Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington’s Disease
Liu, Longbin, Malagu, Karine, Haughan, Alan F., Khetarpal, Vinod, Stott, Andrew J., Esmieu, William, Vater, Huw D., Webster, Stephen J., Van de Poël, Amanda J., Clissold, Cole, Cosgrove, Brett, Sutton, Benjamin, Spencer, Jonathan A., Breccia, Perla, Gancia, Emanuela, Bonomo, Silvia, Ladduwahetty, Tammy, Lazari, Ovadia, Patel, Hiral, Atton, Helen C., Clifton, Steve, Mota, Daniel M., Magnani, Dario, O’Neill, Amy, Stebbeds, Marta, Macabuag, Natsuko, Todd, Daniel, Herva, Maria E., Mitchell, Philip, Visser, Mijke, Compte Sancerni, Sara, Grand Moursel, Laure, da Silva, Marta, Kritikou, Eva, Heikkinen, Taneli T., Bolkvadze, Tamuna, Fodale, Valentina, Spadafora, Debora, Daldin, Manuel, Bresciani, Alberto, Mangette, John E., Doherty, Elizabeth M., Lee, Matthew R., Herbst, Todd, Monteagudo, Edith, Macdonald, Douglas, Plotnikov, Nikolay V., Chambers, Mark, McAllister, George, Muňoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (28.09.2023)
Published in Journal of medicinal chemistry (28.09.2023)
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Journal Article
Evaluation of 5‑(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington’s Disease
Stott, Andrew J, Maillard, Michel C, Beaumont, Vahri, Allcock, David, Aziz, Omar, Borchers, Alexander H, Blackaby, Wesley, Breccia, Perla, Creighton-Gutteridge, Gillian, Haughan, Alan F, Jarvis, Rebecca E, Luckhurst, Christopher A, Matthews, Kim L, McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Van de Poël, Amanda J, Vater, Huw D, Vann, Julie, Williams, Rachel, Yates, Dawn, Muñoz-Sanjuán, Ignacio, Dominguez, Celia
Published in ACS medicinal chemistry letters (11.03.2021)
Published in ACS medicinal chemistry letters (11.03.2021)
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Journal Article
Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington’s Disease Pathology
Macabuag, Natsuko, Esmieu, William, Breccia, Perla, Jarvis, Rebecca, Blackaby, Wesley, Lazari, Ovadia, Urbonas, Liudvikas, Eznarriaga, Maria, Williams, Rachel, Strijbosch, Annelieke, Van de Bospoort, Rhea, Matthews, Kim, Clissold, Cole, Ladduwahetty, Tammy, Vater, Huw, Heaphy, Patrick, Stafford, Douglas G., Wang, Hong-Jun, Mangette, John E., McAllister, George, Beaumont, Vahri, Vogt, Thomas F., Wilkinson, Hilary A., Doherty, Elizabeth M., Dominguez, Celia
Published in Journal of medicinal chemistry (22.09.2022)
Published in Journal of medicinal chemistry (22.09.2022)
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Journal Article
Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class Ila HDAC Inhibitors for Huntington's Disease
Stott, Andrew J., Maillard, Michel C., Beaumont, Vahri, Allcock, David, Aziz, Omar, Borchers, Alexander H., Blackaby, Wesley, Breccia, Perla, Creighton-Gutteridge, Gillian, Haughan, Alan F., Jarvis, Rebecca E., Luckhurst, Christopher A., Matthews, Kim L., McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Van de Poel, Amanda J., Vater, Huw D., Vann, Julie, Williams, Rachel, Yates, Dawn, Munoz-Sanjuan, Ignacio, Dominguez, Celia
Published in ACS medicinal chemistry letters (11.03.2021)
Published in ACS medicinal chemistry letters (11.03.2021)
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Journal Article
Structure-Based Exploration of Selectivity for ATM Inhibitors in Huntington’s Disease
Van de Poël, Amanda, Toledo-Sherman, Leticia, Breccia, Perla, Cachope, Roger, Bate, Jennifer R, Angulo-Herrera, Ivan, Wishart, Grant, Matthews, Kim L, Martin, Sarah L, Peacock, Marcus, Barnard, Amy, Cox, Helen C, Jones, Graham, McAllister, George, Vater, Huw, Esmieu, William, Clissold, Cole, Lamers, Marieke, Leonard, Philip, Jarvis, Rebecca E, Blackaby, Wesley, Eznarriaga, Maria, Lazari, Ovadia, Yates, Dawn, Rose, Mark, Jang, Sung-Wook, Muñoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Journal Article
Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington’s Disease Models
Toledo-Sherman, Leticia, Breccia, Perla, Cachope, Roger, Bate, Jennifer R, Angulo-Herrera, Ivan, Wishart, Grant, Matthews, Kim L, Martin, Sarah L, Cox, Helen C, McAllister, George, Penrose, Stephen D, Vater, Huw, Esmieu, William, Van de Poël, Amanda, Van de Bospoort, Rhea, Strijbosch, Annelieke, Lamers, Marieke, Leonard, Philip, Jarvis, Rebecca E, Blackaby, Wesley, Barnes, Karen, Eznarriaga, Maria, Dowler, Simon, Smith, Graham D, Fischer, David F, Lazari, Ovadia, Yates, Dawn, Rose, Mark, Jang, Sung-Wook, Muñoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (28.03.2019)
