Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation
Moran-Crusio, Kelly, Reavie, Linsey, Shih, Alan, Abdel-Wahab, Omar, Ndiaye-Lobry, Delphine, Lobry, Camille, Figueroa, Maria E., Vasanthakumar, Aparna, Patel, Jay, Zhao, Xinyang, Perna, Fabiana, Pandey, Suveg, Madzo, Jozef, Song, Chunxiao, Dai, Qing, He, Chuan, Ibrahim, Sherif, Beran, Miloslav, Zavadil, Jiri, Nimer, Stephen D., Melnick, Ari, Godley, Lucy A., Aifantis, Iannis, Levine, Ross L.
Published in Cancer cell (12.07.2011)
Published in Cancer cell (12.07.2011)
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Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
Figueroa, Maria E., Abdel-Wahab, Omar, Lu, Chao, Ward, Patrick S., Patel, Jay, Shih, Alan, Li, Yushan, Bhagwat, Neha, Vasanthakumar, Aparna, Fernandez, Hugo F., Tallman, Martin S., Sun, Zhuoxin, Wolniak, Kristy, Peeters, Justine K., Liu, Wei, Choe, Sung E., Fantin, Valeria R., Paietta, Elisabeth, Löwenberg, Bob, Licht, Jonathan D., Godley, Lucy A., Delwel, Ruud, Valk, Peter J.M., Thompson, Craig B., Levine, Ross L., Melnick, Ari
Published in Cancer cell (14.12.2010)
Published in Cancer cell (14.12.2010)
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DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia
Rampal, Raajit, Alkalin, Altuna, Madzo, Jozef, Vasanthakumar, Aparna, Pronier, Elodie, Patel, Jay, Li, Yushan, Ahn, Jihae, Abdel-Wahab, Omar, Shih, Alan, Lu, Chao, Ward, Patrick S, Tsai, Jennifer J, Hricik, Todd, Tosello, Valeria, Tallman, Jacob E, Zhao, Xinyang, Daniels, Danette, Dai, Qing, Ciminio, Luisa, Aifantis, Iannis, He, Chuan, Fuks, Francois, Tallman, Martin S, Ferrando, Adolfo, Nimer, Stephen, Paietta, Elisabeth, Thompson, Craig B, Licht, Jonathan D, Mason, Christopher E, Godley, Lucy A, Melnick, Ari, Figueroa, Maria E, Levine, Ross L
Published in Cell reports (Cambridge) (11.12.2014)
Published in Cell reports (Cambridge) (11.12.2014)
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TET1-Mediated Hydroxymethylation Facilitates Hypoxic Gene Induction in Neuroblastoma
Mariani, Christopher J., Vasanthakumar, Aparna, Madzo, Jozef, Yesilkanal, Ali, Bhagat, Tushar, Yu, Yiting, Bhattacharyya, Sanchari, Wenger, Roland H., Cohn, Susan L., Nanduri, Jayasri, Verma, Amit, Prabhakar, Nanduri R., Godley, Lucy A.
