Search Results - "UTTAMSINGH Vinita" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Altering metabolic profiles of drugs by precision deuteration: reducing mechanism-based inhibition of CYP2D6 by paroxetine

Altering metabolic profiles of drugs by precision deuteration: reducing mechanism-based inhibition of CYP2D6 by paroxetine

by Uttamsingh, Vinita, Gallegos, Richard, Liu, Julie F, Harbeson, Scott L, Bridson, Gary W, Cheng, Changfu, Wells, David S, Graham, Philip B, Zelle, Robert, Tung, Roger
Published in The Journal of pharmacology and experimental therapeutics (01.07.2015)

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Journal Article

RELATIVE CONTRIBUTIONS OF THE FIVE MAJOR HUMAN CYTOCHROMES P450, 1A2, 2C9, 2C19, 2D6, AND 3A4, TO THE HEPATIC METABOLISM OF THE PROTEASOME INHIBITOR BORTEZOMIB

RELATIVE CONTRIBUTIONS OF THE FIVE MAJOR HUMAN CYTOCHROMES P450, 1A2, 2C9, 2C19, 2D6, AND 3A4, TO THE HEPATIC METABOLISM OF THE PROTEASOME INHIBITOR BORTEZOMIB

by UTTAMSINGH, Vinita, CHUANG LU, MIWA, Gerald, GAN, Liang-Shang
Published in Drug metabolism and disposition (01.11.2005)

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Journal Article

Comparison of Intrinsic Clearance in Liver Microsomes and Hepatocytes from Rats and Humans: Evaluation of Free Fraction and Uptake in Hepatocytes

Comparison of Intrinsic Clearance in Liver Microsomes and Hepatocytes from Rats and Humans: Evaluation of Free Fraction and Uptake in Hepatocytes

by CHUANG LU, PING LI, GALLEGOS, Richard, UTTAMSINGH, Vinita, XIA, Cindy Q, MIWA, Gerald T, BALANI, Suresh K, GAN, Liang-Shang
Published in Drug metabolism and disposition (01.09.2006)

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Journal Article

INVESTIGATION OF DRUG-DRUG INTERACTION POTENTIAL OF BORTEZOMIB IN VIVO IN FEMALE SPRAGUE-DAWLEY RATS AND IN VITRO IN HUMAN LIVER MICROSOMES

INVESTIGATION OF DRUG-DRUG INTERACTION POTENTIAL OF BORTEZOMIB IN VIVO IN FEMALE SPRAGUE-DAWLEY RATS AND IN VITRO IN HUMAN LIVER MICROSOMES

by CHUANG LU, GALLEGOS, Richard, PING LI, XIA, Cindy Q, PUSALKAR, Sandeepraj, UTTAMSINGH, Vinita, NIX, Darrell, MIWA, Gerald T, GAN, Liang-Shang
Published in Drug metabolism and disposition (01.04.2006)

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Journal Article

Immunohistochemical Localization of the Acylases that Catalyze the Deacetylation of N-Acetyl-l-cysteine and Haloalkene-Derived Mercapturates

Immunohistochemical Localization of the Acylases that Catalyze the Deacetylation of N-Acetyl-l-cysteine and Haloalkene-Derived Mercapturates

by Uttamsingh, V, Baggs, R B, Krenitsky, D M, Anders, M W
Published in Drug metabolism and disposition (01.06.2000)

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Journal Article

Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development

Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development

by Harbeson, Scott L, Morgan, Adam J, Liu, Julie F, Aslanian, Ara M, Nguyen, Sophia, Bridson, Gary W, Brummel, Christopher L, Wu, Lijun, Tung, Roger D, Pilja, Lana, Braman, Virginia, Uttamsingh, Vinita
Published in The Journal of pharmacology and experimental therapeutics (01.08.2017)

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Journal Article

Selective deuteration of bupropion slows epimerization and reduces metabolism

Selective deuteration of bupropion slows epimerization and reduces metabolism

by Shi, Yuanyuan, Dinh, Jean, Pelletier, Robert, Raccor, Brianne, Yusuff, Naeem, Morgan, Adam J., Harbeson, Scott, Uttamsingh, Vinita, Totah, Rheem A.
Published in Bioorganic & medicinal chemistry letters (15.11.2022)

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Journal Article

Cytochrome P450 3A4 and CYP3A5-Catalyzed Bioactivation of Lapatinib

Cytochrome P450 3A4 and CYP3A5-Catalyzed Bioactivation of Lapatinib

by Towles, Joanna K, Clark, Rebecca N, Wahlin, Michelle D, Uttamsingh, Vinita, Rettie, Allan E, Jackson, Klarissa D
Published in Drug metabolism and disposition (01.10.2016)

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Journal Article

Abstract 6539: RNAi mediated silencing of STAT3 in tumor-associated immune cells induces robust anti-tumor effects in immunotherapy resistant tumors

Abstract 6539: RNAi mediated silencing of STAT3 in tumor-associated immune cells induces robust anti-tumor effects in immunotherapy resistant tumors

by Ganesh, Shanthi, Kim, Minju, Lee, Jenny, Feng, Xudong, Krishnan, Harini Sivagurunatha, Rijnbrand, Rene, Beaudry, Amber, Lockridge, Jennifer A., Uttamsingh, Vinita, Hanrahan, John
Published in Cancer research (Chicago, Ill.) (22.03.2024)

