MET-targeting antibody (emibetuzumab) and kinase inhibitor (merestinib) as single agent or in combination in a cancer model bearing MET exon 14 skipping
Yan, S. Betty, Um, Suzane L., Peek, Victoria L., Stephens, Jennifer R., Zeng, Wei, Konicek, Bruce W., Liu, Ling, Manro, Jason R., Wacheck, Volker, Walgren, Richard A.
Published in Investigational new drugs (01.08.2018)
Published in Investigational new drugs (01.08.2018)
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Journal Article
Merestinib (LY2801653) inhibits neurotrophic receptor kinase (NTRK) and suppresses growth of NTRK fusion bearing tumors
Konicek, Bruce W, Capen, Andrew R, Credille, Kelly M, Ebert, Philip J, Falcon, Beverly L, Heady, Gary L, Patel, Bharvin K R, Peek, Victoria L, Stephens, Jennifer R, Stewart, Julie A, Stout, Stephanie L, Timm, David E, Um, Suzane L, Willard, Melinda D, Wulur, Isabella H, Zeng, Yi, Wang, Yong, Walgren, Richard A, Betty Yan, Sau-Chi
Published in Oncotarget (02.03.2018)
Published in Oncotarget (02.03.2018)
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Journal Article
Prognostic and predictive value of circulating tumor cells and CXCR4 expression as biomarkers for a CXCR4 peptide antagonist in combination with carboplatin-etoposide in small cell lung cancer: exploratory analysis of a phase II study
Salgia, Ravi, Weaver, R. Waide, McCleod, Michael, Stille, John R., Yan, S. Betty, Roberson, Stephanie, Polzer, John, Flynt, Amy, Raddad, Eyas, Peek, Victoria L., Wijayawardana, Sameera R., Um, Suzane L., Gross, Steve, Connelly, Mark C., Morano, Carrie, Repollet, Madeline, Sanders, Renouard, Baeten, Kurt, D’Haese, David, Spigel, David R.
Published in Investigational new drugs (01.06.2017)
Published in Investigational new drugs (01.06.2017)
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Journal Article
Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]
Kinasewitz, Gary T, Yan, S Betty, Basson, Bruce, Comp, Philip, Russell, James A, Cariou, Alain, Um, Suzane L, Utterback, Barbara, Laterre, Pierre-Francois, Dhainaut, Jean-François
Published in Critical care (London, England) (01.04.2004)
Published in Critical care (London, England) (01.04.2004)
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Journal Article
New insights into the protein C pathway: potential implications for the biological activities of drotrecogin alfa (activated)
Macias, William L, Yan, S Betty, Williams, Mark D, Um, Suzane L, Sandusky, George E, Ballard, Darryl W, Planquois, Jean-Michel S
Published in Critical care (London, England) (01.01.2005)
Published in Critical care (London, England) (01.01.2005)
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Journal Article
Circulating endothelial and endothelial progenitor cells in patients with severe sepsis
Schlichting, Douglas E., Waxman, Aaron B., O'Brien, Lee A., Wang, Tiffany, Naum, Chris C., Rubeiz, George J., Um, Suzane L., Williams, Mark, Betty Yan, Sau-Chi
Published in Microvascular research (01.03.2011)
Published in Microvascular research (01.03.2011)
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Journal Article
LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models
Yan, S. Betty, Peek, Victoria L., Ajamie, Rose, Buchanan, Sean G., Graff, Jeremy R., Heidler, Steven A., Hui, Yu-Hua, Huss, Karen L., Konicek, Bruce W., Manro, Jason R., Shih, Chuan, Stewart, Julie A., Stewart, Trent R., Stout, Stephanie L., Uhlik, Mark T., Um, Suzane L., Wang, Yong, Wu, Wenjuan, Yan, Lei, Yang, Wei J., Zhong, Boyu, Walgren, Richard A.
