Evaluation of 5‑(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington’s Disease
Stott, Andrew J, Maillard, Michel C, Beaumont, Vahri, Allcock, David, Aziz, Omar, Borchers, Alexander H, Blackaby, Wesley, Breccia, Perla, Creighton-Gutteridge, Gillian, Haughan, Alan F, Jarvis, Rebecca E, Luckhurst, Christopher A, Matthews, Kim L, McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Van de Poël, Amanda J, Vater, Huw D, Vann, Julie, Williams, Rachel, Yates, Dawn, Muñoz-Sanjuán, Ignacio, Dominguez, Celia
Published in ACS medicinal chemistry letters (11.03.2021)
Published in ACS medicinal chemistry letters (11.03.2021)
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Journal Article
Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986)
Doyle, Kevin, Lönn, Hans, Käck, Helena, Van de Poël, Amanda, Swallow, Steve, Gardiner, Philip, Connolly, Stephen, Root, James, Wikell, Cecilia, Dahl, Göran, Stenvall, Kristina, Johannesson, Petra
Published in Journal of medicinal chemistry (27.10.2016)
Published in Journal of medicinal chemistry (27.10.2016)
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Journal Article
Structure-Based Exploration of Selectivity for ATM Inhibitors in Huntington’s Disease
Van de Poël, Amanda, Toledo-Sherman, Leticia, Breccia, Perla, Cachope, Roger, Bate, Jennifer R, Angulo-Herrera, Ivan, Wishart, Grant, Matthews, Kim L, Martin, Sarah L, Peacock, Marcus, Barnard, Amy, Cox, Helen C, Jones, Graham, McAllister, George, Vater, Huw, Esmieu, William, Clissold, Cole, Lamers, Marieke, Leonard, Philip, Jarvis, Rebecca E, Blackaby, Wesley, Eznarriaga, Maria, Lazari, Ovadia, Yates, Dawn, Rose, Mark, Jang, Sung-Wook, Muñoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (22.04.2021)
Published in Journal of medicinal chemistry (22.04.2021)
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Journal Article
Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington’s Disease Models
Toledo-Sherman, Leticia, Breccia, Perla, Cachope, Roger, Bate, Jennifer R, Angulo-Herrera, Ivan, Wishart, Grant, Matthews, Kim L, Martin, Sarah L, Cox, Helen C, McAllister, George, Penrose, Stephen D, Vater, Huw, Esmieu, William, Van de Poël, Amanda, Van de Bospoort, Rhea, Strijbosch, Annelieke, Lamers, Marieke, Leonard, Philip, Jarvis, Rebecca E, Blackaby, Wesley, Barnes, Karen, Eznarriaga, Maria, Dowler, Simon, Smith, Graham D, Fischer, David F, Lazari, Ovadia, Yates, Dawn, Rose, Mark, Jang, Sung-Wook, Muñoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (28.03.2019)
Published in Journal of medicinal chemistry (28.03.2019)
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DPP1 Inhibitors: Exploring the Role of Water in the S2 Pocket of DPP1 with Substituted Pyrrolidines
Käck, Helena, Doyle, Kevin, Hughes, Samantha J, Bodnarchuk, Michael S, Lönn, Hans, Van De Poël, Amanda, Palmer, Nicholas
Published in ACS medicinal chemistry letters (08.08.2019)
Published in ACS medicinal chemistry letters (08.08.2019)
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Journal Article
Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington’s Disease
Liu, Longbin, Malagu, Karine, Haughan, Alan F., Khetarpal, Vinod, Stott, Andrew J., Esmieu, William, Vater, Huw D., Webster, Stephen J., Van de Poël, Amanda J., Clissold, Cole, Cosgrove, Brett, Sutton, Benjamin, Spencer, Jonathan A., Breccia, Perla, Gancia, Emanuela, Bonomo, Silvia, Ladduwahetty, Tammy, Lazari, Ovadia, Patel, Hiral, Atton, Helen C., Clifton, Steve, Mota, Daniel M., Magnani, Dario, O’Neill, Amy, Stebbeds, Marta, Macabuag, Natsuko, Todd, Daniel, Herva, Maria E., Mitchell, Philip, Visser, Mijke, Compte Sancerni, Sara, Grand Moursel, Laure, da Silva, Marta, Kritikou, Eva, Heikkinen, Taneli T., Bolkvadze, Tamuna, Fodale, Valentina, Spadafora, Debora, Daldin, Manuel, Bresciani, Alberto, Mangette, John E., Doherty, Elizabeth M., Lee, Matthew R., Herbst, Todd, Monteagudo, Edith, Macdonald, Douglas, Plotnikov, Nikolay V., Chambers, Mark, McAllister, George, Muňoz-Sanjuan, Ignacio, Dominguez, Celia
Published in Journal of medicinal chemistry (28.09.2023)
Published in Journal of medicinal chemistry (28.09.2023)
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Journal Article
Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class Ila HDAC Inhibitors for Huntington's Disease
Stott, Andrew J., Maillard, Michel C., Beaumont, Vahri, Allcock, David, Aziz, Omar, Borchers, Alexander H., Blackaby, Wesley, Breccia, Perla, Creighton-Gutteridge, Gillian, Haughan, Alan F., Jarvis, Rebecca E., Luckhurst, Christopher A., Matthews, Kim L., McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Van de Poel, Amanda J., Vater, Huw D., Vann, Julie, Williams, Rachel, Yates, Dawn, Munoz-Sanjuan, Ignacio, Dominguez, Celia
Published in ACS medicinal chemistry letters (11.03.2021)
Published in ACS medicinal chemistry letters (11.03.2021)
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Journal Article
(2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase I inhibitors
Swallow, Steven, Lonn, Hans Roland, Jones, Graham Peter, Watson, David Wyn, Ponten, John Fritiof, Aurell, Carl-Johan, Macritchie, Jaqueline Anne, Connolly, Stephen, Karlsson, Staffan PO, Van De Poel, Amanda Jane, Doyle, Kevin James, Palmer, Nicholas John
