Clofazimine Analogs with Efficacy against Experimental Tuberculosis and Reduced Potential for Accumulation
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Published in Antimicrobial Agents and Chemotherapy (01.11.2011)
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"Upcycling" known molecules and targets for drug-resistant TB
Roubert, Christine, Fontaine, Evelyne, Upton, Anna M
Published in Frontiers in cellular and infection microbiology (06.10.2022)
Published in Frontiers in cellular and infection microbiology (06.10.2022)
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Design, Synthesis, and Structure–Activity Relationship Studies of Tryptanthrins As Antitubercular Agents
Hwang, Jae-Min, Oh, Taegwon, Kaneko, Takushi, Upton, Anna M, Franzblau, Scott G, Ma, Zhenkun, Cho, Sang-Nae, Kim, Pilho
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Published in Journal of natural products (Washington, D.C.) (22.03.2013)
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Synergistic Activity of Nitroimidazole-Oxazolidinone Conjugates against Anaerobic Bacteria
Zhuang, Zhijun, Wan, Dawei, Ding, Jun, He, Shijie, Zhang, Qian, Wang, Xiaomei, Yuan, Ying, Lu, Yu, Ding, Charles Z, Lynch, Anthony Simon, Upton, Anna M, Cooper, Christopher B, Denny, William A, Ma, Zhenkun
Published in Molecules (Basel, Switzerland) (22.05.2020)
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Identification of Less Lipophilic Riminophenazine Derivatives for the Treatment of Drug-Resistant Tuberculosis
Zhang, Dongfeng, Lu, Yu, Liu, Kai, Liu, Binna, Wang, Jingbin, Zhang, Gang, Zhang, Hao, Liu, Yang, Wang, Bin, Zheng, Meiqin, Fu, Lei, Hou, Yanyan, Gong, Ningbo, Lv, Yang, Li, Chun, Cooper, Christopher B, Upton, Anna M, Yin, Dali, Ma, Zhenkun, Huang, Haihong
Published in Journal of medicinal chemistry (11.10.2012)
Published in Journal of medicinal chemistry (11.10.2012)
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Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876-A Less Toxic and More Potent Analogue of Bedaquiline
Choi, Peter J, Conole, Daniel, Sutherland, Hamish S, Blaser, Adrian, Tong, Amy S T, Cooper, Christopher B, Upton, Anna M, Palmer, Brian D, Denny, William A
Published in Molecules (Basel, Switzerland) (20.03.2020)
Published in Molecules (Basel, Switzerland) (20.03.2020)
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The Novel Oxazolidinone TBI-223 Is Effective in Three Preclinical Mouse Models of Methicillin-Resistant Staphylococcus aureus Infection
Gordon, Oren, Dikeman, Dustin A, Ortines, Roger V, Wang, Yu, Youn, Christine, Mumtaz, Mohammed, Orlando, Nicholas, Zhang, Jeffrey, Patel, Aman M, Gough, Ethan, Kaushik, Amit, Nuermberger, Eric L, Upton, Anna M, Fotouhi, Nader, Miller, Lloyd S, Archer, Nathan K
Published in Microbiology spectrum (26.10.2022)
Published in Microbiology spectrum (26.10.2022)
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TBAJ-876 Retains Bedaquiline's Activity against Subunits c and ε of Mycobacterium tuberculosis F-ATP Synthase
Sarathy, Jickky Palmae, Ragunathan, Priya, Shin, Joon, Cooper, Christopher B, Upton, Anna M, Grüber, Gerhard, Dick, Thomas
Published in Antimicrobial agents and chemotherapy (01.10.2019)
Published in Antimicrobial agents and chemotherapy (01.10.2019)
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Contribution of Pretomanid to Novel Regimens Containing Bedaquiline with either Linezolid or Moxifloxacin and Pyrazinamide in Murine Models of Tuberculosis
Xu, Jian, Li, Si-Yang, Almeida, Deepak V, Tasneen, Rokeya, Barnes-Boyle, Kala, Converse, Paul J, Upton, Anna M, Mdluli, Khisimuzi, Fotouhi, Nader, Nuermberger, Eric L
Published in Antimicrobial agents and chemotherapy (01.05.2019)
Published in Antimicrobial agents and chemotherapy (01.05.2019)
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Comparative Efficacy of the Novel Diarylquinoline TBAJ-587 and Bedaquiline against a Resistant Rv0678 Mutant in a Mouse Model of Tuberculosis
Xu, Jian, Converse, Paul J, Upton, Anna M, Mdluli, Khisimuzi, Fotouhi, Nader, Nuermberger, Eric L
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Published in Antimicrobial agents and chemotherapy (18.03.2021)
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Delamanid or pretomanid? A Solomonic judgement
Mudde, Saskia E., Upton, Anna M., Lenaerts, Anne, Bax, Hannelore I., De Steenwinkel, Jurriaan E. M.
