Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models
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Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Published in Journal of medicinal chemistry (25.01.2024)
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BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies
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Published in Journal of medicinal chemistry (09.09.2021)
Published in Journal of medicinal chemistry (09.09.2021)
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Identification of Small Molecules that Modulate Mutant p53 Condensation
Lemos, Clara, Schulze, Luise, Weiske, Joerg, Meyer, Hanna, Braeuer, Nico, Barak, Naomi, Eberspächer, Uwe, Werbeck, Nicolas, Stresemann, Carlo, Lange, Martin, Lesche, Ralf, Zablowsky, Nina, Juenemann, Katrin, Kamburov, Atanas, Luh, Laura Martina, Leissing, Thomas Markus, Mortier, Jeremie, Steckel, Michael, Steuber, Holger, Eis, Knut, Eheim, Ashley, Steigemann, Patrick
Published in iScience (25.09.2020)
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Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A
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Published in ACS omega (09.06.2020)
Published in ACS omega (09.06.2020)
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The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models
Wengner, Antje M, Siemeister, Gerhard, Lücking, Ulrich, Lefranc, Julien, Wortmann, Lars, Lienau, Philip, Bader, Benjamin, Bömer, Ulf, Moosmayer, Dieter, Eberspächer, Uwe, Golfier, Sven, Schatz, Christoph A, Baumgart, Simon J, Haendler, Bernard, Lejeune, Pascale, Schlicker, Andreas, von Nussbaum, Franz, Brands, Michael, Ziegelbauer, Karl, Mumberg, Dominik
Published in Molecular cancer therapeutics (01.01.2020)
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Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis
Santamaria, Anna, Neef, Rüdiger, Eberspächer, Uwe, Eis, Knut, Husemann, Manfred, Mumberg, Dominik, Prechtl, Stefan, Schulze, Volker, Siemeister, Gerhard, Wortmann, Lars, Barr, Francis A, Nigg, Erich A
Published in Molecular biology of the cell (01.10.2007)
Published in Molecular biology of the cell (01.10.2007)
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Affinity Map of Bromodomain Protein 4 (BRD4) Interactions with the Histone H4 Tail and the Small Molecule Inhibitor JQ1
Jung, Marie, Philpott, Martin, Müller, Susanne, Schulze, Jessica, Badock, Volker, Eberspächer, Uwe, Moosmayer, Dieter, Bader, Benjamin, Schmees, Norbert, Fernández-Montalván, Amaury, Haendler, Bernard
Published in The Journal of biological chemistry (28.03.2014)
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Year of Publication 24.11.2023
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Year of Publication 19.07.2023
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Year of Publication 19.07.2023
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2-(morpholin-4-yl)-1,7-naphthyridines
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Year of Publication 20.12.2022
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Year of Publication 20.12.2022
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Year of Publication 28.09.2022
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Year of Publication 28.09.2022
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Year of Publication 24.05.2022
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Year of Publication 28.02.2022
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Year of Publication 28.02.2022
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2-(MORPHOLIN-4-YL)-1,7-NAPHTHYRIDINES
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Year of Publication 18.02.2022
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Year of Publication 31.01.2022
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Year of Publication 31.01.2022
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LIENAU, PHILIP, KOPPITZ, MARCUS, VON NUSSBAUM, FRANZ, SIEMEISTER, GERHARD, LÜCKING, ULRICH, GRUDZINSKA-GOEBEL, JOANNA, BRIEM, HANS, EIS, KNUT, WENGNER, ANTJE-MARGRET, BONE, WILHELM, EBERSPÄCHER, UWE, LEFRANC, JULIEN, MOOSMAYER, DIETER, SCHICK, HANS, WORTMANN, LARS, BADER, BENJAMIN
Year of Publication 31.12.2021
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Year of Publication 31.12.2021
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Year of Publication 13.12.2021
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Year of Publication 13.12.2021
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2-(morpholin-4-yl)-1,7-naphthyridines
Briem, Hans, Eberspächer, Uwe, Wengner, Antje, Von Nussbaum, Franz, Moosmayer, Dieter, Siemeister, Gerhard, Grudzinska-Goebel, Joanna, Lefranc, Julien, Bader, Benjamin, Lienau, Philip, Lücking, Ulrich, Wortmann, Lars, Koppitz, Marcus, Schick, Hans, Eis, Knut, Bone, Wilhelm
Year of Publication 26.11.2021
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Year of Publication 26.11.2021
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2-(MORPHOLIN-4-YL)-1,7-NAPHTHYRIDINES
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Year of Publication 25.11.2021
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Year of Publication 25.11.2021
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