Barta, Thomas E., Rice, John W., Smith, Emilie D., Ommen, Andy J., Ma, Wei, Veal, James M., Fadden, R. Patrick, Barabasz, Amy F., Foley, Briana E., Hughes, Philip F., Hanson, Gunnar J., Markworth, Christopher J., Silinski, Melanie, Partridge, Jeffrey M., Steed, Paul M., Hall, Steven E.
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
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Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors
Stevens, Kirk L., Reno, Michael J., Alberti, Jennifer B., Price, Daniel J., Kane-Carson, Laurie S., Knick, Victoria B., Shewchuk, Lisa M., Hassell, Anne M., Veal, James M., Davis, Stephen T., Griffin, Robert J., Peel, Michael R.
Published in Bioorganic & medicinal chemistry (01.11.2008)
Published in Bioorganic & medicinal chemistry (01.11.2008)
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