Rapamycin-inspired macrocycles with new target specificity
Guo, Zufeng, Hong, Sam Y., Wang, Jingxin, Rehan, Shahid, Liu, Wukun, Peng, Hanjing, Das, Manisha, Li, Wei, Bhat, Shridhar, Peiffer, Brandon, Ullman, Brett R., Tse, Chung-Ming, Tarmakova, Zlatina, Schiene-Fischer, Cordelia, Fischer, Gunter, Coe, Imogen, Paavilainen, Ville O., Sun, Zhaoli, Liu, Jun O.
Published in Nature chemistry (01.03.2019)
Published in Nature chemistry (01.03.2019)
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Influence of stereochemistry on the activity of rapadocin, an isoform-specific inhibitor of the nucleoside transporter ENT1
Wang, Yuefan, Peng, Hanjing, Guo, Zufeng, Ullman, Brett R, Yamamoto, Kana, Hong, Sam Y, Liu, Jun O
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Published in Chemical science (Cambridge) (01.09.2021)
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Design of a new series of potent and selective beta-3 adrenergic receptor (β3-AdrR) antagonists for the treatment of acute decompensated heart failure
Tran, Thuy-Anh, Kramer, Bryan, Shin, Young-Jun, Do, Quyen-Quyen, Ullman, Brett, Sagi, Vasudeva, Adams, John W., Shi, Yunqing, Shu, Hsin-Hui, Unett, David J., Gatlin, Joel, Morgan, Michael E., Reuter, Jaimie, Blackburn, Anthony, Sage, Carleton R., Semple, Graeme
Published in Results in Chemistry (01.01.2022)
Published in Results in Chemistry (01.01.2022)
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First-in-Class Pan Caspase Inhibitor Developed for the Treatment of Liver Disease
Linton, Steven D, Aja, Teresa, Armstrong, Robert A, Bai, Xu, Chen, Long-Shiuh, Chen, Ning, Ching, Brett, Contreras, Patricia, Diaz, Jose-Luis, Fisher, Craig D, Fritz, Lawrence C, Gladstone, Patricia, Groessl, Todd, Gu, Xin, Herrmann, Julia, Hirakawa, Brad P, Hoglen, Niel C, Jahangiri, Kathy G, Kalish, Vincent J, Karanewsky, Donald S, Kodandapani, Lalitha, Krebs, Joseph, McQuiston, Jeff, Meduna, Steven P, Nalley, Kip, Robinson, Edward D, Sayers, Robert O, Sebring, Kristen, Spada, Alfred P, Ternansky, Robert J, Tomaselli, Kevin J, Ullman, Brett R, Valentino, Karen L, Weeks, Suzanne, Winn, David, Wu, Joe C, Yeo, Pauline, Zhang, Cheng-zhi
Published in Journal of medicinal chemistry (03.11.2005)
Published in Journal of medicinal chemistry (03.11.2005)
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Structure–activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads
Ullman, Brett R., Aja, Teresa, Chen, Ning, Diaz, Jose-Luis, Gu, Xin, Herrmann, Julia, Kalish, Vincent J., Karanewsky, Donald S., Kodandapani, Lalitha, Krebs, Joseph J., Linton, Steven D., Meduna, Steven P., Nalley, Kip, Robinson, Edward D., Roggo, Silvio P., Sayers, Robert O., Schmitz, Albert, Ternansky, Robert J., Tomaselli, Kevin J., Wu, Joe C.
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
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Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke
Linton, Steven D., Aja, Teresa, Allegrini, Peter R., Deckwerth, Thomas L., Diaz, Jose-Luis, Hengerer, Bastian, Herrmann, Julia, Jahangiri, Kathy G., Kallen, Joerg, Karanewsky, Donald S., Meduna, Steven P., Nalley, Kip, Robinson, Edward D., Roggo, Silvio, Rovelli, Giorgio, Sauter, Andre, Sayers, Robert O., Schmitz, Albert, Smidt, Robert, Ternansky, Robert J., Tomaselli, Kevin J., Ullman, Brett R., Wiessner, Christoph, Wu, Joe C.
