A red meat-derived glycan promotes inflammation and cancer progression
Samraj, Annie N., Pearce, Oliver M. T., Läubli, Heinz, Crittenden, Alyssa N., Bergfeld, Anne K., Banda, Kalyan, Gregg, Christopher J., Bingman, Andrea E., Secrest, Patrick, Diaz, Sandra L., Varki, Nissi M., Varki, Ajit
Published in Proceedings of the National Academy of Sciences - PNAS (13.01.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (13.01.2015)
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Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis
Bard-Chapeau, Emilie A., Li, Shuangwei, Ding, Jin, Zhang, Sharon S., Zhu, Helen H., Princen, Frederic, Fang, Diane D., Han, Tao, Bailly-Maitre, Beatrice, Poli, Valeria, Varki, Nissi M., Wang, Hongyang, Feng, Gen-Sheng
Published in Cancer cell (17.05.2011)
Published in Cancer cell (17.05.2011)
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Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer
Läubli, Heinz, Pearce, Oliver M. T., Schwarz, Flavio, Siddiqui, Shoib S., Deng, Lingquan, Stanczak, Michal A., Deng, Liwen, Verhagen, Andrea, Secrest, Patrick, Lusk, Chrissy, Schwartz, Ann G., Varki, Nissi M., Bui, Jack D., Varki, Ajit
Published in Proceedings of the National Academy of Sciences - PNAS (30.09.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (30.09.2014)
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Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline
Schwarz, Flavio, Springer, Stevan A., Altheide, Tasha K., Varki, Nissi M., Gagneux, Pascal, Varki, Ajit
Published in Proceedings of the National Academy of Sciences - PNAS (05.01.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (05.01.2016)
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α2-6-Linked Sialic Acids on N-Glycans Modulate Carcinoma Differentiation In vivo
HEDLUND, Maria, NG, Elisa, VARKI, Ajit, VARKI, Nissi M
Published in Cancer research (Chicago, Ill.) (15.01.2008)
Published in Cancer research (Chicago, Ill.) (15.01.2008)
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Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies
Pearce, Oliver M. T., Läubli, Heinz, Verhagen, Andrea, Secrest, Patrick, Zhang, Jiquan, Varki, Nissi M., Crocker, Paul R., Bui, Jack D., Varki, Ajit
Published in Proceedings of the National Academy of Sciences - PNAS (22.04.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (22.04.2014)
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Deficiency of intestinal mucin-2 protects mice from diet-induced fatty liver disease and obesity
Hartmann, Phillipp, Seebauer, Caroline T, Mazagova, Magdalena, Horvath, Angela, Wang, Lirui, Llorente, Cristina, Varki, Nissi M, Brandl, Katharina, Ho, Samuel B, Schnabl, Bernd
Published in American journal of physiology: Gastrointestinal and liver physiology (01.03.2016)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.03.2016)
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Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor
Grewal, Prabhjit K., Aziz, Peter V., Uchiyama, Satoshi, Rubio, Gabriel R., Lardone, Ricardo D., Le, Dzung, Varki, Nissi M., Nizet, Victor, Marth, Jamey D.
Published in Proceedings of the National Academy of Sciences - PNAS (10.12.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (10.12.2013)
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Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products
Diaz, Sandra L, Padler-Karavani, Vered, Ghaderi, Darius, Hurtado-Ziola, Nancy, Yu, Hai, Chen, Xi, Brinkman-Van der Linden, Els C M, Varki, Ajit, Varki, Nissi M
Published in PloS one (21.01.2009)
Published in PloS one (21.01.2009)
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Biomedical differences between human and nonhuman hominids: potential roles for uniquely human aspects of sialic acid biology
Varki, Nissi M, Strobert, Elizabeth, Dick, Jr, Edward J, Benirschke, Kurt, Varki, Ajit
Published in Annual review of pathology (28.02.2011)
Published in Annual review of pathology (28.02.2011)
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Journal Article
Physiological Exploration of the Long Term Evolutionary Selection against Expression of N-Glycolylneuraminic Acid in the Brain
Naito-Matsui, Yuko, Davies, Leela R.L., Takematsu, Hiromu, Chou, Hsun-Hua, Tangvoranuntakul, Pam, Carlin, Aaron F., Verhagen, Andrea, Heyser, Charles J., Yoo, Seung-Wan, Choudhury, Biswa, Paton, James C., Paton, Adrienne W., Varki, Nissi M., Schnaar, Ronald L., Varki, Ajit
Published in The Journal of biological chemistry (17.02.2017)
Published in The Journal of biological chemistry (17.02.2017)
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Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium
Pham, Tho, Gregg, Christopher J., Karp, Felix, Chow, Renee, Padler-Karavani, Vered, Cao, Hongzhi, Chen, Xi, Witztum, Joseph L., Varki, Nissi M., Varki, Ajit
Published in Blood (10.12.2009)
Published in Blood (10.12.2009)
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Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin
Byres, Emma, Paton, Adrienne W., Paton, James C., Löfling, Jonas C., Smith, David F., Wilce, Matthew C. J., Talbot, Ursula M., Chong, Damien C., Yu, Hai, Huang, Shengshu, Chen, Xi, Varki, Nissi M., Varki, Ajit, Rossjohn, Jamie, Beddoe, Travis
Published in Nature (04.12.2008)
Published in Nature (04.12.2008)
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Disruption of Forkhead Transcription Factor (FOXO) Family Members in Mice Reveals Their Functional Diversification
Hosaka, Taisuke, Biggs, William H., Tieu, David, Boyer, Antonia D., Varki, Nissi M., Cavenee, Webster K., Arden, Karen C., White, Raymond L.
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.2004)
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Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions
Lee, Jin, Liao, Rui, Wang, Gaowei, Yang, Bi-Huei, Luo, Xiaolin, Varki, Nissi M., Qiu, Shuang-Jian, Ren, Bing, Fu, Wenxian, Feng, Gen-Sheng
Published in Cell reports (Cambridge) (14.11.2017)
Published in Cell reports (Cambridge) (14.11.2017)
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Synergistic Effects of L- and P-Selectin in Facilitating Tumor Metastasis Can Involve Non-Mucin Ligands and Implicate Leukocytes as Enhancers of Metastasis
Borsig, Lubor, Wong, Richard, Hynes, Richard O., Varki, Nissi M., Varki, Ajit
Published in Proceedings of the National Academy of Sciences - PNAS (19.02.2002)
Published in Proceedings of the National Academy of Sciences - PNAS (19.02.2002)
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