Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases
Van Rompaey, Luc, Galien, René, van der Aar, Ellen M, Clement-Lacroix, Philippe, Nelles, Luc, Smets, Bart, Lepescheux, Liên, Christophe, Thierry, Conrath, Katja, Vandeghinste, Nick, Vayssiere, Béatrice, De Vos, Steve, Fletcher, Stephen, Brys, Reginald, van 't Klooster, Gerben, Feyen, Jean H M, Menet, Christel
Published in The Journal of immunology (1950) (01.10.2013)
Published in The Journal of immunology (1950) (01.10.2013)
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Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634
Menet, Christel J, Fletcher, Stephen R, Van Lommen, Guy, Geney, Raphael, Blanc, Javier, Smits, Koen, Jouannigot, Nolwenn, Deprez, Pierre, van der Aar, Ellen M, Clement-Lacroix, Philippe, Lepescheux, Liên, Galien, René, Vayssiere, Béatrice, Nelles, Luc, Christophe, Thierry, Brys, Reginald, Uhring, Muriel, Ciesielski, Fabrice, Van Rompaey, Luc
Published in Journal of medicinal chemistry (26.11.2014)
Published in Journal of medicinal chemistry (26.11.2014)
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Design of a potent and selective dual JAK1/TYK2 inhibitor
Mammoliti, Oscar, Menet, Christel, Cottereaux, Céline, Blanc, Javier, De Blieck, Ann, Coti, Ghjuvanni, Geney, Raphaël, Oste, Line, Ostyn, Koen, Palisse, Adeline, Quinton, Evelyne, Schmitt, Benoit, Borgonovi, Monica, Parent, Isabelle, Jagerschmidt, Catherine, De Vos, Steve, Vayssiere, Béatrice, López-Ramos, Miriam, Shoji, Kenji, Brys, Reginald, Amantini, David, Galien, René, Joannesse, Caroline
Published in Bioorganic & medicinal chemistry (15.11.2024)
Published in Bioorganic & medicinal chemistry (15.11.2024)
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Gene array analysis of Wnt-regulated genes in C3H10T1/2 cells
Jackson, Amanda, Vayssière, Béatrice, Garcia, Teresa, Newell, William, Baron, Roland, Roman-Roman, Sergio, Rawadi, Georges
Published in Bone (New York, N.Y.) (01.04.2005)
Published in Bone (New York, N.Y.) (01.04.2005)
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Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Modeling of Filgotinib (GLPG0634), a Selective JAK1 Inhibitor, in Support of Phase IIB Dose Selection
Namour, Florence, Diderichsen, Paul Matthias, Cox, Eugène, Vayssière, Béatrice, Van der Aa, Annegret, Tasset, Chantal, Van‘t Klooster, Gerben
Published in Clinical pharmacokinetics (01.08.2015)
Published in Clinical pharmacokinetics (01.08.2015)
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Lrp5-Independent Activation of Wnt Signaling by Lithium Chloride Increases Bone Formation and Bone Mass in Mice
Philippe Clément-Lacroix, Minrong Ai, Frederic Morvan, Sergio Roman-Roman, Béatrice Vayssière, Cecille Belleville, Kenneth Estrera, Warman, Matthew L., Baron, Roland, Georges Rawadi, Prockop, Darwin J.
Published in Proceedings of the National Academy of Sciences - PNAS (29.11.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (29.11.2005)
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Deletion of a Single Allele of the Dkk1 Gene Leads to an Increase in Bone Formation and Bone Mass
Morvan, Frederic, Boulukos, Kim, Clément‐Lacroix, Philippe, Roman, Sergio Roman, Suc‐Royer, Isabelle, Vayssière, Béatrice, Ammann, Patrick, Martin, Patrick, Pinho, Sonia, Pognonec, Philippe, Mollat, Patrick, Niehrs, Christof, Baron, Roland, Rawadi, Georges
Published in Journal of bone and mineral research (01.06.2006)
Published in Journal of bone and mineral research (01.06.2006)
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Interaction between LRP5 and Frat1 Mediates the Activation of the Wnt Canonical Pathway
Hay, Eric, Faucheu, Chi, Suc-Royer, Isabelle, Touitou, Robert, Stiot, Veronique, Vayssière, Béatrice, Baron, Roland, Roman-Roman, Sergio, Rawadi, Georges
Published in The Journal of biological chemistry (08.04.2005)
Published in The Journal of biological chemistry (08.04.2005)
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Expression, purification and functional characterization of Wnt signaling co-receptors LRP5 and LRP6
Fleury, Damien, Vayssiere, Béatrice, Touitou, Robert, Gillard, Corinne, Lebhar, Hélène, Rawadi, Georges, Mollat, Patrick
Published in Protein expression and purification (01.03.2010)
Published in Protein expression and purification (01.03.2010)
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Expression, purification and characterization of murine Dkk1 protein
Fleury, Damien, Gillard, Corinne, Lebhar, Helène, Vayssière, Béatrice, Touitou, Robert, Rawadi, Georges, Mollat, Patrick
Published in Protein expression and purification (01.07.2008)
Published in Protein expression and purification (01.07.2008)
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A New Member of the Amphiphysin Family Connecting Endocytosis and Signal Transduction Pathways
Leprince, Corinne, Romero, Francisco, Cussac, Didier, Vayssiere, Beatrice, Berger, Roland, Tavitian, Armand, Camonis, Jacques H.
