Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography
Ubah, Obinna C, Lake, Eric W, Gunaratne, Gihan S, Gallant, Joseph P, Fernie, Marie, Robertson, Austin J, Marchant, Jonathan S, Bold, Tyler D, Langlois, Ryan A, Matchett, William E, Thiede, Joshua M, Shi, Ke, Yin, Lulu, Moeller, Nicholas H, Banerjee, Surajit, Ferguson, Laura, Kovaleva, Marina, Porter, Andrew J, Aihara, Hideki, LeBeau, Aaron M, Barelle, Caroline J
Published in Nature communications (16.12.2021)
Published in Nature communications (16.12.2021)
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Journal Article
In Vitro ELISA and Cell-Based Assays Confirm the Low Immunogenicity of VNAR Therapeutic Constructs in a Mouse Model of Human RA: An Encouraging Milestone to Further Clinical Drug Development
Ubah, Obinna C., Barelle, Caroline J., Porter, Andrew J.
Published in Journal of immunology research (2020)
Published in Journal of immunology research (2020)
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Journal Article
An Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Model
Ubah, Obinna C, Steven, John, Porter, Andrew J, Barelle, Caroline J
Published in Frontiers in immunology (22.03.2019)
Published in Frontiers in immunology (22.03.2019)
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Journal Article
Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralizing Potency and Multifunctionality, Generated for Therapeutic Development
Ubah, Obinna C, Steven, John, Kovaleva, Marina, Ferguson, Laura, Barelle, Charlotte, Porter, Andrew J R, Barelle, Caroline J
Published in Frontiers in immunology (22.12.2017)
Published in Frontiers in immunology (22.12.2017)
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Journal Article
Phage Display Derived IgNAR V Region Binding Domains for Therapeutic Development
Ubah, Obinna C, Barelle, Caroline J, Buschhaus, Magdalena J, Porter, Andrew J
Published in Current pharmaceutical design (01.01.2016)
Published in Current pharmaceutical design (01.01.2016)
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Journal Article
In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development
Steven, John, Müller, Mischa R, Carvalho, Miguel F, Ubah, Obinna C, Kovaleva, Marina, Donohoe, Gerard, Baddeley, Thomas, Cornock, Dawn, Saunders, Kenneth, Porter, Andrew J, Barelle, Caroline Jane
Published in Frontiers in immunology (23.10.2017)
Published in Frontiers in immunology (23.10.2017)
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Journal Article
Overview, Generation, and Significance of Variable New Antigen Receptors (VNARs) as a Platform for Drug and Diagnostic Development
Pandey, Samata S, Kovaleva, Marina, Barelle, Caroline J, Ubah, Obinna C
Published in Methods in molecular biology (Clifton, N.J.) (2022)
Published in Methods in molecular biology (Clifton, N.J.) (2022)
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Journal Article
Next-generation flexible formats of VNAR domains expand the drug platform's utility and developability
Ubah, Obinna C, Buschhaus, Magdalena J, Ferguson, Laura, Kovaleva, Marina, Steven, John, Porter, Andrew J, Barelle, Caroline J
Published in Biochemical Society transactions (17.12.2018)
Published in Biochemical Society transactions (17.12.2018)
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Journal Article
In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties
Steven, John, Ubah, Obinna C, Buschhaus, Magdalena, Kovaleva, Marina, Ferguson, Laura, Porter, Andrew J, Barelle, Caroline J
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2020)
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2020)
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Journal Article
Uveitis Therapy With Shark Variable Novel Antigen Receptor Domains Targeting Tumor Necrosis Factor Alpha or Inducible T-Cell Costimulatory Ligand
Pepple, Kathryn L, Wilson, Leslie, Van Gelder, Russell N, Kovaleva, Marina, Ubah, Obinna C, Steven, John, Barelle, Caroline J, Porter, Andrew
Published in Translational vision science & technology (01.09.2019)
Published in Translational vision science & technology (01.09.2019)
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