In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)
Ohoka, Nobumichi, Okuhira, Keiichiro, Ito, Masahiro, Nagai, Katsunori, Shibata, Norihito, Hattori, Takayuki, Ujikawa, Osamu, Shimokawa, Kenichiro, Sano, Osamu, Koyama, Ryokichi, Fujita, Hisashi, Teratani, Mika, Matsumoto, Hirokazu, Imaeda, Yasuhiro, Nara, Hiroshi, Cho, Nobuo, Naito, Mikihiko
Published in The Journal of biological chemistry (17.03.2017)
Published in The Journal of biological chemistry (17.03.2017)
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Journal Article
Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER)
Ohoka, Nobumichi, Ujikawa, Osamu, Shimokawa, Kenichiro, Sameshima, Tomoya, Shibata, Norihito, Hattori, Takayuki, Nara, Hiroshi, Cho, Nobuo, Naito, Mikihiko
Published in Chemical & pharmaceutical bulletin (01.03.2019)
Published in Chemical & pharmaceutical bulletin (01.03.2019)
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Journal Article
Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation
Shimokawa, Kenichiro, Shibata, Norihito, Sameshima, Tomoya, Miyamoto, Naoki, Ujikawa, Osamu, Nara, Hiroshi, Ohoka, Nobumichi, Hattori, Takayuki, Cho, Nobuo, Naito, Mikihiko
Published in ACS medicinal chemistry letters (12.10.2017)
Published in ACS medicinal chemistry letters (12.10.2017)
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Journal Article
Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase
Shibata, Norihito, Shimokawa, Kenichiro, Nagai, Katsunori, Ohoka, Nobumichi, Hattori, Takayuki, Miyamoto, Naoki, Ujikawa, Osamu, Sameshima, Tomoya, Nara, Hiroshi, Cho, Nobuo, Naito, Mikihiko
Published in Scientific reports (10.09.2018)
Published in Scientific reports (10.09.2018)
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Journal Article
Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders
Mikami, Satoshi, Sasaki, Shigekazu, Asano, Yasutomi, Ujikawa, Osamu, Fukumoto, Shoji, Nakashima, Kosuke, Oki, Hideyuki, Kamiguchi, Naomi, Imada, Haruka, Iwashita, Hiroki, Taniguchi, Takahiko
Published in Journal of medicinal chemistry (28.09.2017)
Published in Journal of medicinal chemistry (28.09.2017)
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Journal Article
Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands
Shibata, Norihito, Nagai, Katsunori, Morita, Yoko, Ujikawa, Osamu, Ohoka, Nobumichi, Hattori, Takayuki, Koyama, Ryokichi, Sano, Osamu, Imaeda, Yasuhiro, Nara, Hiroshi, Cho, Nobuo, Naito, Mikihiko
Published in Journal of medicinal chemistry (25.01.2018)
Published in Journal of medicinal chemistry (25.01.2018)
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Journal Article
Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-dependent Protein Eraser (SNIPER)
Ohoka, Nobumichi, Ujikawa, Osamu, Shimokawa, Kenichiro, Sameshima, Tomoya, Shibata, Norihito, Hattori, Takayuki, Nara, Hiroshi, Cho, Nobuo, Naito, Mikihiko
Published in Chemical and Pharmaceutical Bulletin (2018)
Published in Chemical and Pharmaceutical Bulletin (2018)
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Journal Article
Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation
Ohoka, Nobumichi, Morita, Yoko, Nagai, Katsunori, Shimokawa, Kenichiro, Ujikawa, Osamu, Fujimori, Ikuo, Ito, Masahiro, Hayase, Youji, Okuhira, Keiichiro, Shibata, Norihito, Hattori, Takayuki, Sameshima, Tomoya, Sano, Osamu, Koyama, Ryokichi, Imaeda, Yasuhiro, Nara, Hiroshi, Cho, Nobuo, Naito, Mikihiko
