In Silico Modeling of Oncogenic Drivers in Waldenstrom Macroglobulinemia to Assess Additional Therapeutic Targets within the BCR Signaling Pathway Identifies MEK1/2 As a Target: Potential Therapeutic Role of Binimetinib
Paulus, Aneel, Akhtar, Sharoon, Vali, Shireen, Kumar, Ansu, Singh, Neeraj Kumar, Usmani, Shahabuddin, Grover, Himanshu, Abbasi, Taher, Chanan-Khan, Asher Alban
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Abstract 5339: Deterministic in silico modeling predicts sensitivity of glioblastoma to targeted therapy
Pingle, Sandeep C., Pastorino, Sandra, Muktharavam, Rajesh, Jiang, Pengfei, Chao, Ying, Abbasi, Taher, Vali, Shireen, Kesari, Santosh
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Icare 1: A Prospective Clinical Trial to Predict Treatment Response Based on Mutanome-Informed Computational Biology in Patients with AML and MDS
Drusbosky, Leylah, Wise, Elizabeth, Vali, Shireen, Abbasi, Taher, Kumar, Ansu, Kumar Singh, Neeraj, Basu, Kabya, Kumar, Chandan, Husain, Amjad, Zou, Fei, Tucker, Caitlin, Brown, Randy A, Norkin, Maxim, Hiemenz, John, Wingard, John R., Hsu, Jack W, Cogle, Christopher R.
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Computational Analysis of Genomic Abnormalities from a Phase 3 Trial of Rigosertib in Higher-Risk MDS: Simulation of a Predictive Signature for Clinical Response
Garcia-Manero, Guillermo, Petrone, Michael E., Fruchtman, Steven M., Brownstein, Bernard, Loferer, Hannes, Azarnia, Nozar, Vali, Shireen, Singh, Neeraj Kumar, Usmani, Shahabuddin, Grover, Himanshu, Abbasi, Taher, Silverman, Lewis R.
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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A Genomic Signature Predicting Venetoclax Treatment Response in AML Identified By Protein Network Mapping and Validated By Ex Vivo Drug Sensitivity Testing: A Beat AML Project Study
Drusbosky, Leylah, Abbasi, Taher, Vali, Shireen, Radhakrishnan, Saumya, Kumar Singh, Neeraj, Usmani, Shahabuddin, Parashar, Deepak, Vidva, Robinson, Druker, Brian J., Tognon, Cristina E., Lo, Pierrette, Tyner, Jeffrey W., Cogle, Christopher R.
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson’s disease
Harish, G., Venkateshappa, C., Mythri, Rajeswara Babu, Dubey, Shiv Kumar, Mishra, Krishna, Singh, Neetu, Vali, Shireen, Bharath, M.M. Srinivas
Published in Bioorganic & medicinal chemistry (01.04.2010)
Published in Bioorganic & medicinal chemistry (01.04.2010)
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Digital Drug Screening and Computational Modeling Identifies Treatment Opportunities Despite Lack of Directly Actionable Mutations in Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS)
Drusbosky, Leylah M., Hawkins, Kimberly E., Turcotte, Madeleine, Murthy, Hemant S., Leather, Helen L., Farhadfar, Nosha, Norkin, Maxim, Wingard, John R., Hiemenz, John W., Castillo, Paul, Brown, Randy A., Slayton, William, Horn, Biljana N., Vasista, Sumanth, Basu, Kabya, Usmani, Shahabuddin, Roy, Kunal Ghosh, Lala, Deepak Anil, Radhakrishnan, Saumya, Kumar, Rajeev, Rajagopalan, Swaminathan, Abbasi, Taher, Vali, Shireen, Cogle, Christopher R.
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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A Genomic Signature Predicting Venetoclax Treatment Response in Acute Myeloid Leukemia (AML) Identified By Protein Network Mapping and Validated By Ex Vivo Ddrug Sensitivity Testing
Drusbosky, Leylah M., Hawkins, Kimberly E., Leather, Helen L., Murthy, Hemant S., Farhadfar, Nosha, Wingard, John R., Norkin, Maxim, Brown, Randy A., Hiemenz, John W., Castillo, Paul, Horn, Biljana N., Kumar, Ansu, Singh, Neeraj Kumar, Kumar, Chandan, Vasista, Sumanth, Abbasi, Taher, Vali, Shireen, Tognon, Cristina E., Kurtz, Stephen E, Druker, Brian J., Tyner, Jeffrey W., Pollyea, Daniel A., Cogle, Christopher R.
