Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: "SLC-Phenotyping" Using Primary Human Hepatocytes
Bi, Yi-An, Costales, Chester, Mathialagan, Sumathy, West, Mark, Eatemadpour, Soraya, Lazzaro, Sarah, Tylaska, Laurie, Scialis, Renato, Zhang, Hui, Umland, John, Kimoto, Emi, Tess, David A, Feng, Bo, Tremaine, Larry M, Varma, Manthena V S, Rodrigues, A David
Published in The Journal of pharmacology and experimental therapeutics (01.07.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2019)
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In Vitro-In Vivo Extrapolation of Key Transporter Activity at the Blood-Brain Barrier
Trapa, Patrick E, Troutman, Matthew D, Lau, Thomas Y, Wager, Travis T, Maurer, Tristan S, Patel, Nandini C, West, Mark A, Umland, John P, Carlo, Anthony A, Feng, Bo, Liras, Jennifer L
Published in Drug metabolism and disposition (01.04.2019)
Published in Drug metabolism and disposition (01.04.2019)
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Development of a new permeability assay using low‐efflux MDCKII cells
Di, Li, Whitney‐Pickett, Carrie, Umland, John P., Zhang, Hui, Zhang, Xun, Gebhard, David F., Lai, Yurong, Federico, James J., Davidson, Ralph E., Smith, Russ, Reyner, Eric L., Lee, Caroline, Feng, Bo, Rotter, Charles, Varma, Manthena V., Kempshall, Sarah, Fenner, Katherine, El‐kattan, Ayman F., Liston, Theodore E., Troutman, Matthew D.
Published in Journal of pharmaceutical sciences (01.11.2011)
Published in Journal of pharmaceutical sciences (01.11.2011)
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Species Independence in Brain Tissue Binding Using Brain Homogenates
LI DI, UMLAND, John P, CHANG, George, YOUPING HUANG, ZHEN LIN, SCOTT, Dennis O, TROUTMAN, Matthew D, LISTON, Theodore E
Published in Drug metabolism and disposition (01.07.2011)
Published in Drug metabolism and disposition (01.07.2011)
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Impaired Inflammatory and Pain Responses in Mice Lacking an Inducible Prostaglandin E Synthase
Trebino, Catherine E., Stock, Jeffrey L., Gibbons, Colleen P., Naiman, Brian M., Wachtmann, Timothy S., Umland, John P., Pandher, Karamjeet, Lapointe, Jean-Martin, Saha, Sipra, Roach, Marsha L., Carter, Demetrius, Thomas, Nathalie A., Durtschi, Becky A., McNeish, John D., Hambor, John E., Jakobsson, Per-Johan, Carty, Thomas J., Perez, Jose R., Audoly, Laurent P.
Published in Proceedings of the National Academy of Sciences - PNAS (22.07.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (22.07.2003)
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Impact of Recovery on Fraction Unbound Using Equilibrium Dialysis
Di, Li, Umland, John P., Trapa, Patrick E., Maurer, Tristan S.
Published in Journal of pharmaceutical sciences (01.03.2012)
Published in Journal of pharmaceutical sciences (01.03.2012)
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High throughput ADME screening: practical considerations, impact on the portfolio and enabler of in silico ADME models
Hop, Cornelis E C A, Cole, Mark J, Davidson, Ralph E, Duignan, David B, Federico, James, Janiszewski, John S, Jenkins, Kelly, Krueger, Suzanne, Lebowitz, Rebecca, Liston, Theodore E, Mitchell, Walter, Snyder, Mark, Steyn, Stefan J, Soglia, John R, Taylor, Christine, Troutman, Matt D, Umland, John, West, Michael, Whalen, Kevin M, Zelesky, Veronica, Zhao, Sabrina X
Published in Current drug metabolism (01.11.2008)
Published in Current drug metabolism (01.11.2008)
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Biarylcarboxylic Acids and -amides: Inhibition of Phosphodiesterase Type IV versus [3H]Rolipram Binding Activity and Their Relationship to Emetic Behavior in the Ferret
Duplantier, Allen J, Biggers, Michael S, Chambers, Robert J, Cheng, John B, Cooper, Kelvin, Damon, David B, Eggler, James F, Kraus, Kenneth G, Marfat, Anthony, Masamune, Hiroko, Pillar, Joann S, Shirley, John T, Umland, John P, Watson, John W
Published in Journal of medicinal chemistry (05.01.1996)
Published in Journal of medicinal chemistry (05.01.1996)
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A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function
Chambers, Robert J., Abrams, Kristin, Castleberry, Tessa A., Cheng, John B., Fisher, Douglas A., Kamath, Ajith V., Marfat, Anthony, Nettleton, David O., Pillar, Joann D., Salter, Eben D., Sheils, Alissa L., Shirley, John T., Turner, Claudia R., Umland, John P., Lam, Kelvin T.
