Transgenic animal models in toxicology: historical perspectives and future outlook
Boverhof, Darrell R, Chamberlain, Mark P, Elcombe, Clifford R, Gonzalez, Frank J, Heflich, Robert H, Hernández, Lya G, Jacobs, Abigail C, Jacobson-Kram, David, Luijten, Mirjam, Maggi, Adriana, Manjanatha, Mugimane G, Benthem, Jan van, Gollapudi, B Bhaskar
Published in Toxicological sciences (01.06.2011)
Published in Toxicological sciences (01.06.2011)
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Journal Article
Strategies in genotoxicology: Acceptance of innovative scientific methods in a regulatory context and from an industrial perspective
Steiblen, Guy, Benthem, Jan van, Johnson, George
Published in Mutation research. Genetic toxicology and environmental mutagenesis (01.05.2020)
Published in Mutation research. Genetic toxicology and environmental mutagenesis (01.05.2020)
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Journal Article
Hazardous compounds in tobacco smoke
Talhout, Reinskje, Schulz, Thomas, Florek, Ewa, van Benthem, Jan, Wester, Piet, Opperhuizen, Antoon
Published in International journal of environmental research and public health (01.02.2011)
Published in International journal of environmental research and public health (01.02.2011)
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Journal Article
Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose–response data
Chepelev, Nikolai, Long, Alexandra S., Beal, Marc, Barton‐Maclaren, Tara, Johnson, George, Dearfield, Kerry L., Roberts, Daniel J., Benthem, Jan, White, Paul
Published in Environmental and molecular mutagenesis (01.01.2023)
Published in Environmental and molecular mutagenesis (01.01.2023)
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Journal Article
Interlaboratory validation of the ToxTracker assay: An in vitro reporter assay for mechanistic genotoxicity assessment
Hendriks, Giel, Adriaens, Els, Allemang, Ashley, Clements, Julie, Cole, Gabrielle, Derr, Remco, Engel, Maria, Hamel, Annie, Kidd, Darren, Kellum, Stephanie, Kiyota, Tomomi, Myhre, Abby, Naëssens, Valerie, Pfuhler, Stefan, Roy, Marise, Settivari, Raja, Schuler, Maik, Zeller, Andreas, Benthem, Jan, Vanparys, Philippe, Kirkland, David
Published in Environmental and molecular mutagenesis (01.01.2024)
Published in Environmental and molecular mutagenesis (01.01.2024)
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Journal Article
Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach
Hernández, Lya G., van Steeg, Harry, Luijten, Mirjam, van Benthem, Jan
Published in Mutation research (01.09.2009)
Published in Mutation research (01.09.2009)
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Journal Article
Application of the adverse outcome pathway framework to genotoxic modes of action
Sasaki, Jennifer C., Allemang, Ashley, Bryce, Steven M., Custer, Laura, Dearfield, Kerry L., Dietz, Yasmin, Elhajouji, Azeddine, Escobar, Patricia A., Fornace, Albert J., Froetschl, Roland, Galloway, Sheila, Hemmann, Ulrike, Hendriks, Giel, Li, Heng‐Hong, Luijten, Mirjam, Ouedraogo, Gladys, Peel, Lauren, Pfuhler, Stefan, Roberts, Daniel J., Thybaud, Véronique, Benthem, Jan, Yauk, Carole L., Schuler, Maik
Published in Environmental and molecular mutagenesis (01.01.2020)
Published in Environmental and molecular mutagenesis (01.01.2020)
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Journal Article
In utero Exposure to Genotoxicants Leading to Genetic Mosaicism: An Overlooked Window of Susceptibility in Genetic Toxicology Testing?
