Substrate-Triggered Formation and Remarkable Stability of the C−H Bond-Cleaving Chloroferryl Intermediate in the Aliphatic Halogenase, SyrB2
Matthews, Megan L, Krest, Courtney M, Barr, Eric W, Vaillancourt, Frédéric H, Walsh, Christopher T, Green, Michael T, Krebs, Carsten, Bollinger, J. Martin
Published in Biochemistry (Easton) (26.05.2009)
Published in Biochemistry (Easton) (26.05.2009)
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Journal Article
Reprogramming RNA processing: an emerging therapeutic landscape
Neil, Christopher R., Seiler, Michael W., Reynolds, Dominic J., Smith, Jesse J., Vaillancourt, Frédéric H., Smith, Peter G., Agrawal, Anant A.
Published in Trends in pharmacological sciences (Regular ed.) (01.05.2022)
Published in Trends in pharmacological sciences (Regular ed.) (01.05.2022)
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Journal Article
The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity
Nguyen, Tuong-Vi, Yao, Shihua, Wang, Yahong, Rolfe, Alan, Selvaraj, Anand, Darman, Rachel, Ke, Jiyuan, Warmuth, Markus, Smith, Peter G., Larsen, Nicholas A., Yu, Lihua, Zhu, Ping, Fekkes, Peter, Vaillancourt, Frédéric H., Bolduc, David M.
Published in The Journal of biological chemistry (08.11.2019)
Published in The Journal of biological chemistry (08.11.2019)
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Journal Article
Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket
Yao, Shihua, Nguyen, Tuong-Vi, Rolfe, Alan, Agrawal, Anant A., Ke, Jiyuan, Peng, Shouyong, Colombo, Federico, Yu, Sean, Bouchard, Patricia, Wu, Jiayi, Huang, Kuan-Chun, Bao, Xingfeng, Omoto, Kiyoyuki, Selvaraj, Anand, Yu, Lihua, Ioannidis, Stephanos, Vaillancourt, Frédéric H., Zhu, Ping, Larsen, Nicholas A., Bolduc, David M.
Published in Cell chemical biology (19.03.2020)
Published in Cell chemical biology (19.03.2020)
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Journal Article
Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication
Vaillancourt, Frédéric H, Pilote, Louise, Cartier, Mireille, Lippens, Julie, Liuzzi, Michel, Bethell, Richard C, Cordingley, Michael G, Kukolj, George
Published in Virology (New York, N.Y.) (25.04.2009)
Published in Virology (New York, N.Y.) (25.04.2009)
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Journal Article
Evaluation of Phosphatidylinositol-4-Kinase IIIα as a Hepatitis C Virus Drug Target
VAILLANCOURT, Frederic H, BRAULT, Martine, CHIU, Tim T, MAHROUCHE, Louiza, FAUCHER, Anne-Marie, CARTIER, Mireille, CORDINGLEY, Michael G, BETHELL, Richard C, HUIPING JIANG, WHITE, Peter W, KUKOLJ, George, PILOTE, Louise, UYTTERSPROT, Nathalie, GAILLARD, Elias T, STOTTZ, James H, KNIGHT, Brian L, PANTAGES, Lynn, MCFARIAND, Mary, BREITFELDER, Steffen
Published in Journal of Virology (01.11.2012)
Published in Journal of Virology (01.11.2012)
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Journal Article
Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1
Rolfe, Alan, Yao, Shihua, Toung-Vi Nguyen, Omoto, Kiyoyuki, Colombo, Federico, Virrankoski, Milena, Vaillancourt, Frederic H., Yu, Lihua, Cook, Andrew, Reynolds, Dominic, Ioannidis, Stephanos, Zhu, Ping, Larsen, Nicholas A., Bolduc, David M.
Published in ACS medicinal chemistry letters (11.06.2020)
Published in ACS medicinal chemistry letters (11.06.2020)
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Journal Article
Nature's Inventory of Halogenation Catalysts: Oxidative Strategies Predominate
Vaillancourt, Frédéric H, Yeh, Ellen, Vosburg, David A, Garneau-Tsodikova, Sylvie, Walsh, Christopher T
Published in Chemical reviews (01.08.2006)
Published in Chemical reviews (01.08.2006)
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Journal Article
The Ins and Outs of Ring-Cleaving Dioxygenases
Vaillancourt, Frédéric H., Bolin, Jeffrey T., Eltis, Lindsay D.
