STAT5A/B Blockade Sensitizes Prostate Cancer to Radiation through Inhibition of RAD51 and DNA Repair
Maranto, Cristina, Udhane, Vindhya, Hoang, David T, Gu, Lei, Alexeev, Vitali, Malas, Kareem, Cardenas, Karmel, Brody, Jonathan R, Rodeck, Ulrich, Bergom, Carmen, Iczkowski, Ken A, Jacobsohn, Ken, See, William, Schmitt, Sara M, Nevalainen, Marja T
Published in Clinical cancer research (15.04.2018)
Published in Clinical cancer research (15.04.2018)
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Journal Article
Second-Generation Jak2 Inhibitors for Advanced Prostate Cancer: Are We Ready for Clinical Development?
Beinhoff, Paul, Sabharwal, Lavannya, Udhane, Vindhya, Maranto, Cristina, LaViolette, Peter S., Jacobsohn, Kenneth M., Tsai, Susan, Iczkowski, Kenneth A., Wang, Liang, Hall, William A., Dehm, Scott M., Kilari, Deepak, Nevalainen, Marja T.
Published in Cancers (17.10.2021)
Published in Cancers (17.10.2021)
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Journal Article
Cytokines, JAK-STAT Signaling and Radiation-Induced DNA Repair in Solid Tumors: Novel Opportunities for Radiation Therapy
Hall, William A., Sabharwal, Lavannya, Udhane, Vindhya, Maranto, Cristina, Nevalainen, Marja T.
Published in The international journal of biochemistry & cell biology (01.10.2020)
Published in The international journal of biochemistry & cell biology (01.10.2020)
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Journal Article
Enzalutamide-Induced Feed-Forward Signaling Loop Promotes Therapy-Resistant Prostate Cancer Growth Providing an Exploitable Molecular Target for Jak2 Inhibitors
Udhane, Vindhya, Maranto, Cristina, Hoang, David T, Gu, Lei, Erickson, Andrew, Devi, Savita, Talati, Pooja G, Banerjee, Anjishnu, Iczkowski, Kenneth A, Jacobsohn, Kenneth, See, William A, Mirtti, Tuomas, Kilari, Deepak, Nevalainen, Marja T
Published in Molecular cancer therapeutics (01.01.2020)
Published in Molecular cancer therapeutics (01.01.2020)
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The role of enzalutamide-induced hyperactive Jak2-Stat5 feed-forward signaling loop on enzalutamide-resistant prostate cancer growth and as a therapeutic target for second-line treatment
Udhane, Vindhya, Maranto, Cristina, Hoang, David, Erickson, Andrew, Devi, Savita, Jacobsohn, Kenneth, Iczkowski, Kenneth, See, William, Kilari, Deepak, Mirtti, Tuomas, Nevalainen, Marja
Published in Journal of clinical oncology (01.03.2019)
Published in Journal of clinical oncology (01.03.2019)
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Positive STAT5 Protein and Locus Amplification Status Predicts Recurrence after Radical Prostatectomy to Assist Clinical Precision Management of Prostate Cancer
Haddad, Bassem R, Erickson, Andrew, Udhane, Vindhya, LaViolette, Peter S, Rone, Janice D, Kallajoki, Markku A, See, William A, Rannikko, Antti, Mirtti, Tuomas, Nevalainen, Marja T
Published in Cancer epidemiology, biomarkers & prevention (01.10.2019)
Published in Cancer epidemiology, biomarkers & prevention (01.10.2019)
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Journal Article
Abstract B073: Stat5a/b blockade sensitizes prostate cancer to radiation through inhibition of Rad51 and DNA repair
Maranto, Cristina, Udhane, Vindhya, Dagvadorj, Ayush, Hoang, David T., Gu, Lei, Alexeev, Vitali, Malas, Kareem, Cardenas, Karmel, Koptyra, Mateusz, Brody, Jonathan R., Rodeck, Ulrich, Bergom, Carmen, Iczkowski, Ken A., Jacobsohn, Ken, See, William, Schmitt, Sara M., Nevalainen, Marja T.
Published in Cancer research (Chicago, Ill.) (15.08.2018)
Published in Cancer research (Chicago, Ill.) (15.08.2018)
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Stat5 induces androgen receptor ( AR ) gene transcription in prostate cancer and offers a druggable pathway to target AR signaling
Maranto, Cristina, Sabharwal, Lavannya, Udhane, Vindhya, Pitzen, Samuel P, McCluskey, Braedan, Qi, Songyan, O'Connor, Christine, Devi, Savita, Johnson, Scott, Jacobsohn, Kenneth, Banerjee, Anjishnu, Iczkowski, Kenneth A, Wang, Liang, Dehm, Scott M, Nevalainen, Marja T
Published in Science advances (01.03.2024)
Published in Science advances (01.03.2024)
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Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo
Maranto, Cristina, Udhane, Vindhya, Jia, Jing, Verma, Ranjit, Müller-Newen, Gerhard, LaViolette, Peter S, Pereckas, Michael, Sabharwal, Lavannya, Terhune, Scott, Pattabiraman, Nagarajan, Njar, Vincent C O, Imig, John D, Wang, Liang, Nevalainen, Marja T
Published in Cancers (18.11.2020)
Published in Cancers (18.11.2020)
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NSG-Pro mouse model for uncovering resistance mechanisms and unique vulnerabilities in human luminal breast cancers
Sun, Yunguang, Yang, Ning, Utama, Fransiscus E, Udhane, Sameer S, Zhang, Junling, Peck, Amy R, Yanac, Alicia, Duffey, Katherine, Langenheim, John F, Udhane, Vindhya, Xia, Guanjun, Peterson, Jess F, Jorns, Julie M, Nevalainen, Marja T, Rouet, Romain, Schofield, Peter, Christ, Daniel, Ormandy, Christopher J, Rosenberg, Anne L, Chervoneva, Inna, Tsaih, Shirng-Wern, Flister, Michael J, Fuchs, Serge Y, Wagner, Kay-Uwe, Rui, Hallgeir
Published in Science advances (17.09.2021)
Published in Science advances (17.09.2021)
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