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Journal Article

JAK TREATMENT OF HAIR LOSS DISORDERS WITH DEUTERATED JAK INHIBITORS

JAK TREATMENT OF HAIR LOSS DISORDERS WITH DEUTERATED JAK INHIBITORS

by GRAHAM PHILIP B, VON HEHN JANA, CASSELLA JAMES V, UTTAMSINGH VINITA, HAMILTON COLLEEN E, BRAMAN VIRGINIA, WAGNER AMANDA T
Year of Publication 15.06.2023

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Patent

Dual Therapeutic Effects of C-10068, a Dextromethorphan Derivative, Against Post-Traumatic Nonconvulsive Seizures and Neuroinflammation in a Rat Model of Penetrating Ballistic-Like Brain Injury

Dual Therapeutic Effects of C-10068, a Dextromethorphan Derivative, Against Post-Traumatic Nonconvulsive Seizures and Neuroinflammation in a Rat Model of Penetrating Ballistic-Like Brain Injury

by Lu, Xi-Chun May, Shear, Deborah A, Graham, Philip B, Bridson, Gary W, Uttamsingh, Vinita, Chen, Zhiyong, Leung, Lai Yee, Tortella, Frank C
Published in Journal of neurotrauma (15.10.2015)

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Journal Article

Abstract 3357: CTP-221, a deuterated S-enantiomer of lenalidomide, is greatly stabilized to epimerization and results in a more desirable pharmacokinetic profile than racemic lenalidomide

by Uttamsingh, Vinita, Gallegos, Richard, Cheng, Changfu, Aslanian, Ara, Liu, Julie Fields, Tung, Roger, Wu, Lijun
Published in Cancer research (Chicago, Ill.) (15.04.2013)

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Journal Article

Optimization of the in Vitro Cardiac Safety of Hydroxamate-Based Histone Deacetylase Inhibitors

Optimization of the in Vitro Cardiac Safety of Hydroxamate-Based Histone Deacetylase Inhibitors

by Shultz, Michael D, Cao, Xueying, Chen, Christine H, Cho, Young Shin, Davis, Nicole R, Eckman, Joe, Fan, Jianmei, Fekete, Alex, Firestone, Brant, Flynn, Julie, Green, Jack, Growney, Joseph D, Holmqvist, Mats, Hsu, Meier, Jansson, Daniel, Jiang, Lei, Kwon, Paul, Liu, Gang, Lombardo, Franco, Lu, Qiang, Majumdar, Dyuti, Meta, Christopher, Perez, Lawrence, Pu, Minying, Ramsey, Tim, Remiszewski, Stacy, Skolnik, Suzanne, Traebert, Martin, Urban, Laszlo, Uttamsingh, Vinita, Wang, Ping, Whitebread, Steven, Whitehead, Lewis, Yan-Neale, Yan, Yao, Yung-Mae, Zhou, Liping, Atadja, Peter
Published in Journal of medicinal chemistry (14.07.2011)

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Journal Article

Methods of treatment with deuterated CFTR potentiators

Methods of treatment with deuterated CFTR potentiators

by Uttamsingh, Vinita
Year of Publication 03.03.2022

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Patent

METHODS OF TREATMENT WITH DEUTERATED CFTR POTENTIATORS

METHODS OF TREATMENT WITH DEUTERATED CFTR POTENTIATORS

by Uttamsingh, Vinita
Year of Publication 25.02.2021

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Patent

중수소화된 JAK 저해제를 이용한 탈모 장애의 치료

중수소화된 JAK 저해제를 이용한 탈모 장애의 치료

by GRAHAM PHILIP B, VON HEHN JANA, CASSELLA JAMES V, UTTAMSINGH VINITA, HAMILTON COLLEEN E, BRAMAN VIRGINIA, WAGNER AMANDA T
Year of Publication 09.01.2019

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Patent

Identification and Characterization of Oxymetazoline Glucuronidation in Human Liver Microsomes: Evidence for the Involvement of UGT1 A9

Identification and Characterization of Oxymetazoline Glucuronidation in Human Liver Microsomes: Evidence for the Involvement of UGT1 A9

by MAHAJAN, Mukesh K, UTTAMSINGH, Vinita, GAN, Liang-Shang, LEDUC, Barbara, WILLIAMS, David A
Published in Journal of pharmaceutical sciences (2011)

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Journal Article

Identification and Characterization of Oxymetazoline Glucuronidation in Human Liver Microsomes: Evidence for the Involvement of UGT1A9

Identification and Characterization of Oxymetazoline Glucuronidation in Human Liver Microsomes: Evidence for the Involvement of UGT1A9

by Mahajan, Mukesh K., Uttamsingh, Vinita, Gan, Liang-Shang, Leduc, Barbara, Williams, David A.
Published in Journal of pharmaceutical sciences (01.02.2011)

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Journal Article

In Vitro Metabolism of Oxymetazoline: Evidence for Bioactivation to a Reactive Metabolite

In Vitro Metabolism of Oxymetazoline: Evidence for Bioactivation to a Reactive Metabolite

by MAHAJAN, Mukesh K, UTTAMSINGH, Vinita, DANIELS, J. Scott, GAN, Liang-Shang, LEDUC, Barbara W, WILLIAMS, David A
Published in Drug metabolism and disposition (01.04.2011)

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Journal Article

Methods of treatment with deuterated CFTR potentiators

Methods of treatment with deuterated CFTR potentiators

by Uttamsingh, Vinita
Year of Publication 16.05.2019

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Patent