The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis
Van Roy, Maarten, Ververken, Cedric, Beirnaert, Els, Hoefman, Sven, Kolkman, Joost, Vierboom, Michel, Breedveld, Elia, 't Hart, Bert, Poelmans, Sofie, Bontinck, Lieselot, Hemeryck, Alex, Jacobs, Sandy, Baumeister, Judith, Ulrichts, Hans
Published in Arthritis research & therapy (20.05.2015)
Published in Arthritis research & therapy (20.05.2015)
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Journal Article
Neutralization of Human Interleukin 23 by Multivalent Nanobodies Explained by the Structure of Cytokine-Nanobody Complex
Desmyter, Aline, Spinelli, Silvia, Boutton, Carlo, Saunders, Michael, Blachetot, Christophe, de Haard, Hans, Denecker, Geertrui, Van Roy, Maarten, Cambillau, Christian, Rommelaere, Heidi
Published in Frontiers in immunology (21.08.2017)
Published in Frontiers in immunology (21.08.2017)
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Journal Article
Protection of zinc against tumor necrosis factor-induced lethal inflammation depends on heat shock protein 70 and allows safe antitumor therapy
VAN MOLLE, Wim, VAN ROY, Maarten, VAN BOGAERT, Tom, DEJAGER, Lien, VAN LINT, Philippe, VANLAERE, Ineke, SEKIKAWA, Kenji, KOLLIAS, George, LIBERTL, Claude
Published in Cancer research (Chicago, Ill.) (01.08.2007)
Published in Cancer research (Chicago, Ill.) (01.08.2007)
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Journal Article
Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFNγ–based cancer therapy in mice
Van Roy, Maarten, Van Lint, Philippe, Van Laere, Ineke, Wielockx, Ben, Wilson, Carole, López-Otin, Carlos, Shapiro, Stephen, Libert, Claude
Published in Molecular cancer therapeutics (01.09.2007)
Published in Molecular cancer therapeutics (01.09.2007)
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Journal Article
Llama-derived Single Variable Domains (Nanobodies) Directed against Chemokine Receptor CXCR7 Reduce Head and Neck Cancer Cell Growth in Vivo
Maussang, David, Mujić-Delić, Azra, Descamps, Francis J., Stortelers, Catelijne, Vanlandschoot, Peter, Stigter-van Walsum, Marijke, Vischer, Henry F., van Roy, Maarten, Vosjan, Maria, Gonzalez-Pajuelo, Maria, van Dongen, Guus A.M.S., Merchiers, Pascal, van Rompaey, Philippe, Smit, Martine J.
Published in The Journal of biological chemistry (11.10.2013)
Published in The Journal of biological chemistry (11.10.2013)
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Journal Article
Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist
Fontaine, Thomas, Busch, Andreas, Laeremans, Toon, De Cesco, Stéphane, Liang, Yi-Lynn, Jaakola, Veli-Pekka, Sands, Zara, Triest, Sarah, Masiulis, Simonas, Dekeyzer, Lies, Samyn, Noor, Loeys, Nicolas, Perneel, Lisa, Debaere, Melanie, Martini, Murielle, Vantieghem, Charlotte, Virmani, Richa, Skieterska, Kamila, Staelens, Stephanie, Barroco, Rosa, Van Roy, Maarten, Menet, Christel
Published in Nature communications (01.10.2024)
Published in Nature communications (01.10.2024)
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Journal Article
Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium
Van Hauwermeiren, Filip, Armaka, Marietta, Karagianni, Niki, Kranidioti, Ksanthi, Vandenbroucke, Roosmarijn E, Loges, Sonja, Van Roy, Maarten, Staelens, Jan, Puimège, Leen, Palagani, Ajay, Berghe, Wim Vanden, Victoratos, Panayiotis, Carmeliet, Peter, Libert, Claude, Kollias, George
Published in The Journal of clinical investigation (01.06.2013)
Published in The Journal of clinical investigation (01.06.2013)
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Journal Article
Human Epidermal Growth Factor Receptor 3-Specific Tumor Uptake and Biodistribution of ^sup 89^Zr-MSB0010853 Visualized by Real-Time and Noninvasive PET Imaging
