Structural and time‐resolved mechanistic investigations of protein hydrolysis by the acidic proline‐specific endoprotease from Aspergillus niger
Pijning, Tjaard, Vujičić‐Žagar, Andreja, Laan, Jan‐Metske, Jong, René M., Ramirez‐Palacios, Carlos, Vente, Andre, Edens, Luppo, Dijkstra, Bauke W.
Published in Protein science (01.01.2024)
Published in Protein science (01.01.2024)
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Directed Evolution Strategies for Enantiocomplementary Haloalkane Dehalogenases: From Chemical Waste to Enantiopure Building Blocks
van Leeuwen, Jan G. E., Wijma, Hein J., Floor, Robert J., van der Laan, Jan-Metske, Janssen, Dick B.
Published in Chembiochem : a European journal of chemical biology (02.01.2012)
Published in Chembiochem : a European journal of chemical biology (02.01.2012)
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Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum
McLean, Kirsty J, Hans, Marcus, Meijrink, Ben, van Scheppingen, Wibo B, Vollebregt, Aad, Tee, Kang Lan, van der Laan, Jan-Metske, Leys, David, Munro, Andrew W, van den Berg, Marco A
Published in Proceedings of the National Academy of Sciences - PNAS (03.03.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (03.03.2015)
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Structures of an Isopenicillin N Converting Ntn-Hydrolase Reveal Different Catalytic Roles for the Active Site Residues of Precursor and Mature Enzyme
Bokhove, Marcel, Yoshida, Hiromi, Hensgens, Charles M.H., Metske van der Laan, Jan, Sutherland, John D., Dijkstra, Bauke W.
Published in Structure (London) (10.03.2010)
Published in Structure (London) (10.03.2010)
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Peroxicretion: a novel secretion pathway in the eukaryotic cell
Sagt, Cees M J, ten Haaft, Peter J, Minneboo, Ingeborg M, Hartog, Miranda P, Damveld, Robbert A, van der Laan, Jan Metske, Akeroyd, Michiel, Wenzel, Thibaut J, Luesken, Francisca A, Veenhuis, Marten, van der Klei, Ida, de Winde, Johannes H
Published in BMC biotechnology (20.05.2009)
Published in BMC biotechnology (20.05.2009)
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Biocatalytic route scouting and enzyme screening toward the synthesis of α-benzyl L-glutamate
Quaedflieg, Peter J. L. M., Jente, Lisanne M. H., Müller, Monika, Vermote, Linda, Plesciuc, Victor, van der Laan, Jan-Metske, Nielsen, Lone, Schürmann, Martin
Published in Frontiers in catalysis (31.01.2024)
Published in Frontiers in catalysis (31.01.2024)
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Protein redesign by learning from data
van den Berg, Bastiaan A., Reinders, Marcel J.T., van der Laan, Jan-Metske, Roubos, Johannes A., de Ridder, Dick
Published in Protein engineering, design and selection (01.09.2014)
Published in Protein engineering, design and selection (01.09.2014)
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Directed evolution of a glutaryl acylase into an adipyl acylase
Sio, Charles F., Riemens, Anja M., van der Laan, Jan‐Metske, Verhaert, Raymond M.D., Quax, Wim J.
Published in European journal of biochemistry (01.09.2002)
Published in European journal of biochemistry (01.09.2002)
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Journal Article
Purification, crystallization and preliminary X-ray diffraction of Cys103Ala acyl coenzyme A:isopenicillin N acyltransferase from Penicillium chrysogenum
Hensgens, Charles M. H., Kroezinga, Els A., Van Montfort, Bart A., Van Der Laan, Jan-Metske, Sutherland, John D., Dijkstra, Bauke W.