Published in Critical reviews in biochemistry and molecular biology (01.07.2006)
Published in Critical reviews in biochemistry and molecular biology (01.07.2006)
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Journal Article
Phosphatidylinositol 4-Kinase III Beta Is Essential for Replication of Human Rhinovirus and Its Inhibition Causes a Lethal Phenotype In Vivo
SPICKLER, Catherine, LIPPENS, Julie, VAILLANCOURT, Fréderic H, DECOR, Anne, O'MEARA, Jeff, FRANTI, Michael, GAUTHIER, Annick, LABERGE, Marie-Kristine, DESMEULES, Sophie, BELLAVANCE, Edith, GARNEAU, Michel, GUO, Tim, HUCKE, Oliver, LEYSSEN, Pieter, NEYTS, Johan
Published in Antimicrobial Agents and Chemotherapy (01.07.2013)
Published in Antimicrobial Agents and Chemotherapy (01.07.2013)
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Journal Article
Covalent ERα Antagonist H3B-6545 Demonstrates Encouraging Preclinical Activity in Therapy-Resistant Breast Cancer
Furman, Craig, Puyang, Xiaoling, Zhang, Zhaojie, Wu, Zhenhua J, Banka, Deepti, Aithal, Kiran B, Albacker, Lee A, Hao, Ming-Hong, Irwin, Sean, Kim, Amy, Montesion, Meagan, Moriarty, Alyssa D, Murugesan, Karthikeyan, Nguyen, Tuong-Vi, Rimkunas, Victoria, Sahmoud, Tarek, Wick, Michael J, Yao, Shihua, Zhang, Xun, Zeng, Hao, Vaillancourt, Frédéric H, Bolduc, David M, Larsen, Nicholas, Zheng, Guo Zhu, Prajapati, Sudeep, Zhu, Ping, Korpal, Manav
Published in Molecular cancer therapeutics (01.06.2022)
Published in Molecular cancer therapeutics (01.06.2022)
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Journal Article
Development and validation of a high-throughput screening assay for the hepatitis C virus p7 viroporin
Gervais, Christian, Dô, Florence, Cantin, Ariane, Kukolj, George, White, Peter W, Gauthier, Annick, Vaillancourt, Frédéric H
Published in Journal of biomolecular screening (01.03.2011)
Published in Journal of biomolecular screening (01.03.2011)
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Journal Article
Abstract 2467: Heme-CMap: Generation and characterization of ~20K L1000 profiles across 11 hematologic malignant lines
Huang, Chia-Ling, Yang, Andrew, Natoli, Ted, Litichevskiy, Lev, Vaillancourt, Frederic, Rolfe, Alan, Xiao, Yonghong, Subramanian, Aravind, Yu, Lihua
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERα WT and ERα MUT Breast Cancer
Puyang, Xiaoling, Furman, Craig, Zheng, Guo Zhu, Wu, Zhenhua J, Banka, Deepti, Aithal, Kiran, Agoulnik, Sergei, Bolduc, David M, Buonamici, Silvia, Caleb, Benjamin, Das, Subhasree, Eckley, Sean, Fekkes, Peter, Hao, Ming-Hong, Hart, Andrew, Houtman, René, Irwin, Sean, Joshi, Jaya J, Karr, Craig, Kim, Amy, Kumar, Namita, Kumar, Pavan, Kuznetsov, Galina, Lai, Weidong G, Larsen, Nicholas, Mackenzie, Crystal, Martin, Lesley-Ann, Melchers, Diana, Moriarty, Alyssa, Nguyen, Tuong-Vi, Norris, John, O'Shea, Morgan, Pancholi, Sunil, Prajapati, Sudeep, Rajagopalan, Sujatha, Reynolds, Dominic J, Rimkunas, Victoria, Rioux, Nathalie, Ribas, Ricardo, Siu, Amy, Sivakumar, Sasirekha, Subramanian, Vanitha, Thomas, Michael, Vaillancourt, Frédéric H, Wang, John, Wardell, Suzanne, Wick, Michael J, Yao, Shihua, Yu, Lihua, Warmuth, Markus, Smith, Peter G, Zhu, Ping, Korpal, Manav
Published in Cancer discovery (01.09.2018)
Published in Cancer discovery (01.09.2018)
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Journal Article
Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete
Ueki, Masashi, Galonić, Danica P, Vaillancourt, Frédéric H, Garneau-Tsodikova, Sylvie, Yeh, Ellen, Vosburg, David A, Schroeder, Frank C, Osada, Hiroyuki, Walsh, Christopher T
Published in Chemistry & biology (01.11.2006)
Published in Chemistry & biology (01.11.2006)
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