Published in The Journal of biological chemistry (13.06.1997)
Published in The Journal of biological chemistry (13.06.1997)
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Deletion of a single allele of the Dkkl gene leads to an increase in bone formation and bone mass
MORVAN, Frederic, BOULUKOS, Kim, MOLLAT, Patrick, NIEHRS, Christof, BARON, Roland, RAWADI, Georges, CLEMENT-LACROIX, Philippe, ROMAN ROMAN, Sergio, SUC-ROYER, Isabelle, VAYSSIERE, Béatrice, AMMANN, Patrick, MARTIN, Patrick, PINHO, Sonia, POGNONEC, Philippe
Published in Journal of bone and mineral research (2006)
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Published in Journal of bone and mineral research (2006)
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Synthetic Glucocorticoids That Dissociate Transactivation and AP-1 Transrepression Exhibit Antiinflammatory Activity in Vivo
Vayssière, Béatrice M, Dupont, Sonia, Choquart, Agnès, Petit, Francis, Garcia, Teresa, Marchandeau, Christian, Gronemeyer, Hinrich, Resche-Rigon, Michèle
Published in Molecular endocrinology (Baltimore, Md.) (01.08.1997)
Published in Molecular endocrinology (Baltimore, Md.) (01.08.1997)
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188 Exploration of GLPG0634, the First Selective JAK1 Inhibitor, in Inflammatory Bowel Disease Is Supported by Early Clinical Results and Mouse DSS-Colitis Data
Galien, Rene, Merciris, Didier, Vanhoutte, Frédéric P, Delachaume, Carole, Namour, Florence S, Vayssière, Béatrice, Van der Aa, Annegret, Brys, Reginald, van't Klooster, Gerben A
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2014)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2014)
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Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo
Vayssière, B M, Dupont, S, Choquart, A, Petit, F, Garcia, T, Marchandeau, C, Gronemeyer, H, Resche-Rigon, M
Published in Molecular endocrinology (Baltimore, Md.) (01.08.1997)
Published in Molecular endocrinology (Baltimore, Md.) (01.08.1997)
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Murine Frizzled-1 Behaves as an Antagonist of the Canonical Wnt/β-Catenin Signaling
Roman-Roman, Sergio, Shi, De-Li, Stiot, Véronique, Haÿ, Eric, Vayssière, Béatrice, Garcia, Teresa, Baron, Roland, Rawadi, Georges
Published in The Journal of biological chemistry (13.02.2004)
Published in The Journal of biological chemistry (13.02.2004)
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High-affinity Src-SH2 ligands which do not activate Tyr(527)-phosphorylated Src in an experimental in vivo system
Mandine, Eliane, Jean-Baptiste, Véronique, Vayssière, Béatrice, Gofflo, Dominique, Bénard, Didier, Sarubbi, Edoardo, Deprez, Pierre, Baron, Roland, Superti-Furga, Giulio, Lesuisse, Dominique
Published in Biochemical and biophysical research communications (25.10.2002)
Published in Biochemical and biophysical research communications (25.10.2002)
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High-affinity Src-SH2 ligands which do not activate Tyr527-phosphorylated Src in an experimental in vivo system
Mandine, Eliane, Jean-Baptiste, Véronique, Vayssière, Béatrice, Gofflo, Dominique, Bénard, Didier, Sarubbi, Edoardo, Deprez, Pierre, Baron, Roland, Superti-Furga, Giulio, Lesuisse, Dominique
Published in Biochemical and biophysical research communications (01.10.2002)
Published in Biochemical and biophysical research communications (01.10.2002)
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