Structural basis of selective cannabinoid CB2 receptor activation
Li, Xiaoting, Chang, Hao, Bouma, Jara, de Paus, Laura V., Mukhopadhyay, Partha, Paloczi, Janos, Mustafa, Mohammed, van der Horst, Cas, Kumar, Sanjay Sunil, Wu, Lijie, Yu, Yanan, van den Berg, Richard J. B. H. N., Janssen, Antonius P. A., Lichtman, Aron, Liu, Zhi-Jie, Pacher, Pal, van der Stelt, Mario, Heitman, Laura H., Hua, Tian
Published in Nature communications (15.03.2023)
Published in Nature communications (15.03.2023)
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Glycosphingolipids-Nature, Function, and Pharmacological Modulation
Wennekes, Tom, van den Berg, Richard J. B. H. N., Boot, Rolf G., van der Marel, Gijsbert A., Overkleeft, Herman S., Aerts, Johannes M. F. G.
Published in Angewandte Chemie (International ed.) (09.11.2009)
Published in Angewandte Chemie (International ed.) (09.11.2009)
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Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding
Deng, Hui, Kooijman, Sander, van den Nieuwendijk, Adrianus M. C. H, Ogasawara, Daisuke, van der Wel, Tom, van Dalen, Floris, Baggelaar, Marc P, Janssen, Freek J, van den Berg, Richard J. B. H. N, den Dulk, Hans, Cravatt, Benjamin F, Overkleeft, Herman S, Rensen, Patrick C. N, van der Stelt, Mario
Published in Journal of medicinal chemistry (12.01.2017)
Published in Journal of medicinal chemistry (12.01.2017)
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A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase
Lahav, Daniël, Liu, Bing, van den Berg, Richard J. B. H. N, van den Nieuwendijk, Adrianus M. C. H, Wennekes, Tom, Ghisaidoobe, Amar T, Breen, Imogen, Ferraz, Maria J, Kuo, Chi-Lin, Wu, Liang, Geurink, Paul P, Ovaa, Huib, van der Marel, Gijsbert A, van der Stelt, Mario, Boot, Rolf G, Davies, Gideon J, Aerts, Johannes M. F. G, Overkleeft, Herman S
Published in Journal of the American Chemical Society (11.10.2017)
Published in Journal of the American Chemical Society (11.10.2017)
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Identification and Development of Biphenyl Substituted Iminosugars as Improved Dual Glucosylceramide Synthase/Neutral Glucosylceramidase Inhibitors
Ghisaidoobe, Amar T, van den Berg, Richard J. B. H. N, Butt, Saleem S, Strijland, Anneke, Donker-Koopman, Wilma E, Scheij, Saskia, van den Nieuwendijk, Adrianus M. C. H, Koomen, Gerrit-Jan, van Loevezijn, Arnold, Leemhuis, Mark, Wennekes, Tom, van der Stelt, Mario, van der Marel, Gijsbert A, van Boeckel, Constant A. A, Aerts, Johannes M. F. G, Overkleeft, Herman S
Published in Journal of medicinal chemistry (13.11.2014)
Published in Journal of medicinal chemistry (13.11.2014)
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A chemical genetic screen reveals that iminosugar inhibitors of plant glucosylceramide synthase inhibit root growth in Arabidopsis and cereals
Rugen, Michael D., Vernet, Mathieu M. J. L., Hantouti, Laila, Soenens, Amalia, Andriotis, Vasilios M. E., Rejzek, Martin, Brett, Paul, van den Berg, Richard J. B. H. N., Aerts, Johannes M. F. G., Overkleeft, Hermen S., Field, Robert A.
Published in Scientific reports (06.11.2018)
Published in Scientific reports (06.11.2018)
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Development of Adamantan-1-yl-methoxy-Functionalized 1-Deoxynojirimycin Derivatives as Selective Inhibitors of Glucosylceramide Metabolism in Man
Wennekes, Tom, van den Berg, Richard J. B. H. N, Donker, Wilma, van der Marel, Gijsbert A, Strijland, Anneke, Aerts, Johannes M. F. G, Overkleeft, Herman S
Published in Journal of organic chemistry (16.02.2007)
Published in Journal of organic chemistry (16.02.2007)
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Synthesis of 6‑Hydroxysphingosine and α‑Hydroxy Ceramide Using a Cross-Metathesis Strategy
Wisse, Patrick, de Geus, Mark A. R, Cross, Gen, van den Nieuwendijk, Adrianus M. C. H, van Rooden, Eva J, van den Berg, Richard J. B. H. N, Aerts, Johannes M. F. G, van der Marel, Gijsbert A, Codée, Jeroen D. C, Overkleeft, Herman S
Published in Journal of organic chemistry (17.07.2015)
Published in Journal of organic chemistry (17.07.2015)
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The Development of an Aza-C-Glycoside Library Based on a Tandem Staudinger/Aza-Wittig/Ugi Three-Component Reaction
Wennekes, Tom, Bonger, Kimberly M., Vogel, Katrin, van den Berg, Richard J. B. H. N., Strijland, Anneke, Donker-Koopman, Wilma E., Aerts, Johannes M. F. G., van der Marel, Gijsbert A., Overkleeft, Herman S.