Published in Journal of medicinal chemistry (28.03.2019)
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Journal Article
헌팅턴병을 치료하기 위한 HTT 조절제
ESMIEU WILLIAM, LIU LONGBIN, COSGROVE BRETT, SPENCER JONATHAN, VATER HUW, DOMINGUEZ CELIA, PLOTNIKOV NIKOLAY V, CHAMBERS MARK, MALAGU KARINE, HAUGHAN ALAN, STOTT ANDREW, CLISSOLD COLE
Year of Publication 26.07.2024
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Year of Publication 26.07.2024
Patent
헌팅턴병을 치료하기 위한 HTT 조절제
MALAGU KARINE FABIENNE, WEBSTER STEPHEN JOHN, DOHERTY ELIZABETH M, HAUGHAN ALAN F, VAN DE POEL AMANDA J, LIU LONGBIN, CHAMBERS MARK STUART, DOMINGUEZ CELIA, BRECCIA PERLA, ESMIEU WILLIAM R. K, VATER HUW D, STOTT ANDREW J, LEE MATTHEW
Year of Publication 28.02.2023
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Year of Publication 28.02.2023
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HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF
WISHART GRANT, PENROSE STEPHEN D, SAVILLE STONES ELIZABETH, JARVIS REBECCA E, RAPHY GILLES, MUNOZ SANJUAN IGNACIO, LUCKHURST CHRISTOPHER A, HAUGHAN ALAN F, ALLEN DANIEL R, BURLI ROLAND W, DOMINGUEZ CELIA, BRECCIA PERLA, WALL MICHAEL, HUGHES SAMANTHA J, VATER HUW D, STOTT ANDREW J
Year of Publication 02.02.2017
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Year of Publication 02.02.2017
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AZETIDINE DERIVATIVES AND USE THEREOF AS DIPEPTIDYL PEPTIDASE 1 INHIBITORS
RIZZI, Andrea, GUARIENTO, Sara, ARMANI, Elisabetta, VAN DE POËL, Hervè Pierre Clotaire, VATER, Huw David
Year of Publication 11.01.2024
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Year of Publication 11.01.2024
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N-(2H-INDAZOL-5-YL)PYRAZINE-2-CARBOXAMIDE DERIVATIVES AND SIMILAR COMPOUNDS AS HTT MODULATORS FOR THE TREATMENT OF HUNTINGTON'S DISEASE
CLISSOLD, Cole, MALAGU, Karine, HAUGHAN, Alan, DOMINGUEZ, Celia, SPENCER, Jonathan, STOTT, Andrew, VATER, Huw, PLOTNIKOV, Nikolay V, COSGROVE, Brett, LIU, Longbin, ESMIEU, William, CHAMBERS, Mark
Year of Publication 25.09.2024
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Year of Publication 25.09.2024
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Htt modulators for treating huntington's disease
Longbin LIU, Alan HAUGHAN, Andrew STOTT, Cole CLISSOLD, Huw VATER, Celia DOMINGUEZ, Karine MALAGU, Nikolay V. PLOTNIKOV, Jonathan SPENCER, William ESMIEU, Brett COSGROVE, Mark CHAMBERS
Year of Publication 01.07.2024
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Year of Publication 01.07.2024
Patent
N-(2H-INDAZOL-5-YL)PYRAZINE-2-CARBOXAMIDE DERIVATIVES AND SIMILAR COMPOUNDS AS HTT MODULATORS FOR THE TREATMENT OF HUNTINGTON'S DISEASE
CLISSOLD, Cole, MALAGU, Karine, HAUGHAN, Alan, DOMINGUEZ, Celia, SPENCER, Jonathan, STOTT, Andrew, VATER, Huw, PLOTNIKOV, Nikolay V, COSGROVE, Brett, LIU, Longbin, ESMIEU, William, CHAMBERS, Mark
Year of Publication 27.06.2024
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Year of Publication 27.06.2024
Patent
N-(2H-INDAZOL-5-YL)PYRAZINE-2-CARBOXAMIDE DERIVATIVES AND SIMILAR COMPOUNDS AS HTT MODULATORS FOR THE TREATMENT OF HUNTINGTON'S DISEASE
CLISSOLD, Cole, MALAGU, Karine, HAUGHAN, Alan, DOMINGUEZ, Celia, SPENCER, Jonathan, STOTT, Andrew, VATER, Huw, PLOTNIKOV, Nikolay V, COSGROVE, Brett, LIU, Longbin, ESMIEU, William, CHAMBERS, Mark
Year of Publication 25.05.2023
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Year of Publication 25.05.2023
Patent
HTT MODULATORS FOR TREATING HUNTINGTON'S DISEASE
CHAMBERS, MARK, VATER, HUW, MALAGU, KARINE, ESMIEU, WILLIAM, HAUGHAN, ALAN, CLISSOLD, COLE, DOMINGUEZ, CELIA, LIU, LONGBIN, COSGROVE, BRETT, PLOTNIKOV, NIKOLAY V, SPENCER, JONATHAN, STOTT, ANDREW
Year of Publication 25.05.2023
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Year of Publication 25.05.2023
Patent
HTT MODULATORS FOR TREATING HUNTINGTON'S DISEASE
Cosgrove, Brett, Haughan, Alan, Stott, Andrew, Esmieu, William, Plotnikov, Nikolay V, Spencer, Jonathan, Malagu, Karine, Chambers, Mark, Liu, Longbin, Vater, Huw, Dominguez, Celia, Clissold, Cole
Year of Publication 25.05.2023
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Year of Publication 25.05.2023
Patent