A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models
Hillen, Hanne, Candi, Aurélie, Vanderhoydonck, Bart, Kowalczyk, Weronika, Sansores-Garcia, Leticia, Kesikiadou, Elena C, Van Huffel, Leen, Spiessens, Lore, Nijs, Marnik, Soons, Erik, Haeck, Wanda, Klaassen, Hugo, Smets, Wim, Spieser, Stéphane A, Marchand, Arnaud, Chaltin, Patrick, Ciesielski, Fabrice, Debaene, Francois, Chen, Lei, Kamal, Adeela, Gwaltney, Stephen L, Versele, Matthias, Halder, Georg A
Published in Molecular cancer therapeutics (03.01.2024)
Published in Molecular cancer therapeutics (03.01.2024)
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Journal Article
Abstract 5229: Discovery of novel potent allosteric inhibitors of YAP/TAZ-TEAD transcription for the treatment of multiple solid tumor types addicted to Hippo signaling
Versele, Matthias, Candi, Aurélie, Nijs, Marnik, Haeck, Wanda, Klaassen, Hugo, Smets, Wim, Spieser, Stéphane, Vanderhoydonck, Bart, Marchand, Arnaud, Chaltin, Patrick, Sansores, Leticia, Halder, Georg
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Mechanism of action of phthalazinone derivatives against rabies virus
Perraud, Victoire, Vanderhoydonck, Bart, Bouvier, Guillaume, Dias de Melo, Guilherme, Kilonda, Amuri, Koukni, Mohamed, Jochmans, Dirk, Rogée, Sophie, Ben Khalifa, Youcef, Kergoat, Lauriane, Lannoy, Julien, Van Buyten, Tina, Izadi-Pruneyre, Nadia, Chaltin, Patrick, Neyts, Johan, Marchand, Arnaud, Larrous, Florence, Bourhy, Hervé
Published in Antiviral research (01.04.2024)
Published in Antiviral research (01.04.2024)
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Journal Article
YAP/TAZ-TEAD 억제를 위한 테트라히드로피라졸로피리미딘 및 관련 유사체
CANDI AURELIE, GWALTNEY II STEPHEN L, VANDERHOYDONCK BART, MARCHAND ARNAUD, SMETS WIM, VERSELE MATTHIAS, KILONDA AMURI
Year of Publication 20.09.2024
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Year of Publication 20.09.2024
Patent
암을 치료하기 위한 YAP/TAZ-TEAD 활성화 억제제로서의 1,2,3,4-테트라히드로퀴놀린 유도체
CANDI AURELIE, GWALTNEY II STEPHEN L, MARCHAND ARNAUD, VANDERHOYDONCK BART, VERSELE MATTHIAS
Year of Publication 28.07.2023
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Year of Publication 28.07.2023
Patent
Synthesis and Evaluation of 5-Substituted 2′-deoxyuridine Monophosphate Analogues As Inhibitors of Flavin-Dependent Thymidylate Synthase in Mycobacterium tuberculosis
Kögler, Martin, Vanderhoydonck, Bart, De Jonghe, Steven, Rozenski, Jef, Van Belle, Kristien, Herman, Jean, Louat, Thierry, Parchina, Anastasia, Sibley, Carol, Lescrinier, Eveline, Herdewijn, Piet
Published in Journal of medicinal chemistry (14.07.2011)
Published in Journal of medicinal chemistry (14.07.2011)
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Journal Article
Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo
Reuberson, James, Horsley, Helen, Franklin, Richard J, Ford, Daniel, Neuss, Judi, Brookings, Daniel, Huang, Qiuya, Vanderhoydonck, Bart, Gao, Ling-Jie, Jang, Mi-Yeon, Herdewijn, Piet, Ghawalkar, Anant, Fallah-Arani, Farnaz, Khan, Adnan R, Henshall, Jamie, Jairaj, Mark, Malcolm, Sarah, Ward, Eleanor, Shuttleworth, Lindsay, Lin, Yuan, Li, Shengqiao, Louat, Thierry, Waer, Mark, Herman, Jean, Payne, Andrew, Ceska, Tom, Doyle, Carl, Pitt, Will, Calmiano, Mark, Augustin, Martin, Steinbacher, Stefan, Lammens, Alfred, Allen, Rodger
