Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins
Lim, Junghyun, Park, Hyunjoo, Heisler, Jason, Maculins, Timurs, Roose-Girma, Merone, Xu, Min, Mckenzie, Brent, van Lookeren Campagne, Menno, Newton, Kim, Murthy, Aditya
Published in eLife (09.07.2019)
Published in eLife (09.07.2019)
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Structural and Functional Analysis of HtrA1 and Its Subdomains
Eigenbrot, Charles, Ultsch, Mark, Lipari, Michael T., Moran, Paul, Lin, S. Jack, Ganesan, Rajkumar, Quan, Clifford, Tom, Jeffrey, Sandoval, Wendy, van Lookeren Campagne, Menno, Kirchhofer, Daniel
Published in Structure (London) (06.06.2012)
Published in Structure (London) (06.06.2012)
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Mechanisms of age-related macular degeneration and therapeutic opportunities
van Lookeren Campagne, Menno, LeCouter, Jennifer, Yaspan, Brian L, Ye, Weilan
Published in The Journal of pathology (01.01.2014)
Published in The Journal of pathology (01.01.2014)
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A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3
Murthy, Aditya, Li, Yun, Peng, Ivan, Reichelt, Mike, Katakam, Anand Kumar, Noubade, Rajkumar, Roose-Girma, Merone, DeVoss, Jason, Diehl, Lauri, Graham, Robert R., van Lookeren Campagne, Menno
Published in Nature (London) (27.02.2014)
Published in Nature (London) (27.02.2014)
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Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer’s disease
Ellwanger, Daniel C., Wang, Shoutang, Brioschi, Simone, Shao, Zhifei, Green, Lydia, Case, Ryan, Yoo, Daniel, Weishuhn, Dawn, Rathanaswami, Palaniswami, Bradley, Jodi, Rao, Sara, Cha, Diana, Luan, Peng, Sambashivan, Shilpa, Gilfillan, Susan, Hasson, Samuel A., Foltz, Ian N., van Lookeren Campagne, Menno, Colonna, Marco
Published in Proceedings of the National Academy of Sciences - PNAS (19.01.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (19.01.2021)
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Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling
Samie, Mohammad, Lim, Junghyun, Verschueren, Erik, Baughman, Joshua M., Peng, Ivan, Wong, Aaron, Kwon, Youngsu, Senbabaoglu, Yasin, Hackney, Jason A., Keir, Mary, Mckenzie, Brent, Kirkpatrick, Donald S., van Lookeren Campagne, Menno, Murthy, Aditya
Published in Nature immunology (01.03.2018)
Published in Nature immunology (01.03.2018)
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RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases
Patel, Snahel, Webster, Joshua D., Varfolomeev, Eugene, Kwon, Youngsu C., Cheng, Jason H., Zhang, Juan, Dugger, Debra L., Wickliffe, Kate E., Maltzman, Allie, Sujatha-Bhaskar, Swathi, Bir Kohli, Pawan, Ramaswamy, Sreema, Deshmukh, Gauri, Liederer, Bianca M., Fong, Rina, Hamilton, Greg, Lupardus, Patrick, Caplazi, Patrick, Lee, Wyne P., van Lookeren Campagne, Menno, Johnson, Adam, McKenzie, Brent S., Junttila, Melissa R., Newton, Kim, Vucic, Domagoj
Published in Cell death and differentiation (01.01.2020)
Published in Cell death and differentiation (01.01.2020)
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Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration
Orozco, Luz D., Chen, Hsu-Hsin, Cox, Christian, Katschke, Kenneth J., Arceo, Rommel, Espiritu, Carmina, Caplazi, Patrick, Nghiem, Sarajane Saturnio, Chen, Ying-Jiun, Modrusan, Zora, Dressen, Amy, Goldstein, Leonard D., Clarke, Christine, Bhangale, Tushar, Yaspan, Brian, Jeanne, Marion, Townsend, Michael J., van Lookeren Campagne, Menno, Hackney, Jason A.