Published in Investigational new drugs (01.08.2013)
Published in Investigational new drugs (01.08.2013)
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Journal Article
Abstract 528: Evaluation of single agent merestinib (LY2801653) or emibetuzumab (LY2875358) and the combination in a xenograft tumor model bearing MET exon 14 skipping
Yan, Sau-Chi Betty, Um, Suzane L., Peek, Victoria L., Stephens, Jennifer R., Zeng, Wei, Konicek, Bruce W., Liu, Ling, Wacheck, Volker, Walgren, Richard A.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract 519: Antitumor activity of MET antibody emibetuzumab (LY2875358) in combination with EGFR inhibitors in erlotinib resistant (ER) xenograft mouse models
Um, Suzane L., Peek, Victoria L., Stephens, Jennifer R., Baker, Jessica A., Cannon, Holly K., Cook, Joel D., Wulur, Isabella H., Agyei, Roger, Chintharlapalli, Sudhakar, Evans, Robert J., Feaver, William J., Huber, Lysiane, Lee, Linda N., Liu, Ling, Ma, Liandong, Novosiadly, Ruslan, Wacheck, Volker, Yan, Sau-Chi Betty
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Abstract 2647: Merestinib (LY2801653), targeting several oncokinases including NTRK1/2/3, shows potent anti-tumor effect in colorectal cell line- and patient-derived xenograft (PDX) model bearing TPM3-NTRK1 fusion
Konicek, Bruce W., Bray, Steve M., Capen, Andrew R., Calley, John N., Credille, Kelly M., Ebert, Philip J., Heady, Gary, Patel, Bharvin K., Peek, Victoria L., Stephens, Jennifer R., Um, Suzane L., Willard, Melinda D., Wulur, Isabella H., Zeng, Yi, Walgren, Richard A., Yan, Sau-Chi Betty
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
CXCR4 expression and circulating tumor cell (CTC) counts evaluated as prognostic markers in extensive disease small cell lung cancer (ED-SCLC) patients (pts)
Stille, John R, Flynt, Amy, Peek, Victoria L, Gross, Steven, Keij, Jan, Connelly, Mark Carle, Baeten, Kurt, Hamid, Oday, Morano, Carrie, Raddad, Eyas, Repollet, Madeline Ivette, Roberson, Stephanie, Sanders, Renouard, Um, Suzane L., Wijayawardana, Sameera R., Yan, S. Betty
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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Journal Article
Abstract 3042: LY2801653: An orally bioavailable MET kinase inhibitor with inhibitory activity against the oncoproteins ROS1 and MKNK1/2
Yan, Sau-Chi B., Thobe, Megan N., Konicek, Bruce W., Peek, Victoria L., Um, Suzane L., Walgren, Richard A., Pei, Huaxing, Burkholder, Timothy P., Graff, Jeremy R.
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Journal Article
Abstract 4403: Preclinical evaluation of LY2801653, an orally bioavailable small molecule oncokinase inhibitor, in cholangiocarcinoma models
Yan, Sau-Chi Betty, Um, Suzane L., Peek, Victoria L., Thobe, Megan N., Credille, Kelly M., Stephens, Jennifer R., Manro, Jason R., Ballard, Darryl W., Baker, Jessica A., Cook, Joel D., Konicek, Bruce W., Graff, Jeremy R., Holzer, Timothy R., Walgren, Richard A.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Abstract A47: Circulating tumor cell (CTC) assay development for detection of phosphohistone H3 (pHH3) as a clinical pharmacodynamic (PD) marker for LY2523355, an Eg5 kinesin inhibitor
Um, Suzane L., Yan, S. Betty, Peek, Victoria L., Yan, Lei, Ye, Xiang S., Westin, Eric H.
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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Journal Article
Abstract 1776: Antitumor activity of Chk1 inhibitor LY2606368 as a single agent in SW1990 human pancreas orthotopic tumor model
Wu, Wenjuan, Bi, Chen, Bence, Aimee K., Um, Suzane L., Yan, Betty, Starling, James J., Marshall, Mark S., Beckmann, Richard P.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Abstract 2087: Detection of KRAS mutations in circulating tumor cells (CTCs) and in formalin-fixed, paraffin-embedded (FFPE) tissue using castPCR method
Thobe, Megan N., Um, Suzane L., Peek, Victoria L., Ballard, Darryl W., Konicek, Bruce W., Credille, Kelly M., Ebert, Philip J., Donoho, Gregory P., Yan, S. Betty
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2
Kramer, R M, Roberts, E F, Um, S L, Börsch-Haubold, A G, Watson, S P, Fisher, M J, Jakubowski, J A
Published in The Journal of biological chemistry (01.11.1996)
Published in The Journal of biological chemistry (01.11.1996)
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Abstract 2339: Prevalence of MET expression, activating mutations of KRAS and IDH1/2, and ROS1 fusions in cholangiocarcinoma patient tumor samples
Thobe, Megan N., Yan, S. Betty, Credille, Kelly M., Nasir, Aejaz, Roseberry Baker, Jessica A., Lajiness, Mary, Brooks, Nathan A., Ballard, Darryl W., Farley, Donna M., Peek, Victoria L., Um, Suzane L., Jin, G. Jason, Gilmour, Raymond, Reinhard, Christoph, Graff, Jeremy R., Schade, Andrew E., Gruver, Aaron M., Colligan, Bruce, Douglass, Larry, Carter, Julia, Walgren, Richard A.
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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