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Uitdehaag, Joost C M, de Roos, Jeroen A D M, van Doornmalen, Antoon M, Prinsen, Martine B W, de Man, Jos, Tanizawa, Yoshinori, Kawase, Yusuke, Yoshino, Kohichiro, Buijsman, Rogier C, Zaman, Guido J R
Published in PloS one (20.03.2014)
Published in PloS one (20.03.2014)
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A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets
Uitdehaag, Joost CM, Verkaar, Folkert, Alwan, Husam, de Man, Jos, Buijsman, Rogier C, Zaman, Guido JR
Published in British journal of pharmacology (01.06.2012)
Published in British journal of pharmacology (01.06.2012)
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Selective Targeting of CTNBB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs
Uitdehaag, Joost C M, de Roos, Jeroen A D M, van Doornmalen, Antoon M, Prinsen, Martine B W, Spijkers-Hagelstein, Jill A P, de Vetter, Judith R F, de Man, Jos, Buijsman, Rogier C, Zaman, Guido J R
Published in PloS one (27.05.2015)
Published in PloS one (27.05.2015)
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Trifluoromethylphenyl as P2 for ketoamide-based cathepsin S inhibitors
Cai, Jiaqiang, Robinson, John, Belshaw, Simone, Everett, Kathryn, Fradera, Xavier, van Zeeland, Mario, van Berkom, Leon, van Rijnsbergen, Peter, Popplestone, Lucy, Baugh, Mark, Dempster, Maureen, Bruin, John, Hamilton, William, Kinghorn, Emma, Westwood, Paul, Kerr, Jennifer, Rankovic, Zoran, Arbuckle, Wullie, Bennett, D. Jonathan, Jones, Philip S., Long, Clive, Martin, Iain, Uitdehaag, Joost C.M., Meulemans, Tommi
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
Published in Bioorganic & medicinal chemistry letters (01.12.2010)
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4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important
Cai, Jiaqiang, Fradera, Xavier, van Zeeland, Mario, Dempster, Maureen, Cameron, Kenneth S., Bennett, D. Jonathan, Robinson, John, Popplestone, Lucy, Baugh, Mark, Westwood, Paul, Bruin, John, Hamilton, William, Kinghorn, Emma, Long, Clive, Uitdehaag, Joost C.M.
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Pharmacological validation of TDO as a target for Parkinson’s disease
Perez‐Pardo, Paula, Grobben, Yvonne, Willemsen‐Seegers, Nicole, Hartog, Mitch, Tutone, Michaela, Muller, Michelle, Adolfs, Youri, Pasterkamp, Ronald Jeroen, Vu‐Pham, Diep, Doornmalen, Antoon M., Cauter, Freek, Wit, Joeri, Gerard Sterrenburg, Jan, Uitdehaag, Joost C.M., Man, Jos, Buijsman, Rogier C., Zaman, Guido J.R., Kraneveld, Aletta D.
Published in The FEBS journal (01.07.2021)
Published in The FEBS journal (01.07.2021)
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TTK Inhibitors as a Targeted Therapy for CTNNB1 ( β -catenin) Mutant Cancers
Zaman, Guido J R, de Roos, Jeroen A D M, Libouban, Marion A A, Prinsen, Martine B W, de Man, Jos, Buijsman, Rogier C, Uitdehaag, Joost C M
Published in Molecular cancer therapeutics (01.11.2017)
Published in Molecular cancer therapeutics (01.11.2017)
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Targeting Indoleamine 2,3-Dioxygenase in Cancer Models Using the Novel Small Molecule Inhibitor NTRC 3883-0
Grobben, Yvonne, de Man, Jos, van Doornmalen, Antoon M, Muller, Michelle, Willemsen-Seegers, Nicole, Vu-Pham, Diep, Mulder, Winfried R, Prinsen, Martine B W, de Wit, Joeri, Sterrenburg, Jan Gerard, van Cauter, Freek, den Ouden, Judith E, van Altena, Anne M, Massuger, Leon F, Uitdehaag, Joost C M, Buijsman, Rogier C, Zaman, Guido J R
Published in Frontiers in immunology (28.01.2021)
Published in Frontiers in immunology (28.01.2021)
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6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors
Cai, Jiaqiang, Baugh, Mark, Black, Darcey, Long, Clive, Jonathan Bennett, D., Dempster, Maureen, Fradera, Xavier, Gillespie, Jonathan, Andrews, Fiona, Boucharens, Sylviane, Bruin, John, Cameron, Kenneth S., Cumming, Iain, Hamilton, William, Jones, Philip S., Kaptein, Allard, Kinghorn, Emma, Maidment, Maurice, Martin, Iain, Mitchell, Ann, Rankovic, Zoran, Robinson, John, Scullion, Paul, Uitdehaag, Joost C.M., Vink, Paul, Westwood, Paul, van Zeeland, Mario, van Berkom, Leon, Bastiani, Martijn, Meulemans, Tommi
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Comparative kinase and cancer cell panel profiling of kinase inhibitors approved for clinical use from 2018 to 2020
Kooijman, Jeffrey J., van Riel, Wilhelmina E., Dylus, Jelle, Prinsen, Martine B. W., Grobben, Yvonne, de Bitter, Tessa J. J., van Doornmalen, Antoon M., Melis, Janneke J. T. M., Uitdehaag, Joost C. M., Narumi, Yugo, Kawase, Yusuke, de Roos, Jeroen A. D. M., Willemsen-Seegers, Nicole, Zaman, Guido J. R.
