Synthesis and structure–activity studies of novel homomorpholine oxazolidinone antibacterial agents
Kim, Ji-Young, Boyer, Frederick E., Choy, Allison L., Huband, Michael D., Pagano, Paul J., Vara Prasad, J.V.N.
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
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Antibacterial Oxazolidinones Possessing a Novel C-5 Side Chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic Acid Amide (PF-00422602), a New Lead Compound
Poel, Toni-Jo, Thomas, Richard C, Adams, Wade J, Aristoff, Paul A, Barbachyn, Michael R, Boyer, Frederick E, Brieland, Joan, Brideau, Roger, Brodfuehrer, Joanne, Brown, Alan P, Choy, Allison L, Dermyer, Michael, Dority, Michael, Ford, Charles W, Gadwood, Robert C, Hanna, Debra, Hongliang, Cai, Huband, Michael D, Huber, Christopher, Kelly, Rose, Kim, Ji-Young, Martin, Joseph P, Pagano, Paul J, Ross, Daniel, Skerlos, Laura, Sulavik, Mark C, Zhu, Tong, Zurenko, Gary E, Prasad, J. V. N. Vara
Published in Journal of medicinal chemistry (29.11.2007)
Published in Journal of medicinal chemistry (29.11.2007)
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Synthesis and SAR of novel conformationally restricted oxazolidinones possessing Gram-positive and fastidious Gram-negative antibacterial activity. Part 2: Amino substitutions on heterocyclic D-ring system
Choy, Allison L., Vara Prasad, J.V.N., Boyer, Frederick E., Huband, Michael D., Dermyer, Michael R.
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
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A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials
Renslo, Adam R., Atuegbu, Andy, Herradura, Prudencio, Jaishankar, Priyadarshini, Ji, Mingzhe, Leach, Karen L., Huband, Michael D., Dermyer, Michael R., Wu, Luping, Vara Prasad, J.V.N., Gordeev, Mikhail F.
Published in Bioorganic & medicinal chemistry letters (15.09.2007)
Published in Bioorganic & medicinal chemistry letters (15.09.2007)
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Implementation of an ADME enabling selection and visualization tool for drug discovery
Stoner, Chad L., Gifford, Eric, Stankovic, Charles, Lepsy, Christopher S., Brodfuehrer, Joanne, Prasad, J.V.N.Vara, Surendran, Narayanan
Published in Journal of pharmaceutical sciences (01.05.2004)
Published in Journal of pharmaceutical sciences (01.05.2004)
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Synthesis and structure–activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents
Vara Prasad, J.V.N., Boyer, Frederick E., Chupak, Lou, Dermyer, Michael, Ding, Qizhu, Gavardinas, K., Hagen, Susan E., Huband, Michael D., Jiao, Wenhua, Kaneko, Takushi, Maiti, Samarendra N., Melnick, Michael, Romero, Karina, Patterson, M., Wu, Xiujuan
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
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4-Hydroxy-2-pyridones: Discovery and evaluation of a novel class of antibacterial agents targeting DNA synthesis
Arnold, Michael A., Gerasyuto, Aleksey I., Wang, Jiashi, Du, Wu, Gorske, Yi Jin Kim, Arasu, Tamil, Baird, John, Almstead, Neil G., Narasimhan, Jana, Peddi, Srinivasa, Ginzburg, Olya, Lue, Stanley W., Hedrick, Jean, Sheedy, Josephine, Lagaud, Guy, Branstrom, Arthur A., Weetall, Marla, Prasad, J.V.N. Vara, Karp, Gary M.
