Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria
Charman, Susan A., Arbe-Barnes, Sarah, Bathurst, Ian C., Brun, Reto, Campbell, Michael, Charman, William N., Chiu, Francis C. K., Chollet, Jacques, Craft, J. Carl, Creek, Darren J., Dong, Yuxiang, Matile, Hugues, Maurer, Melanie, Morizzi, Julia, Nguyen, Tien, Papastogiannidis, Petros, Scheurer, Christian, Shackleford, David M., Sriraghavan, Kamaraj, Stingelin, Lukas, Tang, Yuanqing, Urwyler, Heinrich, Wang, Xiaofang, White, Karen L., Wittlin, Sergio, Zhou, Lin, Vennerstrom, Jonathan L., Wellems, Thomas E.
Published in Proceedings of the National Academy of Sciences - PNAS (15.03.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (15.03.2011)
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Structure–Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439)
Dong, Yuxiang, Wang, Xiaofang, Kamaraj, Sriraghavan, Bulbule, Vivek J, Chiu, Francis C. K, Chollet, Jacques, Dhanasekaran, Manickam, Hein, Christopher D, Papastogiannidis, Petros, Morizzi, Julia, Shackleford, David M, Barker, Helena, Ryan, Eileen, Scheurer, Christian, Tang, Yuanqing, Zhao, Qingjie, Zhou, Lin, White, Karen L, Urwyler, Heinrich, Charman, William N, Matile, Hugues, Wittlin, Sergio, Charman, Susan A, Vennerstrom, Jonathan L
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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In Vitro and In Vivo Properties of Dihydrophthalazine Antifolates, a Novel Family of Antibacterial Drugs
CASPERS, Patrick, BURY, Luc, GAUCHER, Bérangère, HEIM, Jutta, SHAPIRO, Stuart, SIEGRIST, Sibylle, SCHMITT-HOFFMANN, Anne, THENOZ, Laure, URWYLER, Heinrich
Published in Antimicrobial Agents and Chemotherapy (01.09.2009)
Published in Antimicrobial Agents and Chemotherapy (01.09.2009)
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Identification of an antimalarial synthetic trioxolane drug development candidate
Vennerstrom, Jonathan L, Arbe-Barnes, Sarah, Brun, Reto, Charman, Susan A, Chiu, Francis C. K, Chollet, Jacques, Dong, Yuxiang, Dorn, Arnulf, Hunziker, Daniel, Matile, Hugues, McIntosh, Kylie, Padmanilayam, Maniyan, Santo Tomas, Josefina, Scheurer, Christian, Scorneaux, Bernard, Tang, Yuanqing, Urwyler, Heinrich, Wittlin, Sergio, Charman, William N
Published in Nature (19.08.2004)
Published in Nature (19.08.2004)
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The Structure−Activity Relationship of the Antimalarial Ozonide Arterolane (OZ277)
Dong, Yuxiang, Wittlin, Sergio, Sriraghavan, Kamaraj, Chollet, Jacques, Charman, Susan A, Charman, William N, Scheurer, Christian, Urwyler, Heinrich, Santo Tomas, Josefina, Snyder, Christopher, Creek, Darren J, Morizzi, Julia, Koltun, Maria, Matile, Hugues, Wang, Xiaofang, Padmanilayam, Maniyan, Tang, Yuanqing, Dorn, Arnulf, Brun, Reto, Vennerstrom, Jonathan L
Published in Journal of medicinal chemistry (14.01.2010)
Published in Journal of medicinal chemistry (14.01.2010)
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Spiro and Dispiro-1,2,4-trioxolanes as Antimalarial Peroxides: Charting a Workable Structure−Activity Relationship Using Simple Prototypes
Dong, Yuxiang, Chollet, Jacques, Matile, Hugues, Charman, Susan A, Chiu, Francis C. K, Charman, William N, Scorneaux, Bernard, Urwyler, Heinrich, Santo Tomas, Josefina, Scheurer, Christian, Snyder, Christopher, Dorn, Arnulf, Wang, Xiaofang, Karle, Jean M, Tang, Yuanqing, Wittlin, Sergio, Brun, Reto, Vennerstrom, Jonathan L
Published in Journal of medicinal chemistry (28.07.2005)
Published in Journal of medicinal chemistry (28.07.2005)
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Journal Article
Weak base dispiro-1,2,4-trioxolanes: Potent antimalarial ozonides
Tang, Yuanqing, Dong, Yuxiang, Wittlin, Sergio, Charman, Susan A., Chollet, Jacques, Chiu, Francis C.K., Charman, William N., Matile, Hugues, Urwyler, Heinrich, Dorn, Arnulf, Bajpai, Saroj, Wang, Xiaofang, Padmanilayam, Maniyan, Karle, Jean M., Brun, Reto, Vennerstrom, Jonathan L.
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
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Fluoroquinolone antibacterials enhance UVA-induced skin tumors
Klecak, Georg, Urbach, Frederick, Urwyler, Heinrich
Published in Journal of photochemistry and photobiology. B, Biology (01.02.1997)
Published in Journal of photochemistry and photobiology. B, Biology (01.02.1997)
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Journal Article
The comparative antimalarial properties of weak base and neutral synthetic ozonides
Tang, Yuanqing, Wittlin, Sergio, Charman, Susan A., Chollet, Jacques, Chiu, Francis C.K., Morizzi, Julia, Johnson, Lisa M., Tomas, Josefina Santo, Scheurer, Christian, Snyder, Chistopher, Zhou, Lin, Dong, Yuxiang, Charman, William N., Matile, Hugues, Urwyler, Heinrich, Dorn, Arnulf, Vennerstrom, Jonathan L.
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum
RIDLEY, R. G, HOFHEINZ, W, URWYLER, H, HUBER, W, THAIGHONG, S, PETERS, W, MATILE, H, JAQUET, C, DORN, A, MASCIADRI, R, JOLIDON, S, RICHTER, W. F, GUENZI, A, GIROMETTA, M.-A
Published in Antimicrobial Agents and Chemotherapy (01.08.1996)
Published in Antimicrobial Agents and Chemotherapy (01.08.1996)
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Fleroxacin: a review of its chemistry, microbiology, toxicology, pharmacokinetics, clinical efficacy and safety
Cullmann, Wolfgang, Geddes, Alasdair M., Weidekamm, Erhard, Urwyler, Heinrich, Braunsteiner, Alfred
Published in International journal of antimicrobial agents (1993)
Published in International journal of antimicrobial agents (1993)
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Cefetamet pivoxil: a review of its microbiology, toxicology, pharmacokinetics and clinical efficacy
Cullmann, Wolfgang, Edwards, David J., Kissling, Margot, Kneer, Johannes, Stoeckel, Klaus, Urwyler, Heinrich
Published in International Journal of Antimicrobial Agents (1992)
Published in International Journal of Antimicrobial Agents (1992)
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