DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing
Engelberts, Patrick J., Hiemstra, Ida H., de Jong, Bart, Schuurhuis, Danita H., Meesters, Joyce, Beltran Hernandez, Irati, Oostindie, Simone C., Neijssen, Joost, van den Brink, Edward N., Horbach, G. Jean, Verploegen, Sandra, Labrijn, Aran F., Salcedo, Theodora, Schuurman, Janine, Parren, Paul W.H.I, Breij, Esther C.W.
Published in EBioMedicine (01.02.2020)
Published in EBioMedicine (01.02.2020)
Get full text
Journal Article
DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies
Oostindie, Simone C., van der Horst, Hilma J., Kil, Laurens P., Strumane, Kristin, Overdijk, Marije B., van den Brink, Edward N., van den Brakel, Jeroen H. N., Rademaker, Hendrik J., van Kessel, Berris, van den Noort, Juliette, Chamuleau, Martine E. D., Mutis, Tuna, Lindorfer, Margaret A., Taylor, Ronald P., Schuurman, Janine, Parren, Paul W. H. I., Beurskens, Frank J., Breij, Esther C. W.
Published in Blood cancer journal (New York) (28.04.2020)
Published in Blood cancer journal (New York) (28.04.2020)
Get full text
Journal Article
863 In vitro and in vivo studies establish DuoBody®-CD3xB7H4 as a novel drug candidate for the treatment of solid cancers
Koopman, Louise, Vries, Laura Smits-de, Egerod, Frederikke Lihme, Wubben, Sebastiaan, Houtkamp, Mischa, Poot, Stefanie De, Paauwe, Madelon, Brink, Edward van den, Gorlani, Andrea, Verzijl, Dennis, Sasser, Kate, Breij, Esther
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
Get full text
Journal Article
Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets
ter Meulen, Jan, Bakker, Alexander BH, van den Brink, Edward N, Weverling, Gerrit J, Martina, Byron EE, Haagmans, Bart L, Kuiken, Thijs, de Kruif, John, Preiser, Wolfgang, Spaan, Willy, Gelderblom, Hans R, Goudsmit, Jaap, Osterhaus, Albert DME
Published in The Lancet (British edition) (26.06.2004)
Published in The Lancet (British edition) (26.06.2004)
Get full text
Journal Article
Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants
ter Meulen, Jan, van den Brink, Edward N, Poon, Leo L M, Marissen, Wilfred E, Leung, Cynthia S W, Cox, Freek, Cheung, Chung Y, Bakker, Arjen Q, Bogaards, Johannes A, van Deventer, Els, Preiser, Wolfgang, Doerr, Hans Wilhelm, Chow, Vincent T, de Kruif, John, Peiris, Joseph S M, Goudsmit, Jaap
Published in PLoS medicine (01.07.2006)
Published in PLoS medicine (01.07.2006)
Get full text
Journal Article
Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells
Throsby, Mark, van den Brink, Edward, Jongeneelen, Mandy, Poon, Leo L M, Alard, Philippe, Cornelissen, Lisette, Bakker, Arjen, Cox, Freek, van Deventer, Els, Guan, Yi, Cinatl, Jindrich, ter Meulen, Jan, Lasters, Ignace, Carsetti, Rita, Peiris, Malik, de Kruif, John, Goudsmit, Jaap
Published in PloS one (16.12.2008)
Published in PloS one (16.12.2008)
Get full text
Journal Article
Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors
Muik, Alexander, Garralda, Elena, Altintas, Isil, Gieseke, Friederike, Geva, Ravit, Ben-Ami, Eytan, Maurice-Dror, Corinne, Calvo, Emiliano, LoRusso, Patricia M, Alonso, Guzman, Rodriguez-Ruiz, Maria E, Schoedel, Kristina B, Blum, Jordan M, Sänger, Bianca, Salcedo, Theodora W, Burm, Saskia M, Stanganello, Eliana, Verzijl, Dennis, Vascotto, Fulvia, Sette, Angelica, Quinkhardt, Juliane, Plantinga, Theo S, Toker, Aras, van den Brink, Edward N, Fereshteh, Mark, Diken, Mustafa, Satijn, David, Kreiter, Sebastian, Breij, Esther C W, Bajaj, Gaurav, Lagkadinou, Eleni, Sasser, Kate, Türeci, Özlem, Forssmann, Ulf, Ahmadi, Tahamtan, Şahin, Uğur, Jure-Kunkel, Maria, Melero, Ignacio
Published in Cancer discovery (02.05.2022)
Published in Cancer discovery (02.05.2022)
Get full text
Journal Article
CD3 HUMANIZED OR CHIMERIC CD3 ANTIBODIES
NEIJSSEN JOOST J, MEESTERS JOYCE, SCHUURMAN JANINE, VAN DEN BRINK EDWARD, LABRIJN ARAN FRANK, PARREN PAUL
Year of Publication 25.05.2023
