Dabigatran etexilate--a novel, reversible, oral direct thrombin inhibitor: interpretation of coagulation assays and reversal of anticoagulant activity
van Ryn, Joanne, Stangier, Joachim, Haertter, Sebastian, Liesenfeld, Karl-Heinz, Wienen, Wolfgang, Feuring, Martin, Clemens, Andreas
Published in Thrombosis and haemostasis (01.06.2010)
Published in Thrombosis and haemostasis (01.06.2010)
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Reversal of dabigatran anticoagulation ex vivo: Porcine study comparing prothrombin complex concentrates and idarucizumab
Honickel, Markus, Treutler, Stefanie, van Ryn, Joanne, Tillmann, Sabine, Rossaint, Rolf, Grottke, Oliver
Published in Thrombosis and haemostasis (01.07.2015)
Published in Thrombosis and haemostasis (01.07.2015)
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Journal Article
Interpretation of Point-of-care INR Results in Patients Treated with Dabigatran
van Ryn, Joanne, PhD, Baruch, Lawrence, MD, Clemens, Andreas, MD
Published in The American journal of medicine (01.04.2012)
Published in The American journal of medicine (01.04.2012)
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Journal Article
Effects of Dabigatran in Mouse Models of Aging and Cerebral Amyloid Angiopathy
Michael, Neethu, Grigoryan, Mher Mahoney, Kilday, Kelley, Sumbria, Rachita K, Vasilevko, Vitaly, van Ryn, Joanne, Cribbs, David H, Paganini-Hill, Annlia, Fisher, Mark J
Published in Frontiers in neurology (27.09.2019)
Published in Frontiers in neurology (27.09.2019)
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Use of dabigatran etexilate to reduce breast cancer progression
DeFeo, Karen, Hayes, Candace, Chernick, Michael, Van Ryn, Joanne, Gilmour, Susan K.
Published in Cancer biology & therapy (15.11.2010)
Published in Cancer biology & therapy (15.11.2010)
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A randomised study in healthy volunteers to investigate the safety, tolerability and pharmacokinetics of idarucizumab, a specific antidote to dabigatran
Glund, Stephan, Moschetti, Viktoria, Norris, Stephen, Stangier, Joachim, Schmohl, Michael, van Ryn, Joanne, Lang, Benjamin, Ramael, Steven, Reilly, Paul
Published in Thrombosis and haemostasis (01.05.2015)
Published in Thrombosis and haemostasis (01.05.2015)
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Idarucizumab for Dabigatran Reversal — Full Cohort Analysis
Pollack, Charles V, Reilly, Paul A, van Ryn, Joanne, Eikelboom, John W, Glund, Stephan, Bernstein, Richard A, Dubiel, Robert, Huisman, Menno V, Hylek, Elaine M, Kam, Chak-Wah, Kamphuisen, Pieter W, Kreuzer, Jörg, Levy, Jerrold H, Royle, Gordon, Sellke, Frank W, Stangier, Joachim, Steiner, Thorsten, Verhamme, Peter, Wang, Bushi, Young, Laura, Weitz, Jeffrey I
Published in The New England journal of medicine (03.08.2017)
Published in The New England journal of medicine (03.08.2017)
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A specific antidote for dabigatran: functional and structural characterization
Schiele, Felix, van Ryn, Joanne, Canada, Keith, Newsome, Corey, Sepulveda, Eliud, Park, John, Nar, Herbert, Litzenburger, Tobias
Published in Blood (02.05.2013)
Published in Blood (02.05.2013)
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Safety, tolerability, and efficacy of idarucizumab for the reversal of the anticoagulant effect of dabigatran in healthy male volunteers: a randomised, placebo-controlled, double-blind phase 1 trial
Glund, Stephan, Dr, Stangier, Joachim, PhD, Schmohl, Michael, PhD, Gansser, Dietmar, PhD, Norris, Stephen, PhD, van Ryn, Joanne, PhD, Lang, Benjamin, Dipl Math oec, Ramael, Steven, MD, Moschetti, Viktoria, MD, Gruenenfelder, Fredrik, DVM, Reilly, Paul, PhD, Kreuzer, Jörg, Prof
Published in The Lancet (British edition) (15.08.2015)
Published in The Lancet (British edition) (15.08.2015)
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Thrombin promotes diet-induced obesity through fibrin-driven inflammation
Kopec, Anna K, Abrahams, Sara R, Thornton, Sherry, Palumbo, Joseph S, Mullins, Eric S, Divanovic, Senad, Weiler, Hartmut, Owens, 3rd, A Phillip, Mackman, Nigel, Goss, Ashley, van Ryn, Joanne, Luyendyk, James P, Flick, Matthew J
Published in The Journal of clinical investigation (01.08.2017)
Published in The Journal of clinical investigation (01.08.2017)
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Dabigatran Reversal With Idarucizumab in Patients With Renal Impairment
Eikelboom, John W., van Ryn, Joanne, Reilly, Paul, Hylek, Elaine M., Elsaesser, Amelie, Glund, Stephan, Pollack, Charles V., Weitz, Jeffrey I.