Year of Publication 25.05.2017
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Year of Publication 25.05.2017
Patent
(2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase I inhibitors
Swallow, Steven, Lonn, Hans Roland, Jones, Graham Peter, Watson, David Wyn, Ponten, John Fritiof, Aurell, Carl-Johan, Macritchie, Jaqueline Anne, Connolly, Stephen, Karlsson, Staffan PO, Van De Poel, Amanda Jane, Doyle, Kevin James, Palmer, Nicholas John
Year of Publication 09.03.2017
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Year of Publication 09.03.2017
Patent
(2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase I inhibitors
Swallow, Steven, Lonn, Hans Roland, Jones, Graham Peter, Watson, David Wyn, Ponten, John Fritiof, Aurell, Carl-Johan, Macritchie, Jaqueline Anne, Connolly, Stephen, Karlsson, Staffan PO, Van De Poel, Amanda Jane, Doyle, Kevin James, Palmer, Nicholas John
Year of Publication 09.03.2017
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Year of Publication 09.03.2017
Patent
(2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
Swallow, Steven, Lonn, Hans Roland, Jones, Graham Peter, Watson, David Wyn, Ponten, John Fritiof, Aurell, Carl-Johan, Macritchie, Jaqueline Anne, Connolly, Stephen, Karlsson, Staffan PO, Van De Poel, Amanda Jane, Doyle, Kevin James, Palmer, Nicholas John
Year of Publication 16.02.2017
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Year of Publication 16.02.2017
Patent
HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF
HAUGHAN, ALAN F, STOTT, ANDREW J, WISHART, GRANT, VAN DE POEL, AMANDA, DOMINGUEZ, CELIA, WALL, MICHAEL, BRECCIA, PERLA, MAILLARD, MICHEL C, JARVIS, REBECCA E, LUCKHURST, CHRISTOPHER A, SAVILLE-STONES, ELIZABETH A
Year of Publication 09.01.2024
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Year of Publication 09.01.2024
Patent
HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF
HAUGHAN, ALAN F, STOTT, ANDREW J, WISHART, GRANT, VAN DE POEL, AMANDA, DOMINGUEZ, CELIA, WALL, MICHAEL, BRECCIA, PERLA, MAILLARD, MICHEL C, JARVIS, REBECCA E, LUCKHURST, CHRISTOPHER A, SAVILLE-STONES, ELIZABETH A
Year of Publication 26.09.2023
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Year of Publication 26.09.2023
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Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase 1 inhibitors
Swallow, Steven, Lönn, Hans Roland, Jones, Graham Peter, Watson, David Wyn, Aurell, Carl-Johan, Van De Poël, Amanda Jane, Pontén, John Fritiof, Karlsson, Staffan Po, Macritchie, Jaqueline Anne, Connolly, Stephen, Doyle, Kevin James, Palmer, Nicholas John
Year of Publication 06.08.2024
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Year of Publication 06.08.2024
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Histone deacetylase inhibitors and compositions and methods of use thereof
Christopher A. LUCKHURST, Elizabeth A. SAVILLE-STONES, Perla BRECCIA, Celia DOMINGUEZ, Michael WALL, Alan F. HAUGHAN, Amanda VAN DE POEL, Grant WISHART, Andrew J. STOTT, Rebecca E. JARVIS, Michel C. MAILLARD
Year of Publication 01.07.2023
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Year of Publication 01.07.2023
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Histone deacetylase inhibitors and compositions and methods of use thereof
Perla BRECCIA, Christopher A. LUCKHURST, Elizabeth A. SAVILLE-STONES, Celia DOMINGUEZ, Michael WALL, Alan F. HAUGHAN, Amanda VAN DE POEL, Grant WISHART, Rebecca E. JARVIS, Andrew J. STOTT, Michel C. MAILLARD
Year of Publication 01.07.2023
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Year of Publication 01.07.2023
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Histone deacetylase inhibitors and compositions and methods of use thereof
Perla BRECCIA, Christopher A. LUCKHURST, Elizabeth A. SAVILLE-STONES, Celia DOMINGUEZ, Michael WALL, Alan F. HAUGHAN, Amanda VAN DE POEL, Grant WISHART, Rebecca E. JARVIS, Andrew J. STOTT, Michel C. MAILLARD
Year of Publication 01.03.2023
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Year of Publication 01.03.2023
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Histone deacetylase inhibitors and compositions and methods of use thereof
Christopher A. LUCKHURST, Elizabeth A. SAVILLE-STONES, Perla BRECCIA, Celia DOMINGUEZ, Michael WALL, Alan F. HAUGHAN, Amanda VAN DE POEL, Grant WISHART, Andrew J. STOTT, Rebecca E. JARVIS, Michel C. MAILLARD
Year of Publication 01.03.2023
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Year of Publication 01.03.2023
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(2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE I INHIBITORS
AURELL, CARL-JOHAN, VAN DE POEL, AMANDA, JANE, SWALLOW, STEVEN, PALMER, NICHOLAS, JOHN, DOYLE, KEVIN, JAMES, PONTEN, JOHN FRITIOF, MACRITCHIE, JAQUELINE, ANNE, LONN, HANS, RONALD, CONNOLLY, STEPHEN, JONES, GRAHAM, PETER, KARLSSON, STAFFAN PO, WATSON, DAVID, WYN
Year of Publication 19.12.2022
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Year of Publication 19.12.2022
Patent