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Population pharmacokinetics of the GIP/GLP receptor agonist tirzepatide
Schneck, Karen, Urva, Shweta
Published in CPT: pharmacometrics and systems pharmacology (01.03.2024)
Published in CPT: pharmacometrics and systems pharmacology (01.03.2024)
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LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept
Coskun, Tamer, Urva, Shweta, Roell, William C., Qu, Hongchang, Loghin, Corina, Moyers, Julie S., O’Farrell, Libbey S., Briere, Daniel A., Sloop, Kyle W., Thomas, Melissa K., Pirro, Valentina, Wainscott, David B., Willard, Francis S., Abernathy, Matthew, Morford, LaRonda, Du, Yu, Benson, Charles, Gimeno, Ruth E., Haupt, Axel, Milicevic, Zvonko
Published in Cell metabolism (06.09.2022)
Published in Cell metabolism (06.09.2022)
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LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept
Coskun, Tamer, Sloop, Kyle W., Loghin, Corina, Alsina-Fernandez, Jorge, Urva, Shweta, Bokvist, Krister B., Cui, Xuewei, Briere, Daniel A., Cabrera, Over, Roell, William C., Kuchibhotla, Uma, Moyers, Julie S., Benson, Charles T., Gimeno, Ruth E., D'Alessio, David A., Haupt, Axel
Published in Molecular metabolism (Germany) (01.12.2018)
Published in Molecular metabolism (Germany) (01.12.2018)
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Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist
Willard, Francis S., Douros, Jonathan D., Gabe, Maria B.N., Showalter, Aaron D., Wainscott, David B., Suter, Todd M., Capozzi, Megan E., van der Velden, Wijnand J.C., Stutsman, Cynthia, Cardona, Guemalli R., Urva, Shweta, Emmerson, Paul J., Holst, Jens J., D’Alessio, David A., Coghlan, Matthew P., Rosenkilde, Mette M., Campbell, Jonathan E., Sloop, Kyle W.
Published in JCI insight (03.09.2020)
Published in JCI insight (03.09.2020)
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The novel dual glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 (GLP‐1) receptor agonist tirzepatide transiently delays gastric emptying similarly to selective long‐acting GLP‐1 receptor agonists
Urva, Shweta, Coskun, Tamer, Loghin, Corina, Cui, Xuewei, Beebe, Emily, O'Farrell, Libbey, Briere, Daniel A., Benson, Charles, Nauck, Michael A., Haupt, Axel
Published in Diabetes, obesity & metabolism (01.10.2020)
Published in Diabetes, obesity & metabolism (01.10.2020)
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Physiologically based pharmacokinetic model for T84.66: A monoclonal anti-CEA antibody
Urva, Shweta R., Yang, Victor C., Balthasar, Joseph P.
Published in Journal of pharmaceutical sciences (01.03.2010)
Published in Journal of pharmaceutical sciences (01.03.2010)
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Sensitive high performance liquid chromatographic assay for assessment of doxorubicin pharmacokinetics in mouse plasma and tissues
Urva, Shweta R., Shin, Beom Soo, Yang, Victor C., Balthasar, Joseph P.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.03.2009)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.03.2009)
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Characterization of LY2775240, a selective phosphodiesterase‐4 inhibitor, in nonclinical models and in healthy subjects
Patel, Dipak R., Urva, Shweta, Ho, Stephen, Buckman, Cody J., Ma, Yanfei, Lim, Jean, Sissons, Sean E., Zuniga, Mary S., Philips, Diane, Cox, Karen, Dairaghi, Daniel J.
Published in Clinical and translational science (01.05.2021)
Published in Clinical and translational science (01.05.2021)
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Effects of Hepatic Impairment on the Pharmacokinetics of Everolimus: A Single-Dose, Open-Label, Parallel-Group Study
Peveling-Oberhag, Jan, Zeuzem, Stefan, Yong, Wei Peng, Kunz, Tiffany, Paquet, Thierry, Bouillaud, Emmanuel, Urva, Shweta, Anak, Oezlem, Sellami, Dalila, Kobalava, Zhanna
Published in Clinical therapeutics (01.03.2013)
Published in Clinical therapeutics (01.03.2013)
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Feasibility of adding everolimus to carboplatin and paclitaxel, with or without bevacizumab, for treatment-naive, advanced non–small cell lung cancer
Eberhardt, Wilfried E. E., Mitchell, Paul, Schiller, Joan H., Brown, Michael P., Thomas, Michael, Mills, Glenn, Jehl, Valentine, Urva, Shweta R., De Leo, Jeffrey J., Gogov, Sven, Papadimitrakopoulou, Vassiliki
Published in Investigational new drugs (01.02.2014)
Published in Investigational new drugs (01.02.2014)
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Effects of Renal Impairment on the Pharmacokinetics of the Dual GIP and GLP-1 Receptor Agonist Tirzepatide
Urva, Shweta, Quinlan, Tonya, Landry, John, Martin, Jennifer, Loghin, Corina
Published in Clinical pharmacokinetics (01.08.2021)
Published in Clinical pharmacokinetics (01.08.2021)
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A Pharmacometric Method for Quantitative Determination of Improvement in Body Composition and Characterization of the Exposure-Response Relationship during Treatment of Obesity with Tirzepatide
Chigutsa, Emmanuel, Her, Lucy, Ma, Xiaosu, Urva, Shweta, Schneck, Karen
Published in Clinical pharmacology and therapeutics (25.06.2025)
Published in Clinical pharmacology and therapeutics (25.06.2025)
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Muvalaplin, an Oral Small Molecule Inhibitor of Lipoprotein(a) Formation: A Randomized Clinical Trial
Nicholls, Stephen J, Nissen, Steven E, Fleming, Cynthia, Urva, Shweta, Suico, Jeffrey, Berg, Paul H, Linnebjerg, Helle, Ruotolo, Giacomo, Turner, P. Kellie, Michael, Laura F
Published in JAMA : the journal of the American Medical Association (19.09.2023)
Published in JAMA : the journal of the American Medical Association (19.09.2023)
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AN ELISA FOR QUANTIFICATION OF T84.66, A MONOCLONAL ANTI-CEA ANTIBODY, IN MOUSE PLASMA
Urva, Shweta R., Yang, Victor C., Balthasar, Joseph P.
Published in Journal of immunoassay & immunochemistry (01.01.2010)
Published in Journal of immunoassay & immunochemistry (01.01.2010)
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Effects of subcutaneous tirzepatide versus placebo or semaglutide on pancreatic islet function and insulin sensitivity in adults with type 2 diabetes: a multicentre, randomised, double-blind, parallel-arm, phase 1 clinical trial
Heise, Tim, Mari, Andrea, DeVries, J Hans, Urva, Shweta, Li, Jing, Pratt, Edward John, Coskun, Tamer, Thomas, Melissa K, Mather, Kieren J, Haupt, Axel, Milicevic, Zvonko
Published in The lancet. Diabetes & endocrinology (01.06.2022)
Published in The lancet. Diabetes & endocrinology (01.06.2022)
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