Published in Journal of the American College of Cardiology (08.10.2019)
Published in Journal of the American College of Cardiology (08.10.2019)
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Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/liver trauma experimental model
Grottke, Oliver, van Ryn, Joanne, Spronk, Henri M H, Rossaint, Rolf
Published in Critical care (London, England) (05.02.2014)
Published in Critical care (London, England) (05.02.2014)
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Idarucizumab Improves Outcome in Murine Brain Hemorrhage Related to Dabigatran
Na, Shin-Young, Mracsko, Eva, van Ryn, Joanne, Veltkamp, Roland
Published in Annals of neurology (01.07.2015)
Published in Annals of neurology (01.07.2015)
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Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease
Sparkenbaugh, Erica M., Chantrathammachart, Pichika, Mickelson, Jacqueline, van Ryn, Joanne, Hebbel, Robert P., Monroe, Dougald M., Mackman, Nigel, Key, Nigel S., Pawlinski, Rafal
Published in Blood (13.03.2014)
Published in Blood (13.03.2014)
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Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice
Preusch, Michael R, Ieronimakis, Nicholas, Wijelath, Errol S, Cabbage, Sara, Ricks, Jerry, Bea, Florian, Reyes, Morayma, van Ryn, Joanne, Rosenfeld, Michael E
Published in Drug design, development and therapy (01.01.2015)
Published in Drug design, development and therapy (01.01.2015)
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Idarucizumab, a Specific Dabigatran Reversal Agent, Reduces Blood Loss in a Porcine Model of Trauma With Dabigatran Anticoagulation
Grottke, Oliver, MD, PhD, Honickel, Markus, MD, van Ryn, Joanne, PhD, ten Cate, Hugo, MD, PhD, Rossaint, Rolf, MD, Spronk, Henri M., PhD
Published in Journal of the American College of Cardiology (29.09.2015)
Published in Journal of the American College of Cardiology (29.09.2015)
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Therapy with activated prothrombin complex concentrate is effective in reducing dabigatran-associated blood loss in a porcine polytrauma model
Honickel, Markus, Maron, Benjamin, van Ryn, Joanne, Braunschweig, Till, ten Cate, Hugo, Spronk, Henri M H, Rossaint, Rolf, Grottke, Oliver
Published in Thrombosis and haemostasis (2016)
Published in Thrombosis and haemostasis (2016)
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Off‐target effects of oral anticoagulants – vascular effects of vitamin K antagonist and non‐vitamin K antagonist oral anticoagulant dabigatran etexilate
Gorp, Rick H., Dijkgraaf, Ingrid, Bröker, Vanessa, Bauwens, Matthias, Leenders, Peter, Jennen, Danyel, Dweck, Marc R., Bucerius, Jan, Briedé, Jacco J., Ryn, Joanne, Brandenburg, Vincent, Mottaghy, Felix, Spronk, Henri M. H., Reutelingsperger, Chris P., Schurgers, Leon J.
Published in Journal of thrombosis and haemostasis (01.05.2021)
Published in Journal of thrombosis and haemostasis (01.05.2021)
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