Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody–Drug Conjugate SYD985
Elgersma, Ronald C, Coumans, Ruud G. E, Huijbregts, Tijl, Menge, Wiro M. P. B, Joosten, John A. F, Spijker, Henri J, de Groot, Franciscus M. H, van der Lee, Miranda M. C, Ubink, Ruud, van den Dobbelsteen, Diels J, Egging, David F, Dokter, Wim H. A, Verheijden, Gijs F. M, Lemmens, Jacques M, Timmers, C. Marco, Beusker, Patrick H
Published in Molecular pharmaceutics (01.06.2015)
Published in Molecular pharmaceutics (01.06.2015)
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Preclinical profile of the HER2-targeting ADC SYD983/SYD985: introduction of a new duocarmycin-based linker-drug platform
Dokter, Wim, Ubink, Ruud, van der Lee, Miranda, van der Vleuten, Monique, van Achterberg, Tanja, Jacobs, Danielle, Loosveld, Eline, van den Dobbelsteen, Diels, Egging, David, Mattaar, Ellen, Groothuis, Patrick, Beusker, Patrick, Coumans, Ruud, Elgersma, Ronald, Menge, Wiro, Joosten, John, Spijker, Henri, Huijbregts, Tijl, de Groot, Vincent, Eppink, Michel, de Roo, Guy, Verheijden, Gijs, Timmers, Marco
Published in Molecular cancer therapeutics (01.11.2014)
Published in Molecular cancer therapeutics (01.11.2014)
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Journal Article
The Preclinical Profile of the Duocarmycin-Based HER2-Targeting ADC SYD985 Predicts for Clinical Benefit in Low HER2-Expressing Breast Cancers
van der Lee, Miranda M C, Groothuis, Patrick G, Ubink, Ruud, van der Vleuten, Monique A J, van Achterberg, Tanja A, Loosveld, Eline M, Damming, Désirée, Jacobs, Daniëlle C H, Rouwette, Myrthe, Egging, David F, van den Dobbelsteen, Diels, Beusker, Patrick H, Goedings, Peter, Verheijden, Gijs F M, Lemmens, Jacques M, Timmers, Marco, Dokter, Wim H A
Published in Molecular cancer therapeutics (01.03.2015)
Published in Molecular cancer therapeutics (01.03.2015)
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Journal Article
NPY and its involvement in axon guidance, neurogenesis, and feeding
Hökfelt, Tomas, M.D., Ph.D, Stanic, Davor, Ph.D, Sanford, Staci D., B.S, Gatlin, Jesse C., Ph.D, Nilsson, Ida, M.S, Paratcha, Gustavo, Ph.D, Ledda, Fernanda, Ph.D, Fetissov, Serguei, Ph.D, Lindfors, Charlotte, M.S, Herzog, Herbert, Ph.D, Johansen, Jeanette E., Ph.D, Ubink, Ruud, Ph.D, Pfenninger, Karl H., M.D
Published in Nutrition (Burbank, Los Angeles County, Calif.) (01.09.2008)
Published in Nutrition (Burbank, Los Angeles County, Calif.) (01.09.2008)
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Conference Proceeding
Potent in Vitro and In Vivo Efficacy of BYON4413, a Duba-Based Antibody-Drug Conjugate Targeting CD123 in Acute Myeloid Leukemia
van der Lee, Miranda, van Achtenberg, Tanja, Brouwers-Vos, Annet, van der Vleuten, Monique, Kappers, Wendy, Verheijden, Gijs, Huls, Geert A., van Wigcheren, Glenn, Ubink, Ruud, Sesink, Aloys, MacInnes, Alyson, Schuringa, Jan Jacob, Dokter, Wim
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Abstract 926: BYON3521, a novel effective and safe c-Met targeting antibody-drug conjugate
Groothuis, Patrick, Jacobs, Danielle, Hermens, Inge, Damming, Desiree, Mattaar, Ellen, Rouwette, Myrthe, van der Vleuten, Monique, Sesink, Aloys, Dijcks, Fred, Coumans, Ruud, Blomenrohr, Marion, Ubink, Ruud, van der Lee, Miranda, Dokter, Wim H.A.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract 925: Introduction to the preclinical profile of SYD1875, a novel site-specifically conjugated duocarmycin-based 5T4-targeting antibody-drug conjugate
Groothuis, Patrick, Jacobs, Danielle, Berentsen, Kim, van der Vleuten, Monique, Coumans, Ruud, Elgersma, Ronald, Blomenrohr, Marion, van den Dobbelsteen, Diels, Beusker, Patrick, Ubink, Ruud, van der Lee, Miranda, Dokter, Wim H.A.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