Published in Cell reports (Cambridge) (28.01.2020)
Published in Cell reports (Cambridge) (28.01.2020)
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Dual-Track Clearance of Circulating Bacteria Balances Rapid Restoration of Blood Sterility with Induction of Adaptive Immunity
Broadley, Steven P., Plaumann, Ann, Coletti, Raffaele, Lehmann, Christin, Wanisch, Andreas, Seidlmeier, Amelie, Esser, Knud, Luo, Shanshan, Rämer, Patrick C., Massberg, Steffen, Busch, Dirk H., van Lookeren Campagne, Menno, Verschoor, Admar
Published in Cell host & microbe (13.07.2016)
Published in Cell host & microbe (13.07.2016)
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Tropism for tuft cells determines immune promotion of norovirus pathogenesis
Wilen, Craig B, Lee, Sanghyun, Hsieh, Leon L, Orchard, Robert C, Desai, Chandni, Hykes, Jr, Barry L, McAllaster, Michael R, Balce, Dale R, Feehley, Taylor, Brestoff, Jonathan R, Hickey, Christina A, Yokoyama, Christine C, Wang, Ya-Ting, MacDuff, Donna A, Kreamalmayer, Darren, Howitt, Michael R, Neil, Jessica A, Cadwell, Ken, Allen, Paul M, Handley, Scott A, van Lookeren Campagne, Menno, Baldridge, Megan T, Virgin, Herbert W
Published in Science (American Association for the Advancement of Science) (13.04.2018)
Published in Science (American Association for the Advancement of Science) (13.04.2018)
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Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome
Zhao, Boyang, Cao, Zhongzheng, Zheng, Yi, Nguyen, Phuong, Bowen, Alisa, Edwards, Robert H., Stroud, Robert M., Zhou, Yi, Van Lookeren Campagne, Menno, Li, Fei
Published in Nature communications (25.06.2024)
Published in Nature communications (25.06.2024)
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Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy
Katschke, Kenneth J., Xi, Hongkang, Cox, Christian, Truong, Tom, Malato, Yann, Lee, Wyne P., McKenzie, Brent, Arceo, Rommel, Tao, Jianhua, Rangell, Linda, Reichelt, Mike, Diehl, Lauri, Elstrott, Justin, Weimer, Robby M, van Lookeren Campagne, Menno
Published in Scientific reports (09.05.2018)
Published in Scientific reports (09.05.2018)
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Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy
Tom, Irene, Pham, Victoria C., Katschke, Kenneth J., Li, Wei, Liang, Wei-Ching, Gutierrez, Johnny, Young, Andrew Ah, Figueroa, Isabel, Eshghi, Shadi Toghi, Lee, ChingWei V., Kanodia, Jitendra, Snipas, Scott J., Salvesen, Guy S., Lai, Phillip, Honigberg, Lee, van Lookeren Campagne, Menno, Kirchhofer, Daniel, Baruch, Amos, Lill, Jennie R.
Published in Proceedings of the National Academy of Sciences - PNAS (05.05.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (05.05.2020)
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IL-33 amplifies an innate immune response in the degenerating retina
Xi, Hongkang, Katschke, Jr, Kenneth J, Li, Yun, Truong, Tom, Lee, Wyne P, Diehl, Lauri, Rangell, Linda, Tao, Jianhua, Arceo, Rommel, Eastham-Anderson, Jeffrey, Hackney, Jason A, Iglesias, Antonio, Cote-Sierra, Javier, Elstrott, Justin, Weimer, Robby M, van Lookeren Campagne, Menno
Published in The Journal of experimental medicine (08.02.2016)
Published in The Journal of experimental medicine (08.02.2016)
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Humoral immunity goes hormonal
Chavarria-Smith, Joseph, Hazenbos, Wouter L. W., van Lookeren Campagne, Menno
Published in Nature immunology (01.10.2018)
Published in Nature immunology (01.10.2018)
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Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration
Orozco, Luz D., Chen, Hsu-Hsin, Cox, Christian, Katschke, Kenneth J., Rommel Arceo, Espiritu, Carmina, Caplazi, Patrick, Nghiem, Sarajane Saturnio, Chen, Ying-Jiun, Modrusan, Zora, Dressen, Amy, Goldstein, Leonard D., Clarke, Christine, Bhangale, Tushar, Yaspan, Brian, Jeanne, Marion, Townsend, Michael J., van Lookeren Campagne, Menno, Hackney, Jason A.
Published in Cell reports (Cambridge) (28.03.2023)
Published in Cell reports (Cambridge) (28.03.2023)
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Complement inhibition in cynomolgus monkeys by anti-factor d antigen-binding fragment for the treatment of an advanced form of dry age-related macular degeneration
Loyet, Kelly M, Good, Jeremy, Davancaze, Teresa, Sturgeon, Lizette, Wang, Xiangdan, Yang, Jihong, Le, Kha N, Wong, Maureen, Hass, Philip E, van Lookeren Campagne, Menno, Haughney, Peter C, Morimoto, Alyssa, Damico-Beyer, Lisa A, DeForge, Laura E
Published in The Journal of pharmacology and experimental therapeutics (01.12.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2014)
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Development of an ultra-sensitive human IL-33 biomarker assay for age-related macular degeneration and asthma drug development
Mai, Elaine, Chan, Joyce, Goon, Levina, Ego, Braeden K, Bevers, Jack, Wong, Tiffany, Wong, Manda, Corpuz, Racquel, Xi, Hongkang, Wu, Jia, Schneider, Kellen, Seshasayee, Dhaya, Grimbaldeston, Michele, Nakamura, Gerald, Indjeian, Vahan B, van Lookeren Campagne, Menno, Loyet, Kelly M, Comps-Agrar, Laetitia
Published in Journal of translational medicine (20.12.2021)
Published in Journal of translational medicine (20.12.2021)
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Journal Article
IL-1R1-dependent signaling coordinates epithelial regeneration in response to intestinal damage
Cox, Christian B, Storm, Elaine E, Kapoor, Varun N, Chavarria-Smith, Joseph, Lin, David L, Wang, Lifen, Li, Yun, Kljavin, Noelyn, Ota, Naruhisa, Bainbridge, Travis W, Anderson, Keith, Roose-Girma, Merone, Warming, Søren, Arron, Joseph R, Turley, Shannon J, de Sauvage, Frederic J, van Lookeren Campagne, Menno
Published in Science immunology (28.05.2021)
Published in Science immunology (28.05.2021)
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