Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations
Soldner, Frank, Laganière, Josée, Cheng, Albert W., Hockemeyer, Dirk, Gao, Qing, Alagappan, Raaji, Khurana, Vikram, Golbe, Lawrence I., Myers, Richard H., Lindquist, Susan, Zhang, Lei, Guschin, Dmitry, Fong, Lauren K., Vu, B. Joseph, Meng, Xiangdong, Urnov, Fyodor D., Rebar, Edward J., Gregory, Philip D., Zhang, H. Steve, Jaenisch, Rudolf
Published in Cell (22.07.2011)
Published in Cell (22.07.2011)
Get full text
Journal Article
Genome Editing of Isogenic Human Induced Pluripotent Stem Cells Recapitulates Long QT Phenotype for Drug Testing
Wang, Yongming, PhD, Liang, Ping, MD, PhD, Lan, Feng, PhD, Wu, Haodi, PhD, Lisowski, Leszek, PhD, Gu, Mingxia, MD, PhD, Hu, Shijun, PhD, Kay, Mark A., MD, PhD, Urnov, Fyodor D., PhD, Shinnawi, Rami, PhD, Gold, Joseph D., PhD, Gepstein, Lior, MD, PhD, Wu, Joseph C., MD, PhD
Published in Journal of the American College of Cardiology (05.08.2014)
Published in Journal of the American College of Cardiology (05.08.2014)
Get full text
Journal Article
Targeted Genome Editing Across Species Using ZFNs and TALENs
Wood, Andrew J., Lo, Te-Wen, Zeitler, Bryan, Pickle, Catherine S., Ralston, Edward J., Lee, Andrew H., Amora, Rainier, Miller, Jeffrey C., Leung, Elo, Meng, Xiangdong, Zhang, Lei, Rebar, Edward J., Gregory, Philip D., Urnov, Fyodor D., Meyer, Barbara J.
Published in Science (American Association for the Advancement of Science) (15.07.2011)
Published in Science (American Association for the Advancement of Science) (15.07.2011)
Get full text
Journal Article
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases
Amora, Ranier, Miller, Jeffrey C, Mitalipova, Maisam, Katibah, George E, Rebar, Edward J, Urnov, Fyodor D, Jaenisch, Rudolf, Gregory, Philip D, Boydston, Elizabeth A, Beard, Caroline, Hockemeyer, Dirk, Zeitler, Bryan, Meng, Xiangdong, Soldner, Frank, Gao, Qing, Zhang, Lei, DeKelver, Russell C
Published in Nature biotechnology (01.09.2009)
Published in Nature biotechnology (01.09.2009)
Get full text
Journal Article
In vivo cleavage of transgene donors promotes nuclease-mediated targeted integration
Cristea, Sandra, Freyvert, Yevgeniy, Santiago, Yolanda, Holmes, Michael C., Urnov, Fyodor D., Gregory, Philip D., Cost, Gregory J.
Published in Biotechnology and bioengineering (01.03.2013)
Published in Biotechnology and bioengineering (01.03.2013)
Get full text
Journal Article
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery
Genovese, Pietro, Galli, Cesare, Gregory, Philip D, Naldini, Luigi, Beausejour, Christian M, Colleoni, Silvia, Urnov, Fyodor D, Kim, Kenneth A, Ando, Dale, Lombardo, Angelo, Lee, Ya-Li, Holmes, Michael C
Published in Nature biotechnology (01.11.2007)
Published in Nature biotechnology (01.11.2007)
Get full text
Journal Article
Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases
Geurts, Aron M, Cost, Gregory J, Freyvert, Yevgeniy, Zeitler, Bryan, Miller, Jeffrey C, Choi, Vivian M, Jenkins, Shirin S, Wood, Adam, Cui, Xiaoxia, Meng, Xiangdong, Vincent, Anna, Lam, Stephen, Michalkiewicz, Mieczyslaw, Schilling, Rebecca, Foeckler, Jamie, Kalloway, Shawn, Weiler, Hartmut, Ménoret, Séverine, Anegon, Ignacio, Davis, Gregory D, Zhang, Lei, Rebar, Edward J, Gregory, Philip D, Urnov, Fyodor D, Jacob, Howard J, Buelow, Roland
Published in Science (American Association for the Advancement of Science) (24.07.2009)
Published in Science (American Association for the Advancement of Science) (24.07.2009)
Get full text
Journal Article
LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction
Sanders, Laurie H, Laganière, Josée, Cooper, Oliver, Mak, Sally K, Vu, B. Joseph, Huang, Y. Anne, Paschon, David E, Vangipuram, Malini, Sundararajan, Ramya, Urnov, Fyodor D, Langston, J. William, Gregory, Philip D, Zhang, H. Steve, Greenamyre, J. Timothy, Isacson, Ole, Schüle, Birgitt
Published in Neurobiology of disease (01.02.2014)
Published in Neurobiology of disease (01.02.2014)
Get full text
Journal Article
Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation
Sexton, Alec N, Regalado, Samuel G, Lai, Christine S, Cost, Gregory J, O'Neil, Colleen M, Urnov, Fyodor D, Gregory, Philip D, Jaenisch, Rudolf, Collins, Kathleen, Hockemeyer, Dirk
Published in Genes & development (01.09.2014)
Published in Genes & development (01.09.2014)
Get full text
Journal Article
Precise genome modification in the crop species Zea mays using zinc-finger nucleases
