Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency
Schindler, Christina, Collinson, Andie, Matthews, Carl, Pointon, Amy, Jenkinson, Lesley, Minter, Ralph R, Vaughan, Tristan J, Tigue, Natalie J
Published in PloS one (29.03.2019)
Published in PloS one (29.03.2019)
Get full text
Journal Article
Overcoming the Refractory Expression of Secreted Recombinant Proteins in Mammalian Cells through Modification of the Signal Peptide and Adjacent Amino Acids
Güler-Gane, Gülin, Kidd, Sara, Sridharan, Sudharsan, Vaughan, Tristan J, Wilkinson, Trevor C I, Tigue, Natalie J
Published in PloS one (19.05.2016)
Published in PloS one (19.05.2016)
Get full text
Journal Article
Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design
Cannon, Daniel A, Shan, Lu, Du, Qun, Shirinian, Lena, Rickert, Keith W, Rosenthal, Kim L, Korade, 3rd, Martin, van Vlerken-Ysla, Lilian E, Buchanan, Andrew, Vaughan, Tristan J, Damschroder, Melissa M, Popovic, Bojana
Published in PLoS computational biology (01.05.2019)
Published in PLoS computational biology (01.05.2019)
Get full text
Journal Article
Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation
Cohen, E Suzanne, Scott, Ian C, Majithiya, Jayesh B, Rapley, Laura, Kemp, Benjamin P, England, Elizabeth, Rees, D Gareth, Overed-Sayer, Catherine L, Woods, Joanne, Bond, Nicholas J, Veyssier, Christel Séguy, Embrey, Kevin J, Sims, Dorothy A, Snaith, Michael R, Vousden, Katherine A, Strain, Martin D, Chan, Denice T Y, Carmen, Sara, Huntington, Catherine E, Flavell, Liz, Xu, Jianqing, Popovic, Bojana, Brightling, Christopher E, Vaughan, Tristan J, Butler, Robin, Lowe, David C, Higazi, Daniel R, Corkill, Dominic J, May, Richard D, Sleeman, Matthew A, Mustelin, Tomas
Published in Nature communications (14.09.2015)
Published in Nature communications (14.09.2015)
Get full text
Journal Article
High affinity single-chain variable fragments are specific and versatile targeting motifs for extracellular vesicles
Longatti, Andrea, Schindler, Christina, Collinson, Andie, Jenkinson, Lesley, Matthews, Carl, Fitzpatrick, Laura, Blundy, Margaret, Minter, Ralph, Vaughan, Tristan, Shaw, Michael, Tigue, Natalie
Published in Nanoscale (07.08.2018)
Published in Nanoscale (07.08.2018)
Get full text
Journal Article
Machine learning designs new GCGR/GLP-1R dual agonists with enhanced biological potency
Puszkarska, Anna M, Taddese, Bruck, Revell, Jefferson, Davies, Graeme, Field, Joss, Hornigold, David C, Buchanan, Andrew, Vaughan, Tristan J, Colwell, Lucy J
Published in Nature chemistry (01.09.2024)
Published in Nature chemistry (01.09.2024)
Get full text
Journal Article
Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction
England, Elizabeth, Rees, D Gareth, Scott, Ian Christopher, Carmen, Sara, Chan, Denice T Y, Chaillan Huntington, Catherine E, Houslay, Kirsty F, Erngren, Teodor, Penney, Mark, Majithiya, Jayesh B, Rapley, Laura, Sims, Dorothy A, Hollins, Claire, Hinchy, Elizabeth C, Strain, Martin D, Kemp, Benjamin P, Corkill, Dominic J, May, Richard D, Vousden, Katherine A, Butler, Robin J, Mustelin, Tomas, Vaughan, Tristan J, Lowe, David C, Colley, Caroline, Cohen, E Suzanne
Published in Scientific reports (17.06.2023)
Published in Scientific reports (17.06.2023)
Get full text
Journal Article