Published in The Journal of biological chemistry (04.05.2018)
Published in The Journal of biological chemistry (04.05.2018)
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Journal Article
A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: Design and synthesis of benzylpyrazole acylsulfonamides
Rikimaru, Kentaro, Wakabayashi, Takeshi, Abe, Hidenori, Imoto, Hiroshi, Maekawa, Tsuyoshi, Ujikawa, Osamu, Murase, Katsuhito, Matsuo, Takanori, Matsumoto, Mitsuharu, Nomura, Chisako, Tsuge, Hiroko, Arimura, Naoto, Kawakami, Kazutoshi, Sakamoto, Junichi, Funami, Miyuki, Mol, Clifford D., Snell, Gyorgy P., Bragstad, Kenneth A., Sang, Bi-Ching, Dougan, Douglas R., Tanaka, Toshimasa, Katayama, Nozomi, Horiguchi, Yoshiaki, Momose, Yu
Published in Bioorganic & medicinal chemistry (15.01.2012)
Published in Bioorganic & medicinal chemistry (15.01.2012)
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Journal Article
In Vivo Knockdown of Pathogenic Proteins via S pecific and N ongenetic I nhibitor of Apoptosis Protein (IAP)-dependent P rotein Er asers (SNIPERs)
Ohoka, Nobumichi, Okuhira, Keiichiro, Ito, Masahiro, Nagai, Katsunori, Shibata, Norihito, Hattori, Takayuki, Ujikawa, Osamu, Shimokawa, Kenichiro, Sano, Osamu, Koyama, Ryokichi, Fujita, Hisashi, Teratani, Mika, Matsumoto, Hirokazu, Imaeda, Yasuhiro, Nara, Hiroshi, Cho, Nobuo, Naito, Mikihiko
Published in The Journal of biological chemistry (17.03.2017)
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Published in The Journal of biological chemistry (17.03.2017)
Journal Article
HETEROCYCLIC COMPOUND
MAEZAKI Hironobu, CHO Nobuo, ITO Masahiro, MORISHITA Nao, NAGAI Katsunori, UJIKAWA Osamu, OKUHIRA Keiichiro, MORITA Yoko, HOMMA Misaki, NARA Hiroshi, FUJIMORI Ikuo, OHOKA Nobumichi, SHIMOKAWA Kenichiro, SHIBATA Norihito, NAITO Mikihiko, MIYAMOTO Naoki
Year of Publication 12.04.2018
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Year of Publication 12.04.2018
Patent
A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) γ agonists: Design and synthesis of benzylpyrazole acylsulfonamides: Symposium-in-Print: Chemical Proteomics
RIKIMARU, Kentaro, WAKABAYASHI, Takeshi, TSUGE, Hiroko, ARIMURA, Naoto, KAWAKAMI, Kazutoshi, SAKAMOTO, Junichi, FUNAMI, Miyuki, MOL, Clifford D, SNELL, Gyorgy P, BRAGSTAD, Kenneth A, SANG, Bi-Ching, DOUGAN, Douglas R, ABE, Hidenori, TANAKA, Toshimasa, KATAYAMA, Nozomi, HORIGUCHI, Yoshiaki, MOMOSE, Yu, IMOTO, Hiroshi, MAEKAWA, Tsuyoshi, UJIKAWA, Osamu, MURASE, Katsuhito, MATSUO, Takanori, MATSUMOTO, Mitsuharu, NOMURA, Chisako
Published in Bioorganic & medicinal chemistry (2012)
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Published in Bioorganic & medicinal chemistry (2012)
Journal Article
HETEROCYCLIC COMPOUND AND USE THEREOF
MOCHIZUKI MICHIYO, UJIKAWA OSAMU, KORI MASAKUNI, ASANO YASUTOMI, NAKAMURA SHINJI, HONDA EIJI, IMAEDA TOSHIHIRO, TOYOFUKU MASASHI
Year of Publication 19.12.2013
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Year of Publication 19.12.2013
Patent
HETEROCYCLIC COMPOUND AND USE THEREOF
ASANO, Yasutomi, IMAEDA, Toshihiro, UJIKAWA, Osamu, NAKAMURA, Shinji, KORI, Masakuni, TOYOFUKU, Masashi, HONDA, Eiji, MOCHIZUKI, Michiyo
Year of Publication 31.10.2024
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Year of Publication 31.10.2024
Patent