Godschalk, Roger W. L., Yauk, Carole L., Benthem, Jan, Douglas, George R., Marchetti, Francesco
Published in Environmental and molecular mutagenesis (01.01.2020)
Published in Environmental and molecular mutagenesis (01.01.2020)
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Journal Article
Impact of sampling time on the detection of mutations in rapidly proliferating tissues using transgenic rodent gene mutation models: A review
Douglas, George R., Beevers, Carol, Gollapudi, Bhaskar, Keig‐Shevlin, Zena, Kirkland, David, O'Brien, Jason M., Benthem, Jan, Yauk, Carole L., Young, Robert R., Marchetti, Francesco
Published in Environmental and molecular mutagenesis (01.12.2022)
Published in Environmental and molecular mutagenesis (01.12.2022)
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Journal Article
Utility of a next generation framework for assessment of genomic damage: A case study using the industrial chemical benzene
Luijten, Mirjam, Ball, Nicholas S., Dearfield, Kerry L., Gollapudi, B. Bhaskar, Johnson, George E., Madia, Federica, Peel, Lauren, Pfuhler, Stefan, Settivari, Raja S., Burg, Wouter, White, Paul A., Benthem, Jan
Published in Environmental and molecular mutagenesis (01.01.2020)
Published in Environmental and molecular mutagenesis (01.01.2020)
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Journal Article
Comparison of clastogen-induced gene expression profiles in wild-type and DNA repair-deficient Rad54/Rad54B cells
Mahabir, Anuska G, Schaap, Mirjam M, Pennings, Jeroen L A, van Benthem, Jan, Hendriksen, Coenraad F M, van Steeg, Harry
Published in BMC genomics (12.01.2010)
Published in BMC genomics (12.01.2010)
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Journal Article
Simulation of mouse and rat spermatogenesis to inform genotoxicity testing using OECD test guideline 488
Marchetti, Francesco, Aardema, Marilyn, Beevers, Carol, van Benthem, Jan, Douglas, George R., Godschalk, Roger, Yauk, Carole L., Young, Robert, Williams, Andrew
Published in Mutation research. Genetic toxicology and environmental mutagenesis (01.08.2018)
Published in Mutation research. Genetic toxicology and environmental mutagenesis (01.08.2018)
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Journal Article
Main issues addressed in the 2014–2015 revisions to the OECD Genetic Toxicology Test Guidelines
Thybaud, Veronique, Lorge, Elisabeth, Levy, Dan D., Benthem, Jan, Douglas, George R., Marchetti, Francesco, Moore, Martha M., Schoeny, Rita, Gibbons, Catherine
Published in Environmental and molecular mutagenesis (01.06.2017)
Published in Environmental and molecular mutagenesis (01.06.2017)
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Journal Article
Clarification of some aspects related to genotoxicity assessment
Hardy, Anthony, Benford, Diane, Halldorsson, Thorhallur, Jeger, Michael, Knutsen, Helle Katrine, More, Simon, Naegeli, Hanspeter, Noteborn, Hubert, Ockleford, Colin, Ricci, Antonia, Rychen, Guido, Silano, Vittorio, Solecki, Roland, Turck, Dominique, Younes, Maged, Aquilina, Gabriele, Crebelli, Riccardo, Gürtler, Rainer, Hirsch‐Ernst, Karen Ildico, Mosesso, Pasquale, Nielsen, Elsa, van Benthem, Jan, Carfì, Maria, Georgiadis, Nikolaos, Maurici, Daniela, Parra Morte, Juan, Schlatter, Josef
Published in EFSA journal (01.12.2017)
Published in EFSA journal (01.12.2017)
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Journal Article
Prediction of carcinogenic potential of chemicals using repeated-dose (13-week) toxicity data
Woutersen, Ruud A., Soffers, Ans E.M.F., Kroese, E. Dinant, Krul, Cyrille A.M., van der Laan, Jan Willem, van Benthem, Jan, Luijten, Mirjam
Published in Regulatory toxicology and pharmacology (01.11.2016)
Published in Regulatory toxicology and pharmacology (01.11.2016)
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Journal Article
Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities—Report from an ECVAM workshop
Pfuhler, Stefan, Kirkland, David, Kasper, Peter, Hayashi, Makoto, Vanparys, Philippe, Carmichael, Paul, Dertinger, Stephen, Eastmond, David, Elhajouji, Azeddine, Krul, Cyrille, Rothfuss, Andreas, Schoening, Gabriele, Smith, Andrew, Speit, Guenter, Thomas, Claire, van Benthem, Jan, Corvi, Raffaella
Published in Mutation research (01.11.2009)
Published in Mutation research (01.11.2009)
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Journal Article
ECVAM retrospective validation of in vitro micronucleus test (MNT)
Corvi, Raffaella, Albertini, Silvio, Hartung, Thomas, Hoffmann, Sebastian, Maurici, Daniela, Pfuhler, Stefan, van Benthem, Jan, Vanparys, Philippe
Published in Mutagenesis (01.07.2008)
Published in Mutagenesis (01.07.2008)
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Journal Article
Differential Contributions of Mammalian Rad54 Paralogs to Recombination, DNA Damage Repair, and Meiosis
Wesoly, Joanna, Agarwal, Sheba, Sigurdsson, Stefan, Bussen, Wendy, Van Komen, Stephen, Qin, Jian, van Steeg, Harry, van Benthem, Jan, Wassenaar, Evelyne, Baarends, Willy M., Ghazvini, Mehrnaz, Tafel, Agnieszka A., Heath, Helen, Galjart, Niels, Essers, Jeroen, Grootegoed, J. Anton, Arnheim, Norman, Bezzubova, Olga, Buerstedde, Jean-Marie, Sung, Patrick, Kanaar, Roland
Published in Molecular and Cellular Biology (01.02.2006)
Published in Molecular and Cellular Biology (01.02.2006)
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Journal Article
Approaches for identifying germ cell mutagens: Report of the 2013 IWGT workshop on germ cell assays
Yauk, Carole L., Aardema, Marilyn J., Benthem, Jan van, Bishop, Jack B., Dearfield, Kerry L., DeMarini, David M., Dubrova, Yuri E., Honma, Masamitsu, Lupski, James R., Marchetti, Francesco, Meistrich, Marvin L., Pacchierotti, Francesca, Stewart, Jane, Waters, Michael D., Douglas, George R.
Published in Mutation research. Genetic toxicology and environmental mutagenesis (01.05.2015)
Published in Mutation research. Genetic toxicology and environmental mutagenesis (01.05.2015)
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Journal Article