Published in Journal of medicinal chemistry (09.08.2018)
Published in Journal of medicinal chemistry (09.08.2018)
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Journal Article
Abstract 3945: Novel antagonists of TEAD palmitoylation inhibit the growth of Hippo-altered cancers in preclinical models
Kamal, Adeela, Candi, Aurélie, Versele, Matthias, Vanderhoydonck, Bart, Marchand, Arnaud, de Jong, Ron, Hoang, Thuy, Halder, Georg, Chaltin, Patrick, Gwaltney, Stephen L., Burgess, Mike
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Abstract 4964: SW-682: A novel TEAD inhibitor for the treatment of cancers bearing mutations in the Hippo signaling pathway
Chen, Lei, de Marval, Paula Milani, Powell, Kendall, Johnson, Mark, Falls, Greg, Lawhorn, Brian, Candi, Aurélie, Kilonda, Amuri, Vanderhoydonck, Bart, Marchand, Arnaud, Versele, Matthias, Halder, Georg, Gwaltney, Stephen L., Kamal, Adeela
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Discovery of 7-N-Piperazinylthiazolo[5,4-d]pyrimidine Analogues as a Novel Class of Immunosuppressive Agents with in Vivo Biological Activity
Jang, Mi-Yeon, Lin, Yuan, De Jonghe, Steven, Gao, Ling-Jie, Vanderhoydonck, Bart, Froeyen, Mathy, Rozenski, Jef, Herman, Jean, Louat, Thierry, Van Belle, Kristien, Waer, Mark, Herdewijn, Piet
Published in Journal of medicinal chemistry (27.01.2011)
Published in Journal of medicinal chemistry (27.01.2011)
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Journal Article
Synthesis and Antibacterial Evaluation of a Novel Series of 2-(1,2-Dihydro-3-oxo-3H-pyrazol-2-yl)benzothiazoles
Stella, Alessandro, Segers, Kenneth, De Jonghe, Steven, Vanderhoydonck, Bart, Rozenski, Jef, Anné, Jozef, Herdewijn, Piet
Published in Chemistry & biodiversity (01.02.2011)
Published in Chemistry & biodiversity (01.02.2011)
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Journal Article
THERAPEUTICALLY ACTIVE PYRAZOLO-PYRIMIDINE DERIVATIVES
FRANKLIN RICHARD JEREMY, HORSLEY HELEN TRACEY, VANDERHOYDONCK BART, REUBERSON JAMES THOMAS, HUANG QIUYA, FORD DANIEL JAMES, GHAWALKAR ANANT RAMRAO
Year of Publication 05.10.2015
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Year of Publication 05.10.2015
Patent
SPIROS AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD
VANDERHOYDONCK, Bart, MARCHAND, Arnaud, CANDI, Aurélie, VERSELE, Matthias
Year of Publication 30.10.2024
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Year of Publication 30.10.2024
Patent
TETRAHYDROBENZOAZEPINONES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD
VANDERHOYDONCK, Bart, MARCHAND, Arnaud, CANDI, Aurélie, VERSELE, Matthias
Year of Publication 30.10.2024
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Year of Publication 30.10.2024
Patent
TETRAHYDROBENZOAZEPINONES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD
VANDERHOYDONCK, Bart, MARCHAND, Arnaud, CANDI, Aurélie, VERSELE, Matthias
Year of Publication 18.07.2024
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Year of Publication 18.07.2024
Patent
DIHYDROQUINAZOLINONES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD
VANDERHOYDONCK, Bart, MARCHAND, Arnaud, CANDI, Aurélie, VERSELE, Matthias
Year of Publication 11.07.2024
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Year of Publication 11.07.2024
Patent