A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
Chang, Diana, Nalls, Mike A, Hallgrímsdóttir, Ingileif B, Hunkapiller, Julie, van der Brug, Marcel, Cai, Fang, Kerchner, Geoffrey A, Ayalon, Gai, Bingol, Baris, Sheng, Morgan, Hinds, David, Behrens, Timothy W, Singleton, Andrew B, Bhangale, Tushar R, Graham, Robert R
Published in Nature genetics (01.10.2017)
Published in Nature genetics (01.10.2017)
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Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain
Gibbs, J Raphael, van der Brug, Marcel P, Hernandez, Dena G, Traynor, Bryan J, Nalls, Michael A, Lai, Shiao-Lin, Arepalli, Sampath, Dillman, Allissa, Rafferty, Ian P, Troncoso, Juan, Johnson, Robert, Zielke, H Ronald, Ferrucci, Luigi, Longo, Dan L, Cookson, Mark R, Singleton, Andrew B
Published in PLoS genetics (13.05.2010)
Published in PLoS genetics (13.05.2010)
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Multi-ancestry GWAS analysis identifies two novel loci associated with diabetic eye disease and highlights APOL1 as a high risk locus in patients with diabetic macular edema
Stockwell, Amy D, Chang, Michael C, Mahajan, Anubha, Forrest, William, Anegondi, Neha, Pendergrass, Rion K, Selvaraj, Suresh, Reeder, Jens, Wei, Eric, Iglesias, Victor A, Creps, Natalie M, Macri, Laura, Neeranjan, Andrea N, van der Brug, Marcel P, Scales, Suzie J, McCarthy, Mark I, Yaspan, Brian L
Published in PLoS genetics (16.08.2023)
Published in PLoS genetics (16.08.2023)
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Calpain-mediated tau fragmentation is altered in Alzheimer's disease progression
Chen, Hsu-Hsin, Liu, Peter, Auger, Paul, Lee, Seung-Hye, Adolfsson, Oskar, Rey-Bellet, Lorianne, Lafrance-Vanasse, Julien, Friedman, Brad A, Pihlgren, Maria, Muhs, Andreas, Pfeifer, Andrea, Ernst, James, Ayalon, Gai, Wildsmith, Kristin R, Beach, Thomas G, van der Brug, Marcel P
Published in Scientific reports (13.11.2018)
Published in Scientific reports (13.11.2018)
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RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways
van der Brug, Marcel P, Blackinton, Jeff, Chandran, Jayanth, Hao, Ling-Yang, Lal, Ashish, Mazan-Mamczarz, Krystyna, Martindale, Jennifer, Xie, Chengsong, Ahmad, Rili, Thomas, Kelly J, Beilina, Alexandra, Gibbs, J. Raphael, Ding, Jinhui, Myers, Amanda J, Zhan, Ming, Cai, Huaibin, Bonini, Nancy M, Gorospe, Myriam, Cookson, Mark R
Published in Proceedings of the National Academy of Sciences - PNAS (22.07.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (22.07.2008)
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Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies
Bien-Ly, Nga, Boswell, C. Andrew, Jeet, Surinder, Beach, Thomas G., Hoyte, Kwame, Luk, Wilman, Shihadeh, Vera, Ulufatu, Sheila, Foreman, Oded, Lu, Yanmei, DeVoss, Jason, van der Brug, Marcel, Watts, Ryan J.
Published in Neuron (Cambridge, Mass.) (21.10.2015)
Published in Neuron (Cambridge, Mass.) (21.10.2015)
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Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models
Friedman, Brad A., Srinivasan, Karpagam, Ayalon, Gai, Meilandt, William J., Lin, Han, Huntley, Melanie A., Cao, Yi, Lee, Seung-Hye, Haddick, Patrick C.G., Ngu, Hai, Modrusan, Zora, Larson, Jessica L., Kaminker, Joshua S., van der Brug, Marcel P., Hansen, David V.
Published in Cell reports (Cambridge) (16.01.2018)
Published in Cell reports (Cambridge) (16.01.2018)
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Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation
MODARRESI, Farzaneh, ALI FAGHIHI, Mohammad, LOPEZ-TOLEDANO, Miguel A, PEDRAM FATEMI, Roya, MAGISTRI, Marco, BROTHERS, Shaun P, DER BRUG, Marcel P.van, WAHLESTEDT, Claes
Published in Nature biotechnology (01.05.2012)
Published in Nature biotechnology (01.05.2012)
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Untangling the brain's neuroinflammatory and neurodegenerative transcriptional responses
Srinivasan, Karpagam, Friedman, Brad A, Larson, Jessica L, Lauffer, Benjamin E, Goldstein, Leonard D, Appling, Laurie L, Borneo, Jovencio, Poon, Chungkee, Ho, Terence, Cai, Fang, Steiner, Pascal, van der Brug, Marcel P, Modrusan, Zora, Kaminker, Joshua S, Hansen, David V
Published in Nature communications (21.04.2016)
Published in Nature communications (21.04.2016)
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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
Greggio, Elisa, Jain, Shushant, Kingsbury, Ann, Bandopadhyay, Rina, Lewis, Patrick, Kaganovich, Alice, van der Brug, Marcel P., Beilina, Alexandra, Blackinton, Jeff, Thomas, Kelly Jean, Ahmad, Rili, Miller, David W., Kesavapany, Sashi, Singleton, Andrew, Lees, Andrew, Harvey, Robert J., Harvey, Kirsten, Cookson, Mark R.