A Platform for the Generation of Site-Specific Antibody–Drug Conjugates That Allows for Selective Reduction of Engineered Cysteines
Coumans, Ruud G. E, Ariaans, Gerry J. A, Spijker, Henri J, Renart Verkerk, Pascal, Beusker, Patrick H, Kokke, Bas P. A, Schouten, Jan, Blomenröhr, Marion, van der Lee, Miranda M. C, Groothuis, Patrick G, Ubink, Ruud, Dokter, Wim H. A, Timmers, C. Marco
Published in Bioconjugate chemistry (16.09.2020)
Published in Bioconjugate chemistry (16.09.2020)
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Journal Article
Preclinical Profile of BYON3521 Predicts an Effective and Safe MET Antibody-Drug Conjugate
Groothuis, Patrick G, Jacobs, Daniëlle C H, Hermens, Inge A T, Damming, Désirée, Berentsen, Kim, Mattaar-Hepp, Ellen, Stokman, Marloes E M, Boekel, Tinie van, Rouwette, Myrthe, van der Vleuten, Monique A J, Sesink, Aloys, Dijcks, Fred A, Coumans, Ruud G E, Schouten, Jan, Glaudemans, Dirk H, Wijk, Daniëlle van, Blomenröhr, Marion, Kappers, Wendela A, Ubink, Ruud, van der Lee, Miranda M C, Dokter, Wim H A
Published in Molecular cancer therapeutics (01.06.2023)
Published in Molecular cancer therapeutics (01.06.2023)
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Journal Article
Unraveling the Interaction between Carboxylesterase 1c and the Antibody-Drug Conjugate SYD985: Improved Translational PK/PD by Using Ces1c Knockout Mice
Ubink, Ruud, Dirksen, Eef H C, Rouwette, Myrthe, Bos, Ebo S, Janssen, Ingrid, Egging, David F, Loosveld, Eline M, van Achterberg, Tanja A, Berentsen, Kim, van der Lee, Miranda M C, Bichat, Francis, Raguin, Olivier, van der Vleuten, Monique A J, Groothuis, Patrick G, Dokter, Wim H A
Published in Molecular cancer therapeutics (01.11.2018)
Published in Molecular cancer therapeutics (01.11.2018)
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Journal Article
Discovery of SYD5115, a novel orally active small molecule TSH-R antagonist
Karstens, Willem F.J., M.B.P. Menge, Wiro, Martens, Gijs, op het Veld, Sanne J.N., Th.H. van Eupen, Jacobus, Demon, Marco, van Achterberg, Tanja A.E., Arisse-Thijssen, Monica J., Santegoeds-Lenssen, Ellen W.H., van der Lee, Miranda M.C., Ubink, Ruud, Arends, Roel J., Sesink, Aloys, Blomenröhr, Marion, Marco Timmers, C.
Published in Bioorganic & medicinal chemistry (15.04.2023)
Published in Bioorganic & medicinal chemistry (15.04.2023)
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Journal Article
Abstract 3129: BYON4413, an in vivo active CD123-targeting antibody-drug conjugate, combines effectively with azacitidine and venetoclax in acute myeloid leukemia cell lines
van der Lee, Miranda M.C., van Achterberg, Tanja, Hersmus, Kaylee, Brouwers-Vos, Annet, van der Vleuten, Monique, Pruis, Maurien, Kappers, Wendy, Verheijden, Gijs, Huls, Gerwin, van Wigcheren, Glenn, Ubink, Ruud, Sesink, Aloys, MacInnes, Alyson, Schuringa, Jan Jacob, Dokter, Wim
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting
Meyer, Saskia, Nederend, Maaike, Jansen, J H Marco, Reiding, Karli R, Jacobino, Shamir R, Meeldijk, Jan, Bovenschen, Niels, Wuhrer, Manfred, Valerius, Thomas, Ubink, Ruud, Boross, Peter, Rouwendal, Gerard, Leusen, Jeanette H W
Published in mAbs (01.01.2016)
Published in mAbs (01.01.2016)
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Journal Article
Abstract P4-15-14: Preclinical data of SYD985 support the clinical investigation of this novel anti-HER2 antibody-drug conjugate in breast cancer patients with low levels of HER2 expression
Verheijden, Gijs, Beusker, Patrick, Ubink, Ruud, Lee, Miranda van der, Groothuis, Patrick, Goedings, Peter, Egging, David, Timmers, Marco, Dokter, Wim
Published in Cancer research (Chicago, Ill.) (01.05.2015)