Warnders, Frank J, van Scheltinga, Anton GT Terwisscha, Knuehl, Christine, van Roy, Maarten, de Vries, Eirk FJ, W Kosterink, Jos G, de Vries, Elisabeth GE, N Lub-de Hooge, Marjolijn
Published in The Journal of nuclear medicine (1978) (01.08.2017)
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Published in The Journal of nuclear medicine (1978) (01.08.2017)
Journal Article
Human Epidermal Growth Factor Receptor 3-Specific Tumor Uptake and Biodistribution of 89 Zr-MSB0010853 Visualized by Real-Time and Noninvasive PET Imaging
Warnders, Frank J, Terwisscha van Scheltinga, Anton G T, Knuehl, Christine, van Roy, Maarten, de Vries, Erik F J, Kosterink, Jos G W, de Vries, Elisabeth G E, Lub-de Hooge, Marjolijn N
Published in Journal of Nuclear Medicine (01.08.2017)
Published in Journal of Nuclear Medicine (01.08.2017)
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Journal Article
Nonclinical safety assessment of the RANK-L targeting Nanobody® ALX-0141
Jacobs, Sandy, Van Roy, Maarten, Hemeryck, Alex, Ottevaere, Ingrid, Baumeister, Judith
Published in Toxicology letters (17.06.2012)
Published in Toxicology letters (17.06.2012)
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Journal Article
Human Epidermal Growth Factor Receptor 3-Specific Tumor Uptake and Biodistribution of 89Zr-MSB0010853 Visualized by Real-Time and Noninvasive PET Imaging
Warnders, Frank J, Terwisscha van Scheltinga, Anton G T, Knuehl, Christine, van Roy, Maarten, de Vries, Erik F J, Kosterink, Jos G W, de Vries, Elisabeth G E, Lub-de Hooge, Marjolijn N
Published in The Journal of nuclear medicine (1978) (01.08.2017)
Published in The Journal of nuclear medicine (1978) (01.08.2017)
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Journal Article
Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFNgamma-based cancer therapy in mice
Van Roy, Maarten, Van Lint, Philippe, Van Laere, Ineke, Wielockx, Ben, Wilson, Carole, López-Otin, Carlos, Shapiro, Stephen, Libert, Claude
Published in Molecular cancer therapeutics (01.09.2007)
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Published in Molecular cancer therapeutics (01.09.2007)
Journal Article
Description and Mapping of the Resistance of DBA/2 Mice to TNF-Induced Lethal Shock
Wielockx, Ben, Staelens, Jan, Puimege, Leen, Vanlaere, Ineke, Van Roy, Maarten, van Lint, Philippe, Van Roy, Frans, Libert, Claude
Published in Journal of Immunology (15.04.2007)
Published in Journal of Immunology (15.04.2007)
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Journal Article
IMPROVED AMINO ACID SEQUENCES DIRECTED AGAINST IL-6R AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF IL-6R RELATED DISEASES AND DISORDERS
Ververken, Cedric Jozef Néotére, Kolkman, Joost Alexander, Beirnaert, Els Anna Alice, van Roy, Maarten
Year of Publication 15.05.2019
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Year of Publication 15.05.2019
Patent
IMPROVED AMINO ACID SEQUENCES DIRECTED AGAINST IL-6R AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF IL-6R RELATED DISEASES AND DISORDERS
Ververken, Cedric Jozef Néotére, Kolkman, Joost Alexander, Beirnaert, Els Anna Alice, van Roy, Maarten
Year of Publication 03.04.2019
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Year of Publication 03.04.2019
Patent
IMPROVED AMINO ACID SEQUENCES DIRECTED AGAINST IL-6R AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF IL-6R RELATED DISEASES AND DISORDERS
KOLKMAN, Joost Alexander, BEIRNAERT, Els, Anna Alice, VAN ROY, Maarten, VERVERKEN, Cedric Jozef Néotère
Year of Publication 27.02.2019
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Year of Publication 27.02.2019
Patent