Published in Bioorganic & medicinal chemistry letters (15.11.2017)
Published in Bioorganic & medicinal chemistry letters (15.11.2017)
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class of selective antibacterials derived from a protein kinase inhibitor pharmacophore
Miller, J. Richard, Dunham, Steve, Mochalkin, Igor, Banotai, Craig, Bowman, Matthew, Buist, Susan, Dunkle, Bill, Hanna, Debra, Harwood, H. James, Huband, Michael D, Karnovsky, Alla, Kuhn, Michael, Limberakis, Chris, Liu, Jia Y, Mehrens, Shawn, Mueller, W. Thomas, Narasimhan, Lakshmi, Ogden, Adam, Ohren, Jeff, Prasad, J.V.N. Vara, Shelly, John A, Skerlos, Laura, Sulavik, Mark, Thomas, V. Hayden, VanderRoest, Steve, Wang, LiAnn, Wang, Zhigang, Whitton, Amy, Zhu, Tong, Stover, C. Kendall
Published in Proceedings of the National Academy of Sciences - PNAS (10.02.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (10.02.2009)
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Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches
Mochalkin, Igor, Miller, J. Richard, Narasimhan, Lakshmi, Thanabal, Venkataraman, Erdman, Paul, Cox, Philip B, Prasad, J. V. N. Vara, Lightle, Sandra, Huband, Michael D, Stover, C. Kendall
Published in ACS chemical biology (19.06.2009)
Published in ACS chemical biology (19.06.2009)
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Novel Series of Achiral, Low Molecular Weight, and Potent HIV-1 Protease Inhibitors
Vara Prasad, J. V. N, Para, Kimberly S, Lunney, Elizabeth A, Ortwine, Daniel F, Dunbar, James B, Ferguson, Donna, Tummino, Peter J, Hupe, Donald, Tait, Bradley D
Published in Journal of the American Chemical Society (01.07.1994)
Published in Journal of the American Chemical Society (01.07.1994)
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Effect of hydroxyl group configuration in hydroxyethylamine dipeptide isosteres on HIV protease inhibition. Evidence for multiple binding modes
Rich, Daniel H, Sun, Chong Qing, Prasad, J. V. N. Vara, Pathiasseril, Ahammadunny, Toth, Mihaly V, Marshall, Garland R, Clare, Michael, Mueller, Richard A, Houseman, Kathryn
Published in Journal of medicinal chemistry (01.03.1991)
Published in Journal of medicinal chemistry (01.03.1991)
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Synthesis and SAR of novel conformationally-restricted oxazolidinones possessing Gram-positive and fastidious Gram-negative antibacterial activity. Part 1: Substituted pyrazoles
Boyer, Frederick E., Vara Prasad, J.V.N., Choy, Allison L., Chupak, Louis, Dermyer, Michael R., Ding, Qizhu, Huband, Michael D., Jiao, Wenhua, Kaneko, Takushi, Khlebnikov, Vladimir, Kim, Ji-Young, Lall, Manjinder S., Maiti, Samarendra N., Romero, Karina, Wu, Xiujuan
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
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Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure–activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones
Renslo, Adam R., Gao, Hongwu, Jaishankar, Priyadarshini, Venkatachalam, Revathy, Gómez, Marcela, Blais, Johanne, Huband, Michael, Vara Prasad, J.V.N., Gordeev, Mikhail F.
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
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5,6-Dihydropyran-2-ones Possessing Various Sulfonyl Functionalities: Potent Nonpeptidic Inhibitors of HIV Protease
Boyer, Frederick E, Vara Prasad, J. V. N, Domagala, John M, Ellsworth, Edmund L, Gajda, Christopher, Hagen, Susan E, Markoski, Larry J, Tait, Bradley D, Lunney, Elizabeth A, Palovsky, Alexander, Ferguson, Donna, Graham, Neil, Holler, Tod, Hupe, Donald, Nouhan, Carolyn, Tummino, Peter J, Urumov, A, Zeikus, Eric, Zeikus, Greg, Gracheck, Stephen J, Sanders, James M, VanderRoest, Steven, Brodfuehrer, Joanne, Iyer, Krishna, Sinz, Michael, Gulnik, Sergei V, Erickson, John W
Published in Journal of medicinal chemistry (09.03.2000)
Published in Journal of medicinal chemistry (09.03.2000)
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Synthesis of 5,6-Dihydro-4-hydroxy-2- pyrones as HIV-1 Protease Inhibitors: The Profound Effect of Polarity on Antiviral Activity
Hagen, Susan E, Vara Prasad, J. V. N, Boyer, Frederick E, Domagala, John M, Ellsworth, Edmund L, Gajda, Christopher, Hamilton, Harriet W, Markoski, Larry J, Steinbaugh, Bruce A, Tait, Bradley D, Lunney, Elizabeth A, Tummino, Peter J, Ferguson, Donna, Hupe, Donald, Nouhan, Carolyn, Gracheck, Stephen J, Saunders, James M, VanderRoest, Steven
Published in Journal of medicinal chemistry (07.11.1997)
Published in Journal of medicinal chemistry (07.11.1997)
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Chiral Synthesis via Organoboranes. 11. Hydroboration. 82. Asymmetric Hydroboration of 1-Heteroarylcycloalkenes with Monoisopinocampheylborane. Synthesis of trans-2-Heteroarylcycloalkyl Boronates and Derived Alcohols of Very High Enantiomeric Purity
Brown, Herbert C, Gupta, Ashok K, Vara Prasad, J. V. N
Published in Bulletin of the Chemical Society of Japan (01.01.1988)
Published in Bulletin of the Chemical Society of Japan (01.01.1988)
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