New Modalities for Challenging Targets in Drug Discovery
Valeur, Eric, Guéret, Stéphanie M., Adihou, Hélène, Gopalakrishnan, Ranganath, Lemurell, Malin, Waldmann, Herbert, Grossmann, Tom N., Plowright, Alleyn T.
Published in Angewandte Chemie International Edition (21.08.2017)
Published in Angewandte Chemie International Edition (21.08.2017)
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Journal Article
Directing evolution: the next revolution in drug discovery?
Davis, Andrew M., Plowright, Alleyn T., Valeur, Eric
Published in Nature reviews. Drug discovery (01.10.2017)
Published in Nature reviews. Drug discovery (01.10.2017)
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Journal Article
Late‐Stage Functionalization of Histidine in Unprotected Peptides
Noisier, Anaïs F. M., Johansson, Magnus J., Knerr, Laurent, Hayes, Martin A., Drury, William J., Valeur, Eric, Malins, Lara R., Gopalakrishnan, Ranganath
Published in Angewandte Chemie International Edition (19.12.2019)
Published in Angewandte Chemie International Edition (19.12.2019)
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Journal Article
Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell
Knerr, Laurent, Prakash, Thazha P, Lee, Richard, Drury III, William J, Nikan, Mehran, Fu, Wuxia, Pirie, Elaine, Maria, Leonardo De, Valeur, Eric, Hayen, Ahlke, Ölwegård-Halvarsson, Maria, Broddefalk, Johan, Ämmälä, Carina, Østergaard, Michael E, Meuller, Johan, Sundström, Linda, Andersson, Patrik, Janzén, David, Jansson-Löfmark, Rasmus, Seth, Punit P, Andersson, Shalini
Published in Journal of the American Chemical Society (10.03.2021)
Published in Journal of the American Chemical Society (10.03.2021)
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Journal Article
A protein tertiary structure mimetic modulator of the Hippo signalling pathway
Adihou, Hélène, Gopalakrishnan, Ranganath, Förster, Tim, Guéret, Stéphanie M., Gasper, Raphael, Geschwindner, Stefan, Carrillo García, Carmen, Karatas, Hacer, Pobbati, Ajaybabu V., Vazquez‐Chantada, Mercedes, Davey, Paul, Wassvik, Carola M., Pang, Jeremy Kah Sheng, Soh, Boon Seng, Hong, Wanjin, Chiarparin, Elisabetta, Schade, Dennis, Plowright, Alleyn T., Valeur, Eric, Lemurell, Malin, Grossmann, Tom N., Waldmann, Herbert
Published in Nature communications (27.10.2020)
Published in Nature communications (27.10.2020)
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Journal Article
Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency
Hardcastle, Ian R, Liu, Junfeng, Valeur, Eric, Watson, Anna, Ahmed, Shafiq U, Blackburn, Timothy J, Bennaceur, Karim, Clegg, William, Drummond, Catherine, Endicott, Jane A, Golding, Bernard T, Griffin, Roger J, Gruber, Jan, Haggerty, Karen, Harrington, Ross W, Hutton, Claire, Kemp, Stuart, Lu, Xiaohong, McDonnell, James M, Newell, David R, Noble, Martin E. M, Payne, Sara L, Revill, Charlotte H, Riedinger, Christiane, Xu, Qing, Lunec, John
Published in Journal of medicinal chemistry (10.03.2011)
Published in Journal of medicinal chemistry (10.03.2011)
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Journal Article
Neue Modalitäten für schwierige Zielstrukturen in der Wirkstoffentwicklung
Valeur, Eric, Guéret, Stéphanie M., Adihou, Hélène, Gopalakrishnan, Ranganath, Lemurell, Malin, Waldmann, Herbert, Grossmann, Tom N., Plowright, Alleyn T.