Published in Journal of antimicrobial chemotherapy (31.03.2022)
Published in Journal of antimicrobial chemotherapy (31.03.2022)
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Comparative Efficacy of the Novel Diarylquinoline TBAJ-876 and Bedaquiline against a Resistant Rv0678 Mutant in a Mouse Model of Tuberculosis
Almeida, Deepak, Converse, Paul J, Li, Si-Yang, Upton, Anna M, Fotouhi, Nader, Nuermberger, Eric L
Published in Antimicrobial agents and chemotherapy (17.11.2021)
Published in Antimicrobial agents and chemotherapy (17.11.2021)
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TBAJ-876 Displays Bedaquiline-Like Mycobactericidal Potency without Retaining the Parental Drug's Uncoupler Activity
Sarathy, Jickky Palmae, Ragunathan, Priya, Cooper, Christopher B, Upton, Anna M, Grüber, Gerhard, Dick, Thomas
Published in Antimicrobial agents and chemotherapy (27.01.2020)
Published in Antimicrobial agents and chemotherapy (27.01.2020)
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3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel
Sutherland, Hamish S., Tong, Amy S.T., Choi, Peter J., Blaser, Adrian, Conole, Daniel, Franzblau, Scott G., Lotlikar, Manisha U., Cooper, Christopher B., Upton, Anna M., Denny, William A., Palmer, Brian D.
Published in Bioorganic & medicinal chemistry (01.04.2019)
Published in Bioorganic & medicinal chemistry (01.04.2019)
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Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles
Sutherland, Hamish S., Tong, Amy S.T., Choi, Peter J., Conole, Daniel, Blaser, Adrian, Franzblau, Scott G., Cooper, Christopher B., Upton, Anna M., Lotlikar, Manisha U., Denny, William A., Palmer, Brian D.
Published in Bioorganic & medicinal chemistry (01.05.2018)
Published in Bioorganic & medicinal chemistry (01.05.2018)
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Bactericidal and sterilizing activity of novel regimens combining bedaquiline or TBAJ-587 with GSK2556286 and TBA-7371 in a mouse model of tuberculosis
Li, Si-Yang, Tyagi, Sandeep, Soni, Heena, Betoudji, Fabrice, Converse, Paul J, Mdluli, Khisimuzi, Upton, Anna M, Fotouhi, Nader, Barros-Aguirre, David, Ballell, Lluís, Jimenez-Navarro, Elena, Nuermberger, Eric L
Published in Antimicrobial agents and chemotherapy (03.04.2024)
Published in Antimicrobial agents and chemotherapy (03.04.2024)
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Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline
Blaser, Adrian, Sutherland, Hamish S., Tong, Amy S.T., Choi, Peter J., Conole, Daniel, Franzblau, Scott G., Cooper, Christopher B., Upton, Anna M., Lotlikar, Manisha, Denny, William A., Palmer, Brian D.
Published in Bioorganic & medicinal chemistry (01.04.2019)
Published in Bioorganic & medicinal chemistry (01.04.2019)
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Contribution of the nitroimidazoles PA-824 and TBA-354 to the activity of novel regimens in murine models of tuberculosis
Tasneen, Rokeya, Williams, Kathy, Amoabeng, Opokua, Minkowski, Austin, Mdluli, Khisimuzi E, Upton, Anna M, Nuermberger, Eric L
Published in Antimicrobial agents and chemotherapy (01.01.2015)
Published in Antimicrobial agents and chemotherapy (01.01.2015)
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