Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain
Zhao, Peishen, Lieu, TinaMarie, Barlow, Nicholas, Sostegni, Silvia, Haerteis, Silke, Korbmacher, Christoph, Liedtke, Wolfgang, Jimenez-Vargas, Nestor N., Vanner, Stephen J., Bunnett, Nigel W.
Published in The Journal of biological chemistry (29.05.2015)
Published in The Journal of biological chemistry (29.05.2015)
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Journal Article
The TGR5 receptor mediates bile acid-induced itch and analgesia
Alemi, Farzad, Kwon, Edwin, Poole, Daniel P, Lieu, TinaMarie, Lyo, Victoria, Cattaruzza, Fiore, Cevikbas, Ferda, Steinhoff, Martin, Nassini, Romina, Materazzi, Serena, Guerrero-Alba, Raquel, Valdez-Morales, Eduardo, Cottrell, Graeme S, Schoonjans, Kristina, Geppetti, Pierangelo, Vanner, Stephen J, Bunnett, Nigel W, Corvera, Carlos U
Published in The Journal of clinical investigation (01.04.2013)
Published in The Journal of clinical investigation (01.04.2013)
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Journal Article
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome
Jimenez-Vargas, Nestor N., Pattison, Luke A., Zhao, Peishen, Lieu, TinaMarie, Latorre, Rocco, Jensen, Dane D., Castro, Joel, Aurelio, Luigi, Le, Giang T., Flynn, Bernard, Herenbrink, Carmen Klein, Yeatman, Holly R., Edgington-Mitchell, Laura, Porter, Christopher J. H., Halls, Michelle L., Canals, Meritxell, Veldhuis, Nicholas A., Poole, Daniel P., McLean, Peter, Hicks, Gareth A., Scheff, Nicole, Chen, Elyssa, Bhattacharya, Aditi, Schmidt, Brian L., Brierley, Stuart M., Vanner, Stephen J., Bunnett, Nigel W.
Published in Proceedings of the National Academy of Sciences - PNAS (31.07.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (31.07.2018)
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Journal Article
Stool substitute transplant therapy for the eradication of Clostridium difficile infection: 'RePOOPulating' the gut
Petrof, Elaine O, Gloor, Gregory B, Vanner, Stephen J, Weese, Scott J, Carter, David, Daigneault, Michelle C, Brown, Eric M, Schroeter, Kathleen, Allen-Vercoe, Emma
Published in Microbiome (09.01.2013)
Published in Microbiome (09.01.2013)
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Journal Article
Participation of interleukin 17A in neuroimmune interactions
Moynes, Derek M, Vanner, Stephen J, Lomax, Alan E
Published in Brain, behavior, and immunity (01.10.2014)
Published in Brain, behavior, and immunity (01.10.2014)
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Journal Article
Sensitization of peripheral sensory nerves by mediators from colonic biopsies of diarrhea-predominant irritable bowel syndrome patients: a role for PAR2
Valdez-Morales, Eduardo E, Overington, Jeff, Guerrero-Alba, Raquel, Ochoa-Cortes, Fernando, Ibeakanma, Charles O, Spreadbury, Ian, Bunnett, Nigel W, Beyak, Michael, Vanner, Stephen J
Published in The American journal of gastroenterology (01.10.2013)
Published in The American journal of gastroenterology (01.10.2013)
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Journal Article
Application of metabolomics to the study of irritable bowel syndrome
Bennet, Sean M., Keshteli, Ammar H., Bercik, Premysl, Madsen, Karen L., Reed, David, Vanner, Stephen J.
