Build–Couple–Transform: A Paradigm for Lead-like Library Synthesis with Scaffold Diversity
Uguen, Mélanie, Davison, Gemma, Sprenger, Lukas J., Hunter, James H., Martin, Mathew P., Turberville, Shannon, Watt, Jessica E., Golding, Bernard T., Noble, Martin E. M., Stewart, Hannah L., Waring, Michael J.
Published in Journal of medicinal chemistry (25.08.2022)
Published in Journal of medicinal chemistry (25.08.2022)
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SETDB1 Triple Tudor Domain Ligand, (R,R)‑59, Promotes Methylation of Akt1 in Cells
Uguen, Mélanie, Deng, Yu, Li, Fengling, Shell, Devan J., Norris-Drouin, Jacqueline L., Stashko, Michael A., Ackloo, Suzanne, Arrowsmith, Cheryl H., James, Lindsey I., Liu, Pengda, Pearce, Kenneth H., Frye, Stephen V.
Published in ACS chemical biology (18.08.2023)
Published in ACS chemical biology (18.08.2023)
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Microwave-assisted synthesis of 4-oxo-2-butenoic acids by aldol-condensation of glyoxylic acid
Uguen, Mélanie, Gai, Conghao, Sprenger, Lukas J, Liu, Hang, Leach, Andrew G, Waring, Michael J
Published in RSC advances (05.10.2021)
Published in RSC advances (05.10.2021)
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Discovery of hit compounds for methyl-lysine reader proteins from a target class DNA-encoded library
Shell, Devan J., Rectenwald, Justin M., Buttery, Peter H., Johnson, Rebecca L., Foley, Caroline A., Guduru, Shiva K.R., Uguen, Mélanie, Rubiano, Juanita Sanchez, Zhang, Xindi, Li, Fengling, Norris-Drouin, Jacqueline L., Axtman, Matthew, Brian Hardy, P., Vedadi, Masoud, Frye, Stephen V., James, Lindsey I., Pearce, Kenneth H.
Published in SLAS discovery (01.12.2022)
Published in SLAS discovery (01.12.2022)
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Journal Article
SETDB1 Triple Tudor Domain Ligand, ( R,R )-59, Promotes Methylation of Akt1 in Cells
Uguen, Mélanie, Deng, Yu, Li, Fengling, Shell, Devan J, Norris-Drouin, Jacqueline L, Stashko, Michael A, Ackloo, Suzanne, Arrowsmith, Cheryl H, James, Lindsey I, Liu, Pengda, Pearce, Kenneth H, Frye, Stephen V
Published in bioRxiv : the preprint server for biology (10.05.2023)
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Published in bioRxiv : the preprint server for biology (10.05.2023)
Journal Article
Potent and Selective SETDB1 Covalent Negative Allosteric Modulator Reduces Methyltransferase Activity in Cells
Uguen, Mélanie, Shell, Devan J, Silva, Madhushika, Deng, Yu, Li, Fengling, Szewczyk, Magdalena M, Yang, Ka, Zhao, Yani, Stashko, Michael A, Norris-Drouin, Jacqueline L, Waybright, Jarod M, Beldar, Serap, Rectenwald, Justin M, Mordant, Angie L, Webb, Thomas S, Herring, Laura E, Arrowsmith, Cheryl H, Ackloo, Suzanne, Gygi, Steven P, McGinty, Robert K, Barsyte-Lovejoy, Dalia, Liu, Pengda, Halabelian, Levon, James, Lindsey I, Pearce, Kenneth H, Frye, Stephen V
Published in bioRxiv (28.09.2024)
Published in bioRxiv (28.09.2024)
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