Published in Cell reports (Cambridge) (12.06.2014)
Published in Cell reports (Cambridge) (12.06.2014)
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TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia
Yamazaki, Jumpei, Jelinek, Jaroslav, Lu, Yue, Cesaroni, Matteo, Madzo, Jozef, Neumann, Frank, He, Rong, Taby, Rodolphe, Vasanthakumar, Aparna, Macrae, Trisha, Ostler, Kelly R, Kantarjian, Hagop M, Liang, Shoudan, Estecio, Marcos R, Godley, Lucy A, Issa, Jean-Pierre J
Published in Cancer research (Chicago, Ill.) (15.07.2015)
Published in Cancer research (Chicago, Ill.) (15.07.2015)
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DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID
Dominguez, Pilar M., Teater, Matt, Chambwe, Nyasha, Kormaksson, Matthias, Redmond, David, Ishii, Jennifer, Vuong, Bao, Chaudhuri, Jayanta, Melnick, Ari, Vasanthakumar, Aparna, Godley, Lucy A., Papavasiliou, F. Nina, Elemento, Olivier, Shaknovich, Rita
Published in Cell reports (Cambridge) (29.09.2015)
Published in Cell reports (Cambridge) (29.09.2015)
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Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma
Clozel, Thomas, Yang, ShaoNing, Elstrom, Rebecca L, Tam, Wayne, Martin, Peter, Kormaksson, Matthias, Banerjee, Samprit, Vasanthakumar, Aparna, Culjkovic, Biljana, Scott, David W, Wyman, Sarah, Leser, Micheal, Shaknovich, Rita, Chadburn, Amy, Tabbo, Fabrizio, Godley, Lucy A, Gascoyne, Randy D, Borden, Katherine L, Inghirami, Giorgio, Leonard, John P, Melnick, Ari, Cerchietti, Leandro
Published in Cancer discovery (01.09.2013)
Published in Cancer discovery (01.09.2013)
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Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors
Pronier, Elodie, Almire, Carole, Mokrani, Hayat, Vasanthakumar, Aparna, Simon, Audrey, da Costa Reis Monte Mor, Barbara, Massé, Aline, Le Couédic, Jean-Pierre, Pendino, Frédéric, Carbonne, Bruno, Larghero, Jérôme, Ravanat, Jean-Luc, Casadevall, Nicole, Bernard, Olivier A., Droin, Nathalie, Solary, Eric, Godley, Lucy A., Vainchenker, William, Plo, Isabelle, Delhommeau, François
Published in Blood (01.09.2011)
Published in Blood (01.09.2011)
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Journal Article
DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation
Shaknovich, Rita, Cerchietti, Leandro, Tsikitas, Lucas, Kormaksson, Matthias, De, Subhajyoti, Figueroa, Maria E., Ballon, Gianna, Yang, Shao Ning, Weinhold, Nils, Reimers, Mark, Clozel, Thomas, Luttrop, Karin, Ekstrom, Tomas J., Frank, Jared, Vasanthakumar, Aparna, Godley, Lucy A., Michor, Franziska, Elemento, Olivier, Melnick, Ari
Published in Blood (29.09.2011)
Published in Blood (29.09.2011)
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Journal Article
Editorial: Women in science: Genetics
de Vasconcellos, Jaira Ferreira, Abedalthagafi, Malak, Calo, Silvia, Dajani, Rana, Dlamini, Zodwa, Hidalgo, Bertha, Le Goff, Carine, Vasanthakumar, Aparna
Published in Frontiers in genetics (03.10.2022)
Published in Frontiers in genetics (03.10.2022)
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Diversity of CFTR variants across ancestries characterized using 454,727 UK biobank whole exome sequences
Ideozu, Justin E, Liu, Mengzhen, Riley-Gillis, Bridget M, Paladugu, Sri R, Rahimov, Fedik, Krishnan, Preethi, Tripathi, Rakesh, Dorr, Patrick, Levy, Hara, Singh, Ashvani, Waring, Jeffrey F, Vasanthakumar, Aparna
Published in Genome medicine (21.03.2024)
Published in Genome medicine (21.03.2024)
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Brca1 deficiency causes bone marrow failure and spontaneous hematologic malignancies in mice
Vasanthakumar, Aparna, Arnovitz, Stephen, Marquez, Rafael, Lepore, Janet, Rafidi, George, Asom, Anase, Weatherly, Madison, Davis, Elizabeth M., Neistadt, Barbara, Duszynski, Robert, Vardiman, James W., Le Beau, Michelle M., Godley, Lucy A., Churpek, Jane E.