Shukla, Vipula K, Doyon, Yannick, Miller, Jeffrey C, DeKelver, Russell C, Moehle, Erica A, Worden, Sarah E, Mitchell, Jon C, Arnold, Nicole L, Gopalan, Sunita, Meng, Xiangdong, Choi, Vivian M, Rock, Jeremy M, Wu, Ying-Ying, Katibah, George E, Zhifang, Gao
Published in Nature (21.05.2009)
Published in Nature (21.05.2009)
Get full text
Journal Article
Piloting an integrated SARS-CoV-2 testing and data system for outbreak containment among college students: A prospective cohort study
Packel, Laura, Reingold, Arthur, Hunter, Lauren, Facente, Shelley, Li, Yi, Harte, Anna, Nicolette, Guy, Urnov, Fyodor D, Lu, Michael, Petersen, Maya
Published in PloS one (26.01.2021)
Published in PloS one (26.01.2021)
Get full text
Journal Article
Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells
Drubin, David G, Lee, Andrew H, Cheng, Aaron T, Doyon, Yannick, Vo, Thuy D, Miller, Jeffrey C, Cherone, Jennifer M, Cheng, Jackie, Santiago, Yolanda, Urnov, Fyodor D, Paschon, David E, Doyon, Jeffrey B, Zhang, Lei, Rebar, Edward J, Gregory, Philip D, Zeitler, Bryan
Published in Nature cell biology (01.03.2011)
Published in Nature cell biology (01.03.2011)
Get full text
Journal Article
Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases
Straimer, Judith, Lee, Marcus C S, Lee, Andrew H, Zeitler, Bryan, Williams, April E, Pearl, Jocelynn R, Zhang, Lei, Rebar, Edward J, Gregory, Philip D, Llinás, Manuel, Urnov, Fyodor D, Fidock, David A
Published in Nature methods (01.10.2012)
Published in Nature methods (01.10.2012)
Get full text
Journal Article
Disruption of the BCL11A Erythroid Enhancer Reactivates Fetal Hemoglobin in Erythroid Cells of Patients with β-Thalassemia Major
Psatha, Nikoletta, Reik, Andreas, Phelps, Susan, Zhou, Yuanyue, Dalas, Demetri, Yannaki, Evangelia, Levasseur, Dana N., Urnov, Fyodor D., Holmes, Michael C., Papayannopoulou, Thalia
Published in Molecular therapy. Methods & clinical development (21.09.2018)
Published in Molecular therapy. Methods & clinical development (21.09.2018)
Get full text
Journal Article
Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases
Santiago, Yolanda, Chan, Edmond, Liu, Pei-Qi, Orlando, Salvatore, Zhang, Lin, Urnov, Fyodor D, Holmes, Michael C, Guschin, Dmitry, Waite, Adam, Miller, Jeffrey C, Rebar, Edward J, Gregory, Philip D, Klug, Aaron, Collingwood, Trevor N
Published in Proceedings of the National Academy of Sciences - PNAS (15.04.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (15.04.2008)
Get full text
Journal Article
Long-Term Engraftment and Fetal Globin Induction upon BCL11A Gene Editing in Bone-Marrow-Derived CD34 + Hematopoietic Stem and Progenitor Cells
Chang, Kai-Hsin, Smith, Sarah E, Sullivan, Timothy, Chen, Kai, Zhou, Qianhe, West, Jason A, Liu, Mei, Liu, Yingchun, Vieira, Benjamin F, Sun, Chao, Hong, Vu P, Zhang, Mingxuan, Yang, Xiao, Reik, Andreas, Urnov, Fyodor D, Rebar, Edward J, Holmes, Michael C, Danos, Olivier, Jiang, Haiyan, Tan, Siyuan
Published in Molecular therapy. Methods & clinical development (17.03.2017)
Published in Molecular therapy. Methods & clinical development (17.03.2017)
Get full text
Journal Article
Robotic RNA extraction for SARS-CoV-2 surveillance using saliva samples
Hamilton, Jennifer R, Stahl, Elizabeth C, Tsuchida, Connor A, Lin-Shiao, Enrique, Tsui, C Kimberly, Pestal, Kathleen, Gildea, Holly K, Witkowsky, Lea B, Moehle, Erica A, McDevitt, Shana L, McElroy, Matthew, Keller, Amanda, Sylvain, Iman, Hirsh, Ariana, Ciling, Alison, Ehrenberg, Alexander J, Ringeisen, Bradley R, Huberty, Garth, Urnov, Fyodor D, Giannikopoulos, Petros, Doudna, Jennifer A
Published in PloS one (05.08.2021)
Published in PloS one (05.08.2021)
Get full text
Journal Article
Improved specificity of TALE-based genome editing using an expanded RVD repertoire
Miller, Jeffrey C, Zhang, Lei, Xia, Danny F, Campo, John J, Ankoudinova, Irina V, Guschin, Dmitry Y, Babiarz, Joshua E, Meng, Xiangdong, Hinkley, Sarah J, Lam, Stephen C, Paschon, David E, Vincent, Anna I, Dulay, Gladys P, Barlow, Kyle A, Shivak, David A, Leung, Elo, Kim, Jinwon D, Amora, Rainier, Urnov, Fyodor D, Gregory, Philip D, Rebar, Edward J
Published in Nature methods (01.05.2015)
Published in Nature methods (01.05.2015)
Get full text
Journal Article
Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases
Moehle, E.A, Rock, J.M, Lee, Y.L, Jouvenot, Y, DeKelver, R.C, Gregory, P.D, Urnov, F.D, Holmes, M.C
Published in Proceedings of the National Academy of Sciences - PNAS (27.02.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (27.02.2007)
Get full text
Journal Article