TPX-0131, a Potent CNS-penetrant, Next-generation Inhibitor of Wild-type ALK and ALK-resistant Mutations
Murray, Brion W, Zhai, Dayong, Deng, Wei, Zhang, Xin, Ung, Jane, Nguyen, Vivian, Zhang, Han, Barrera, Maria, Parra, Ana, Cowell, Jessica, Lee, Dong J, Aloysius, Herve, Rogers, Evan
Published in Molecular cancer therapeutics (01.09.2021)
Published in Molecular cancer therapeutics (01.09.2021)
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Journal Article
Abstract 1469: TPX-0131, a potent inhibitor of wild type ALK and a broad spectrum of both single and compound ALK resistance mutations
Murray, Brion W., Zhai, Dayong, Deng, Wei, Rogers, Evan, Zhang, Xin, Ung, Jane, Nguyen, Vivian, Zhang, Han, Barrera, Maria, Parra, Ana, Cowell, Jessica, Lee, Dong, Aloysius, Herve
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract 5226: TPX-0131: A next generation macrocyclic ALK inhibitor that overcomes ALK resistant mutations refractory to current approved ALK inhibitors
Cui, J. Jean, Rogers, Evan, Zhai, Dayong, Deng, Wei, Ung, Jane, Nguyen, Vivian, Zhang, Han, Zhang, Xin, Parra, Ana, Barrera, Maria, Lee, Dong, Murray, Brion
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
The next-generation RET inhibitor TPX-0046 is active in drug-resistant and naïve RET-driven cancer models
Drilon, Alexander E., Zhai, Dayong, Rogers, Evan, Deng, Wei, Zhang, Xin, Ung, Jane, Lee, Dong, Rodon, Laura, Graber, Armin, Zimmerman, Zachary Franklin, Murray, Brion W, Subbiah, Vivek
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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Journal Article
Abstract 1325: TPX-0022, a polypharmacology inhibitor of MET/CSF1R/SRC inhibits tumor growth by promoting anti-tumor immune responses
Deng, Wei, Zhai, Dayong, Rogers, Evan, Zhang, Xin, Lee, Dong, Ung, Jane, Zhang, Han, Liu, Jing, Lu, Yuelie, Huang, John, Graber, Armin, Zimmerman, Zach, Lim, John, Whitten, Jeffrey, Cui, J. Jean
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract 1321: TPX-0022, a polypharmacology inhibitor of MET/CSF1R/SRC for treatment of cancers with abnormal HGF/MET signaling
Zhai, Dayong, Rogers, Evan, Deng, Wei, Zhang, Xin, Lee, Dong, Ung, Jane, Zhang, Han, Liu, Jing, Lu, Yuelie, Huang, John, Graber, Armin, Zimmerman, Zach, Lim, John, Whitten, Jeffrey, Cui, J. Jean
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
질환 치료에 사용하기 위한 거대고리
UNG JANE, NGUYEN VIVIAN, ZHAI DAYONG, DENG WEI, CUI JINGRONG J, ROGERS EVAN W
Year of Publication 05.10.2022
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Year of Publication 05.10.2022
Patent
P3.02a-009 TPX-0005: A Multi-Faceted Approach to Overcoming Clinical Resistances from Current ALK or ROS1 Inhibitor Treatment in Lung Cancer
Cui, J. Jean, Zhai, Dayong, Deng, Wei, Huang, Zhongdong, Rogers, Evan, Ung, Jane, Whitten, Jeffrey, Li, Yishan
Published in Journal of thoracic oncology (01.01.2017)
Published in Journal of thoracic oncology (01.01.2017)
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Journal Article
P3.02a-009 TPX-0005: A Multi-Faceted Approach to Overcoming Clinical Resistances from Current ALK or ROS1 Inhibitor Treatment in Lung Cancer: Topic: ALK Biomarkers
Cui, J. Jean, Zhai, Dayong, Deng, Wei, Huang, Zhongdong, Rogers, Evan, Ung, Jane, Whitten, Jeffrey, Li, Yishan
Published in Journal of thoracic oncology (01.01.2017)
Published in Journal of thoracic oncology (01.01.2017)
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Journal Article
Discovery and development of a novel class of phenoxyacetyl amides as highly potent TRPM8 agonists for use as cooling agents
Noncovich, Alain, Priest, Chad, Ung, Jane, Patron, Andrew P., Servant, Guy, Brust, Paul, Servant, Nicole, Faber, Nathan, Liu, Hanghui, Gonsalves, Nicole S., Ditschun, Tanya L.
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
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질병 치료용 대환식 화합물
UNG JANE, CUI JINGRONG JEAN, ZHAI DAYONG, ZHANG HAN, DENG WEI, ROGERS EVAN W, WHITTEN JEFFREY
Year of Publication 27.08.2020
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Year of Publication 27.08.2020
Patent
거대환형 화합물 및 이의 용도
UNG JANE, CUI JINGRONG JEAN, ZHAI DAYONG, ZHANG HAN, HUANG ZHONGDONG, DENG WEI, ROGERS EVAN W, ZHANG XIN, LIU JING, WHITTEN JEFFREY
Year of Publication 01.04.2020
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Year of Publication 01.04.2020
Patent
단백질 키나제의 조절물질로서 키랄 디아릴 매크로사이클
UNG JANE, LI YISHAN, ZHAI DAYONG, CUI JINGRONG J, DENG WEI, ROGERS EVAN W
Year of Publication 07.03.2018
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Year of Publication 07.03.2018
Patent
MACROCYCLES FOR USE IN TREATING DISEASE
NGUYEN, Vivian, UNG, Jane, DENG, Wei, ZHAI, Dayong, CUI, Jingrong J, ROGERS, Evan W
Year of Publication 03.07.2024
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Year of Publication 03.07.2024
Patent
INDAZOLE CONTAINING MACROCYCLES AND THEIR USE
RUI, Eugene Yuanjin, UNG, Jane, CUI, Jingrong Jean, ROGERS, Evan W, SARKAR, Anindya
Year of Publication 14.12.2023
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Year of Publication 14.12.2023
Patent
MACROCYCLES FOR USE IN TREATING DISEASE
Cui, Jingrong J, Rogers, Evan W, Ung, Jane, Deng, Wei, Nguyen, Vivian, Zhai, Dayong
Year of Publication 12.10.2023
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Year of Publication 12.10.2023
Patent
Macrocyclic compounds for treating disease
UNG, Jane, DENG, Wei, ZHANG, Han, ZHAI, Dayong, ROGERS, Evan W, CUI, Jingrong Jean, WHITTEN, Jeffrey
Year of Publication 03.08.2023
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Year of Publication 03.08.2023
Patent