The Effects of Conformational Constraints and Steric Bulk in the Amino Acid Moiety of Philanthotoxins on AMPAR Antagonism
Jørgensen, Malene R, Olsen, Christian A, Mellor, Ian R, Usherwood, Peter N. R, Witt, Matthias, Franzyk, Henrik, Jaroszewski, Jerzy W
Published in Journal of medicinal chemistry (13.01.2005)
Published in Journal of medicinal chemistry (13.01.2005)
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Journal Article
Contrasting Actions of Philanthotoxin-343 and Philanthotoxin-(12) on Human Muscle Nicotinic Acetylcholine Receptors
Tim J. Brier, Ian R. Mellor, Denis B. Tikhonov, Ioana Neagoe, Zuoyi Shao, Matt J. Brierley, Kristian Strømgaard, Jerzy W. Jaroszewski, Povl Krogsgaard-Larsen, Peter N. R. Usherwood
Published in Molecular pharmacology (01.10.2003)
Published in Molecular pharmacology (01.10.2003)
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Journal Article
Modeling Noncompetitive Antagonism of a Nicotinic Acetylcholine Receptor
Tikhonov, Denis B., Mellor, Ian R., Usherwood, Peter N.R.
Published in Biophysical journal (01.07.2004)
Published in Biophysical journal (01.07.2004)
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Journal Article
Tuning Wasp Toxin Structure for Nicotinic Receptor Antagonism: Cyclohexylalanine-Containing Analogues as Potent and Voltage-Dependent Blockers
Olsen, Christian A., Mellor, Ian R., Wellendorph, Petrine, Usherwood, Peter N. R., Witt, Matthias, Franzyk, Henrik, Jaroszewski, Jerzy W.
Published in ChemMedChem (13.03.2006)
Published in ChemMedChem (13.03.2006)
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Journal Article
The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels
Vais, Horia, Williamson, Martin S, Devonshire, Alan L, Usherwood, Peter N R
Published in Pest management science (01.10.2001)
Published in Pest management science (01.10.2001)
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Journal Article
Conference Proceeding
Single channel study of deltamethrin interactions with wild-type and mutated rat Na(V)1.2 sodium channels expressed in Xenopus oocytes
Peng, Fang, Mellor, Ian R, Williamson, Martin S, Davies, T G Emyr, Field, Linda M, Usherwood, Peter N R
Published in Neurotoxicology (Park Forest South) (01.05.2009)
Published in Neurotoxicology (Park Forest South) (01.05.2009)
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Journal Article
Solid-Phase Synthesis and Biological Evaluation of a Combinatorial Library of Philanthotoxin Analogues
Strømgaard, Kristian, Brier, Tim J, Andersen, Kim, Mellor, Ian R, Saghyan, Alex, Tikhonov, Denis, Usherwood, Peter N. R, Krogsgaard-Larsen, Povl, Jaroszewski, Jerzy W
Published in Journal of medicinal chemistry (16.11.2000)
Published in Journal of medicinal chemistry (16.11.2000)
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Journal Article
Inhibition of Nicotinic Acetylcholine Receptor by Philanthotoxin-343: Kinetic Investigations in the Microsecond Time Region Using a Laser-Pulse Photolysis Technique
Jayaraman, Vasanthi, Usherwood, Peter N. R, Hess, George P
Published in Biochemistry (Easton) (31.08.1999)
Published in Biochemistry (Easton) (31.08.1999)
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Journal Article
Solid-phase synthesis and pharmacological evaluation of analogues of PhTX-12: A potent and selective nicotinic acetylcholine receptor antagonist
STRØMGAARD, Kristian, MELLOR, Ian R, ANDERSEN, Kim, NEAGOE, Ioana, PLUTEANU, Florentina, USHERWOOD, Peter N. R, KROGSGAARD-LARSEN, Povl, JAROSZEWSKI, Jerzy W
Published in Bioorganic & medicinal chemistry letters (22.04.2002)
Published in Bioorganic & medicinal chemistry letters (22.04.2002)
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Journal Article
Analogues of Neuroactive Polyamine Wasp Toxins That Lack Inner Basic Sites Exhibit Enhanced Antagonism Toward a Muscle-Type Mammalian Nicotinic Acetylcholine Receptor
Strømgaard, Kristian, Brierley, Matthew J, Andersen, Kim, Sløk, Frank A, Mellor, Ian R, Usherwood, Peter N. R, Krogsgaard-Larsen, Povl, Jaroszewski, Jerzy W
Published in Journal of medicinal chemistry (16.12.1999)
Published in Journal of medicinal chemistry (16.12.1999)
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Journal Article
Design, Synthesis, and Biological Evaluation of Symmetrically and Unsymmetrically Substituted Methoctramine-Related Polyamines as Muscular Nicotinic Receptor Noncompetitive Antagonists
Rosini, Michela, Budriesi, Roberta, Bixel, M. Gabriele, Bolognesi, Maria L, Chiarini, Alberto, Hucho, Ferdinand, Krogsgaard-Larsen, Povl, Mellor, Ian R, Minarini, Anna, Tumiatti, Vincenzo, Usherwood, Peter N. R, Melchiorre, Carlo
Published in Journal of medicinal chemistry (16.12.1999)
Published in Journal of medicinal chemistry (16.12.1999)
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Journal Article
Cover Picture: Tuning Wasp Toxin Structure for Nicotinic Receptor Antagonism: Cyclohexylalanine-Containing Analogues as Potent and Voltage-Dependent Blockers (ChemMedChem 3/2006)
Olsen, Christian A., Mellor, Ian R., Wellendorph, Petrine, Usherwood, Peter N. R., Witt, Matthias, Franzyk, Henrik, Jaroszewski, Jerzy W.
Published in ChemMedChem (13.03.2006)
Published in ChemMedChem (13.03.2006)
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Journal Article
Targeting ionotropic receptors with polyamine-containing toxins
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Book Review
Journal Article
Single channel study of deltamethrin interactions with wild-type and mutated rat Nav1.2 sodium channels expressed in Xenopus oocytes
FANG PENG, MELLOR, Ian R, WILLIAMSON, Martin S, EMYR DAVIES, T. G, FIELD, Linda M, USHERWOOD, Peter N. R
Published in Neurotoxicology (Park Forest South) (01.05.2009)
Published in Neurotoxicology (Park Forest South) (01.05.2009)
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Journal Article
The Choice of Phosphane Reagent in Fukuyama−Mitsunobu Alkylation: Intramolecular Selectivity Between Primary and Secondary Alcohols in the Preparation of Asymmetric Tetraamine Building Blocks for Synthesis of Philanthotoxins
Olsen, Christian A., Jørgensen, Malene R., Witt, Matthias, Mellor, Ian R., Usherwood, Peter N. R., Jaroszewski, Jerzy W., Franzyk, Henrik
Published in European journal of organic chemistry (01.09.2003)
Published in European journal of organic chemistry (01.09.2003)
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Journal Article