Indole Naphthyridinones as Inhibitors of Bacterial Enoyl-ACP Reductases FabI and FabK
Seefeld, Mark A, Miller, William H, Newlander, Kenneth A, Burgess, Walter J, DeWolf, Walter E, Elkins, Patricia A, Head, Martha S, Jakas, Dalia R, Janson, Cheryl A, Keller, Paul M, Manley, Peter J, Moore, Terrance D, Payne, David J, Pearson, Stewart, Polizzi, Brian J, Qiu, Xiayang, Rittenhouse, Stephen F, Uzinskas, Irene N, Wallis, Nicola G, Huffman, William F
Published in Journal of medicinal chemistry (24.04.2003)
Published in Journal of medicinal chemistry (24.04.2003)
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Discovery of Aminopyridine-Based Inhibitors of Bacterial Enoyl-ACP Reductase (FabI)
Miller, William H, Seefeld, Mark A, Newlander, Kenneth A, Uzinskas, Irene N, Burgess, Walter J, Heerding, Dirk A, Yuan, Catherine C. K, Head, Martha S, Payne, David J, Rittenhouse, Stephen F, Moore, Terrance D, Pearson, Stewart C, Berry, Valerie, DeWolf, Walter E, Keller, Paul M, Polizzi, Brian J, Qiu, Xiayang, Janson, Cheryl A, Huffman, William F
Published in Journal of medicinal chemistry (18.07.2002)
Published in Journal of medicinal chemistry (18.07.2002)
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Use of X-ray Co-crystal Structures and Molecular Modeling To Design Potent and Selective Non-peptide Inhibitors of Cathepsin K
DesJarlais, Renee L, Yamashita, Dennis S, Oh, Hye-Ja, Uzinskas, Irene N, Erhard, Karl F, Allen, Andrew C, Haltiwanger, R. Curtis, Zhao, Baoguang, Smith, Ward W, Abdel-Meguid, Sherin S, D'Alessio, Karla, Janson, Cheryl A, McQueney, Michael S, Tomaszek, Thaddeus A, Levy, Mark A, Veber, Daniel F
Published in Journal of the American Chemical Society (09.09.1998)
Published in Journal of the American Chemical Society (09.09.1998)
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Synthesis and structure-activity relationship studies of a series of 5-aryl-4,6-dithianonanedioic acids and related compounds: a novel class of leukotriene antagonists
Perchonock, Carl D, Uzinskas, Irene, McCarthy, Mary E, Erhard, Karl F, Gleason, John G, Wasserman, Martin A, Muccitelli, Roseanna M, DeVan, Jeris F, Tucker, Stephanie S
Published in Journal of medicinal chemistry (01.08.1986)
Published in Journal of medicinal chemistry (01.08.1986)
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Discovery of Orally Active Nonpeptide Vitronectin Receptor Antagonists Based on a 2-Benzazepine Gly-Asp Mimetic
Miller, William H, Alberts, Doreen P, Bhatnagar, Pradip K, Bondinell, William E, Callahan, James F, Calvo, Raul R, Cousins, Russell D, Erhard, Karl F, Heerding, Dirk A, Keenan, Richard M, Kwon, Chet, Manley, Peter J, Newlander, Kenneth A, Ross, Stephen T, Samanen, James M, Uzinskas, Irene N, Venslavsky, Joseph W, Yuan, Catherine C.-K, Haltiwanger, R. Curtis, Gowen, Maxine, Hwang, Shing-Mei, James, Ian E, Lark, Michael W, Rieman, David J, Stroup, George B, Azzarano, Leonard M, Salyers, Kevin L, Smith, Brian R, Ward, Keith W, Johanson, Kyung O, Huffman, William F
Published in Journal of medicinal chemistry (13.01.2000)
Published in Journal of medicinal chemistry (13.01.2000)
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Conformational Preferences in a Benzodiazepine Series of Potent Nonpeptide Fibrinogen Receptor Antagonists
Keenan, Richard M, Callahan, James F, Samanen, James M, Bondinell, William E, Calvo, Raul R, Chen, Lichong, DeBrosse, Charles, Eggleston, Drake S, Haltiwanger, R. Curtis, Hwang, Shing Mei, Jakas, Dalia R, Ku, Thomas W, Miller, William H, Newlander, Kenneth A, Nichols, Andrew, Parker, Michael F, Southhall, Linda S, Uzinskas, Irene, Vasko-Moser, Janice A, Venslavsky, Joseph W, Wong, Angela S, Huffman, William F
Published in Journal of medicinal chemistry (25.02.1999)
Published in Journal of medicinal chemistry (25.02.1999)
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Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin αvβ3) antagonists
Miller, William H, Manley, Peter J, Cousins, Russell D, Erhard, Karl F, Heerding, Dirk A, Kwon, Chet, Ross, Stephen T, Samanen, James M, Takata, Dennis T, Uzinskas, Irene N, Yuan, Catherine C.K, Haltiwanger, R.Curtis, Gress, Catherine J, Lark, Michael W, Hwang, Shing-Mei, James, Ian E, Rieman, David J, Willette, Robert N, Yue, Tian-Li, Azzarano, Leonard M, Salyers, Kevin L, Smith, Brian R, Ward, Keith W, Johanson, Kyung O, Huffman, William F
Published in Bioorganic & medicinal chemistry letters (17.04.2003)
Published in Bioorganic & medicinal chemistry letters (17.04.2003)
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Direct design of a potent non-peptide fibrinogen receptor antagonist based on the structure and conformation of a highly constrained cyclic RGD peptide
Ku, Thomas W, Ali, Fadia E, Barton, Linda S, Bean, John W, Bondinell, William E, Burgess, Joelle L, Callahan, James F, Calvo, Raul R, Chen, Lichong
Published in Journal of the American Chemical Society (01.09.1993)
