Real-time trafficking and signaling of the glucagon-like peptide-1 receptor
Roed, Sarah Noerklit, Wismann, Pernille, Underwood, Christina Rye, Kulahin, Nikolaj, Iversen, Helle, Cappelen, Karen Arevad, Schäffer, Lauge, Lehtonen, Janne, Hecksher-Soerensen, Jacob, Secher, Anna, Mathiesen, Jesper Mosolff, Bräuner-Osborne, Hans, Whistler, Jennifer L., Knudsen, Sanne Moeller, Waldhoer, Maria
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Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors
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Published in Nature chemistry (01.11.2016)
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In vitro cell cultures of Brunner's glands from male mouse to study GLP-1 receptor function
Voetmann, Louise M, Underwood, Christina R, Rolin, Bidda, Hansen, Axel K, Kirk, Rikke K, Pyke, Charles, Knudsen, Lotte B, Frederiksen, Klaus S
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Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359
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Published in European journal of medicinal chemistry (05.08.2018)
Published in European journal of medicinal chemistry (05.08.2018)
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Delineation of molecular determinants for FR900359 inhibition of Gq/11 unlocks inhibition of Gαs
Boesgaard, Michael W., Harpsøe, Kasper, Malmberg, Michelle, Underwood, Christina R., Inoue, Asuka, Mathiesen, Jesper M., König, Gabriele M., Kostenis, Evi, Gloriam, David E., Bräuner-Osborne, Hans
Published in The Journal of biological chemistry (02.10.2020)
Published in The Journal of biological chemistry (02.10.2020)
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Structure–Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM‐254890, Targeting the Gq Protein
Zhang, Hang, Xiong, Xiao‐Feng, Boesgaard, Michael W., Underwood, Christina R., Bräuner‐Osborne, Hans, Strømgaard, Kristian
Published in ChemMedChem (07.06.2017)
Published in ChemMedChem (07.06.2017)
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Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists
Zhang, Xin, Belousoff, Matthew J., Zhao, Peishen, Kooistra, Albert J., Truong, Tin T., Ang, Sheng Yu, Underwood, Christina Rye, Egebjerg, Thomas, Šenel, Petr, Stewart, Gregory D., Liang, Yi-Lynn, Glukhova, Alisa, Venugopal, Hari, Christopoulos, Arthur, Furness, Sebastian G.B., Miller, Laurence J., Reedtz-Runge, Steffen, Langmead, Christopher J., Gloriam, David E., Danev, Radostin, Sexton, Patrick M., Wootten, Denise
Published in Molecular cell (05.11.2020)
Published in Molecular cell (05.11.2020)
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Dysregulated lysosomal exocytosis drives protease-mediated cartilage pathogenesis in multiple lysosomal disorders
Lee, Jen-Jie, Wang, Tong, Wiggins, Kali, Lu, Po Nien, Underwood, Christina, Ochenkowska, Katarzyna, Samarut, Eric, Pollard, Laura M., Flanagan-Steet, Heather, Steet, Richard
Published in iScience (19.04.2024)
Published in iScience (19.04.2024)
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Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor
Underwood, Christina Rye, Garibay, Patrick, Knudsen, Lotte Bjerre, Hastrup, Sven, Peters, Günther H., Rudolph, Rainer, Reedtz-Runge, Steffen
Published in The Journal of biological chemistry (01.01.2010)
Published in The Journal of biological chemistry (01.01.2010)
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Structure-Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the G q Protein
Zhang, Hang, Xiong, Xiao-Feng, Boesgaard, Michael W, Underwood, Christina R, Bräuner-Osborne, Hans, Strømgaard, Kristian
Published in ChemMedChem (07.06.2017)
Published in ChemMedChem (07.06.2017)
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Cover Picture: Structure–Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM‐254890, Targeting the Gq Protein (ChemMedChem 11/2017)
Zhang, Hang, Xiong, Xiao‐Feng, Boesgaard, Michael W., Underwood, Christina R., Bräuner‐Osborne, Hans, Strømgaard, Kristian
Published in ChemMedChem (07.06.2017)
Published in ChemMedChem (07.06.2017)
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Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function
Jørgensen, Stine, Have, Christian Theil, Underwood, Christina Rye, Dan Johansen, Lars, Wellendorph, Petrine, Gjesing, Anette Prior, Jørgensen, Christinna V., Quan, Shi, Rui, Gao, Inoue, Asuka, Linneberg, Allan, Grarup, Niels, Jun, Wang, Pedersen, Oluf, Hansen, Torben, Bräuner-Osborne, Hans
Published in The Journal of biological chemistry (27.01.2017)
Published in The Journal of biological chemistry (27.01.2017)
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Overlapping Binding Site for the Endogenous Agonist, Small-Molecule Agonists, and Ago-allosteric Modulators on the Ghrelin Receptor
Holst, Birgitte, Frimurer, Thomas M, Mokrosinski, Jacek, Halkjaer, Tine, Cullberg, Karina B, Underwood, Christina R, Schwartz, Thue W
Published in Molecular pharmacology (01.01.2009)
Published in Molecular pharmacology (01.01.2009)
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Transmembrane α-Helix 2 and 7 Are Important for Small Molecule-Mediated Activation of the GLP-1 Receptor
Rye Underwood, Christina, Møller Knudsen, Sanne, Schjellerup Wulff, Birgitte, Bräuner-Osborne, Hans, Lau, Jesper, Knudsen, Lotte Bjerre, Peters, Günther H., Reedtz-Runge, Steffen
Published in Pharmacology (01.01.2011)
Published in Pharmacology (01.01.2011)
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Structure-Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the G(q) Protein
Zhang, Hang, Xiong, Xiao-Feng, Boesgaard, Michael W., Underwood, Christina R., Brauner-Osborne, Hans, Stromgaard, Kristian
Published in ChemMedChem (07.06.2017)
Published in ChemMedChem (07.06.2017)
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