Computational Design of Epitope-Specific Functional Antibodies
Nimrod, Guy, Fischman, Sharon, Austin, Mark, Herman, Asael, Keyes, Feenagh, Leiderman, Olga, Hargreaves, David, Strajbl, Marek, Breed, Jason, Klompus, Shelley, Minton, Kevin, Spooner, Jennifer, Buchanan, Andrew, Vaughan, Tristan J., Ofran, Yanay
Published in Cell reports (Cambridge) (20.11.2018)
Published in Cell reports (Cambridge) (20.11.2018)
Get full text
Journal Article
A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis
MacGregor, Paula, Gonzalez-Munoz, Andrea L, Jobe, Fatoumatta, Taylor, Martin C, Rust, Steven, Sandercock, Alan M, Macleod, Olivia J S, Van Bocxlaer, Katrien, Francisco, Amanda F, D'Hooge, Francois, Tiberghien, Arnaud, Barry, Conor S, Howard, Philip, Higgins, Matthew K, Vaughan, Tristan J, Minter, Ralph, Carrington, Mark
Published in PLoS neglected tropical diseases (01.05.2019)
Published in PLoS neglected tropical diseases (01.05.2019)
Get full text
Journal Article
Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain
Williams, Wendy A, Linley, John E, Jones, Clare A, Shibata, Yoko, Snijder, Arjan, Button, James, Hatcher, Jon P, Huang, Ling, Taddese, Bruck, Thornton, Peter, Schofield, Darren J, Thom, George, Popovic, Bojana, Dosanjh, Bhupinder, Wilkinson, Trevor, Hughes, Jane, Dobson, Claire L, Groves, Maria A, Webster, Carl I, Billinton, Andy, Vaughan, Tristan J, Chessell, Iain
Published in Pain (Amsterdam) (01.09.2019)
Published in Pain (Amsterdam) (01.09.2019)
Get full text
Journal Article
A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies
Macleod, Olivia J S, Bart, Jean-Mathieu, MacGregor, Paula, Peacock, Lori, Savill, Nicholas J, Hester, Svenja, Ravel, Sophie, Sunter, Jack D, Trevor, Camilla, Rust, Steven, Vaughan, Tristan J, Minter, Ralph, Mohammed, Shabaz, Gibson, Wendy, Taylor, Martin C, Higgins, Matthew K, Carrington, Mark
Published in Nature communications (12.03.2020)
Published in Nature communications (12.03.2020)
Get full text
Journal Article
A direct role for SNX9 in the biogenesis of filopodia
Jarsch, Iris K, Gadsby, Jonathan R, Nuccitelli, Annalisa, Mason, Julia, Shimo, Hanae, Pilloux, Ludovic, Marzook, Bishara, Mulvey, Claire M, Dobramysl, Ulrich, Bradshaw, Charles R, Lilley, Kathryn S, Hayward, Richard D, Vaughan, Tristan J, Dobson, Claire L, Gallop, Jennifer L
Published in The Journal of cell biology (06.04.2020)
Published in The Journal of cell biology (06.04.2020)
Get full text
Journal Article
Rate of Asparagine Deamidation in a Monoclonal Antibody Correlating with Hydrogen Exchange Rate at Adjacent Downstream Residues
Phillips, Jonathan J, Buchanan, Andrew, Andrews, John, Chodorge, Matthieu, Sridharan, Sudharsan, Mitchell, Laura, Burmeister, Nicole, Kippen, Alistair D, Vaughan, Tristan J, Higazi, Daniel R, Lowe, David
Published in Analytical chemistry (Washington) (21.02.2017)
Published in Analytical chemistry (Washington) (21.02.2017)
Get full text
Journal Article
Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo
Dobson, Claire L, Devine, Paul W A, Phillips, Jonathan J, Higazi, Daniel R, Lloyd, Christopher, Popovic, Bojana, Arnold, Joanne, Buchanan, Andrew, Lewis, Arthur, Goodman, Joanne, van der Walle, Christopher F, Thornton, Peter, Vinall, Lisa, Lowne, David, Aagaard, Anna, Olsson, Lise-Lotte, Ridderstad Wollberg, Anna, Welsh, Fraser, Karamanos, Theodoros K, Pashley, Clare L, Iadanza, Matthew G, Ranson, Neil A, Ashcroft, Alison E, Kippen, Alistair D, Vaughan, Tristan J, Radford, Sheena E, Lowe, David C
