What We Learned in 25 Years of Interactive Molecular Design Sessions
Kuhn, Bernd, Haap, Wolfgang, Obst‐Sander, Ulrike, Kramer, Christian, Stahl, Martin
Published in ChemMedChem (16.09.2021)
Published in ChemMedChem (16.09.2021)
Get full text
Journal Article
Fluorine in Medicinal Chemistry
Böhm, Hans-Joachim, Banner, David, Bendels, Stefanie, Kansy, Manfred, Kuhn, Bernd, Müller, Klaus, Obst-Sander, Ulrike, Stahl, Martin
Published in Chembiochem : a European journal of chemical biology (03.05.2004)
Published in Chembiochem : a European journal of chemical biology (03.05.2004)
Get full text
Journal Article
A Fluorine Scan of Thrombin Inhibitors to Map the Fluorophilicity/Fluorophobicity of an Enzyme Active Site: Evidence for CF⋅⋅⋅CO Interactions
Olsen, Jacob A., Banner, David W., Seiler, Paul, Obst Sander, Ulrike, D'Arcy, Allan, Stihle, Martine, Müller, Klaus, Diederich, François
Published in Angewandte Chemie (International ed.) (06.06.2003)
Published in Angewandte Chemie (International ed.) (06.06.2003)
Get full text
Journal Article
2-Phenoxy-nicotinamides are Potent Agonists at the Bile Acid Receptor GPBAR1 (TGR5)
Martin, Rainer E., Bissantz, Caterina, Gavelle, Olivier, Kuratli, Christoph, Dehmlow, Henrietta, Richter, Hans G. F., Obst Sander, Ulrike, Erickson, Shawn D., Kim, Kyungjin, Pietranico-Cole, Sherrie Lynn, Alvarez-Sánchez, Rubén, Ullmer, Christoph
Published in ChemMedChem (01.04.2013)
Published in ChemMedChem (01.04.2013)
Get full text
Journal Article
A Fluorine Scan at the Catalytic Center of Thrombin: CF, COH, and COMe Bioisosterism and Fluorine Effects on pKa and log D Values
Schweizer, Eliane, Hoffmann-Röder, Anja, Schärer, Kaspar, Olsen, Jacob A., Fäh, Christoph, Seiler, Paul, Obst-Sander, Ulrike, Wagner, Björn, Kansy, Manfred, Diederich, François
Published in ChemMedChem (01.06.2006)
Published in ChemMedChem (01.06.2006)
Get full text
Journal Article
Quantification of Cation-π Interactions in Protein-Ligand Complexes: Crystal-Structure Analysis of Factor Xa Bound to a Quaternary Ammonium Ion Ligand
Schärer, Kaspar, Morgenthaler, Martin, Paulini, Ralph, Obst-Sander, Ulrike, Banner, David W., Schlatter, Daniel, Benz, Jörg, Stihle, Martine, Diederich, François
Published in Angewandte Chemie (International ed.) (11.07.2005)
Published in Angewandte Chemie (International ed.) (11.07.2005)
Get full text
Journal Article
Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists
Dehmlow, Henrietta, Alvarez Sánchez, Rubén, Bachmann, Stephan, Bissantz, Caterina, Bliss, Fritz, Conde-Knape, Karin, Graf, Martin, Martin, Rainer E., Obst Sander, Ulrike, Raab, Susanne, Richter, Hans G.F., Sewing, Sabine, Sprecher, Urs, Ullmer, Christoph, Mattei, Patrizio
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
Get full text
Journal Article
Fluorine Interactions at the Thrombin Active Site: Protein Backbone Fragments HCαCO Comprise a Favorable CF Environment and Interactions of CF with Electrophiles
Olsen, Jacob A, Banner, David W, Seiler, Paul, Wagner, Björn, Tschopp, Thomas, Obst-Sander, Ulrike, Kansy, Manfred, Müller, Klaus, Diederich, François
Published in Chembiochem : a European journal of chemical biology (03.05.2004)
Published in Chembiochem : a European journal of chemical biology (03.05.2004)
Get full text
Journal Article
Dose-dependent antithrombotic activity of an orally active tissue factor/factor VIIa inhibitor without concomitant enhancement of bleeding propensity
Zbinden, Katrin Groebke, Banner, David W., Hilpert, Kurt, Himber, Jacques, Lavé, Thierry, Riederer, Markus A., Stahl, Martin, Tschopp, Thomas B., Obst-Sander, Ulrike
Published in Bioorganic & medicinal chemistry (01.08.2006)
Published in Bioorganic & medicinal chemistry (01.08.2006)
Get full text
Journal Article
Mapping the Fluorophilicity of a Hydrophobic Pocket: Synthesis and Biological Evaluation of Tricyclic Thrombin Inhibitors Directing Fluorinated Alkyl Groups into the P Pocket
Hoffmann-Röder, Anja, Schweizer, Eliane, Egger, Jonas, Seiler, Paul, Obst-Sander, Ulrike, Wagner, Björn, Kansy, Manfred, Banner, David W., Diederich, François
Published in ChemMedChem (01.11.2006)
Published in ChemMedChem (01.11.2006)
Get full text
Journal Article
Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors
Zbinden, Katrin Groebke, Obst-Sander, Ulrike, Hilpert, Kurt, Kühne, Holger, Banner, David W., Böhm, Hans-Joachim, Stahl, Martin, Ackermann, Jean, Alig, Leo, Weber, Lutz, Wessel, Hans Peter, Riederer, Markus A., Tschopp, Thomas B., Lavé, Thierry
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
Get full text
Journal Article
Enantiomerically Pure Thrombin Inhibitors for Exploring the Molecular-Recognition Features of the Oxyanion Hole
Schärer, Kaspar, Morgenthaler, Martin, Seiler, Paul, Diederich, François, Banner, David W., Tschopp, Thomas, Obst-Sander, Ulrike
Published in Helvetica chimica acta (01.10.2004)
Published in Helvetica chimica acta (01.10.2004)
Get full text
Journal Article
Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib
Obst-Sander, Ulrike, Ricci, Antonio, Kuhn, Bernd, Friess, Thomas, Koldewey, Philipp, Kuglstatter, Andreas, Hewings, David, Goergler, Annick, Steiner, Sandra, Rueher, Daniel, Imhoff, Marie-Paule, Raschetti, Noemi, Marty, Hans-Peter, Dietzig, Aline, Rynn, Caroline, Ehler, Andreas, Burger, Dominique, Kornacker, Martin, Schaffland, Jeannine Petrig, Herting, Frank, Pao, William, Bischoff, James R., Martoglio, Bruno, Alice Nagel, Yvonne, Jaeschke, Georg
Published in Journal of medicinal chemistry (13.10.2022)
Published in Journal of medicinal chemistry (13.10.2022)
Get full text
Journal Article
Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors
Kühne, Holger, Obst-Sander, Ulrike, Kuhn, Bernd, Conte, Aurelia, Ceccarelli, Simona M., Neidhart, Werner, Rudolph, Markus G., Ottaviani, Giorgio, Gasser, Rodolfo, So, Sung-Sau, Li, Shirley, Zhang, Xiaolei, Gao, Lin, Myers, Michael
Published in Bioorganic & medicinal chemistry letters (15.10.2016)
Published in Bioorganic & medicinal chemistry letters (15.10.2016)
Get full text
Journal Article
A Fluorine Scan of Thrombin Inhibitors to Map the Fluorophilicity/Fluorophobicity of an Enzyme Active Site: Evidence for CF⋅⋅⋅CO Interactions
Olsen, Jacob A., Banner, David W., Seiler, Paul, Obst Sander, Ulrike, D'Arcy, Allan, Stihle, Martine, Müller, Klaus, Diederich, François
Published in Angewandte Chemie (06.06.2003)
Published in Angewandte Chemie (06.06.2003)
Get full text
Journal Article
A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...CN interactions
Olsen, Jacob, Seiler, Paul, Wagner, Björn, Fischer, Holger, Tschopp, Thomas, Obst-Sander, Ulrike, Banner, David W, Kansy, Manfred, Müller, Klaus, Diederich, François
Published in Organic & biomolecular chemistry (07.05.2004)
Published in Organic & biomolecular chemistry (07.05.2004)
Get full text
Journal Article
Quantifizierung von Kation-π-Wechselwirkungen in Protein-Ligand-Komplexen: Kristallstrukturanalyse eines Komplexes von Faktor Xa und einem quartären Ammonium-Ion-Liganden
Schärer, Kaspar, Morgenthaler, Martin, Paulini, Ralph, Obst-Sander, Ulrike, Banner, David W., Schlatter, Daniel, Benz, Jörg, Stihle, Martine, Diederich, François
Published in Angewandte Chemie (11.07.2005)
Published in Angewandte Chemie (11.07.2005)
Get full text
Journal Article
Enantiomerically Pure Thrombin Inhibitors for Exploring the Molecular-Recognition Features of the Oxyanion Hole
Schaerer, Kaspar, Morgenthaler, Martin, Seiler, Paul, Diederich, Francois, Banner, David W., Tschopp, Thomas, Obst-Sander, Ulrike
Published in ChemInform (15.02.2005)
Published in ChemInform (15.02.2005)
Get full text
Journal Article
Cover Picture: 2-Phenoxy-nicotinamides are Potent Agonists at the Bile Acid Receptor GPBAR1 (TGR5) (ChemMedChem 4/2013)
Martin, Rainer E., Bissantz, Caterina, Gavelle, Olivier, Kuratli, Christoph, Dehmlow, Henrietta, Richter, Hans G. F., Obst Sander, Ulrike, Erickson, Shawn D., Kim, Kyungjin, Pietranico-Cole, Sherrie Lynn, Alvarez-Sánchez, Rubén, Ullmer, Christoph
Published in ChemMedChem (01.04.2013)
Published in ChemMedChem (01.04.2013)
Get full text
Journal Article
Multipolar interactions in the D pocket of thrombin: large differences between tricyclic imide and lactam inhibitors
Schweizer, Eliane, Hoffmann-Roeder, Anja, Olsen, Jacob A., Seiler, Paul, Obst-Sander, Ulrike, Wagner, Bjorn, Kansy, Manfred, Banner, David W., Diederich, Francois
Published in Organic & biomolecular chemistry (01.01.2006)
Published in Organic & biomolecular chemistry (01.01.2006)
Get more information
Journal Article