Get full text
Year of Publication 25.05.2023
Patent
CD3 CD20 Bispecific Antibodies against CD3 and CD20
BREIJ ESTHER, SCHUURMAN JANINE, ALTINTAS ISIL, VAN DEN BRINK EDWARD, ENGELBERTS PATRICK, VERPLOEGEN SANDRA, RADEMAKER RIK, RADERSMA RIEMKE VAN DIJKHUIZEN, PARREN PAUL, SATIJN DAVID
Year of Publication 13.05.2024
Get full text
Year of Publication 13.05.2024
Patent
ANTIBODIES BINDING AXL
BREIJ ESTHER, VAN DIJKHUIZEN RADERSMA RIEMKE, DE JONG ROB N, VAN DEN BRINK EDWARD NORBERT, VERZIJL DENNIS, PARREN PAUL, SATIJN DAVID
Year of Publication 19.10.2023
Get full text
Year of Publication 19.10.2023
Patent
B7H4에 결합하는 항체
KOOPMAN LOUISE, EGEROD FREDERIKKE L, BREIJ ESTHER C W, SATIJIN DAVID, VAN DEN BRINK EDWARD N, ENGELBERTS PATRICK, VERZIJL DENNIS, BOSGRA SIETO, RADEMAKER RIK
Year of Publication 22.11.2022
Get full text
Year of Publication 22.11.2022
Patent
Mechanistic and pharmacodynamic studies of DuoBody-CD3x5T4 in preclinical tumor models
Kemper, Kristel, Gielen, Ellis, Boross, Peter, Houtkamp, Mischa, Plantinga, Theo S, de Poot, Stefanie Ah, Burm, Saskia M, Janmaat, Maarten L, Koopman, Louise A, van den Brink, Edward N, Rademaker, Rik, Verzijl, Dennis, Engelberts, Patrick J, Satijn, David, Sasser, A Kate, Breij, Esther Cw
Published in Life science alliance (01.11.2022)
Published in Life science alliance (01.11.2022)
Get full text
Journal Article
PD-L1에 대한 항체
ALTINTAS ISIL, DE GOEIJ BART, VAN DEN BRINK EDWARD, VERZIJL DENNIS, RADEMAKER RIK, PARREN PAUL, SATIJN DAVID
Year of Publication 18.11.2019
Get full text
Year of Publication 18.11.2019
Patent
HER2 monoclonal antibodies that do not interfere with receptor heterodimerization-mediated signaling induce effective internalization and represent valuable components for rational antibody-drug conjugate design
de Goeij, Bart ECG, Peipp, Matthias, de Haij, Simone, van den Brink, Edward N, Kellner, Christian, Riedl, Thilo, de Jong, Rob, Vink, Tom, Strumane, Kristin, Bleeker, Wim K, Parren, Paul WHI
Published in mAbs (01.03.2014)
Published in mAbs (01.03.2014)
Get full text
Journal Article
항체
BREIJ ESTHER C W, KEMPER KRISTEL, HORBACH SJENG, DE GOEIJ BART E C G, VAN DEN BRINK EDWARD N, ENGELBERTS PATRICK, VERZIJL DENNIS, RADEMAKER RIK, PARREN PAUL, SATIJN DAVID
Year of Publication 19.11.2020
Get full text
Year of Publication 19.11.2020
Patent
이중특이적 항-CD37 항체를 포함하는 제약 조성물
BREIJ ESTHER C W, RAZVI ABBAS, GRAPENTIN CHRISTOPH, CIMANDER CHRISTIAN, VAN DEN BRINK EDWARD N, BEURSKENS FRANK, OOSTINDIE SIMONE, OVERDIJK MARIJE, MUTIS TUNA, TAYLOR RONALD, CHAMULEAU MARTINE E D, HOLLENSTEIN ANDREAS, REN SHAN, LINDORFER MARGARET, PARREN PAUL, VAN DER HORST HILMA, SAHLIN MARTIN
Year of Publication 27.09.2021
Get full text
Year of Publication 27.09.2021
Patent
이중특이적 항-CD37 항체, 모노클로날 항-CD37 항체 및 그의 사용 방법
BREIJ ESTHER, E.D. CHAMULEAU MARTINE, BEURSKENS FRANK, VAN DEN BRINK EDWARD, HOLLENSTEIN ANDREAS, OOSTINDIE SIMONE, OVERDIJK MARIJE, LINDORFER MARGARET, PARREN PAUL, VAN DER HORST HILMA, MUTIS TUNA, TAYLOR RONALD
Year of Publication 25.06.2020
Get full text
Year of Publication 25.06.2020
Patent
치료를 위한 제제, 용도 및 방법
STUMMANN TINA, MALIK IBRAHIM JOHN, EGEBJERG JAN, RAND KASPER DYRBERG, GERRITSEN ARNOUT, VAN DEN BRINK EDWARD, STAVENHAGEN JEFFREY B, TRABJERG ESBEN, CHRISTENSEN SOREN, PARREN PAUL, BIILMANN RONN LARS CHRISTIAN
Year of Publication 24.03.2020
Get full text
Year of Publication 24.03.2020
Patent
HUMANIZED OR CHIMERIC CD3 ANTIBODIES
NEIJSSEN JOOST J, MEESTERS JOYCE, SCHUURMAN JANINE, VAN DEN BRINK EDWARD, LABRIJN ARAN FRANK, PARREN PAUL
Year of Publication 09.03.2016
Get full text
Year of Publication 09.03.2016
Patent
소르틸린에 결합하고 프로그라눌린의 결합을 억제하는 항체
MALIK IBRAHIM JOHN, EGEBJERG JAN, DE JONG ROB, GERRITSEN ARNOUT, VAN DEN BRINK EDWARD, STAVENHAGEN JEFFREY B, CHRISTENSEN SOREN, PARREN PAUL, BIILMANN RONN LARS CHRISTIAN
Year of Publication 21.03.2018
Get full text
Year of Publication 21.03.2018
Patent