Published in Blood (21.01.2016)
Published in Blood (21.01.2016)
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Journal Article
Hydroxymethylation at Gene Regulatory Regions Directs Stem/Early Progenitor Cell Commitment during Erythropoiesis
Madzo, Jozef, Liu, Hui, Rodriguez, Alexis, Vasanthakumar, Aparna, Sundaravel, Sriram, Caces, Donne Bennett D., Looney, Timothy J., Zhang, Li, Lepore, Janet B., Macrae, Trisha, Duszynski, Robert, Shih, Alan H., Song, Chun-Xiao, Yu, Miao, Yu, Yiting, Grossman, Robert, Raumann, Brigitte, Verma, Amit, He, Chuan, Levine, Ross L., Lavelle, Don, Lahn, Bruce T., Wickrema, Amittha, Godley, Lucy A.
Published in Cell reports (Cambridge) (01.01.2014)
Published in Cell reports (Cambridge) (01.01.2014)
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Journal Article
Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia
Yamazaki, Jumpei, Taby, Rodolphe, Vasanthakumar, Aparna, Macrae, Trisha, Ostler, Kelly R., Shen, Lanlan, Kantarjian, Hagop M., Estecio, Marcos R., Jelinek, Jaroslav, Godley, Lucy A., Issa, Jean-Pierre J.
Published in Epigenetics (01.02.2012)
Published in Epigenetics (01.02.2012)
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Reduced ITPase activity and favorable IL28B genetic variant protect against ribavirin-induced anemia in interferon-free regimens
Vasanthakumar, Aparna, Davis, Justin W, Abunimeh, Manal, Söderholm, Jonas, Zha, Jiuhong, Dumas, Emily O, Cohen, Daniel E, Waring, Jeffrey F, Lagging, Martin
Published in PloS one (31.05.2018)
Published in PloS one (31.05.2018)
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Navitoclax safety, tolerability, and effect on biomarkers of senescence and neurodegeneration in aged nonhuman primates
Greenberg, Edward F., Voorbach, Martin J., Smith, Alexandra, Reuter, David R., Zhuang, Yuchuan, Wang, Ji-Quan, Wooten, Dustin W., Asque, Elizabeth, Hu, Min, Hoft, Carolin, Duggan, Ryan, Townsend, Matthew, Orsi, Karin, Dalecki, Karen, Amberg, Willi, Duggan, Lori, Knight, Heather, Spina, Joseph S., He, Yupeng, Marsh, Kennan, Zhao, Vivian, Ybarra, Suzanne, Mollon, Jennifer, Fang, Yuni, Vasanthakumar, Aparna, Westmoreland, Susan, Droescher, Mathias, Finnema, Sjoerd J., Florian, Hana
Published in Heliyon (30.08.2024)
Published in Heliyon (30.08.2024)
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DNMT3B7, a Truncated DNMT3B Isoform Expressed in Human Tumors, Disrupts Embryonic Development and Accelerates Lymphomagenesis
SHAH, Mrinal Y, VASANTHAKUMAR, Aparna, LE BEAU, Michelle M, MOSKOWITZ, Ivan P, MELNICK, Ari, PYTEL, Peter, GODLY, Lucy A, BARNES, Natalie Y, FIGUEROA, Maria E, KAMP, Anna, HENDRICK, Christopher, OSTLER, Kelly R, DAVIS, Elizabeth M, SHANG LIN, ANASTASI, John
Published in Cancer research (Chicago, Ill.) (15.07.2010)
Published in Cancer research (Chicago, Ill.) (15.07.2010)
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Evidence That Phosphorylation of Iron Regulatory Protein 1 at Serine 138 Destabilizes the [4Fe-4S] Cluster in Cytosolic Aconitase by Enhancing 4Fe-3Fe Cycling
Deck, Kathryn M., Vasanthakumar, Aparna, Anderson, Sheila A., Goforth, Jeremy B., Kennedy, M. Claire, Antholine, William E., Eisenstein, Richard S.
Published in The Journal of biological chemistry (08.05.2009)
Published in The Journal of biological chemistry (08.05.2009)
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