Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone
Kodaira, Hiroshi, Kusuhara, Hiroyuki, Ushiki, Junko, Fuse, Eiichi, Sugiyama, Yuichi
Published in The Journal of pharmacology and experimental therapeutics (01.06.2010)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2010)
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Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate
Kodaira, Hiroshi, Kusuhara, Hiroyuki, Fujita, Takuya, Ushiki, Junko, Fuse, Eiichi, Sugiyama, Yuichi
Published in The Journal of pharmacology and experimental therapeutics (01.12.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2011)
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Quantitative investigation of the brain-to-cerebrospinal fluid unbound drug concentration ratio under steady-state conditions in rats using a pharmacokinetic model and scaling factors for active efflux transporters
Kodaira, Hiroshi, Kusuhara, Hiroyuki, Fuse, Eiichi, Ushiki, Junko, Sugiyama, Yuichi
Published in Drug metabolism and disposition (01.06.2014)
Published in Drug metabolism and disposition (01.06.2014)
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Potent and Selective Inhibitors of Platelet-Derived Growth Factor Receptor Phosphorylation. 3. Replacement of Quinazoline Moiety and Improvement of Metabolic Polymorphism of 4-[4-(N-Substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline Derivatives
Matsuno, Kenji, Ushiki, Junko, Seishi, Takashi, Ichimura, Michio, Giese, Neill A, Yu, Jin-Chen, Takahashi, Shusuke, Oda, Shoji, Nomoto, Yuji
Published in Journal of medicinal chemistry (06.11.2003)
Published in Journal of medicinal chemistry (06.11.2003)
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Effect of Benidipine on Simvastatin Metabolism in Human Liver Microsomes
Sugiyama, Yuka, Mimura, Nobuhito, Kuwabara, Takashi, Kobayashi, Hiroyuki, Ushiki, Junko, Fuse, Eiichi
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2007)
Published in DRUG METABOLISM AND PHARMACOKINETICS (01.01.2007)
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Potent and Selective Inhibitors of Platelet-Derived Growth Factor Receptor Phosphorylation. 1. Synthesis, Structure−Activity Relationship, and Biological Effects of a New Class of Quinazoline Derivatives
Matsuno, Kenji, Ichimura, Michio, Nakajima, Takao, Tahara, Keiko, Fujiwara, Shigeki, Kase, Hiroshi, Ushiki, Junko, Giese, Neill A, Pandey, Anjali, Scarborough, Robert M, Lokker, Nathalie A, Yu, Jin-Chen, Irie, Junko, Tsukuda, Eiji, Ide, Shin-ichi, Oda, Shoji, Nomoto, Yuji
Published in Journal of medicinal chemistry (04.07.2002)
Published in Journal of medicinal chemistry (04.07.2002)
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L-ascorbic acid stimulates expression of smooth muscle-specific markers in smooth muscle cells both in vitro and in vivo
Arakawa, Emi, Hasegawa, Kazuhide, Irie, Junko, Ide, Shinichi, Ushiki, Junko, Yamaguchi, Kazuo, Oda, Shoji, Matsuda, Yuzuru
Published in Journal of cardiovascular pharmacology (01.12.2003)
Published in Journal of cardiovascular pharmacology (01.12.2003)
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Potent and Selective Inhibitors of PDGF Receptor Phosphorylation. 2. Synthesis, Structure Activity Relationship, Improvement of Aqueous Solubility, and Biological Effects of 4-[4-(N-Substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline Derivatives
Matsuno, Kenji, Nakajima, Takao, Ichimura, Michio, Giese, Neill A, Yu, Jin-Chen, Lokker, Nathalie A, Ushiki, Junko, Ide, Shin-ichi, Oda, Shoji, Nomoto, Yuji
Published in Journal of medicinal chemistry (26.09.2002)
Published in Journal of medicinal chemistry (26.09.2002)
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Investigation of drug-drug interactions caused by human pregnane X receptor-mediated induction of CYP3A4 and CYP2C subfamilies in chimeric mice with a humanized liver
Hasegawa, Maki, Tahara, Harunobu, Inoue, Ryo, Kakuni, Masakazu, Tateno, Chise, Ushiki, Junko
Published in Drug metabolism and disposition (01.03.2012)
Published in Drug metabolism and disposition (01.03.2012)
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An iminium ion metabolite hampers the production of the pharmacologically active metabolite of a multikinase inhibitor KW‐2449 in primates: irreversible inhibition of aldehyde oxidase and covalent binding with endogenous proteins
Hosogi, Jun, Ohashi, Rui, Maeda, Hiroshi, Fujita, Kazuhiro, Ushiki, Junko, Kuwabara, Takashi, Yamamoto, Yorihiro, Imamura, Toru
Published in Biopharmaceutics & drug disposition (01.03.2018)
Published in Biopharmaceutics & drug disposition (01.03.2018)
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Species differences in the pharmacokinetics of KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide]: formation of hydrolyzed metabolite in human and animals
Maeda, Hiroshi, Kodaira, Hiroshi, Fujita, Kazuhiro, Kobayashi, Hiroyuki, Ushiki, Junko, Nakanishi, Takeo, Tamai, Ikumi
Published in Xenobiotica (01.07.2012)
Published in Xenobiotica (01.07.2012)
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