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Clinical translation pathway to Precision Medicine in GBM through simulation and repurposing
Pingle, Sandeep C., Jiang, Pengfei, Mukthavaram, Rajesh, Nomura, Natsuko, Nair, Prashant, Kumar, Ansu, Singh, Neeraj, Abbasi, Taher, Vali, Shireen, Kesari, Santosh
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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Computational Drug Treatment Simulations on Projections of Dysregulated Protein Networks Derived from the Myelodysplastic Mutanome Match Clinical Response in Patients
Drusbosky, Leylah, Medina, Cindy, Martuscello, Regina, Hawkins, Kimberly E, Chang, Myron, Lamba, Jatinder K, Vali, Shireen, Kumar, Ansu, Singh, Neeraj Kumar, Abbasi, Taher, Sekeres, Mikkael A, Mallo, Mar, Sole, Francesc, Bejar, Rafael, Cogle, Christopher R
Published in Leukemia research (01.01.2017)
Published in Leukemia research (01.01.2017)
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Abstract 5577: STAT3 phosphorylation and Bcl-2 expression as a predictive signature for stratifying clinical lymphomas
Kang, Jia, Ooi, Vignette Z. Q., Vali, Shireen, Kapoor, Shweta, Kumar, Ansu, Abbasi, Taher, Pervaiz, Shazib
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses
Borgwardt, Derek S., Martin, Aaron D., Van Hemert, Jonathan R., Yang, Jianyi, Fischer, Carol L., Recker, Erica N., Nair, Prashant R., Vidva, Robinson, Chandrashekaraiah, Shwetha, Progulske-Fox, Ann, Drake, David, Cavanaugh, Joseph E., Vali, Shireen, Zhang, Yang, Brogden, Kim A.
Published in Scientific reports (29.01.2014)
Published in Scientific reports (29.01.2014)
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Correction: novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugs
Jiang, Pengfei, Mukthavaram, Rajesh, Chao, Ying, Bharati, Ila Sri, Fogal, Valentina, Pastorino, Sandra, Cong, Xiuli, Nomura, Natsuko, Gallagher, Matt, Abbasi, Taher, Vali, Shireen, Pingle, Sandeep C, Makale, Milan, Kesari, Santosh
Published in Journal of translational medicine (13.05.2014)
Published in Journal of translational medicine (13.05.2014)
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Icare 1: A Prospective Clinical Trial to Predict Treatment Response Based on Mutanome-Informed Computational Biology in Patients with Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS)
Drusbosky, Leylah M., Hawkins, Kimberly E., Salan, Cesia, Turcotte, Madeleine, Anderson, Glenda G., Singh, Neeraj Kumar, Radhakrishnan, Saumya, Ullal, Yashaswini, Talawdekar, Anay, Sikora, Huzaifa, Nair, Prashant, Bhowmick, Priyanka, Abbasi, Taher, Vali, Shireen, Zou, Fei, Farhadfar, Nosha, Murthy, Hemant S., Horn, Biljana N., Leather, Helen L., Castillo, Paul, Sawicki, Barry, Brown, Randy A., Norkin, Maxim, Hiemenz, John W., Hsu, Jack W., Slayton, William, Wingard, John R., Cogle, Christopher R.
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Therapy Personalization Using Predictive Simulation Approach with Ex-Vivo Clinical Validations
Doudican, Nicole A, Vij, Ravi, Fiala, Mark A, King, Justin, Vali, Shireen, Basu, Kabya, Kumar, Ansu, Singh, Neeraj Kumar, Sultana, Zeba, Abbasi, Taher, Mazumder, Amitabha
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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Journal Article
A Novel and Personalized Method Using Simulation for Predicting Effective Therapeutics for Waldenströms Macroglobulinemia
Azab, Abdel Kareem, Paulus, Aneel, Azab, Feda, Akhtar, Sharoon, Vali, Shireen, Kumar, Ansu, Singh, Neeraj Kumar, Kapoor, Shweta, Abbasi, Taher, Chanan-Khan, Asher, Chitta, Kasyapa S.
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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A Novel Method of Using Molecular Profiling in Myelodysplastic Syndromes to Predict Patient-Specific Potential Therapeutics
Cogle, Christopher R., Trikha, Gaurav, Sayeski, Peter P., Vali, Shireen, Kumar, Ansu, Singh, Neeraj Kumar, Nair, Prashant R, Lala, Deepak Anil, Basu, Kabya, Abbasi, Taher, Albitar, Maher
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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A Novel Simulation Method for Mapping Dysregulated Pathways and Predicting Effective Therapeutics in the Myelodysplastic Syndromes
Cogle, Christopher R., Tohyama, Kaoru, Vali, Shireen, Kumar, Ansu, Singh, Neeraj Kumar, Tiwari, Krishna Kumar, Tyagi, Anuj, Abbasi, Taher, Sayeski, Peter P.
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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Dual epidermal growth factor receptor (EGFR)/insulin-like growth factor-1 receptor (IGF-1R) inhibitor: A novel approach for overcoming resistance in anticancer treatment
Tandon, Ruchi, Kapoor, Shweta, Vali, Shireen, Senthil, V., Nithya, D., Venkataramanan, R., Sharma, Ashish, Talwadkar, Anay, Ray, Abhijit, Bhatnagar, Pradip K., Dastidar, Sunanda G.
Published in European journal of pharmacology (30.09.2011)
Published in European journal of pharmacology (30.09.2011)
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