Published in Neurobiology of disease (01.08.2006)
Published in Neurobiology of disease (01.08.2006)
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Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice
Matsuki, Tohru, Zaka, Mariam, Guerreiro, Rita, van der Brug, Marcel P, Cooper, Jonathan A, Cookson, Mark R, Hardy, John A, Howell, Brian W
Published in PloS one (15.02.2012)
Published in PloS one (15.02.2012)
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Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1
Greggio, Elisa, Lewis, Patrick A, van der Brug, Marcel P, Ahmad, Rili, Kaganovich, Alice, Ding, Jinhui, Beilina, Alexandra, Baker, Acacia K, Cookson, Mark R
Published in Journal of neurochemistry (01.07.2007)
Published in Journal of neurochemistry (01.07.2007)
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Neurodegenerative Mutation in Cytoplasmic Dynein Alters Its Organization and Dynein-Dynactin and Dynein-Kinesin Interactions
Deng, Wenhan, Garrett, Caroline, Dombert, Benjamin, Soura, Violetta, Banks, Gareth, Fisher, Elizabeth M.C., van der Brug, Marcel P., Hafezparast, Majid
Published in The Journal of biological chemistry (17.12.2010)
Published in The Journal of biological chemistry (17.12.2010)
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Evidence for natural antisense transcript-mediated inhibition of microRNA function
Faghihi, Mohammad Ali, Zhang, Ming, Huang, Jia, Modarresi, Farzaneh, Van der Brug, Marcel P, Nalls, Michael A, Cookson, Mark R, St-Laurent, 3rd, Georges, Wahlestedt, Claes
Published in Genome biology (27.05.2010)
Published in Genome biology (27.05.2010)
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Parkinson's disease: From human genetics to clinical trials
van der Brug, Marcel P, Singleton, Andrew, Gasser, Thomas, Lewis, Patrick A
Published in Science translational medicine (16.09.2015)
Published in Science translational medicine (16.09.2015)
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Molecular Mechanisms of Alzheimer Disease Protection by the A673T Allele of Amyloid Precursor Protein
Maloney, Janice A., Bainbridge, Travis, Gustafson, Amy, Zhang, Shuo, Kyauk, Roxanne, Steiner, Pascal, van der Brug, Marcel, Liu, Yichin, Ernst, James A., Watts, Ryan J., Atwal, Jasvinder K.
Published in The Journal of biological chemistry (07.11.2014)
Published in The Journal of biological chemistry (07.11.2014)
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Kinesin-associated protein 3 (KIFAP3) has no effect on survival in a population-based cohort of ALS patients
Traynor, Bryan J., Nalls, Michael, Lai, Shiao-Lin, Gibbs, Raphael J., Schymick, Jennifer C., Arepalli, Sampath, Hernandez, Dena, van der Brug, Marcel P., Johnson, Janel O., Dillman, Allissa, Cookson, Mark, Moglia, Cristina, Calvo, Andrea, Restagno, Gabriella, Mora, Gabriele, Chiò, Adriano, Cleveland, Don W.
Published in Proceedings of the National Academy of Sciences - PNAS (06.07.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (06.07.2010)
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Pathogenic LRRK2 mutations do not alter gene expression in cell model systems or human brain tissue
Devine, Michael J, Kaganovich, Alice, Ryten, Mina, Mamais, Adamantios, Trabzuni, Daniah, Manzoni, Claudia, McGoldrick, Philip, Chan, Diane, Dillman, Allissa, Zerle, Julia, Horan, Susannah, Taanman, Jan-Willem, Hardy, John, Marti-Masso, Jose-Felix, Healy, Daniel, Healey, Daniel, Schapira, Anthony H, Wolozin, Benjamin, Bandopadhyay, Rina, Cookson, Mark R, van der Brug, Marcel P, Lewis, Patrick A
Published in PloS one (22.07.2011)
Published in PloS one (22.07.2011)
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Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations
Sheng, Zejuan, Zhang, Shuo, Bustos, Daisy, Kleinheinz, Tracy, Le Pichon, Claire E, Dominguez, Sara L, Solanoy, Hilda O, Drummond, Jason, Zhang, Xiaolin, Ding, Xiao, Cai, Fang, Song, Qinghua, Li, Xianting, Yue, Zhenyu, van der Brug, Marcel P, Burdick, Daniel J, Gunzner-Toste, Janet, Chen, Huifen, Liu, Xingrong, Estrada, Anthony A, Sweeney, Zachary K, Scearce-Levie, Kimberly, Moffat, John G, Kirkpatrick, Donald S, Zhu, Haitao
Published in Science translational medicine (12.12.2012)
Published in Science translational medicine (12.12.2012)
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DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy
THOMAS, Kelly Jean, MCCOY, Melissa K, BLACKINTON, Jeff, BEILINA, Alexandra, VAN DER BRUG, Marcel, SANDEBRING, Anna, MILLER, David, MARIC, Dragan, CEDAZO-MINGUEZ, Angel, COOKSON, Mark R
Published in Human molecular genetics (01.01.2011)
Published in Human molecular genetics (01.01.2011)
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