Published in Frontiers in oncology (14.09.2022)
Published in Frontiers in oncology (14.09.2022)
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2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors
Cai, Jiaqiang, Bennett, D. Jonathan, Rankovic, Zoran, Dempster, Maureen, Fradera, Xavier, Gillespie, Jonathan, Cumming, Iain, Finlay, William, Baugh, Mark, Boucharens, Sylviane, Bruin, John, Cameron, Kenneth S., Hamilton, William, Kerr, Jennifer, Kinghorn, Emma, McGarry, George, Robinson, John, Scullion, Paul, Uitdehaag, Joost C.M., van Zeeland, Mario, Potin, Dominique, Saniere, Laurent, Fouquet, Andre, Chevallier, Francois, Deronzier, Hortense, Dorleans, Cecile, Nicolai, Eric
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Properties and applications of starch-converting enzymes of the α-amylase family
van der Maarel, Marc J.E.C, van der Veen, Bart, Uitdehaag, Joost C.M, Leemhuis, Hans, Dijkhuizen, L
Published in Journal of Biotechnology (28.03.2002)
Published in Journal of Biotechnology (28.03.2002)
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Book Review
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Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin K: Improving selectivity over hERG
Rankovic, Zoran, Cai, Jiaqiang, Kerr, Jennifer, Fradera, Xavier, Robinson, John, Mistry, Ashvin, Finlay, William, McGarry, George, Andrews, Fiona, Caulfield, Wilson, Cumming, Iain, Dempster, Maureen, Waller, John, Arbuckle, Wullie, Anderson, Mark, Martin, Iain, Mitchell, Ann, Long, Clive, Baugh, Mark, Westwood, Paul, Kinghorn, Emma, Jones, Phil, Uitdehaag, Joost C.M., van Zeeland, Mario, Potin, Dominique, Saniere, Laurent, Fouquet, Andre, Chevallier, François, Deronzier, Hortense, Dorleans, Cecile, Nicolai, Eric
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
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Identification of Acceptor Substrate Binding Subsites +2 and +3 in the Amylomaltase from Thermus thermophilus HB8
Kaper, Thijs, Leemhuis, Hans, Uitdehaag, Joost C. M, van der Veen, Bart A, Dijkstra, Bauke W, van der Maarel, Marc J. E. C, Dijkhuizen, Lubbert
Published in Biochemistry (Easton) (01.05.2007)
Published in Biochemistry (Easton) (01.05.2007)
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Multidimensional profiling of CSF1R screening hits and inhibitors: assessing cellular activity, target residence time, and selectivity in a higher throughput way
Uitdehaag, Joost C M, Sünnen, Cecile M, van Doornmalen, Antoon M, de Rouw, Nikki, Oubrie, Arthur, Azevedo, Rita, Ziebell, Michael, Nickbarg, Elliott, Karstens, Willem-Jan, Ruygrok, Simone
Published in Journal of biomolecular screening (01.10.2011)
Published in Journal of biomolecular screening (01.10.2011)
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Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance
Willemsen-Seegers, Nicole, Uitdehaag, Joost C.M., Prinsen, Martine B.W., de Vetter, Judith R.F., de Man, Jos, Sawa, Masaaki, Kawase, Yusuke, Buijsman, Rogier C., Zaman, Guido J.R.
Published in Journal of molecular biology (17.02.2017)
Published in Journal of molecular biology (17.02.2017)
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