Published in European journal of organic chemistry (01.11.2012)
Published in European journal of organic chemistry (01.11.2012)
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Journal Article
Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-alpha and ABHD6 inhibitors
Deng, Hui, van der Wel, Tom, van den Berg, Richard J. B. H. N., van den Nieuwendijk, Adrianus M. C. H., Janssen, Freek J., Baggelaar, Marc P., Overkleeft, Hermen S., van der Stelt, Mario
Published in MedChemComm (01.05.2017)
Published in MedChemComm (01.05.2017)
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Synthesis of l-altro-1-Deoxynojirimycin, d-allo-1-Deoxynojirimycin, and d-galacto-1-Deoxynojirimycin from a Single Chiral Cyanohydrin
van den Nieuwendijk, Adrianus M. C. H, Ruben, Mark, Engelsma, Sander E, Risseeuw, Martijn D. P, van den Berg, Richard J. B. H. N, Boot, Rolf G, Aerts, Johannes M, Brussee, Johannes, van der Marel, Gijs A, Overkleeft, Herman S
Published in Organic letters (03.09.2010)
Published in Organic letters (03.09.2010)
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Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase
Scherpenzeel, Monique van, van den Berg, Richard J.B.H.N., Donker-Koopman, Wilma E., Liskamp, Rob M.J., Aerts, Johannes M.F.G., Overkleeft, Herman S., Pieters, Roland J.
Published in Bioorganic & medicinal chemistry (2010)
Published in Bioorganic & medicinal chemistry (2010)
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Synthesis and evaluation of homo-bivalent GnRHR ligands
Bonger, Kimberly M., van den Berg, Richard J.B.H.N., Heitman, Laura H., IJzerman, Ad P., Oosterom, Julia, Timmers, Cornelis M., Overkleeft, Herman S., van der Marel, Gijsbert A.
Published in Bioorganic & medicinal chemistry (15.07.2007)
Published in Bioorganic & medicinal chemistry (15.07.2007)
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Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA
Bakker, Alexander T., Kotsogianni, Ioli, Mirenda, Liza, Straub, Verena M., Avalos, Mariana, van den Berg, Richard J. B. H. N., Florea, Bogdan I., van Wezel, Gilles P., Janssen, Antonius P. A., Martin, Nathaniel I., van der Stelt, Mario
Published in Journal of the American Chemical Society (18.01.2023)
Published in Journal of the American Chemical Society (18.01.2023)
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Discovery of a Photoaffinity Probe that Captures the Active Conformation of the Cannabinoid CB2 Receptor
De Paus, Laura V., An, Yu, Janssen, Antonius P. A., Berg, Richard J. B. H. N., Heitman, Laura H., Stelt, Mario
Published in Chembiochem : a European journal of chemical biology (02.04.2024)
Published in Chembiochem : a European journal of chemical biology (02.04.2024)
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Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria
Bakker, Alexander T., Kotsogianni, Ioli, Avalos, Mariana, Punt, Jeroen M., Liu, Bing, Piermarini, Diana, Gagestein, Berend, Slingerland, Cornelis J., Zhang, Le, Willemse, Joost J., Ghimire, Leela B., van den Berg, Richard J. H. B. N., Janssen, Antonius P. A., Ottenhoff, Tom H. M., van Boeckel, Constant A. A., van Wezel, Gilles P., Ghilarov, Dmitry, Martin, Nathaniel I., van der Stelt, Mario
Published in Nature chemistry (01.09.2024)
Published in Nature chemistry (01.09.2024)
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Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish
Lelieveld, Lindsey T, Mirzaian, Mina, Kuo, Chi-Lin, Artola, Marta, Ferraz, Maria J, Peter, Remco E A, Akiyama, Hisako, Greimel, Peter, van den Berg, Richard J B H N, Overkleeft, Herman S, Boot, Rolf G, Meijer, Annemarie H, Aerts, Johannes M F G
Published in Journal of lipid research (01.11.2019)
Published in Journal of lipid research (01.11.2019)
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Limits of miniaturization: assessing ITP performance in sub-micron and nanochannels
Janssen, Kjeld G H, Li, Jiajie, Hoang, Hanh T, Vulto, Paul, van den Berg, Richard J B H N, Overkleeft, Herman S, Eijkel, Jan C T, Tas, Niels R, van der Linden, Heiko J, Hankemeier, Thomas
Published in Lab on a chip (21.08.2012)
Published in Lab on a chip (21.08.2012)
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Assessment of Partially Deoxygenated Deoxynojirimycin Derivatives as Glucosylceramide Synthase Inhibitors
van den Berg, Richard J. B. H. N, Wennekes, Tom, Ghisaidoobe, Amar, Donker-Koopman, Wilma E, Strijland, Anneke, Boot, Rolf G, van der Marel, Gijsbert A, Aerts, Johannes M. F. G, Overkleeft, Herman S
Published in ACS medicinal chemistry letters (14.07.2011)
Published in ACS medicinal chemistry letters (14.07.2011)
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