Published in Scientific reports (20.12.2016)
Published in Scientific reports (20.12.2016)
Get full text
Journal Article
MEDI1814 selectively reduces free Aβ42 in cerebrospinal fluid of non-clinical species and Alzheimer's disease patients
Lloyd, Christopher, Freskgård, Per-Ola, Newton, Philip, Lowne, David, Nickson, Adrian, Bogstedt, Anna, Eketjäll, Susanna, Höglund, Kina, Gustavsson, Susanne, Welsh, Fraser, Chessell, Tharani, McFarlane, Mary, Bhat, Ratan V, Turner, Richard, Perkinton, Michael S, Santisteban Valencia, Zulma, Lindqvist, Eva, Pomfret, Michael, Dudley, Amanda D, Vaughan, Tristan J, Groves, Maria T, Natanegara, Fanni, Feng, Yingdong, Sims, John R, Proctor, Nicholas Kyle, Dage, Jeffrey L, Shering, Craig, Tan, Keith, Ostenfeld, Thor, Billinton, Andy, Chessell, Iain P
Published in Alzheimer's & dementia (25.09.2024)
Published in Alzheimer's & dementia (25.09.2024)
Get full text
Journal Article
Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation
Chan, Denice T. Y., Jenkinson, Lesley, Haynes, Stuart W., Austin, Mark, Diamandakis, Agata, Burschowsky, Daniel, Seewooruthun, Chitra, Addyman, Alexandra, Fiedler, Sebastian, Ryman, Stephanie, Whitehouse, Jessica, Slater, Louise H., Gowans, Ellen, Shibata, Yoko, Barnard, Michelle, Wilkinson, Robert W., Vaughan, Tristan J., Holt, Sarah V., Cerundolo, Vincenzo, Carr, Mark D., Groves, Maria A. T.
Published in Proceedings of the National Academy of Sciences - PNAS (21.07.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (21.07.2020)
Get full text
Journal Article
Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1
Vousden, Katherine A, Lundqvist, Tomas, Popovic, Bojana, Naiman, Brian, Carruthers, Alan M, Newton, Philip, Johnson, Daniel J D, Pomowski, Anja, Wilkinson, Trevor, Dufner, Patrick, de Mendez, Isabelle, Mallinder, Philip R, Murray, Clare, Strain, Martin, Connor, Jane, Murray, Lynne A, Sleeman, Matthew A, Lowe, David C, Huntington, James A, Vaughan, Tristan J
Published in Scientific reports (07.02.2019)
Published in Scientific reports (07.02.2019)
Get full text
Journal Article
Haplosaurus computes protein haplotypes for use in precision drug design
Spooner, William, McLaren, William, Slidel, Timothy, Finch, Donna K, Butler, Robin, Campbell, Jamie, Eghobamien, Laura, Rider, David, Kiefer, Christine Mione, Robinson, Matthew J, Hardman, Colin, Cunningham, Fiona, Vaughan, Tristan, Flicek, Paul, Huntington, Catherine Chaillan
Published in Nature communications (08.10.2018)
Published in Nature communications (08.10.2018)
Get full text
Journal Article
Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors
Colley, Caroline S, Popovic, Bojana, Sridharan, Sudharsan, Debreczeni, Judit E, Hargeaves, David, Fung, Michael, An, Ling-Ling, Edwards, Bryan, Arnold, Joanne, England, Elizabeth, Eghobamien, Laura, Sivars, Ulf, Flavell, Liz, Renshaw, Jonathan, Wickson, Kate, Warrener, Paul, Zha, Jingying, Bonnell, Jessica, Woods, Rob, Wilkinson, Trevor, Dobson, Claire, Vaughan, Tristan J
Published in mAbs (01.01.2018)
Published in mAbs (01.01.2018)
Get full text
Journal Article