Published in Bioorganic & medicinal chemistry letters (17.05.2004)
Published in Bioorganic & medicinal chemistry letters (17.05.2004)
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Journal Article
Structure-activity relationships within a series of caspase inhibitors: Effect of leaving group modifications
ULLMAN, Brett R, AJA, Teresa, ROGGO, Silvio P, SAYERS, Robert O, SCHMITZ, Albert, TERNANSKY, Robert J, TOMASELLI, Kevin J, WU, Joe C, DECKWERTH, Thomas L, DIAZ, Jose-Luis, HERRMANN, Julia, KALISH, Vincent J, KARANEWSKY, Donald S, MEDUNA, Steven P, NALLEY, Kip, ROBINSON, Edward D
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
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A New Bromo Trienyne: Synthesis of all-E, Conjugated Tetra-, Penta-, and Hexaenes Common to Oxo Polyene Macrolide Antibiotics
Lipshutz, Bruce H, Ullman, Brett, Lindsley, Craig, Pecchi, Sabina, Buzard, D. J, Dickson, David
Published in Journal of organic chemistry (04.09.1998)
Published in Journal of organic chemistry (04.09.1998)
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Acyl dipeptides as reversible caspase inhibitors. Part 2: Further optimization
LINTON, Steven D, KARANEWSKY, Donald S, WU, Joe C, PHAM, Brian, KODANDAPANI, Lalitha, SMIDT, Robert, DIAZ, Jose-Luis, FRITZ, Lawrence C, VON KROSIGK, U, ROGGO, Silvio, SCHMITZ, Albert, TOMASELLI, Kevin J, TERNANSKY, Robert J, NING CHEN, GUO, Xian, JAHANGIRI, Kathy G, KALISH, Vincent J, MEDUNA, Steven P, ROBINSON, Edward D, ULLMAN, Brett R
Published in Bioorganic & medicinal chemistry letters (21.10.2002)
Published in Bioorganic & medicinal chemistry letters (21.10.2002)
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라파푸신 유도체 화합물 및 이의 사용 방법
SCHMITT JENNIFER C, YAMAMOTO KANA, KUMAR PUNEET, LIU JUN, HONG SAM, ULLMAN BRETT R, SEMPLE JOSEPH E, SADAGOPAN MAGESH
Year of Publication 21.06.2022
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Year of Publication 21.06.2022
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MOODY JEANNE V, ZHU XIUWEN, JONES ROBERT M, HAN SANGDON, KIM SUN HEE, ULLMAN BRETT, BUZARD DANIEL J, LEHMANN JUERG, STIRN SCOTT
Year of Publication 21.06.2022
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Year of Publication 21.06.2022
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Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate‑1 Receptor
Buzard, Daniel J, Kim, Sun Hee, Lopez, Luis, Kawasaki, Andrew, Zhu, Xiuwen, Moody, Jeanne, Thoresen, Lars, Calderon, Imelda, Ullman, Brett, Han, Sangdon, Lehmann, Juerg, Gharbaoui, Tawfik, Sengupta, Dipanjan, Calvano, Lorene, Montalban, Antonio Garrido, Ma, You-An, Sage, Carleton, Gao, Yinghong, Semple, Graeme, Edwards, Jeff, Barden, Jeremy, Morgan, Michael, Chen, Weichao, Usmani, Khawja, Chen, Chuan, Sadeque, Abu, Christopher, Ronald J, Thatte, Jayant, Fu, Lixia, Solomon, Michelle, Mills, David, Whelan, Kevin, Al-Shamma, Hussien, Gatlin, Joel, Le, Minh, Gaidarov, Ibragim, Anthony, Todd, Unett, David J, Blackburn, Anthony, Rueter, Jaimie, Stirn, Scott, Behan, Dominic P, Jones, Robert M
Published in ACS medicinal chemistry letters (11.12.2014)
Published in ACS medicinal chemistry letters (11.12.2014)
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MOODY JEANNE V, ZHU XIUWEN, JONES ROBERT M, HAN SANGDON, KIM SUN HEE, ULLMAN BRETT, BUZARD DANIEL J, LEHMANN JUERG, STIRN SCOTT
Year of Publication 11.08.2021
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Year of Publication 11.08.2021
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1234-[]-3- SUBSTITUTED 1234- TETRAHYDROCYCLOPENTA[]INDOL-3-YL ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
MOODY JEANNE V, ZHU XIUWEN, JONES ROBERT M, HAN SANGDON, KIM SUN HEE, ULLMAN BRETT, BUZARD DANIEL J, LEHMANN JUERG, STIRN SCOTT
Year of Publication 13.10.2020
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Year of Publication 13.10.2020
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MOODY JEANNE V, ZHU XIUWEN, JONES ROBERT M, HAN SANGDON, KIM SUN HEE, ULLMAN BRETT, BUZARD DANIEL J, LEHMANN JUERG, STIRN SCOTT
Year of Publication 27.11.2019
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Year of Publication 27.11.2019
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1234-[]-3- SUBSTITUTED 1234- TETRAHYDROCYCLOPENTA[]INDOL-3-YL ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS
MOODY JEANNE V, ZHU XIUWEN, JONES ROBERT M, HAN SANGDON, KIM SUN HEE, ULLMAN BRETT, BUZARD DANIEL J, LEHMANN JUERG, STIRN SCOTT
Year of Publication 14.01.2019
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Year of Publication 14.01.2019
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Identification of fused bicyclic heterocycles as potent and selective 5-HT2A receptor antagonists for the treatment of insomnia
Xiong, Yifeng, Ullman, Brett, Choi, Jin-Sun Karoline, Cherrier, Martin, Strah-Pleynet, Sonja, Decaire, Marc, Feichtinger, Konrad, Frazer, John M., Yoon, Woo H., Whelan, Kevin, Sanabria, Erin K., Grottick, Andrew J., Al-Shamma, Hussien, Semple, Graeme
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
Published in Bioorganic & medicinal chemistry letters (01.03.2012)
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MOODY JEANNE V, ZHU XIUWEN, JONES ROBERT M, HAN SANGDON, KIM SUN HEE, ULLMAN BRETT, BUZARD DANIEL J, LEHMANN JUERG, STIRN SCOTT
Year of Publication 06.03.2018
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Year of Publication 06.03.2018
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Discovery and Structure-Activity Relationship of 3-Methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): A Highly Selective 5-Hydroxytryptamine(2A) Receptor Inverse Agonist for the Treatment of Arterial Thrombosis
Xiong, Yifeng, Teegarden, Bradley R., Choi, Jin-Sun Karoline, Strah-Pleynet, Sonja, Decaire, Marc, Jayakumar, Honnappa, Dosa, Peter I., Casper, Martin D., Pham, Lan, Feichtinger, Konrad, Ullman, Brett, Adams, John, Yuskin, Diane, Frazer, John, Morgan, Michael, Sadeque, Abu, Chen, Weichao, Webb, Robert R., Connolly, Daniel T., Semple, Graeme, Al-Shamma, Hussien
Published in Journal of medicinal chemistry (10.06.2010)
Published in Journal of medicinal chemistry (10.06.2010)
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