Published in Journal of the American Chemical Society (01.09.1993)
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Discovery of a Novel and Potent Class of FabI-Directed Antibacterial Agents
PAYNE, David J, MILLER, William H, HEERDING, Dirk A, JANSON, Cheryl A, JAWORSKI, Deborah D, KELLER, Paul M, MANLEY, Peter J, MOORE, Terrance D, NEWLANDER, Kenneth A, PEARSON, Stewart, POLIZZI, Brian J, XIAYANG QIU, BERRY, Valerie, RITTENHOUSE, Stephen F, SLATER-RADOSTI, Courtney, SALYERS, Kevin L, SEEFELD, Mark A, SMYTH, Martin G, TAKATA, Dennis T, UZINSKAS, Irene N, VAIDYA, Kalindi, WALLIS, Nicola G, WINRAM, Scott B, BROSKY, John, YUAN, Catherine C. K, HUFFMAN, William F, BURGESS, Walter J, CHEN, Emile, DEWOLF, Walter E, FOSBERRY, Andrew P, GREENWOOD, Rebecca, HEAD, Martha S
Published in Antimicrobial Agents and Chemotherapy (01.10.2002)
Published in Antimicrobial Agents and Chemotherapy (01.10.2002)
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Journal Article
Orally bioavailable nonpeptide vitronectin receptor antagonists containing 2-aminopyridine arginine mimetics
Keenan, Richard M., Miller, William H., Barton, Linda S., Bondinell, William E., Cousins, Russell D., Eppley, Daniel F., Hwang, Shing-Mei, Kwon, Chet, Lago, M.Amparo, Nguyen, Thomas T., Smith, Brian R., Uzinskas, Irene N., Yuan, Catherine C.K.
Published in Bioorganic & medicinal chemistry letters (05.07.1999)
Published in Bioorganic & medicinal chemistry letters (05.07.1999)
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Journal Article
Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonists
Keenan, Richard M., Miller, William H., Lago, M.Amparo, Ali, Fadia E., Bondinell, William E., Callahan, James F., Calvo, Raul R., Cousins, Russell D., Hwang, Shing-Mei, Jakas, Dalia R., Ku, Thomas W., Kwon, Chet, Nguyen, Thomas T., Reader, Valerie A., Rieman, David J., Ross, Steven T., Takata, Dennis T., Uzinskas, Irene N., Yuan, Catherine C.K., Smith, Brian R.
Published in Bioorganic & medicinal chemistry letters (17.11.1998)
Published in Bioorganic & medicinal chemistry letters (17.11.1998)
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Fab i inhibitors
DEWOLF WALTER E.JR, JAKAS DALIA R, NEWLANDER KENNETH A, MILLER WILLIAM H, SEEFELD MARK A, UZINSKAS IRENE N
Year of Publication 28.05.2015
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Year of Publication 28.05.2015
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The use of rabbit intestinal permeability as an in vitro assay in the search for orally active GPIIb/IIIa antagonists
Samanen, James M., Lee, Chao-Pin, Smith, Philip L., Bondinell, William E., Calvo, Raul R., Jakas, Dalia R., Newlander, Kenneth A., Parker, Michael, Uzinskas, Irene, Yellin, Tobias O., Nichols, Andrew J.
Published in Advanced drug delivery reviews (15.01.1997)
Published in Advanced drug delivery reviews (15.01.1997)
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Structure-activity relationships in 3-oxo-1,4-benzodiazepine-2-acetic acid GPIIb/IIIa antagonists. The 2-benzazepine series
Miller, William H., Ali, Fadia E., Bondinell, William E., Callahan, James F., Calvo, Raul R., Eggleston, Drake S., Curtis Haltiwanger, R., Huffman, William F., Hwang, Shing-Mei, Jakas, Dalia R., Keenan, Richard M., Koster, Paul F., Ku, Thomas W., Kwon, Chet, Newlander, Kenneth A., Nichols, Andrew J., Parker, Michael F., Samanen, James M., Southall, Linda S., Takata, Dennis T., Uzinskas, Irene N., Valocik, Richard E., Vasko-Moser, Janice A., Wong, Angela S., Yellin, Tobias O., Yuan, Catherine C.K.
Published in Bioorganic & medicinal chemistry letters (05.11.1996)
Published in Bioorganic & medicinal chemistry letters (05.11.1996)
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Journal Article
FAB I inhibitors
Miller, William H, Newlander, Kenneth A, Seefeld, Mark A, Uzinskas, Irene N, Dewolf, Jr, Walter E, Jakas, Dalia R
Year of Publication 08.05.2012
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Year of Publication 08.05.2012
Patent
Fab I Inhibitors
BURGESS WALTER J, HUFFMAN WILLIAM F, JAKAS DALIA, NEWLANDER KENNETH A, MILLER WILLIAM H, SEEFELD MARK A, UZINSKAS IRENE N
Year of Publication 28.04.2011
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Year of Publication 28.04.2011
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FAB I inhibitors
DEWOLF, JR. WALTER E, JAKAS DALIA R, NEWLANDER KENNETH A, MILLER WILLIAM H, SEEFELD MARK A, UZINSKAS IRENE N
Year of Publication 08.05.2012
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Year of Publication 08.05.2012
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Fab I inhibitors
BURGESS WALTER J, HUFFMAN WILLIAM F, JAKAS DALIA R, NEWLANDER KENNETH A, MILLER WILLIAM H, SEEFELD MARK A, UZINSKAS IRENE N
Year of Publication 10.04.2012
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Year of Publication 10.04.2012
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