Published in Cancer research (Chicago, Ill.) (01.05.2015)
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Journal Article
A comparison of anti-HER2 IgA and IgG1 in vivo efficacy is facilitated by high N-glycan sialylation of the IgA
Rouwendal, Gerard Ja, van der Lee, Miranda M, Meyer, Saskia, Reiding, Karli R, Schouten, Jan, de Roo, Guy, Egging, David F, Leusen, Jeanette Hw, Boross, Peter, Wuhrer, Manfred, Verheijden, Gijs F, Dokter, Wim H, Timmers, Marco, Ubink, Ruud
Published in mAbs (01.01.2016)
Published in mAbs (01.01.2016)
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Journal Article
BYON4228 is a pan-allelic antagonistic SIRPα antibody that potentiates destruction of antibody-opsonized tumor cells and lacks binding to SIRPγ on T cells
van Helden, Mary J, Zwarthoff, Seline A, Arends, Roel J, Reinieren-Beeren, Inge M J, Paradé, Marc C B C, Driessen-Engels, Lilian, de Laat-Arts, Karin, Damming, Désirée, Santegoeds-Lenssen, Ellen W H, van Kuppeveld, Daphne W J, Lodewijks, Imke, Olsman, Hugo, Matlung, Hanke L, Franke, Katka, Mattaar-Hepp, Ellen, Stokman, Marloes E M, de Wit, Benny, Glaudemans, Dirk H R F, van Wijk, Daniëlle E J W, Joosten-Stoffels, Lonnie, Schouten, Jan, Boersema, Paul J, van der Vleuten, Monique, Sanderink, Jorien W H, Kappers, Wendela A, van den Dobbelsteen, Diels, Timmers, Marco, Ubink, Ruud, Rouwendal, Gerard J A, Verheijden, Gijs, van der Lee, Miranda M C, Dokter, Wim H A, van den Berg, Timo K
Published in Journal for immunotherapy of cancer (01.04.2023)
Published in Journal for immunotherapy of cancer (01.04.2023)
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Journal Article
Abstract 5360: The preclinical profile of the duocarmycin-based HER2-targeting ADC SYD985 predicts for clinical benefit in low HER2-expressing breast cancers
Dokter, Willem, van der Lee, Miranda, Groothuis, Patrick, Ubink, Ruud, van der Vleuten, Monique, van Achterberg, Tanja, Loosveld, Eline, Damming, Desirée, Rouwette, Myrthe, Egging, David, van den Dobbelsteen, Diels, Beusker, Patrick, goedings, peter, Verheijden, Gijs, Lemmens, Jacques, Timmers, Marco
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Toward clinical development of SYD985, a novel HER2-targeting antibody-drug conjugate (ADC)
Verheijden, Gijs, Beusker, Patrick, Ubink, Ruud, van der Lee, Miranda, Groothuis, Patrick, Goedings, Peter J., Egging, David, Mattaar, Ellen, Timmers, Macro, Dokter, Wim
Published in Journal of clinical oncology (20.05.2014)
Published in Journal of clinical oncology (20.05.2014)
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Journal Article
Simultaneous Targeting of FcγRs and FcαRI Enhances Tumor Cell Killing
Brandsma, Arianne M, Ten Broeke, Toine, Nederend, Maaike, Meulenbroek, Laura A P M, van Tetering, Geert, Meyer, Saskia, Jansen, J H Marco, Beltrán Buitrago, M Alejandra, Nagelkerke, Sietse Q, Németh, István, Ubink, Ruud, Rouwendal, Gerard, Lohse, Stefan, Valerius, Thomas, Leusen, Jeanette H W, Boross, Peter
Published in Cancer immunology research (01.12.2015)
Published in Cancer immunology research (01.12.2015)
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Abstract 5589: BYON4228 is a pan-allelic SIRPα antibody that potentiates killing of antibody-opsonized tumor cells and lacks binding to T cells
van Helden, Mary, Zwarthoff, Seline, Olsman, Hugo, Paradé, Marc, Mattaar, Ellen, de Laat, Karin, Lodewijks, Imke, Boersema, Paul, Driessen-Engels, Lilian, Sanderink, Jorien, Kappers, Wendy, van den Dobbelsteen, Diels, Ubink, Ruud, Arends, Roel, Rouwendal, Gerard, Verheijden, Gijs, van der Lee, Miranda, Dokter, Wim, Van den Berg, Timo
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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