Novel indole and azaindole (pyrrolopyridine) cannabinoid (CB) receptor agonists: Design, synthesis, structure–activity relationships, physicochemical properties and biological activity
Blaazer, Antoni R., Lange, Jos H.M., van der Neut, Martina A.W., Mulder, Arie, den Boon, Femke S., Werkman, Taco R., Kruse, Chris G., Wadman, Wytse J.
Published in European journal of medicinal chemistry (01.10.2011)
Published in European journal of medicinal chemistry (01.10.2011)
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Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB1 Receptor Antagonism
Lange, Jos H. M, Coolen, Hein K. A. C, van der Neut, Martina A. W, Borst, Alice J. M, Stork, Bob, Verveer, Peter C, Kruse, Chris G
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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N′-(Arylsulfonyl)pyrazoline-1-carboxamidines as Novel, Neutral 5-Hydroxytryptamine 6 Receptor (5-HT6R) Antagonists with Unique Structural Features
van Loevezijn, Arnold, Venhorst, Jennifer, Iwema Bakker, Wouter I, de Korte, Cor G, de Looff, Wouter, Verhoog, Stefan, van Wees, Jan-Willem, van Hoeve, Martijn, van de Woestijne, Rob P, van der Neut, Martina A. W, Borst, Alice J. M, van Dongen, Maria J. P, de Bruin, Natasja M. W. J, Keizer, Hiskias G, Kruse, Chris G
Published in Journal of medicinal chemistry (27.10.2011)
Published in Journal of medicinal chemistry (27.10.2011)
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Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB2 receptor antagonists with high binding efficiencies
LANGE, Jos H. M, VAN DER NEUT, Martina A. W, VAN VLIET, Bernard J, WALS, Henri C, KUIL, Gijs D, BORST, Alice J. M, MULDER, Arie, DEN HARTOG, Arnold P, ZILAOUT, Hicham, GOUTIER, Wouter, VAN STUIVENBERG, Herman H
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Two distinct classes of novel pyrazolinecarboxamides as potent cannabinoid CB1 receptor agonists
LANGE, Jos H. M, ATTALI, Amos, VAN DER NEUT, Martina A. W, WALS, Henri C, MULDER, Arie, ZILAOUT, Hicham, DUURSMA, Ate, VAN AKEN, Hans H. M, VAN VLIET, Bernard J
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Probing the cannabinoid CB1/CB2 receptor subtype selectivity limits of 1,2-diarylimidazole-4-carboxamides by fine-tuning their 5-substitution pattern
LANGE, Jos H. M, VAN DER NEUT, Martina A. W, BORST, Alice J. M, YILDIRIM, Mahmut, VAN STUIVENBERG, Herman H, VAN VLIET, Bernard J, KRUSE, Chris G
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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Journal Article
Optimization of N′-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket
van Loevezijn, Arnold, Venhorst, Jennifer, Iwema Bakker, Wouter I., Lange, Jos H.M., de Looff, Wouter, Henzen, Remco, de Vries, Jelle, van de Woestijne, Rob P., den Hartog, Arnold P., Verhoog, Stefan, van der Neut, Martina A.W., de Bruin, Natasja M.W.J., Kruse, Chris G.
Published in Bioorganic & medicinal chemistry letters (15.03.2016)
Published in Bioorganic & medicinal chemistry letters (15.03.2016)
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Synthesis, SAR and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles as potent cannabinoid CB1 receptor antagonists
LANGE, Jos H. M, VAN DER NEUT, Martina A. W, DEN HARTOG, Arnold P, WALS, Henri C, HOOGENDOORN, Jan, VAN STUIVENBERG, Herman H, VAN VLIET, Bernard J, KRUSE, Chris G
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
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Journal Article
ChemInform Abstract: Novel Indole and Azaindole (Pyrrolopyridine) Cannabinoid (CB) Receptor Agonists: Design, Synthesis, Structure-Activity Relationships, Physicochemical Properties and Biological Activity
Blaazer, Antoni R., Lange, Jos H. M., van der Neut, Martina A. W., Mulder, Arie, den Boon, Femke S., Werkman, Taco R., Kruse, Chris G., Wadman, Wytse J.
Published in ChemInform (07.02.2012)
Published in ChemInform (07.02.2012)
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Journal Article
Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB 1 Receptor Antagonism
Lange, Jos H. M., Coolen, Hein K. A. C., van der Neut, Martina A. W., Borst, Alice J. M., Stork, Bob, Verveer, Peter C., Kruse, Chris G.
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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Journal Article
Optimization of N'-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT sub(6) antagonistic binding pocket
Loevezijn, Arnold van, Venhorst, Jennifer, Bakker, Wouter IIwema, Lange, Jos HM, Looff, Wouter de, Henzen, Remco, Vries, Jelle de, Woestijne, Rob Pvan de, Hartog, Arnold Pden, Verhoog, Stefan, van der Neut, Martina AW, Bruin, Natasja MWJde, Kruse, Chris G
Published in Bioorganic & medicinal chemistry letters (15.03.2016)
Published in Bioorganic & medicinal chemistry letters (15.03.2016)
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Journal Article
Probing the cannabinoid CB sub(1)/CB sub(2) receptor subtype selectivity limits of 1,2-diarylimidazole-4-carboxamides by fine-tuning their 5-substitution pattern
Lange, Jos HM, Van der Neut, Martina AW, Borst, Alice JM, Yildirim, Mahmut, Van Stuivenberg, Herman H, Van Vliet, Bernard J, Kruse, Chris G
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
Published in Bioorganic & medicinal chemistry letters (01.05.2010)
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Journal Article
Synthesis, SAR and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles as potent cannabinoid CB sub(1) receptor antagonists
Lange, Jos HM, Van der Neut, Martina AW, Hartog, Arnold Pden, Wals, Henri C, Hoogendoorn, Jan, Van Stuivenberg, Herman H, Van Vliet, Bernard J, Kruse, Chris G
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
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Journal Article
Synthesis and SAR of novel imidazoles as potent and selective cannabinoid CB sub(2) receptor antagonists with high binding efficiencies
Lange, Jos HM, Van der Neut, Martina AW, Wals, Henri C, Kuil, Gijs D, Borst, Alice JM, Mulder, Arie, Hartog, Arnold Pden, Zilaout, Hicham, Goutier, Wouter, Van Stuivenberg, Herman H, Van Vliet, Bernard J
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Journal Article
Synthesis, SAR and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles as potent cannabinoid CB(1) receptor antagonists
Lange, Jos H M, van der Neut, Martina A W, den Hartog, Arnold P, Wals, Henri C, Hoogendoorn, Jan, van Stuivenberg, Herman H, van Vliet, Bernard J, Kruse, Chris G
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
Published in Bioorganic & medicinal chemistry letters (01.03.2010)
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Journal Article