Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors
Flanagan, Mark E, Abramite, Joseph A, Anderson, Dennis P, Aulabaugh, Ann, Dahal, Upendra P, Gilbert, Adam M, Li, Chao, Montgomery, Justin, Oppenheimer, Stacey R, Ryder, Tim, Schuff, Brandon P, Uccello, Daniel P, Walker, Gregory S, Wu, Yan, Brown, Matthew F, Chen, Jinshan M, Hayward, Matthew M, Noe, Mark C, Obach, R. Scott, Philippe, Laurence, Shanmugasundaram, Veerabahu, Shapiro, Michael J, Starr, Jeremy, Stroh, Justin, Che, Ye
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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A covalent BTK ternary complex compatible with targeted protein degradation
Schiemer, James, Maxwell, Andrew, Horst, Reto, Liu, Shenping, Uccello, Daniel P, Borzilleri, Kris, Rajamohan, Nisha, Brown, Matthew F, Calabrese, Matthew F
Published in Nature communications (02.03.2023)
Published in Nature communications (02.03.2023)
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Journal Article
Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes
Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I., Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P., Leverett, Carolyn, Brown, Stephen, Che, Ye, Brown, Matthew F., Hayward, Matthew M., Gilbert, Adam M., Noe, Mark C., Calabrese, Matthew F.
Published in Nature chemical biology (01.02.2021)
Published in Nature chemical biology (01.02.2021)
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Journal Article
Delineating the role of cooperativity in the design of potent PROTACs for BTK
Zorba, Adelajda, Nguyen, Chuong, Xu, Yingrong, Starr, Jeremy, Borzilleri, Kris, Smith, James, Zhu, Hongyao, Farley, Kathleen A., Ding, WeiDong, Schiemer, James, Feng, Xidong, Chang, Jeanne S., Uccello, Daniel P., Young, Jennifer A., Garcia-Irrizary, Carmen N., Czabaniuk, Lara, Schuff, Brandon, Oliver, Robert, Montgomery, Justin, Hayward, Matthew M., Coe, Jotham, Chen, Jinshan, Niosi, Mark, Luthra, Suman, Shah, Jaymin C., El-Kattan, Ayman, Qiu, Xiayang, West, Graham M., Noe, Mark C., Shanmugasundaram, Veerabahu, Gilbert, Adam M., Brown, Matthew F., Calabrese, Matthew F.
Published in Proceedings of the National Academy of Sciences - PNAS (31.07.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (31.07.2018)
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Journal Article
Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes
Schiemer, James, Horst, Reto, Meng, Yilin, Montgomery, Justin I, Xu, Yingrong, Feng, Xidong, Borzilleri, Kris, Uccello, Daniel P, Leverett, Carolyn, Brown, Stephen, Che, Ye, Brown, Matthew F, Hayward, Matthew M, Gilbert, Adam M, Noe, Mark C, Calabrese, Matthew F
Published in Nature chemical biology (01.02.2021)
Published in Nature chemical biology (01.02.2021)
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Journal Article
Synthesis of PEG-Functionalized Amines Using Ruthenium-Catalyzed Hydrogen Borrowing
Rossi, Federico V, Starr, Jeremy T, Uccello, Daniel P, Young, Jennifer A
Published in Organic letters (07.08.2020)
Published in Organic letters (07.08.2020)
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Journal Article
One-Pot Oxidation and Rearrangement of Propargylamines and in Situ Pyrazole Synthesis
Chen, Jinshan, Properzi, Roberta, Uccello, Daniel P, Young, Jennifer A, Dushin, Russell G, Starr, Jeremy T
Published in Organic letters (15.08.2014)
Published in Organic letters (15.08.2014)
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Journal Article
Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation
McAllister, Laura A, Butler, Christopher R, Mente, Scot, O’Neil, Steven V, Fonseca, Kari R, Piro, Justin R, Cianfrogna, Julie A, Foley, Timothy L, Gilbert, Adam M, Harris, Anthony R, Helal, Christopher J, Johnson, Douglas S, Montgomery, Justin I, Nason, Deane M, Noell, Stephen, Pandit, Jayvardhan, Rogers, Bruce N, Samad, Tarek A, Shaffer, Christopher L, da Silva, Rafael G, Uccello, Daniel P, Webb, Damien, Brodney, Michael A
Published in Journal of medicinal chemistry (12.04.2018)
Published in Journal of medicinal chemistry (12.04.2018)
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Journal Article
Novel 3-fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV
Mitton-Fry, Mark J., Brickner, Steven J., Hamel, Judith C., Barham, Rose, Brennan, Lori, Casavant, Jeffrey M., Ding, Xiaoyuan, Finegan, Steven, Hardink, Joel, Hoang, Thuy, Huband, Michael D., Maloney, Meghan, Marfat, Anthony, McCurdy, Sandra P., McLeod, Dale, Subramanyam, Chakrapani, Plotkin, Michael, Reilly, Usa, Schafer, John, Stone, Gregory G., Uccello, Daniel P., Wisialowski, Todd, Yoon, Kwansik, Zaniewski, Richard, Zook, Christopher
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
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Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)
Huard, Kim, Brown, Janice, Jones, Jessica C, Cabral, Shawn, Futatsugi, Kentaro, Gorgoglione, Matthew, Lanba, Adhiraj, Vera, Nicholas B, Zhu, Yimin, Yan, Qingyun, Zhou, Yingjiang, Vernochet, Cecile, Riccardi, Keith, Wolford, Angela, Pirman, David, Niosi, Mark, Aspnes, Gary, Herr, Michael, Genung, Nathan E, Magee, Thomas V, Uccello, Daniel P, Loria, Paula, Di, Li, Gosset, James R, Hepworth, David, Rolph, Timothy, Pfefferkorn, Jeffrey A, Erion, Derek M
Published in Scientific reports (01.12.2015)
Published in Scientific reports (01.12.2015)
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Journal Article
Pyridone Methylsulfone Hydroxamate LpxC Inhibitors for the Treatment of Serious Gram-Negative Infections
Montgomery, Justin I, Brown, Matthew F, Reilly, Usa, Price, Loren M, Abramite, Joseph A, Arcari, Joel, Barham, Rose, Che, Ye, Chen, Jinshan Michael, Chung, Seung Won, Collantes, Elizabeth M, Desbonnet, Charlene, Doroski, Matthew, Doty, Jonathan, Engtrakul, Juntyma J, Harris, Thomas M, Huband, Michael, Knafels, John D, Leach, Karen L, Liu, Shenping, Marfat, Anthony, McAllister, Laura, McElroy, Eric, Menard, Carol A, Mitton-Fry, Mark, Mullins, Lisa, Noe, Mark C, O’Donnell, John, Oliver, Robert, Penzien, Joseph, Plummer, Mark, Shanmugasundaram, Veerabahu, Thoma, Christy, Tomaras, Andrew P, Uccello, Daniel P, Vaz, Alfin, Wishka, Donn G
Published in Journal of medicinal chemistry (23.02.2012)
Published in Journal of medicinal chemistry (23.02.2012)
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Journal Article
Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family
Huard, Kim, Gosset, James R, Montgomery, Justin I, Gilbert, Adam, Hayward, Matthew M, Magee, Thomas V, Cabral, Shawn, Uccello, Daniel P, Bahnck, Kevin, Brown, Janice, Purkal, Julie, Gorgoglione, Matthew, Lanba, Adhiraj, Futatsugi, Kentaro, Herr, Michael, Genung, Nathan E, Aspnes, Gary, Polivkova, Jana, Garcia-Irizarry, Carmen N, Li, Qifang, Canterbury, Daniel, Niosi, Mark, Vera, Nicholas B, Li, Zhenhong, Khunte, Bhagyashree, Siderewicz, Jaclyn, Rolph, Timothy, Erion, Derek M
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
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Journal Article
Potent Inhibitors of LpxC for the Treatment of Gram-Negative Infections