Published in Bioorganic & medicinal chemistry letters (01.02.2006)
Published in Bioorganic & medicinal chemistry letters (01.02.2006)
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Mechanistic insights on clearance and inhibition discordance between liver microsomes and hepatocytes when clearance in liver microsomes is higher than in hepatocytes
Keefer, Christopher, Chang, George, Carlo, Anthony, Novak, Jonathan J., Banker, Michael, Carey, Jackie, Cianfrogna, Julie, Eng, Heather, Jagla, Caitlin, Johnson, Nathaniel, Jones, Rhys, Jordan, Samantha, Lazzaro, Sarah, Liu, JianHua, Scott Obach, R., Riccardi, Keith, Tess, David, Umland, John, Racich, Jillian, Varma, Manthena, Visswanathan, Ravi, Di, Li
Published in European journal of pharmaceutical sciences (01.12.2020)
Published in European journal of pharmaceutical sciences (01.12.2020)
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7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as Novel Inhibitors of Human Eosinophil Phosphodiesterase
Duplantier, Allen J, Andresen, Catharine J, Cheng, John B, Cohan, Victoria L, Decker, Christian, DiCapua, Frank M, Kraus, Kenneth G, Johnson, Kerry L, Turner, Claudia R, UmLand, John P, Watson, John W, Wester, Ronald T, Williams, Alison S, Williams, John A
Published in Journal of medicinal chemistry (18.06.1998)
Published in Journal of medicinal chemistry (18.06.1998)
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Development of a high-speed, multiplexed sample-delivery instrument for LC-MS/MS bioanalysis
Janiszewski, John, Schneider, Richard, Kapinos, Brendon, West, Mike, Funk, Carrie, Federico, James, Umland, John, Piotrowski, Mary, Mitchell, Walter, Zhang, Hui, Zelesky, Veronica, Gobey, Jason, Whalen, Kevin, Liston, Theodore, Troutman, Matthew
Published in Bioanalysis (01.05.2012)
Published in Bioanalysis (01.05.2012)
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Pharmacokinetic-pharmacodynamic modelling of the effect of Moxifloxacin on QTc prolongation in telemetered cynomolgus monkeys
Watson, Kenny J, Gorczyca, William P, Umland, John, Zhang, Ying, Chen, Xian, Sun, Sunny Z, Fermini, Bernard, Holbrook, Mark, Van Der Graaf, Piet H
Published in Journal of pharmacological and toxicological methods (01.05.2011)
Published in Journal of pharmacological and toxicological methods (01.05.2011)
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Pharmacokinetic-pharmacodynamic modelling of the effect of Moxifloxacin on QT sub(c prolongation in telemetered cynomolgus monkeys)
Watson, Kenny J, Gorczyca, William P, Umland, John, Zhang, Ying, Chen, Xian, Sun, Sunny Z, Fermini, Bernard, Holbrook, Mark, Van der Graaf, Piet H
Published in Journal of pharmacological and toxicological methods (01.06.2011)
Published in Journal of pharmacological and toxicological methods (01.06.2011)
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Pharmacokinetic–pharmacodynamic modelling of the effect of Moxifloxacin on QT c prolongation in telemetered cynomolgus monkeys
Watson, Kenny J., Gorczyca, William P., Umland, John, Zhang, Ying, Chen, Xian, Sun, Sunny Z., Fermini, Bernard, Holbrook, Mark, Van Der Graaf, Piet H.
Published in Journal of pharmacological and toxicological methods (2011)
Published in Journal of pharmacological and toxicological methods (2011)
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Discovery of micromolar PDE IV inhibitors that exhibit much reduced affinity for the [ 3H]rolipram binding site: 3-norbornyloxy-4-methoxyphenylmethylene oxindoles
Masamune, Hiroko, Cheng, John B., Cooper, Kelvin, Eggier, James F., Marfat, Anthony, Marshall, Sally C., Shirley, John T., Tickner, Jeanene E., Umland, John P., Vazquez, Enrique
Published in Bioorganic & medicinal chemistry letters (07.09.1995)
Published in Bioorganic & medicinal chemistry letters (07.09.1995)
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Synthesis and in vitro profile of a novel series of catechol benzimidazoles. The discovery of potent, selective phosphodiesterase type IV inhibitors with greatly attenuated affinity for the [ 3H]rolipram binding site
Cheng, John B., Cooper, Kelvin, Duplantier, Allen J., Eggler, James F., Kraus, Kenneth G., Marshall, Sally C., Marfat, Anthony, Masamune, Hiroko, Shirley, John T., Tickner, Jeenene E., Umland, John P.
Published in Bioorganic & medicinal chemistry letters (07.09.1995)
Published in Bioorganic & medicinal chemistry letters (07.09.1995)
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7-Oxo-4,5,6,7-tetrahydro-1 H -pyrazolo[3,4- c ]pyridines as Novel Inhibitors of Human Eosinophil Phosphodiesterase
Duplantier, Allen J., Andresen, Catharine J., Cheng, John B., Cohan, Victoria L., Decker, Christian, DiCapua, Frank M., Kraus, Kenneth G., Johnson, Kerry L., Turner, Claudia R., UmLand, John P., Watson, John W., Wester, Ronald T., Williams, Alison S., Williams, John A.
Published in Journal of medicinal chemistry (01.06.1998)
Published in Journal of medicinal chemistry (01.06.1998)
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