Published in Angewandte Chemie (21.08.2017)
Published in Angewandte Chemie (21.08.2017)
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Journal Article
Small-molecule factor B inhibitor for the treatment of complement-mediated diseases
Schubart, Anna, Anderson, Karen, Mainolfi, Nello, Sellner, Holger, Ehara, Takeru, Adams, Christopher M., Sweeney, Aengus Mac, Liao, Sha-Mei, Crowley, Maura, Littlewood-Evans, Amanda, Sarret, Sophie, Wieczorek, Grazyna, Perrot, Ludovic, Dubost, Valérie, Flandre, Thierry, Zhang, Yuzhou, Smith, Richard J. H., Risitano, Antonio M., Karki, Rajeshri G., Zhang, Chun, Valeur, Eric, Sirockin, Finton, Gerhartz, Bernd, Erbel, Paulus, Hughes, Nicola, Smith, Thomas M., Cumin, Frederic, Argikar, Upendra A., Haraldsson, Börje, Mogi, Muneto, Sedrani, Richard, Wiesmann, Christian, Jaffee, Bruce, Maibaum, Jürgen, Flohr, Stefanie, Harrison, Richard, Eder, Jörg
Published in Proceedings of the National Academy of Sciences - PNAS (16.04.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (16.04.2019)
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Journal Article
Emerging modes-of-action in drug discovery
Valeur, Eric, Narjes, Frank, Ottmann, Christian, Plowright, Alleyn T
Published in MedChemComm (01.09.2019)
Published in MedChemComm (01.09.2019)
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Journal Article
Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments
Guéret, Stéphanie M, Thavam, Sasikala, Carbajo, Rodrigo J, Potowski, Marco, Larsson, Niklas, Dahl, Göran, Dellsén, Anita, Grossmann, Tom N, Plowright, Alleyn T, Valeur, Eric, Lemurell, Malin, Waldmann, Herbert
Published in Journal of the American Chemical Society (11.03.2020)
Published in Journal of the American Chemical Society (11.03.2020)
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Journal Article
Targeted delivery for regenerative medicines: an untapped opportunity for drug conjugates
Valeur, Eric, Knerr, Laurent, Ölwegård-Halvarsson, Maria, Lemurell, Malin
Published in Drug discovery today (01.06.2017)
Published in Drug discovery today (01.06.2017)
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Journal Article
Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases
Mainolfi, Nello, Ehara, Takeru, Karki, Rajeshri G., Anderson, Karen, Mac Sweeney, Aengus, Liao, Sha-Mei, Argikar, Upendra A., Jendza, Keith, Zhang, Chun, Powers, James, Klosowski, Daniel W., Crowley, Maura, Kawanami, Toshio, Ding, Jian, April, Myriam, Forster, Cornelia, Serrano-Wu, Michael, Capparelli, Michael, Ramqaj, Rrezarta, Solovay, Catherine, Cumin, Frederic, Smith, Thomas M., Ferrara, Luciana, Lee, Wendy, Long, Debby, Prentiss, Melissa, De Erkenez, Andrea, Yang, Louis, Liu, Fang, Sellner, Holger, Sirockin, Finton, Valeur, Eric, Erbel, Paulus, Ostermeier, Daniela, Ramage, Paul, Gerhartz, Bernd, Schubart, Anna, Flohr, Stefanie, Gradoux, Nathalie, Feifel, Roland, Vogg, Barbara, Wiesmann, Christian, Maibaum, Juergen, Eder, Joerg, Sedrani, Richard, Harrison, Richard A., Mogi, Muneto, Jaffee, Bruce D., Adams, Christopher M.
Published in Journal of medicinal chemistry (11.06.2020)
Published in Journal of medicinal chemistry (11.06.2020)
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Journal Article
Inhibition of low-density lipoprotein receptor degradation with a cyclic peptide that disrupts the homodimerization of IDOL E3 ubiquitin ligase
Leitch, Eilidh K., Elumalai, Nagarajan, Friden-Saxin, Maria, Dahl, Goran, Wan, Paul, Clarkson, Paul, Valeur, Eric, Pairaudeau, Garry, Boyd, Helen, Tavassoli, Ali
Published in Chemical science (Cambridge) (21.07.2018)
Published in Chemical science (Cambridge) (21.07.2018)
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Journal Article
이작용성 분자 및 이의 사용 방법
GUTTMAN MITCHELL, STEBBINS NATHAN WILSON, VALEUR ERIC BRUNO, YUAN CHIH CHI, PORTNEY BENJAMIN ANDREW
Year of Publication 10.01.2023
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Year of Publication 10.01.2023
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