Brown, Matthew F, Reilly, Usa, Abramite, Joseph A, Arcari, Joel T, Oliver, Robert, Barham, Rose A, Che, Ye, Chen, Jinshan Michael, Collantes, Elizabeth M, Chung, Seung Won, Desbonnet, Charlene, Doty, Jonathan, Doroski, Matthew, Engtrakul, Juntyma J, Harris, Thomas M, Huband, Michael, Knafels, John D, Leach, Karen L, Liu, Shenping, Marfat, Anthony, Marra, Andrea, McElroy, Eric, Melnick, Michael, Menard, Carol A, Montgomery, Justin I, Mullins, Lisa, Noe, Mark. C, O’Donnell, John, Penzien, Joseph, Plummer, Mark S, Price, Loren M, Shanmugasundaram, Veerabahu, Thoma, Christy, Uccello, Daniel P, Warmus, Joseph S, Wishka, Donn G
Published in Journal of medicinal chemistry (26.01.2012)
Published in Journal of medicinal chemistry (26.01.2012)
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Journal Article
Intramolecular Ring-Opening Decomposition of Aryl Azetidines
Bai, Guoyun, O’Connell, Thomas N, Brodney, Michael A, Butler, Christopher R, Czabaniuk, Lara C, Gilbert, Adam M, LaChapelle, Erik A, Li, Chao, McAllister, Laura A, Ogilvie, Kevin, Philippe, Laurence, Salomon-Ferrer, Romelia, Shapiro, Michael J, Starr, Jeremy T, Uccello, Daniel P, Withka, Jane M, Yan, Jiangli, Brown, Matthew F
Published in ACS medicinal chemistry letters (14.10.2021)
Published in ACS medicinal chemistry letters (14.10.2021)
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Journal Article
Trimethylaluminium-Facilitated Direct Amidation of Carboxylic Acids
Chung, SeungWon, Uccello, Daniel P., Choi, Huiwon, Montgomery, Justin I., Chen, Jinshan
Published in Synlett (01.09.2011)
Published in Synlett (01.09.2011)
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Journal Article
Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents
McAllister, Laura A., Montgomery, Justin I., Abramite, Joseph A., Reilly, Usa, Brown, Matthew F., Chen, Jinshan M., Barham, Rose A., Che, Ye, Chung, Seung Won, Menard, Carol A., Mitton-Fry, Mark, Mullins, Lisa M., Noe, Mark C., O’Donnell, John P., Oliver, Robert M., Penzien, Joseph B., Plummer, Mark, Price, Loren M., Shanmugasundaram, Veerabahu, Tomaras, Andrew P., Uccello, Daniel P.
Published in Bioorganic & medicinal chemistry letters (15.11.2012)
Published in Bioorganic & medicinal chemistry letters (15.11.2012)
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Journal Article
The synthesis of C-13 functionalized pleuromutilins via C–H amidation and subsequent novel rearrangement product
Uccello, Daniel P., Miller, Shawn M., Dieterich, Noah A., Stepan, Antonia F., Chung, SeungWon, Farley, Kathleen A., Samas, Brian, Chen, Jinshan, Montgomery, Justin I.
Published in Tetrahedron letters (17.08.2011)
Published in Tetrahedron letters (17.08.2011)
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Effect of Solvent and Temperature on the Lithium−Bromine Exchange of Vinyl Bromides: Reactions of n-Butyllithium and t-Butyllithium with (E)-5-Bromo-5-decene
Bailey, William F, Luderer, Mark R, Uccello, Daniel P, Bartelson, Ashley L
Published in Journal of organic chemistry (16.04.2010)
Published in Journal of organic chemistry (16.04.2010)
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Journal Article
One-Pot (1-Ethoxycarbonylcyclopropyl)triphenylphosphonium Tetrafluoroborate Ring-Opening and Wittig Reaction
Chung, Seung Won, Plummer, Mark S, McAllister, Laura A, Oliver, Robert M, Abramite, Joseph A, Shen, Yue, Sun, Jianmin, Uccello, Daniel P, Arcari, Joel T, Price, Loren M, Montgomery, Justin I
Published in Organic letters (07.10.2011)
Published in Organic letters (07.10.2011)
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