Published in Neurogastroenterology and motility (01.06.2020)
Published in Neurogastroenterology and motility (01.06.2020)
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Journal Article
Telomere length in the colon is related to colorectal adenoma prevalence
Peacock, Sarah D, Massey, Thomas E, Vanner, Stephen J, King, Will D
Published in PloS one (17.10.2018)
Published in PloS one (17.10.2018)
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Journal Article
Split-dose picosulfate, magnesium oxide, and citric acid solution markedly enhances colon cleansing before colonoscopy: a randomized, controlled trial
Flemming, Jennifer A., MD, FRCPC, Vanner, Stephen J., MSc, MD, FRCPC, Hookey, Lawrence C., MD, FRCPC
Published in Gastrointestinal endoscopy (01.03.2012)
Published in Gastrointestinal endoscopy (01.03.2012)
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Journal Article
Defined microbial communities and their soluble products protect mice from Clostridioides difficile infection
Douchant, Katya, He, Shu-Mei, Noordhof, Curtis, Greenlaw, Jill, Vancuren, Sarah, Schroeter, Kathleen, Allen-Vercoe, Emma, Sjaarda, Calvin, Vanner, Stephen J., Petrof, Elaine O., Sheth, Prameet M., Guzman, Mabel
Published in Communications biology (27.01.2024)
Published in Communications biology (27.01.2024)
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Journal Article
Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons
David E Reed, Carlos Barajas-Lopez, Graeme Cottrell, Sara Velazquez-Rocha, Olivier Dery, Eileen F Grady, Nigel W Bunnett, Stephen J Vanner
Published in The Journal of physiology (01.03.2003)
Published in The Journal of physiology (01.03.2003)
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Journal Article
Characterization of the Cysteinyl Leukotriene 2 Receptor in Novel Expression Sites of the Gastrointestinal Tract
Barajas-Espinosa, Alma, Ochoa-Cortes, Fernando, Moos, Michael P, Daniel Ramirez, F, Vanner, Stephen J, Funk, Colin D
Published in The American journal of pathology (01.06.2011)
Published in The American journal of pathology (01.06.2011)
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Journal Article
Local immune response to food antigens drives meal-induced abdominal pain
Aguilera-Lizarraga, Javier, Florens, Morgane V., Viola, Maria Francesca, Jain, Piyush, Decraecker, Lisse, Appeltans, Iris, Cuende-Estevez, Maria, Fabre, Naomi, Van Beek, Kim, Perna, Eluisa, Balemans, Dafne, Stakenborg, Nathalie, Theofanous, Stavroula, Bosmans, Goele, Mondelaers, Stéphanie U., Matteoli, Gianluca, Ibiza Martínez, Sales, Lopez-Lopez, Cintya, Jaramillo-Polanco, Josue, Talavera, Karel, Alpizar, Yeranddy A., Feyerabend, Thorsten B., Rodewald, Hans-Reimer, Farre, Ricard, Redegeld, Frank A., Si, Jiyeon, Raes, Jeroen, Breynaert, Christine, Schrijvers, Rik, Bosteels, Cédric, Lambrecht, Bart N., Boyd, Scott D., Hoh, Ramona A., Cabooter, Deirdre, Nelis, Maxim, Augustijns, Patrick, Hendrix, Sven, Strid, Jessica, Bisschops, Raf, Reed, David E., Vanner, Stephen J., Denadai-Souza, Alexandre, Wouters, Mira M., Boeckxstaens, Guy E.
Published in Nature (London) (04.02.2021)
Published in Nature (London) (04.02.2021)
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Journal Article
Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice
De Palma, Giada, Shimbori, Chiko, Reed, David E, Yu, Yang, Rabbia, Virginia, Lu, Jun, Jimenez-Vargas, Nestor, Sessenwein, Jessica, Lopez-Lopez, Cintya, Pigrau, Marc, Jaramillo-Polanco, Josue, Zhang, Yong, Baerg, Lauren, Manzar, Ahmad, Pujo, Julien, Bai, Xiaopeng, Pinto-Sanchez, Maria Ines, Caminero, Alberto, Madsen, Karen, Surette, Michael G, Beyak, Michael, Lomax, Alan E, Verdu, Elena F, Collins, Stephen M, Vanner, Stephen J, Bercik, Premysl
Published in Science translational medicine (27.07.2022)
Published in Science translational medicine (27.07.2022)
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Journal Article
TNBS ileitis evokes hyperexcitability and changes in ionic membrane properties of nociceptive DRG neurons
Moore, Beverley A, Stewart, Timothy M R, Hill, Ceredwyn, Vanner, Stephen J
Published in American journal of physiology: Gastrointestinal and liver physiology (01.06.2002)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.06.2002)
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Journal Article
Canadian Digestive Health Foundation Public Impact Series 3: irritable bowel syndrome in Canada. Incidence, prevalence, and direct and indirect economic impact
Fedorak, Richard N, Vanner, Stephen J, Paterson, William G, Bridges, Ron J
Published in Canadian journal of gastroenterology (01.05.2012)
Published in Canadian journal of gastroenterology (01.05.2012)
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Journal Article
Cannabinoid 1 and mu-Opioid Receptor Agonists Synergistically Inhibit Abdominal Pain and Lack Side Effects in Mice
Yu, Yang, Tsang, Quentin K, Jaramillo-Polanco, Josue, Lomax, Alan E, Vanner, Stephen J, Reed, David E
Published in The Journal of neuroscience (17.08.2022)
Published in The Journal of neuroscience (17.08.2022)
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Journal Article
Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain
Jimenez-Vargas, Nestor N., Gong, Jing, Wisdom, Matthew J., Jensen, Dane D., Latorre, Rocco, Hegron, Alan, Teng, Shavonne, DiCello, Jesse J., Rajasekhar, Pradeep, Veldhuis, Nicholas A., Carbone, Simona E., Yu, Yang, Lopez-Lopez, Cintya, Jaramillo-Polanco, Josue, Canals, Meritxell, Reed, David E., Lomax, Alan E., Schmidt, Brian L., Leong, Kam W., Vanner, Stephen J., Halls, Michelle L., Bunnett, Nigel W., Poole, Daniel P.
Published in Proceedings of the National Academy of Sciences - PNAS (30.06.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (30.06.2020)
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