Published in Acta crystallographica. Section D, Biological crystallography. (01.04.2002)
Published in Acta crystallographica. Section D, Biological crystallography. (01.04.2002)
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Journal Article
Characterization of the beta-lactam binding site of penicillin acylase of Escherichia coli by structural and site-directed mutagenesis studies
Alkema, W B, Hensgens, C M, Kroezinga, E H, de Vries, E, Floris, R, van der Laan, J M, Dijkstra, B W, Janssen, D B
Published in Protein engineering (01.12.2000)
Published in Protein engineering (01.12.2000)
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Cloning, Sequence Analysis, and Expression in Escherichia coli of the Gene Encoding an α-Amino Acid Ester Hydrolase from Acetobacter turbidans
POLDERMAN-TIJMES, Jolanda J, JEKEL, Peter A, DE VRIES, Erik J, VAN MERODE, Annet E. J, FLORIS, René, VAN DER LAAN, Jan-Metske, SONKE, Theo, JANSSEN, Dick B
Published in Applied and Environmental Microbiology (01.01.2002)
Published in Applied and Environmental Microbiology (01.01.2002)
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Journal Article
Identification of the catalytic residues of alpha-amino acid ester hydrolase from Acetobacter turbidans by labeling and site-directed mutagenesis
Polderman-Tijmes, Jolanda J, Jekel, Peter A, Jeronimus-Stratingh, C Margot, Bruins, Andries P, Van Der Laan, Jan-Metske, Sonke, Theo, Janssen, Dick B
Published in The Journal of biological chemistry (09.08.2002)
Published in The Journal of biological chemistry (09.08.2002)
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Journal Article
Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming ofPenicillium chrysogenum
McLean, Kirsty J., Hans, Marcus, Meijrink, Ben, van Scheppingen, Wibo B., Vollebregt, Aad, Tee, Kang Lan, van der Laan, Jan-Metske, Leys, David, Munro, Andrew W., van den Berg, Marco A.
Published in Proceedings of the National Academy of Sciences - PNAS (03.03.2015)
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Published in Proceedings of the National Academy of Sciences - PNAS (03.03.2015)
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ENZYMATIC REMOVAL OF CHLOROPHYLL SUBSTRATES FROM TRIACYLGLYCEROL-BASED OILS
Dayton, Christopher Loren Gene, Sein, Arjen, Van Rij, Evert Tjeerd, Van Der Laan, Jan Metske
Year of Publication 01.12.2022
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Year of Publication 01.12.2022
Patent
Enzymatic removal of chlorophyll substrates from triacylglycerol-based oils
Dayton, Christopher Loren Gene, Sein, Arjen, Van Rij, Evert Tjeerd, Van Der Laan, Jan Metske
Year of Publication 20.09.2022
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Year of Publication 20.09.2022
Patent
An approach to prevent aggregation during the purification and crystallization of wild type acyl coenzyme A: Isopenicillin N acyltransferase from Penicillium chrysogenum
Yoshida, Hiromi, Hensgens, Charles M.H., van der Laan, Jan Metske, Sutherland, John D., Hart, Darren J., Dijkstra, Bauke W.
Published in Protein expression and purification (01.05.2005)
Published in Protein expression and purification (01.05.2005)
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Journal Article
Identification of the Catalytic Residues of α-Amino Acid Ester Hydrolase from Acetobacter turbidans by Labeling and Site-directed Mutagenesis
Jolanda J. Polderman-Tijmes, Peter A. Jekel, C. Margot Jeronimus-Stratingh, Andries P. Bruins, Jan-Metske van der Laan, Theo Sonke, Dick B. Janssen
Published in The Journal of biological chemistry (09.08.2002)
Published in The Journal of biological chemistry (09.08.2002)
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Journal Article
ENZYMATIC REMOVAL OF CHLOROPHYLL SUBSTRATES FROM TRIACYLGLYCEROL-BASED OILS
Dayton, Christopher Loren Gene, Sein, Arjen, Van Rij, Evert Tjeerd, Van Der Laan, Jan Metske
Year of Publication 07.01.2021
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Year of Publication 07.01.2021
Patent